{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T18:51:51Z","timestamp":1790707911129,"version":"4.1.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,3]]},"abstract":"\n Carbohydrate response element-binding protein (ChREBP) is critical in the regulation of fatty acid and triglyceride synthesis in the liver. Interestingly,\n Chrebp<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n mice show reduced levels of plasma cholesterol, which is critical for steroid hormone synthesis in adrenal glands. Furthermore,\n Chrebp<\/jats:italic>\n mRNA expression was previously reported in human adrenal glands. Thus, it remains to be investigated whether ChREBP plays a role directly or indirectly in steroid hormone synthesis and release in adrenal glands. In the present study, we find that\n Chrebp<\/jats:italic>\n mRNA is expressed in mouse adrenal glands and that ChREBP binds to carbohydrate response elements. Histological analysis of\n Chrebp<\/jats:italic>\n \n \u2212\/\u2212<\/jats:italic>\n <\/jats:sup>\n mice shows no adrenal hyperplasia and less oil red O staining compared with that in WT mice. In adrenal glands of\n \n Chrebp\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice, expression of\n Fasn<\/jats:italic>\n and\n Scd1<\/jats:italic>\n , two enzymes critical for fatty acid synthesis, was substantially lower and triglyceride content was reduced. Expression of\n Srebf2<\/jats:italic>\n , a key transcription factor controlling synthesis and uptake of cholesterol and the target genes, was upregulated, while cholesterol content was not significantly altered in the adrenal glands of\n \n Chrebp\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice. Adrenal corticosterone content and plasma adrenocorticotropic hormone and corticosterone levels were not significantly altered in\n \n Chrebp\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice. Consistently, expression of genes related to steroid hormone synthesis was not altered. Corticosterone secretion in response to two different stimuli, namely 24-h starvation and cosyntropin administration, was also not altered in\n \n Chrebp\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice. Taking these results together, corticosterone synthesis and release were not affected in\n \n Chrebp\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice despite reduced plasma cholesterol levels.\n <\/jats:p>","DOI":"10.1530\/joe-20-0442","type":"journal-article","created":{"date-parts":[[2021,2,4]],"date-time":"2021-02-04T10:36:51Z","timestamp":1612435011000},"page":"317-324","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":12,"title":["Effects of ChREBP deficiency on adrenal lipogenesis and steroidogenesis"],"prefix":"10.1530","volume":"248","author":[{"given":"Ken","family":"Takao","sequence":"first","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katsumi","family":"Iizuka","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanyan","family":"Liu","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruaki","family":"Sakurai","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sodai","family":"Kubota","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"},{"name":"2Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saki","family":"Kubota-Okamoto","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"},{"name":"2Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshinori","family":"Imaizumi","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshihiro","family":"Takahashi","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yermek","family":"Rakhat","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"},{"name":"2Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Satoko","family":"Komori","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tokuyuki","family":"Hirose","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kenta","family":"Nonomura","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takehiro","family":"Kato","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masami","family":"Mizuno","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tetsuya","family":"Suwa","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yukio","family":"Horikawa","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Masakatsu","family":"Sone","sequence":"additional","affiliation":[{"name":"3Division of Metabolism and Endocrinology, Department of Internal Medicine, St. Marianna University School of Medicine, Kawasaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daisuke","family":"Yabe","sequence":"additional","affiliation":[{"name":"1Department of Diabetes and Endocrinology, Gifu University Graduate School of Medicine, Gifu, Japan"},{"name":"2Yutaka Seino Distinguished Center for Diabetes Research, Kansai Electric Power Medical Research Institute, Kobe, Japan"},{"name":"4Division of Molecular and Metabolic Medicine, Department of Physiology and Cell Biology, Kobe University Graduate School of Medicine, Kobe, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of 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