{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:13Z","timestamp":1784557273479,"version":"3.55.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,5,1]]},"abstract":"<jats:p>\n                    Yes-associated protein (YAP), as a co-activator of transcription factors, is a downstream protein in the Hippo signaling pathway with important functions in cell proliferation, apoptosis, invasion and migration. YAP also plays a key role in the development of CCl\n                    <jats:sub>4<\/jats:sub>\n                    -induced liver fibrosis. However, the mechanism of YAP during hepatic fibrosis progression and reversion is still unclear. Mild liver fibrosis was developed after 4 months of high-fat diet (HFD) stimulation, and we found that the YAP signaling pathway was activated. Here, we aim to reveal whether specific knockout of\n                    <jats:italic>Yap<\/jats:italic>\n                    gene in the liver can improve liver fibrosis induced by insulin resistance (IR) stimulated by HFD, and further explain its specific mechanism. We found that liver-specific\n                    <jats:italic>Yap<\/jats:italic>\n                    gene knockout improved IR-induced liver fibrosis and liver dysfunction, and this mechanism is related to the inhibition of the insulin signal pathway at the FoxO1 level. These findings provide a new insight, and\n                    <jats:italic>Yap<\/jats:italic>\n                    is expected to be a new target to reverse the early stage of liver fibrosis induced by IR.\n                  <\/jats:p>","DOI":"10.1530\/joe-20-0561","type":"journal-article","created":{"date-parts":[[2021,3,24]],"date-time":"2021-03-24T13:40:59Z","timestamp":1616593259000},"page":"149-161","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":17,"title":["Liver knockout YAP gene improved insulin resistance-induced hepatic fibrosis"],"prefix":"10.1530","volume":"249","author":[{"given":"Yujiao","family":"Dai","sequence":"first","affiliation":[{"name":"1School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Hao","sequence":"additional","affiliation":[{"name":"1School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhimei","family":"Sun","sequence":"additional","affiliation":[{"name":"1School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyi","family":"Guo","sequence":"additional","affiliation":[{"name":"2School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hong","family":"Xu","sequence":"additional","affiliation":[{"name":"2School of Public Health, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lihui","family":"Xue","sequence":"additional","affiliation":[{"name":"3Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hongyu","family":"Song","sequence":"additional","affiliation":[{"name":"3Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yida","family":"Li","sequence":"additional","affiliation":[{"name":"3Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shuang","family":"Li","sequence":"additional","affiliation":[{"name":"3Department of Pharmacy, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingming","family":"Gao","sequence":"additional","affiliation":[{"name":"1School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teng","family":"Si","sequence":"additional","affiliation":[{"name":"1School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yuxin","family":"Zhang","sequence":"additional","affiliation":[{"name":"1School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China"},{"name":"4Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China"},{"name":"5Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yajuan","family":"Qi","sequence":"additional","affiliation":[{"name":"1School of Basic Medical Sciences, North China University of Science and Technology, Tangshan, Hebei, China"},{"name":"4Hebei Key Laboratory for Chronic Diseases, North China University of Science and Technology, Tangshan, Hebei, China"},{"name":"5Tangshan Key Laboratory of Basic Research in Medicine Development, North China University of Science and Technology, Tangshan, Hebei, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/249\/2\/JOE-20-0561.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/249\/2\/JOE-20-0561.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:57:25Z","timestamp":1784555845000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/249\/2\/149-161\/5434"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,5,1]]},"references-count":0,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/joe-20-0561","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,5,1]]}}}