{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T03:44:49Z","timestamp":1792640689882,"version":"4.5.0"},"reference-count":0,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,1,1]]},"abstract":"\n Changes in dietary habits have occurred concomitantly with a rise of type 2 diabetes (T2D) and obesity. Intestine is the first organ facing nutrient ingestion and has to adapt its metabolism with these dietary changes. HNF-4\u03b3, a transcription factor member of the nuclear receptor superfamily and mainly expressed in intestine, has been suggested to be involved in susceptibility to T2D. Our aim was to investigate the role of HNF-4\u03b3 in metabolic disorders and related mechanisms.\n \n Hnf4g\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice were fed high-fat\/high-fructose (HF-HF) diet for 6 weeks to induce obesity and T2D. Glucose homeostasis, energy homeostasis in metabolic cages, body composition and stool energy composition, as well as gene expression analysis in the jejunum were analyzed. Despite an absence of decrease in calorie intake, of increase in locomotor activity or energy expenditure,\n \n Hnf4g\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice fed with HF-HF are protected against weight gain after 6 weeks of HF-HF diet. We showed that\n \n Hnf4g\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice fed HF-HF display an increase in fecal calorie loss, mainly due to intestinal lipid malabsorption. Gene expression of lipid transporters,\n Fatp4<\/jats:italic>\n and\n Scarb1<\/jats:italic>\n and of triglyceride-rich lipoprotein secretion proteins,\n Mttp<\/jats:italic>\n and\n ApoB<\/jats:italic>\n are decreased in gut epithelium of\n \n Hnf4g\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice fed HF-HF, showing the HNF-4\u03b3 role in intestine lipid absorption. Furthermore, plasma GLP-1 and jejunal GLP-1 content are increased in\n \n Hnf4g\n \u2212\/\u2212<\/jats:sup>\n <\/jats:italic>\n mice fed HF-HF, which could contribute to the glucose intolerance protection. The loss of HNF-4\u03b3 leads to a protection against a diet-induced weight gain and to a deregulated glucose homeostasis, associated with lipid malabsorption.\n <\/jats:p>","DOI":"10.1530\/joe-21-0092","type":"journal-article","created":{"date-parts":[[2021,10,14]],"date-time":"2021-10-14T08:13:18Z","timestamp":1634199198000},"page":"31-44","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":15,"title":["Hnf4g invalidation prevents diet-induced obesity via intestinal lipid malabsorption"],"prefix":"10.1530","volume":"252","author":[{"given":"Sami","family":"Ayari","sequence":"first","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"Gil-Iturbe","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L\u00e9a","family":"le Gl\u00e9au","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C\u00e9line","family":"Osinski","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathalie","family":"Kapel","sequence":"additional","affiliation":[{"name":"2AP-HP H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Functional Coprology Department, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hedi Antoine","family":"Soula","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Armelle","family":"Leturque","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrizio","family":"Andreelli","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"},{"name":"3AP-HP H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Nutrition Department, Paris, France"},{"name":"4AP-HP H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Diabetology-Metabolism Department, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karine","family":"Cl\u00e9ment","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"},{"name":"3AP-HP H\u00f4pital Piti\u00e9-Salp\u00eatri\u00e8re-Charles Foix, Nutrition Department, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Serradas","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2063-6084","authenticated-orcid":true,"given":"Agn\u00e8s","family":"Ribeiro","sequence":"additional","affiliation":[{"name":"1Sorbonne Universit\u00e9, INSERM, Nutrition and Obesities: Systemic Approaches, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/252\/1\/JOE-21-0092.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/252\/1\/JOE-21-0092.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:57:30Z","timestamp":1784555850000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/252\/1\/31-44\/5483"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,1,1]]},"references-count":0,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.1530\/joe-21-0092","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,1,1]]}}}