{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,20]],"date-time":"2026-08-20T14:58:03Z","timestamp":1787237883346,"version":"build-2736575974"},"reference-count":52,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2022,9,1]],"date-time":"2022-09-01T00:00:00Z","timestamp":1661990400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,9,1]]},"abstract":"<jats:p>\n                    Patients with advanced chronic kidney disease (CKD) often present with skeletal abnormalities, a condition known as renal osteodystrophy (ROD). While tissue non-specific alkaline phosphatase (TNAP) and PHOSPHO1 are critical for bone mineralization, their role in the etiology of ROD is unclear. To address this, ROD was induced in both WT and\n                    <jats:italic>Phospho1<\/jats:italic>\n                    knockout (P1KO) mice through dietary adenine supplementation. The mice presented with hyperphosphatemia, hyperparathyroidism, and elevated levels of FGF23 and bone turnover markers. In particular, we noted that in CKD mice, bone mineral density (BMD) was increased in cortical bone (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009 &lt; 0.05) but decreased in trabecular bone (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009 &lt; 0.05). These changes were accompanied by decreased TNAP (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009 &lt; 0.01) and increased PHOSPHO1 (\n                    <jats:italic>P<\/jats:italic>\n                    \u2009 &lt; 0.001) expression in WT CKD bones. In P1KO CKD mice, the cortical BMD phenotype was rescued, suggesting that the increased cortical BMD of CKD mice was driven by increased PHOSPHO1 expression. Other structural parameters were also improved in P1KO CKD mice. We further investigated the driver of the mineralization defects, by studying the effects of FGF23, PTH, and phosphate administration on PHOSPHO1 and TNAP expression by primary murine osteoblasts. We found both PHOSPHO1 and TNAP expressions to be downregulated in response to phosphate and PTH. The\n                    <jats:italic>in vitro<\/jats:italic>\n                    data suggest that the TNAP reduction in CKD-MBD is driven by the hyperphosphatemia and\/or hyperparathyroidism noted in these mice, while the higher PHOSPHO1 expression may be a compensatory mechanism. Increased PHOSPHO1 expression in ROD may contribute to the disordered skeletal mineralization characteristic of this progressive disorder.\n                  <\/jats:p>","DOI":"10.1530\/joe-22-0097","type":"journal-article","created":{"date-parts":[[2022,7,27]],"date-time":"2022-07-27T13:38:31Z","timestamp":1658929111000},"page":"153-167","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":20,"title":["Increased PHOSPHO1 expression mediates cortical bone mineral density in renal osteodystrophy"],"prefix":"10.1530","volume":"254","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8014-6311","authenticated-orcid":true,"given":"Shun-Neng","family":"Hsu","sequence":"first","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"},{"name":"Division of Nephrology, Department of Medicine, Tri-Service General Hospital, National Defense Medical Center, Taipei, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise A","family":"Stephen","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Dillon","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elspeth","family":"Milne","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Behzad","family":"Javaheri","sequence":"additional","affiliation":[{"name":"Comparative Biomedical Sciences, The Royal Veterinary College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew A","family":"Pitsillides","sequence":"additional","affiliation":[{"name":"Comparative Biomedical Sciences, The Royal Veterinary College, London, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amanda","family":"Novak","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jose Luis","family":"Mill\u00e1n","sequence":"additional","affiliation":[{"name":"Sanford Burnham Prebys Medical Discovery Institute, La Jolla, California, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky E","family":"MacRae","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katherine A","family":"Staines","sequence":"additional","affiliation":[{"name":"Centre for Stress and Age-Related Disease, University of Brighton, Brighton, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4970-4039","authenticated-orcid":true,"given":"Colin","family":"Farquharson","sequence":"additional","affiliation":[{"name":"The Roslin Institute and Royal (Dick) School of Veterinary Studies, University of Edinburgh, Easter Bush, Midlothian, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"BMC Nephrology","article-title":"Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism","volume":"19","author":"Bajwa","year":"2018","unstructured":"Bajwa NMSanchez CPLindsey RCWatt HMohan S2018Cortical and trabecular bone are equally affected in rats with renal failure and secondary hyperparathyroidism. BMC Nephrology19 24. (https:\/\/doi.org\/10.1186\/s12882-018-0822-8)"},{"key":"bib2","series-title":"PNAS","doi-asserted-by":"publisher","first-page":"8352","DOI":"10.1073\/pnas.140021997","article-title":"Phosphate is a specific signal for induction of osteopontin gene expression","volume":"97","author":"Beck","year":"2000","unstructured":"Beck Jr GRZerler BMoran E2000Phosphate is a specific signal for induction of osteopontin gene expression. PNAS978352\u20138357. (https:\/\/doi.org\/10.1073\/pnas.140021997)10.1073\/pnas.140021997"},{"key":"bib3","series-title":"Journal of Bone and Mineral Research","doi-asserted-by":"publisher","first-page":"1101","DOI":"10.1002\/jbmr.3691","article-title":"Slc20a2, encoding the phosphate transporter PiT2, is an important genetic determinant of bone quality and strength","volume":"34","author":"Beck-Cormier","year":"2019","unstructured":"Beck-Cormier SLelliott CJLogan JGLafont DTMerametdjian LLeitch VDButterfield NCProtheroe HJCroucher PIBaldock PA2019Slc20a2, encoding the phosphate transporter PiT2, is an important genetic determinant of bone quality and strength. Journal of Bone and Mineral Research341101\u20131114. (https:\/\/doi.org\/10.1002\/jbmr.3691)10.1002\/jbmr.3691"},{"key":"bib4","series-title":"American Journal of Kidney Diseases","doi-asserted-by":"publisher","first-page":"997","DOI":"10.1016\/S0272-6386(03)00197-5","article-title":"Useful biochemical markers for diagnosing renal osteodystrophy in predialysis end-stage renal failure patients","volume":"41","author":"Bervoets","year":"2003","unstructured":"Bervoets ARJSpasovski GBBehets GJDams GPolenakovic MHZafirovska KVan Hoof VODe Broe MED'Haese PC2003Useful biochemical markers for diagnosing renal osteodystrophy in predialysis end-stage renal failure patients. American Journal of Kidney Diseases41997\u20131007. (https:\/\/doi.org\/10.1016\/s0272-6386(0300197-5)10.1016\/S0272-6386(03)00197-5"},{"key":"bib5","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1007\/s00223-018-0399-z","article-title":"Alkaline phosphatases in the complex chronic kidney disease-mineral and bone disorders","volume":"103","author":"Bover","year":"2018","unstructured":"Bover JUre\u00f1a PAguilar AMazzaferro SBenito SL\u00f3pez-B\u00e1ez VRamos AdaSilva ICozzolino M2018Alkaline phosphatases in the complex chronic kidney disease-mineral and bone disorders. Calcified Tissue International103111\u2013124. (https:\/\/doi.org\/10.1007\/s00223-018-0399-z)10.1007\/s00223-018-0399-z"},{"key":"bib6","series-title":"Journal of Anatomy","doi-asserted-by":"publisher","first-page":"298","DOI":"10.1111\/joa.12628","article-title":"A distinctive patchy osteomalacia characterises phospho1-deficient mice","volume":"231","author":"Boyde","year":"2017","unstructured":"Boyde AStaines KAJavaheri BMillan JLPitsillides AAFarquharson C2017A distinctive patchy osteomalacia characterises phospho1-deficient mice. Journal of Anatomy231298\u2013308. (https:\/\/doi.org\/10.1111\/joa.12628)10.1111\/joa.12628"},{"key":"bib7","series-title":"Nature Reviews: Endocrinology","first-page":"637","article-title":"Role of phosphate sensing in bone and mineral metabolism","volume":"14","author":"Chande","year":"2018","unstructured":"Chande SBergwitz C2018Role of phosphate sensing in bone and mineral metabolism. Nature Reviews: Endocrinology14637\u2013655. (https:\/\/doi.org\/10.1038\/s41574-018-0076-3)"},{"key":"bib8","series-title":"Matrix Biology","first-page":"284","article-title":"Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro","volume":"52\u201354","author":"Chaudhary","year":"2016","unstructured":"Chaudhary SCKuzynski MBottini MBeniash EDokland TMobley CGYadav MCPoliard AKellermann OMill\u00e1n JL2016Phosphate induces formation of matrix vesicles during odontoblast-initiated mineralization in vitro. Matrix Biology52\u201354284\u2013300. (https:\/\/doi.org\/10.1016\/j.matbio.2016.02.003)"},{"key":"bib9","series-title":"Journal of Bone and Mineral Research","first-page":"716","article-title":"Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles","volume":"25","author":"Ciancaglini","year":"2010","unstructured":"Ciancaglini PYadav MCSim\u00e3o AMNarisawa SPizauro JMFarquharson CHoylaerts MFMill\u00e1n JL2010Kinetic analysis of substrate utilization by native and TNAP-, NPP1-, or PHOSPHO1-deficient matrix vesicles. Journal of Bone and Mineral Research25716\u2013723. (https:\/\/doi.org\/10.1359\/jbmr.091023)"},{"key":"bib10","series-title":"Journal of Clinical Investigation","doi-asserted-by":"publisher","first-page":"6510","DOI":"10.1172\/JCI135665","article-title":"Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion","volume":"130","author":"Clerin","year":"2020","unstructured":"Clerin VSaito HFilipski KJNguyen AHGarren JKisucka JReyes MJ\u00fcppner H2020Selective pharmacological inhibition of the sodium-dependent phosphate cotransporter NPT2a promotes phosphate excretion. Journal of Clinical Investigation1306510\u20136522. (https:\/\/doi.org\/10.1172\/JCI135665)10.1172\/JCI135665"},{"key":"bib11","series-title":"Kidney International","doi-asserted-by":"publisher","first-page":"S70","DOI":"10.1046\/j.1523-1755.1999.07308.x","article-title":"Low bone turnover in patients with renal failure","volume":"56","author":"Couttenye","year":"1999","unstructured":"Couttenye MMD'Haese PCVerschoren WJBehets GJSchrooten IDe Broe ME1999Low bone turnover in patients with renal failure. Kidney International56S70\u2013S76. (https:\/\/doi.org\/10.1046\/j.1523-1755.1999.07308.x)10.1046\/j.1523-1755.1999.07308.x"},{"key":"bib12","series-title":"Plant, Cell and Environment","doi-asserted-by":"publisher","first-page":"191","DOI":"10.1111\/pce.14191","article-title":"Rice acid phosphatase 1 regulates Pi stress adaptation by maintaining intracellular Pi homeostasis","volume":"45","author":"Deng","year":"2022","unstructured":"Deng SLi JDu ZWu ZYang JCai HWu GXu FHuang YWang S2022Rice acid phosphatase 1 regulates Pi stress adaptation by maintaining intracellular Pi homeostasis. Plant, Cell and Environment45191\u2013205. (https:\/\/doi.org\/10.1111\/pce.14191)10.1111\/pce.14191"},{"key":"bib13","series-title":"JBMR Plus","article-title":"How to build a bone: PHOSPHO1, biomineralization, and beyond","volume":"3","author":"Dillon","year":"2019","unstructured":"Dillon SStaines KAMill\u00e1n JLFarquharson C2019How to build a bone: PHOSPHO1, biomineralization, and beyond. JBMR Plus3 e10202. (https:\/\/doi.org\/10.1002\/jbm4.10202)"},{"key":"bib14","series-title":"Kidney International","doi-asserted-by":"publisher","first-page":"289","DOI":"10.1016\/j.kint.2015.12.004","article-title":"Changing bone patterns with progression of chronic kidney disease","volume":"89","author":"Dr\u00fceke","year":"2016","unstructured":"Dr\u00fceke TBMassy ZA2016Changing bone patterns with progression of chronic kidney disease. Kidney International89289\u2013302. (https:\/\/doi.org\/10.1016\/j.kint.2015.12.004)10.1016\/j.kint.2015.12.004"},{"key":"bib15","series-title":"Kidney International","doi-asserted-by":"publisher","first-page":"235","DOI":"10.1038\/ki.2015.156","article-title":"Sclerostin and DKK1: new players in renal bone and vascular disease","volume":"88","author":"Evenepoel","year":"2015","unstructured":"Evenepoel PD'Haese PBrandenburg V2015Sclerostin and DKK1: new players in renal bone and vascular disease. Kidney International88235\u2013240. (https:\/\/doi.org\/10.1038\/ki.2015.156)10.1038\/ki.2015.156"},{"key":"bib16","series-title":"Kidney International","doi-asserted-by":"publisher","first-page":"142","DOI":"10.1038\/ki.2013.271","article-title":"Early chronic kidney disease-mineral bone disorder stimulates vascular calcification","volume":"85","author":"Fang","year":"2014","unstructured":"Fang YGinsberg CSugatani TMonier-Faugere MCMalluche HHruska KA2014Early chronic kidney disease-mineral bone disorder stimulates vascular calcification. Kidney International85142\u2013150. (https:\/\/doi.org\/10.1038\/ki.2013.271)10.1038\/ki.2013.271"},{"key":"bib17","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"103","DOI":"10.1007\/s00223-005-0184-7","article-title":"Regulation of cementoblast gene expression by inorganic phosphate in vitro","volume":"78","author":"Foster","year":"2006","unstructured":"Foster BLNociti Jr FHSwanson ECMatsa-Dunn DBerry JECupp CJZhang PSomerman MJ2006Regulation of cementoblast gene expression by inorganic phosphate in vitro. Calcified Tissue International78103\u2013112. (https:\/\/doi.org\/10.1007\/s00223-005-0184-7)10.1007\/s00223-005-0184-7"},{"key":"bib18","series-title":"Advances in Chronic Kidney Disease","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1053\/j.ackd.2006.10.010","article-title":"Bone health in chronic kidney disease-mineral and bone disease","volume":"14","author":"Gal-Moscovici","year":"2007","unstructured":"Gal-Moscovici ASprague SM2007Bone health in chronic kidney disease-mineral and bone disease. Advances in Chronic Kidney Disease1427\u201336. (https:\/\/doi.org\/10.1053\/j.ackd.2006.10.010)10.1053\/j.ackd.2006.10.010"},{"key":"bib19","series-title":"Kidney International","doi-asserted-by":"publisher","first-page":"1436","DOI":"10.1016\/j.kint.2016.12.029","article-title":"The complexity of chronic kidney disease-mineral and bone disorder across stages of chronic kidney disease","volume":"91","author":"Graciolli","year":"2017","unstructured":"Graciolli FGNeves KRBarreto FBarreto DVDos Reis LMCanziani MESabbagh YCarvalho ABJorgetti VElias RM2017The complexity of chronic kidney disease-mineral and bone disorder across stages of chronic kidney disease. Kidney International911436\u20131446. (https:\/\/doi.org\/10.1016\/j.kint.2016.12.029)10.1016\/j.kint.2016.12.029"},{"key":"bib20","series-title":"PNAS","doi-asserted-by":"publisher","first-page":"9445","DOI":"10.1073\/pnas.142063399","article-title":"Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization","volume":"99","author":"Hessle","year":"2002","unstructured":"Hessle LJohnson KAAnderson HCNarisawa SSali AGoding JWTerkeltaub RMillan JL2002Tissue-nonspecific alkaline phosphatase and plasma cell membrane glycoprotein-1 are central antagonistic regulators of bone mineralization. PNAS999445\u20139449. (https:\/\/doi.org\/10.1073\/pnas.142063399)10.1073\/pnas.142063399"},{"key":"bib21","series-title":"Bone","doi-asserted-by":"publisher","first-page":"629","DOI":"10.1016\/j.bone.2003.12.023","article-title":"PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage","volume":"34","author":"Houston","year":"2004","unstructured":"Houston BStewart AJFarquharson C2004PHOSPHO1-A novel phosphatase specifically expressed at sites of mineralisation in bone and cartilage. Bone34629\u2013637. (https:\/\/doi.org\/10.1016\/j.bone.2003.12.023)10.1016\/j.bone.2003.12.023"},{"key":"bib22","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"510","DOI":"10.1007\/s00223-016-0176-9","article-title":"The expression of PHOSPHO1, nSMase2 and TNAP is coordinately regulated by continuous PTH exposure in mineralising osteoblast cultures","volume":"99","author":"Houston","year":"2016","unstructured":"Houston DAMyers KMacRae VEStaines KAFarquharson C2016The expression of PHOSPHO1, nSMase2 and TNAP is coordinately regulated by continuous PTH exposure in mineralising osteoblast cultures. Calcified Tissue International99510\u2013524. (https:\/\/doi.org\/10.1007\/s00223-016-0176-9)10.1007\/s00223-016-0176-9"},{"key":"bib23","series-title":"Kidney International","doi-asserted-by":"publisher","first-page":"148","DOI":"10.1038\/ki.2008.130","article-title":"Hyperphosphatemia of chronic kidney disease","volume":"74","author":"Hruska","year":"2008","unstructured":"Hruska KAMathew SLund RQiu PPratt R2008Hyperphosphatemia of chronic kidney disease. Kidney International74148\u2013157. (https:\/\/doi.org\/10.1038\/ki.2008.130)10.1038\/ki.2008.130"},{"key":"bib24","series-title":"Biochemistry and Biophysics Reports","doi-asserted-by":"publisher","first-page":"196","DOI":"10.1016\/j.bbrep.2015.09.013","article-title":"The functional co-operativity of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization","volume":"4","author":"Huesa","year":"2015","unstructured":"Huesa CHouston DKiffer-Moreira TYadav MMMillan JLFarquharson C2015The functional co-operativity of tissue-nonspecific alkaline phosphatase (TNAP) and PHOSPHO1 during initiation of skeletal mineralization. Biochemistry and Biophysics Reports4196\u2013201. (https:\/\/doi.org\/10.1016\/j.bbrep.2015.09.013)10.1016\/j.bbrep.2015.09.013"},{"key":"bib25","series-title":"BMC Nephrology","article-title":"A novel model of adenine-induced tubulointerstitial nephropathy in mice","volume":"14","author":"Jia","year":"2013","unstructured":"Jia TOlauson HLindberg KAmin REdvardsson KLindholm BAndersson GWernerson ASabbagh YSchiavi S2013A novel model of adenine-induced tubulointerstitial nephropathy in mice. BMC Nephrology14 116. (https:\/\/doi.org\/10.1186\/1471-2369-14-116)"},{"key":"bib26","series-title":"Inflammation Research","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00011-018-1200-5","article-title":"The role of osteopontin in kidney diseases","volume":"68","author":"Kaleta","year":"2019","unstructured":"Kaleta B2019The role of osteopontin in kidney diseases. Inflammation Research6893\u2013102. (https:\/\/doi.org\/10.1007\/s00011-018-1200-5)10.1007\/s00011-018-1200-5"},{"key":"bib27","series-title":"Kidney International Supplements","doi-asserted-by":"publisher","first-page":"446","DOI":"10.1038\/kisup.2013.93","article-title":"Uremic osteoporosis","volume":"3","author":"Kazama","year":"2013","unstructured":"Kazama JJIwasaki YFukagawa M2013Uremic osteoporosis. Kidney International Supplements3446\u2013450. (https:\/\/doi.org\/10.1038\/kisup.2013.93)10.1038\/kisup.2013.93"},{"key":"bib28","series-title":"Nephrology, Dialysis, Transplantation","doi-asserted-by":"publisher","first-page":"62","DOI":"10.1093\/ndt\/gfs333","article-title":"High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease","volume":"28","author":"Lau","year":"2013","unstructured":"Lau WLLinnes MChu EYFoster BLBartley BASomerman MJGiachelli CM2013High phosphate feeding promotes mineral and bone abnormalities in mice with chronic kidney disease. Nephrology, Dialysis, Transplantation2862\u201369. (https:\/\/doi.org\/10.1093\/ndt\/gfs333)10.1093\/ndt\/gfs333"},{"key":"bib29","series-title":"Endocrinology","doi-asserted-by":"publisher","first-page":"4047","DOI":"10.1210\/endo.142.9.8356","article-title":"Catabolic effects of continuous human PTH (1\u201338) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation","volume":"142","author":"Ma","year":"2001","unstructured":"Ma YLCain RLHalladay DLYang XZeng QMiles RRChandrasekhar SMartin TJOnyia JE2001Catabolic effects of continuous human PTH (1\u201338) in vivo is associated with sustained stimulation of RANKL and inhibition of osteoprotegerin and gene-associated bone formation. Endocrinology1424047\u20134054. (https:\/\/doi.org\/10.1210\/endo.142.9.8356)10.1210\/endo.142.9.8356"},{"key":"bib30","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"392","DOI":"10.1007\/s00223-019-00642-w","article-title":"Elevations in cortical porosity occur prior to significant rise in serum parathyroid hormone in young female mice with adenine-induced CKD","volume":"106","author":"Metzger","year":"2020","unstructured":"Metzger CESwallow EAAllen MR2020Elevations in cortical porosity occur prior to significant rise in serum parathyroid hormone in young female mice with adenine-induced CKD. Calcified Tissue International106392\u2013400. (https:\/\/doi.org\/10.1007\/s00223-019-00642-w)10.1007\/s00223-019-00642-w"},{"key":"bib31","series-title":"PLoS ONE","article-title":"Adenine-induced chronic kidney disease induces a similar skeletal phenotype in male and female C57BL\/6 mice with more severe deficits in cortical bone properties of male mice","volume":"16","author":"Metzger","year":"2021","unstructured":"Metzger CESwallow EAStacy AJAllen MR2021Adenine-induced chronic kidney disease induces a similar skeletal phenotype in male and female C57BL\/6 mice with more severe deficits in cortical bone properties of male mice. PLoS ONE16 e0250438. (https:\/\/doi.org\/10.1371\/journal.pone.0250438)"},{"key":"bib32","series-title":"Bone","doi-asserted-by":"publisher","first-page":"257","DOI":"10.1016\/S8756-3282(98)00098-2","article-title":"Disparate effects of mild, moderate, and severe secondary hyperparathyroidism on cancellous and cortical bone in rats with chronic renal insufficiency","volume":"23","author":"Miller","year":"1998","unstructured":"Miller MAChin JMiller SCFox J1998Disparate effects of mild, moderate, and severe secondary hyperparathyroidism on cancellous and cortical bone in rats with chronic renal insufficiency. Bone23257\u2013266. (https:\/\/doi.org\/10.1016\/s8756-3282(9800098-2)10.1016\/S8756-3282(98)00098-2"},{"key":"bib33","series-title":"Nephrology, Dialysis, Transplantation","doi-asserted-by":"publisher","first-page":"3125","DOI":"10.1093\/ndt\/gfp205","article-title":"Relationship between circulating FGF23 and total body atherosclerosis in the community","volume":"24","author":"Mirza","year":"2009","unstructured":"Mirza MAHansen TJohansson LAhlstr\u00f6m HLarsson ALind LLarsson TE2009Relationship between circulating FGF23 and total body atherosclerosis in the community. Nephrology, Dialysis, Transplantation243125\u20133131. (https:\/\/doi.org\/10.1093\/ndt\/gfp205)10.1093\/ndt\/gfp205"},{"key":"bib34","series-title":"Kidney International","doi-asserted-by":"publisher","first-page":"1945","DOI":"10.1038\/sj.ki.5000414","article-title":"Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO)","volume":"69","author":"Moe","year":"2006","unstructured":"Moe SDr\u00fceke TCunningham JGoodman WMartin KOlgaard KOtt SSprague SLameire NEknoyan G2006Definition, evaluation, and classification of renal osteodystrophy: a position statement from kidney disease: improving global outcomes (KDIGO). Kidney International691945\u20131953. (https:\/\/doi.org\/10.1038\/sj.ki.5000414)10.1038\/sj.ki.5000414"},{"key":"bib35","series-title":"PLoS Biology","article-title":"Excessive osteocytic FGF23 secretion contributes to pyrophosphate accumulation and mineralization defect in Hyp mice","volume":"14","author":"Murali","year":"2016a","unstructured":"Murali SKAndrukhova OClinkenbeard ELWhite KEErben RG2016aExcessive osteocytic FGF23 secretion contributes to pyrophosphate accumulation and mineralization defect in Hyp mice. PLoS Biology14 e1002427. (https:\/\/doi.org\/10.1371\/journal.pbio.1002427)"},{"key":"bib36","series-title":"Journal of Bone and Mineral Research","doi-asserted-by":"publisher","first-page":"129","DOI":"10.1002\/jbmr.2606","article-title":"FGF23 regulates bone mineralization in a 1,25(OH)2 D3 and klotho-independent manner","volume":"31","author":"Murali","year":"2016b","unstructured":"Murali SKRoschger PZeitz UKlaushofer KAndrukhova OErben RG2016bFGF23 regulates bone mineralization in a 1,25(OH)2 D3 and klotho-independent manner. Journal of Bone and Mineral Research31129\u2013142. (https:\/\/doi.org\/10.1002\/jbmr.2606)10.1002\/jbmr.2606"},{"key":"bib37","series-title":"Journal of Bone and Mineral Research","doi-asserted-by":"publisher","first-page":"1811","DOI":"10.1002\/jbmr.1916","article-title":"Rapid cortical bone loss in patients with chronic kidney disease","volume":"28","author":"Nickolas","year":"2013","unstructured":"Nickolas TLStein EMDworakowski ENishiyama KKKomandah-Kosseh MZhang CAMcMahon DJLiu XSBoutroy SCremers S2013Rapid cortical bone loss in patients with chronic kidney disease. Journal of Bone and Mineral Research281811\u20131820. (https:\/\/doi.org\/10.1002\/jbmr.1916)10.1002\/jbmr.1916"},{"key":"bib38","series-title":"Endocrine Journal","doi-asserted-by":"publisher","first-page":"407","DOI":"10.1507\/endocrj.K05-009","article-title":"Sex difference of adenine effects in rats: renal function, bone mineral density and sex steroidogenesis","volume":"53","author":"Ogirima","year":"2006","unstructured":"Ogirima TTano KKanehara MGao MWang XGuo YZhang YGuo LIshida T2006Sex difference of adenine effects in rats: renal function, bone mineral density and sex steroidogenesis. Endocrine Journal53407\u2013413. (https:\/\/doi.org\/10.1507\/endocrj.k05-009)10.1507\/endocrj.K05-009"},{"key":"bib39","series-title":"Trends in Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"60","DOI":"10.1016\/j.tem.2004.01.006","article-title":"Parathyroid hormone: a double-edged sword for bone metabolism","volume":"15","author":"Qin","year":"2004","unstructured":"Qin LRaggatt LJPartridge NC2004Parathyroid hormone: a double-edged sword for bone metabolism. Trends in Endocrinology and Metabolism1560\u201365. (https:\/\/doi.org\/10.1016\/j.tem.2004.01.006)10.1016\/j.tem.2004.01.006"},{"key":"bib40","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"474","DOI":"10.1007\/s00223-013-9831-6","article-title":"Effects of extracellular phosphate on gene expression in murine osteoblasts","volume":"94","author":"Rendenbach","year":"2014","unstructured":"Rendenbach CYorgan TAHeckt TOtto BBaldauf CJeschke AStreichert TDavid JPAmling MSchinke T2014Effects of extracellular phosphate on gene expression in murine osteoblasts. Calcified Tissue International94474\u2013483. (https:\/\/doi.org\/10.1007\/s00223-013-9831-6)10.1007\/s00223-013-9831-6"},{"key":"bib41","series-title":"Journal of Bone and Mineral Research","doi-asserted-by":"publisher","first-page":"617","DOI":"10.1359\/jbmr.070108","article-title":"Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization","volume":"22","author":"Roberts","year":"2007","unstructured":"Roberts SNarisawa SHarmey DMillan JLFarquharson C2007Functional involvement of PHOSPHO1 in matrix vesicle-mediated skeletal mineralization. Journal of Bone and Mineral Research22617\u2013627. (https:\/\/doi.org\/10.1359\/jbmr.070108)10.1359\/jbmr.070108"},{"key":"bib42","series-title":"Calcified Tissue International","doi-asserted-by":"publisher","first-page":"140","DOI":"10.1007\/s00223-011-9501-5","article-title":"Fibroblast growth factor 23 (FGF23) and alpha-klotho stimulate osteoblastic MC3T3.E1 cell proliferation and inhibit mineralization","volume":"89","author":"Shalhoub","year":"2011","unstructured":"Shalhoub VWard SCSun BStevens JRenshaw LHawkins NRichards WG2011Fibroblast growth factor 23 (FGF23) and alpha-klotho stimulate osteoblastic MC3T3.E1 cell proliferation and inhibit mineralization. Calcified Tissue International89140\u2013150. (https:\/\/doi.org\/10.1007\/s00223-011-9501-5)10.1007\/s00223-011-9501-5"},{"key":"bib43","series-title":"Journal of Clinical Investigation","doi-asserted-by":"publisher","first-page":"561","DOI":"10.1172\/JCI200419081","article-title":"Targeted ablation of FGF23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism","volume":"113","author":"Shimada","year":"2004","unstructured":"Shimada TKakitani MYamazaki YHasegawa HTakeuchi YFujita TFukumoto STomizuka KYamashita T2004Targeted ablation of FGF23 demonstrates an essential physiological role of FGF23 in phosphate and vitamin D metabolism. Journal of Clinical Investigation113561\u2013568. (https:\/\/doi.org\/10.1172\/JCI19081)10.1172\/JCI200419081"},{"key":"bib44","series-title":"Physiologia Plantarum","doi-asserted-by":"publisher","first-page":"138","DOI":"10.1034\/j.1399-3054.2003.00091.x","article-title":"Differential expression of the LePS2 phosphatase gene family in response to phosphate availability, pathogen infection and during development","volume":"118","author":"Stenzel","year":"2003","unstructured":"Stenzel IZiethe KSchurath JHertel SCBosse DK\u00f6ck M2003Differential expression of the LePS2 phosphatase gene family in response to phosphate availability, pathogen infection and during development. Physiologia Plantarum118138\u2013146. (https:\/\/doi.org\/10.1034\/j.1399-3054.2003.00091.x)10.1034\/j.1399-3054.2003.00091.x"},{"key":"bib45","series-title":"Histochemistry and Cell Biology","doi-asserted-by":"publisher","first-page":"483","DOI":"10.1007\/s00418-009-0557-5","article-title":"Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model","volume":"131","author":"Tamura","year":"2009","unstructured":"Tamura MAizawa RHori MOzaki H2009Progressive renal dysfunction and macrophage infiltration in interstitial fibrosis in an adenine-induced tubulointerstitial nephritis mouse model. Histochemistry and Cell Biology131483\u2013490. (https:\/\/doi.org\/10.1007\/s00418-009-0557-5)10.1007\/s00418-009-0557-5"},{"key":"bib46","series-title":"Journal of Clinical Investigation","doi-asserted-by":"publisher","first-page":"4065","DOI":"10.1172\/JCI42004","article-title":"Lipocalin 2 is essential for chronic kidney disease progression in mice and humans","volume":"120","author":"Viau","year":"2010","unstructured":"Viau AEl Karoui KLaouari DBurtin MNguyen CMori KPillebout EBerger TMak TWKnebelmann B2010Lipocalin 2 is essential for chronic kidney disease progression in mice and humans. Journal of Clinical Investigation1204065\u20134076. (https:\/\/doi.org\/10.1172\/JCI42004)10.1172\/JCI42004"},{"key":"bib47","series-title":"Arteriosclerosis, Thrombosis, and Vascular Biology","doi-asserted-by":"publisher","first-page":"761","DOI":"10.1161\/ATVBAHA.108.183384","article-title":"Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition","volume":"29","author":"Villa-Bellosta","year":"2009","unstructured":"Villa-Bellosta RSorribas V2009Phosphonoformic acid prevents vascular smooth muscle cell calcification by inhibiting calcium-phosphate deposition. Arteriosclerosis, Thrombosis, and Vascular Biology29761\u2013766. (https:\/\/doi.org\/10.1161\/ATVBAHA.108.183384)10.1161\/ATVBAHA.108.183384"},{"key":"bib48","series-title":"Principles of Bone Biology","first-page":"1573","article-title":"Chapter 73: Hypophosphatasia: nature\u2019s window on alkaline phosphatase function in humans","author":"Whyte","year":"2008","unstructured":"Whyte MP2008Chapter 73: Hypophosphatasia: nature\u2019s window on alkaline phosphatase function in humans. In Principles of Bone Biology, 3rd ed., pp. 1573\u20131598. Eds BilezikianJPRaiszLGMartinTJ. San Diego: Academic Press. (ISBN10: 0080568750)"},{"key":"bib49","series-title":"Journal of Bone and Mineral Research","doi-asserted-by":"publisher","first-page":"286","DOI":"10.1002\/jbmr.195","article-title":"Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification","volume":"26","author":"Yadav","year":"2011","unstructured":"Yadav MCSim\u00e3o AMSNarisawa SHuesa CMcKee MDFarquharson CMill\u00e1n JL2011Loss of skeletal mineralization by the simultaneous ablation of PHOSPHO1 and alkaline phosphatase function: a unified model of the mechanisms of initiation of skeletal calcification. Journal of Bone and Mineral Research26286\u2013297. (https:\/\/doi.org\/10.1002\/jbmr.195)10.1002\/jbmr.195"},{"key":"bib50","series-title":"Biochemical and Biophysical Research Communications","doi-asserted-by":"publisher","first-page":"553","DOI":"10.1016\/j.bbrc.2017.11.071","article-title":"Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice","volume":"495","author":"Yamada","year":"2018","unstructured":"Yamada SWallingford MCBorgeia SCox TCGiachelli CM2018Loss of PiT-2 results in abnormal bone development and decreased bone mineral density and length in mice. Biochemical and Biophysical Research Communications495553\u2013559. (https:\/\/doi.org\/10.1016\/j.bbrc.2017.11.071)10.1016\/j.bbrc.2017.11.071"},{"key":"bib51","series-title":"Molecular and Cellular Biology","doi-asserted-by":"publisher","first-page":"4465","DOI":"10.1128\/MCB.00104-07","article-title":"Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization","volume":"27","author":"Yoshiko","year":"2007","unstructured":"Yoshiko YCandeliere GAMaeda NAubin JE2007Osteoblast autonomous Pi regulation via Pit1 plays a role in bone mineralization. Molecular and Cellular Biology274465\u20134474. (https:\/\/doi.org\/10.1128\/MCB.00104-07)10.1128\/MCB.00104-07"},{"key":"bib52","series-title":"Bone","doi-asserted-by":"publisher","first-page":"57","DOI":"10.1016\/j.bone.2016.03.017","article-title":"Bone loss in chronic kidney disease: quantity or quality?","volume":"87","author":"Zheng","year":"2016","unstructured":"Zheng CMZheng JQWu CCLu CLShyu JFYung-Ho HWu MYChiu IJWang YHLin YF2016Bone loss in chronic kidney disease: quantity or quality?Bone8757\u201370. (https:\/\/doi.org\/10.1016\/j.bone.2016.03.017)10.1016\/j.bone.2016.03.017"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/254\/3\/JOE-22-0097.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/254\/3\/JOE-22-0097.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/254\/3\/JOE-22-0097.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:57:43Z","timestamp":1784555863000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/254\/3\/167-181\/5533"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,9,1]]},"references-count":52,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/joe-22-0097","relation":{"has-preprint":[{"id-type":"doi","id":"10.1101\/2021.08.06.455411","asserted-by":"object"}]},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,9,1]]}}}