{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:13Z","timestamp":1784557273470,"version":"3.55.0"},"reference-count":35,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2022,12,1]],"date-time":"2022-12-01T00:00:00Z","timestamp":1669852800000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,12,1]]},"abstract":"<jats:p>\n                    The aged phenotype shares several metabolic similarities with that of circulatory glucocorticoid excess (Cushing\u2019s syndrome), including type 2 diabetes, obesity, hypertension, and myopathy. We hypothesise that local tissue generation of glucocorticoids by 11\u03b2-hydroxysteroid dehydrogenase type 1 (11\u03b2-HSD1), which converts 11-dehydrocorticosterone to active corticosterone in rodents (corticosterone to cortisol in man), plays a role in driving age-related chronic disease. In this study, we have examined the impact of ageing on glucocorticoid metabolism, insulin tolerance, adiposity, muscle strength, and blood pressure in both wildtype (WT) and transgenic male mice with a global deletion of 11\u03b2-HSD1 (11\u03b2-HSD1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    ) following 4 months high-fat feeding. We found that high fat-fed 11\u03b2-HSD1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were protected from age-related glucose intolerance and hyperinsulinemia when compared to age\/diet-matched WTs. By contrast, aged 11\u03b2-HSD1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were not protected from the onset of sarcopenia observed in the aged WTs. Young 11\u03b2-HSD1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice were partially protected from diet-induced obesity; however, this partial protection was lost with age. Despite greater overall obesity, the aged 11\u03b2-HSD1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    animals stored fat in more metabolically safer adipose depots as compared to the aged WTs. Serum analysis revealed both WT and 11\u03b2-HSD1\n                    <jats:sup>\u2212\/\u2212<\/jats:sup>\n                    mice had an age-related increase in morning corticosterone. Surprisingly, 11\u03b2-HSD1 oxo-reductase activity in the liver and skeletal muscle was unchanged with age in WT mice and decreased in gonadal adipose tissue. These data suggest that deletion of 11\u03b2-HSD1 in high fat-fed, but not chow-fed, male mice protects from age-related insulin resistance and supports a metabolically favourable fat distribution.\n                  <\/jats:p>","DOI":"10.1530\/joe-22-0169","type":"journal-article","created":{"date-parts":[[2022,10,4]],"date-time":"2022-10-04T12:44:36Z","timestamp":1664887476000},"page":"117-129","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":11,"title":["11\u03b2-HSD1 contributes to age-related metabolic decline in male mice"],"prefix":"10.1530","volume":"255","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-1799-3582","authenticated-orcid":true,"given":"Stuart A","family":"Morgan","sequence":"first","affiliation":[{"name":"Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK"},{"name":"Department of Biosciences, Nottingham Trent University, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5983-0306","authenticated-orcid":true,"given":"Laura L","family":"Gathercole","sequence":"additional","affiliation":[{"name":"Department of Biological & Medical Sciences, Oxford Brooks University, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zaki K","family":"Hassan-Smith","sequence":"additional","affiliation":[{"name":"Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3170-8533","authenticated-orcid":true,"given":"Jeremy","family":"Tomlinson","sequence":"additional","affiliation":[{"name":"Radcliffe Department of Medicine, University of Oxford, Oxford, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul M","family":"Stewart","sequence":"additional","affiliation":[{"name":"Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK"},{"name":"NEXUS, Discovery Way, University of Leeds, Leeds, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gareth G","family":"Lavery","sequence":"additional","affiliation":[{"name":"Institute of Metabolism & Systems Research, University of Birmingham, Birmingham, UK"},{"name":"Department of Biosciences, Nottingham Trent University, Nottingham, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Molecular and Cellular Endocrinology","doi-asserted-by":"publisher","first-page":"183","DOI":"10.1016\/0303-7207(95)03501-W","article-title":"Sex- and tissue-specific regulation of 11 beta-hydroxysteroid dehydrogenase mRNA","volume":"109","author":"Albiston","year":"1995","unstructured":"Albiston ALSmith REKrozowski ZS1995Sex- and tissue-specific regulation of 11 beta-hydroxysteroid dehydrogenase mRNA. 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