{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:15Z","timestamp":1784557275128,"version":"3.55.0"},"reference-count":59,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,14]]},"abstract":"<jats:p>Interest in epigenetics has gained substantial momentum as a result of their identified role in the regulation of tumor progression as well as their ability to pharmacologically target genes. Pituitary neuroendocrine tumors (PitNETs) tend to be inactivated via epigenetic modification, and although emerging evidence has suggested a role for epigenetic factors in PitNET tumorigenesis, the degree to which these factors may be targeted by new therapeutic strategies still remains poorly understood. The objective of the present study was to examine the participation of the EZH2\/H3K27me3 axis in the proliferation of lactotroph tumor cells. We demonstrated that the levels of EZH2 and H3K27me3 were increased in murine experimental prolactin (PRL) tumors with respect to a control pituitary, in contrast with the low p21 mRNA levels encountered, with an H3K27me3 enrichment being observed in its promoter region in a GH3 tumor cell. Furthermore, specific EZH2\/H3K27me3 axis inhibition blocked the proliferation of primary tumor cell culture and GH3 cells, thereby making it an attractive therapeutic target for PRL PitNETs.<\/jats:p>","DOI":"10.1530\/joe-22-0195","type":"journal-article","created":{"date-parts":[[2023,2,14]],"date-time":"2023-02-14T09:01:32Z","timestamp":1676365292000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":2,"title":["The epigenetic EZH2\/H3K27me3 axis modulates lactotroph tumor cell proliferation"],"prefix":"10.1530","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0268-9342","authenticated-orcid":true,"given":"N","family":"Zlocowski","sequence":"first","affiliation":[{"name":"Centro de Microscop\u00eda Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, ArgentinaFacultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L d V","family":"Sosa","sequence":"additional","affiliation":[{"name":"Centro de Microscop\u00eda Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, ArgentinaFacultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"B","family":"De la Cruz-Thea","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Neurobiology Department, CONICET - Universidad Nacional de C\u00f3rdoba - Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C B","family":"Guido","sequence":"additional","affiliation":[{"name":"Centro de Microscop\u00eda Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, ArgentinaFacultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M G","family":"Mart\u00edn","sequence":"additional","affiliation":[{"name":"Cellular and Molecular Neurobiology Department, CONICET - Universidad Nacional de C\u00f3rdoba - Instituto de Investigaci\u00f3n M\u00e9dica Mercedes y Mart\u00edn Ferreyra, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J H","family":"Mukdsi","sequence":"additional","affiliation":[{"name":"Centro de Microscop\u00eda Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, ArgentinaFacultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A I","family":"Torres","sequence":"additional","affiliation":[{"name":"Centro de Microscop\u00eda Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, ArgentinaFacultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J P","family":"Petiti","sequence":"additional","affiliation":[{"name":"Centro de Microscop\u00eda Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, ArgentinaFacultad de Ciencias M\u00e9dicas (CME-FCM) - Instituto de Investigaciones en Ciencias de la Salud, Consejo Nacional de Investigaciones Cient\u00edficas T\u00e9cnicas (INICSA-CONICET), Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Seminars in Cell and Developmental Biology","first-page":"209","article-title":"Histone methyltransferases in cancer","volume":"21","author":"Albert","year":"2010","unstructured":"Albert MHelin K2010Histone methyltransferases in cancer. 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