{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:17Z","timestamp":1784557277004,"version":"3.55.0"},"reference-count":44,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,23]]},"abstract":"<jats:p>\n                    Patients suffering from chronic kidney disease (CKD) often experience bone loss and arterial calcifications. It is unclear if hypogonadism contributes to the development of these complications and whether androgen therapy might prevent them. Male adult rats were randomized into four groups. The first group received standard chow (control), while three other groups were fed a 0.25% adenine\/low vitamin K diet (CKD). Two CKD groups were treated with testosterone or dihydrotestosterone (DHT), whereas the control group and one CKD group received vehicle (VEH). CKD animals had 10-fold higher serum creatinine and more than 15-fold higher parathyroid hormone levels compared to controls. Serum testosterone levels were more than two-fold lower in the CKDVEH group compared to control\u2009+\u2009VEH and CKD\u2009+\u2009testosterone groups. Seminal vesicle weight was reduced by 50% in CKDVEH animals and restored by testosterone and DHT. CKD animals showed a low bone mass phenotype with decreased trabecular bone volume fraction and increased cortical porosity, which was not rescued by androgen treatment. Aortic calcification was much more prominent in CKD animals and not unequivocally prevented by androgens. Messenger RNA expression of the androgen receptor-responsive genes\n                    <jats:italic>Acta1<\/jats:italic>\n                    and\n                    <jats:italic>Col1a1<\/jats:italic>\n                    was reduced by CKD and stimulated by androgen treatment in levator ani muscle but not in the bone or aortic tissue. We conclude that adenine-induced CKD results in the development of hypogonadism in male rats. Androgen therapy is effective in restoring serum testosterone levels and androgen-sensitive organ weights but does not prevent bone loss or arterial calcifications, at least not in the presence of severe hyperparathyroidism.\n                  <\/jats:p>","DOI":"10.1530\/joe-22-0319","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T09:58:59Z","timestamp":1679565539000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":3,"title":["Androgen therapy does not prevent bone loss and arterial calcifications in male rats with chronic kidney disease"],"prefix":"10.1530","volume":"257","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6050-6677","authenticated-orcid":true,"given":"K","family":"David","sequence":"first","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven"},{"name":"Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Dubois","sequence":"additional","affiliation":[{"name":"Basic and Translational Endocrinology, Department of Basic and Applied Medical Sciences, UGent, Ghent, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A","family":"Verhulst","sequence":"additional","affiliation":[{"name":"Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"V","family":"Sommers","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Schollaert","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L","family":"Deboel","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K","family":"Moermans","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"G","family":"Carmeliet","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"D\u2019Haese","sequence":"additional","affiliation":[{"name":"Laboratory of Pathophysiology, Department of Biomedical Sciences, University of Antwerp, Antwerp, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D","family":"Vanderschueren","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven"},{"name":"Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"F","family":"Claessens","sequence":"additional","affiliation":[{"name":"Molecular Endocrinology, Department of Cellular and Molecular Medicine, KU Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"P","family":"Evenepoel","sequence":"additional","affiliation":[{"name":"Nephrology and Renal Transplantation Research Group, Department of Microbiology, Immunology and Transplantation, KU Leuven, Leuven, Belgium"},{"name":"Department of Nephrology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4153-4757","authenticated-orcid":true,"given":"B","family":"Decallonne","sequence":"additional","affiliation":[{"name":"Laboratory of Clinical and Experimental Endocrinology, Department of Chronic Diseases and Metabolism, KU Leuven, Leuven"},{"name":"Department of Endocrinology, University Hospitals Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Archives of Andrology","first-page":"37","article-title":"Effect of experimentally induced renal failure on testicular testosterone synthesis in rats","volume":"43","author":"Adachi","year":"1999","unstructured":"Adachi Y & Nakada T1999Effect of experimentally induced renal failure on testicular testosterone synthesis in rats. 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