{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:18Z","timestamp":1784557278130,"version":"3.55.0"},"reference-count":32,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,3]]},"abstract":"<jats:p>\n                    Serum prolactin increases from birth to adulthood in rats, being higher in females from birth. The maturation of hypothalamic\/gonadal prolactin-releasing and -inhibiting factors does not explain some sex differences observed. During the first weeks of life, prolactin secretion increases, even when lactotrophs are isolated\n                    <jats:italic>in vitro,<\/jats:italic>\n                    in the absence of those controls, suggesting the participation of intra-pituitary factors in this control. The present work aimed to study the involvement of pituitary activins in the regulation of prolactin secretion during post-natal development. Sex differences were also highlighted. Female and male Sprague\u2013Dawley rats at 11, 23 and 45postnatal days were used. Pituitary expression of activin subunits and activin receptors was maximum in p11 female pituitaries\n                    <jats:italic>,<\/jats:italic>\n                    being even higher than that observed in males. Those expressions decrease with age in females, and then the gender differences disappear at p23.\n                    <jats:italic>Inhbb<\/jats:italic>\n                    expression strongly increases at p45 in males, being the predominant subunit in this sex in adulthood. Activin inhibition of prolactin is mediated by the inhibition of\n                    <jats:italic>Pit-1<\/jats:italic>\n                    expression. This action involves not only the canonical pSMAD pathway but also the phosphorylation of p38MAPK. At p11, almost all lactotrophs express p-p38MAPK in females, and its expression decreases with age with a concomitant increase in\n                    <jats:italic>Pit-1<\/jats:italic>\n                    . Our findings suggest that the inhibitory regulation of pituitary activins on prolactin secretion is sex specific; this regulation is more relevant in females during the first week of life and decreases with age; this intra-pituitary regulation is involved in the sex differences observed in serum prolactin levels during postnatal development.\n                  <\/jats:p>","DOI":"10.1530\/joe-23-0020","type":"journal-article","created":{"date-parts":[[2023,7,7]],"date-time":"2023-07-07T06:41:11Z","timestamp":1688712071000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":4,"title":["Sex-specific regulation of prolactin secretion by pituitary activins in postnatal development"],"prefix":"10.1530","volume":"258","author":[{"given":"Alejandra","family":"Abeledo-Machado","sequence":"first","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dana","family":"Bornancini","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Milagros","family":"Pe\u00f1a-Zanoni","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mar\u00eda Andrea","family":"Camilletti","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erika Yanil","family":"Faraoni","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-6893","authenticated-orcid":true,"given":"Graciela","family":"D\u00edaz-Torga","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME), CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Endocrinology","first-page":"29","article-title":"TGF\u03b21 regulates prolactin secretion during postnatal development: gender differences","volume":"246","author":"Abeledo-Machado","year":"2020","unstructured":"Abeledo-Machado AP\u00e9rez PACamilletti MAFaraoni EYPicech FPetiti JPGuti\u00e9rrez S & Diaz-Torga G2020TGF\u03b21 regulates prolactin secretion during postnatal development: gender differences. 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