{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,28]],"date-time":"2026-09-28T23:38:40Z","timestamp":1790638720126,"version":"4.1.0"},"reference-count":43,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,12]]},"abstract":"<jats:p>\n                    Fibroblast growth factor 23 (FGF23) is a phosphaturic hormone. X-linked hypophosphatemia (XLH) is the most prevalent inherited phosphate wasting disorder due to mutations in the\n                    <jats:italic>PHEX<\/jats:italic>\n                    gene, which cause elevated circulating FGF23 levels. Clinically, it is characterized by growth impairment and defective mineralization of bones and teeth. Treatment of XLH is challenging. Since 2018, neutralizing antibodies against FGF23 have dramatically improved the therapy of XLH patients, although not all patients fully respond to the treatment, and it is very costly. C-terminal fragments of FGF23 have recently emerged as blockers of intact FGF23 signaling. Here, we analyzed the effect on growth and bone of a short 26 residues long C-terminal FGF23 (cFGF23) fragment and two N-acetylated and C-amidated cFGF23 peptides using young XLH mice (\n                    <jats:italic>Phex<\/jats:italic>\n                    <jats:sup>C733RMhda<\/jats:sup>\n                    mice). Although no major changes in blood parameters were observed after 7 days of treatment with these peptides, bone length and growth plate structure improved. The modified peptides accelerated the growth rate probably by improving growth plate structure and dynamics. The processes of chondrocyte proliferation, death, hypertrophy, and the cartilaginous composition in the growth plate were partially improved in young treated XLH mice. In conclusion, these findings contribute to understand the role of FGF23 signaling in growth plate metabolism and show that this may occur despite continuous hypophosphatemia.\n                  <\/jats:p>","DOI":"10.1530\/joe-23-0025","type":"journal-article","created":{"date-parts":[[2023,7,13]],"date-time":"2023-07-13T06:47:33Z","timestamp":1689230853000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":2,"title":["Blocking FGF23 signaling improves the growth plate of mice with X-linked hypophosphatemia"],"prefix":"10.1530","volume":"259","author":[{"given":"Roc\u00edo","family":"Fuente","sequence":"first","affiliation":[{"name":"Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland"},{"name":"Division of Pediatrics, University of Oviedo, Oviedo, Spain"},{"name":"Department of Pediatrics, Hospital Universitario Central, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva-Maria","family":"Pastor-Arroyo","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicole","family":"Gehring","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia","family":"Oro Carbajosa","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, University of Oviedo, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Laura","family":"Alonso-Dur\u00e1n","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, University of Oviedo, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"Zderic","sequence":"additional","affiliation":[{"name":"AO Research Institute Davos, AO Foundation, Clavadelerstrasse, Davos Platz, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Tapia-Dean","sequence":"additional","affiliation":[{"name":"Department of Pediatrics, Hospital Universitario Central, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ahmad Kamal","family":"Hamid","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla","family":"Bettoni","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando","family":"Santos","sequence":"additional","affiliation":[{"name":"Division of Pediatrics, University of Oviedo, Oviedo, Spain"},{"name":"Department of Pediatrics, Hospital Universitario Central, Oviedo, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carsten A","family":"Wagner","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1051-9511","authenticated-orcid":true,"given":"Isabel","family":"Rubio-Aliaga","sequence":"additional","affiliation":[{"name":"Institute of Physiology, University of Zurich, and National Center of Competence in Research NNCR Kidney, Zurich, CH, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Haematologica","first-page":"391","article-title":"C-FGF23 peptide alleviates hypoferremia during acute inflammation","volume":"106","author":"Agoro","year":"2021","unstructured":"Agoro RPark MYLe Henaff CJankauskas SGaias AChen GMohammadi M & Sitara D2021C-FGF23 peptide alleviates hypoferremia during acute inflammation. 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