{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,12]],"date-time":"2026-08-12T17:11:20Z","timestamp":1786554680180,"version":"build-2736575974"},"reference-count":52,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2023,7,18]],"date-time":"2023-07-18T00:00:00Z","timestamp":1689638400000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,7,18]]},"abstract":"<jats:p>\n                    Our previous studies showed that microinjection into the median eminence of the sheep of glucagon-like peptide- 1 (GLP-1) or its receptor agonist exendin-4 stimulates luteinising hormone (LH) secretion, but it is unknown whether the same effect may be obtained by systemic administration of the same. The present study measured the response in terms of plasma LH concentrations to intravenous (iv) infusion of exendin-4. A preliminary study showed that infusion of 2 mg exendin-4 into ewes produced a greater LH response in the follicular phase of the oestrous cycle than the luteal phase. Accordingly, the main study monitored plasma LH levels in response to either 0.5 mg or 2 mg exendin-4 or vehicle (normal saline) delivered by jugular infusion for 1 h in the follicular phase of the oestrous cycle. Blood samples were collected at 10 min intervals before, during and after infusion. Both doses of exendin-4 increased mean plasma LH concentrations and increased LH peripheral pulse amplitude. There was no effect on inter-pulse interval or timing of the preovulatory LH surge. These doses of exendin-4 did not alter plasma insulin or glucose concentrations. Quantitative PCR of the gastrointestinal tract samples from a population of ewes confirmed the expression of the preproglucagon gene (\n                    <jats:italic>GCG<\/jats:italic>\n                    ). Expression increased aborally and was greatest in the rectum. It is concluded that endogenous GLP-1, most likely derived from the hindgut, may act systemically to stimulate LH secretion. The present data suggest that this effect may be obtained with levels of agonist that are lower than those functioning as an incretin.\n                  <\/jats:p>","DOI":"10.1530\/joe-23-0105","type":"journal-article","created":{"date-parts":[[2023,7,19]],"date-time":"2023-07-19T07:29:18Z","timestamp":1689751758000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":8,"title":["The GLP-1 agonist, exendin-4, stimulates LH secretion in female sheep"],"prefix":"10.1530","volume":"259","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5107-9300","authenticated-orcid":true,"given":"Elizabeth M","family":"Simpson","sequence":"first","affiliation":[{"name":"School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia"},{"name":"Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iain J","family":"Clarke","sequence":"additional","affiliation":[{"name":"School of Agriculture Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher J","family":"Scott","sequence":"additional","affiliation":[{"name":"School of Dentistry and Medical Science, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cyril P","family":"Stephen","sequence":"additional","affiliation":[{"name":"School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia"},{"name":"Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandra","family":"Rao","sequence":"additional","affiliation":[{"name":"School of Agriculture Food and Ecosystem Sciences, Faculty of Science, The University of Melbourne, Parkville, VIC, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4712-2630","authenticated-orcid":true,"given":"Allan J","family":"Gunn","sequence":"additional","affiliation":[{"name":"School of Agricultural, Environmental and Veterinary Sciences, Faculty of Science and Health, Charles Sturt University, Wagga Wagga, NSW, Australia"},{"name":"Gulbali Institute, Charles Sturt University, Wagga Wagga, NSW, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Endocrinology","first-page":"325","article-title":"Glucagon-like peptide-1 control of GnRH secretion in female sheep","volume":"248","author":"Arbabi","year":"2021","unstructured":"Arbabi LLi QHenry BA & Clarke IJ2021Glucagon-like peptide-1 control of GnRH secretion in female sheep. Journal of Endocrinology248325\u2013335. (https:\/\/doi.org\/10.1530\/JOE-20-0335)"},{"key":"bib2","series-title":"Neuroendocrinology","first-page":"27","article-title":"Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes","volume":"91","author":"Backholer","year":"2010","unstructured":"Backholer KBowden MGamber KBj\u00f8rb\u00e6k CIqbal J & Clarke IJ2010Melanocortins mimic the effects of leptin to restore reproductive function in lean hypogonadotropic ewes. Neuroendocrinology9127\u201340. (https:\/\/doi.org\/10.1159\/000260060)"},{"key":"bib3","series-title":"Gastroenterology","first-page":"2131","article-title":"Biology of incretins: GLP-1 and GIP","volume":"132","author":"Baggio","year":"2007","unstructured":"Baggio LL & Drucker DJ2007Biology of incretins: GLP-1 and GIP. Gastroenterology1322131\u20132157. (https:\/\/doi.org\/10.1053\/j.gastro.2007.03.054)"},{"key":"bib4","series-title":"Journal of Endocrinology","first-page":"565","article-title":"The role of neuropeptide Y (NPY) in the control of LH secretion in the ewe with respect to season, NPY receptor subtype and the site of action in the hypothalamus","volume":"147","author":"Barker-Gibb","year":"1995","unstructured":"Barker-Gibb MLScott CJBoublik JH & Clarke IJ1995The role of neuropeptide Y (NPY) in the control of LH secretion in the ewe with respect to season, NPY receptor subtype and the site of action in the hypothalamus. Journal of Endocrinology147565\u2013579. (https:\/\/doi.org\/10.1677\/joe.0.1470565)"},{"key":"bib5","series-title":"Journal of Clinical Investigation","first-page":"1334","article-title":"Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line","volume":"101","author":"Beak","year":"1998","unstructured":"Beak SAHeath MMSmall CJMorgan DGGhatei MATaylor ADBuckingham JCBloom SR & Smith DM1998Glucagon-like peptide-1 stimulates luteinizing hormone-releasing hormone secretion in a rodent hypothalamic neuronal cell line. Journal of Clinical Investigation1011334\u20131341. (https:\/\/doi.org\/10.1172\/JCI610)"},{"key":"bib6","series-title":"Endocrinology","first-page":"2968","article-title":"Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor","volume":"137","author":"Bullock","year":"1996","unstructured":"Bullock BPHeller RS & Habener JF1996Tissue distribution of messenger ribonucleic acid encoding the rat glucagon-like peptide-1 receptor. Endocrinology1372968\u20132978. (https:\/\/doi.org\/10.1210\/endo.137.7.8770921)"},{"key":"bib7","series-title":"Endocrinology","first-page":"2156","article-title":"Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse","volume":"134","author":"Campos","year":"1994","unstructured":"Campos RVLee YC & Drucker DJ1994Divergent tissue-specific and developmental expression of receptors for glucagon and glucagon-like peptide-1 in the mouse. Endocrinology1342156\u20132164. (https:\/\/doi.org\/10.1210\/endo.134.5.8156917)"},{"key":"bib8","series-title":"Endocrinology","first-page":"1624","article-title":"Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomised ewes","volume":"133","author":"Clarke","year":"1993","unstructured":"Clarke IJ1993Variable patterns of gonadotropin-releasing hormone secretion during the estrogen-induced luteinizing hormone surge in ovariectomised ewes. Endocrinology1331624\u20131632. (https:\/\/doi.org\/10.1210\/endo.133.4.8404603)"},{"key":"bib9","series-title":"Hormones and Behavior","first-page":"15","article-title":"Interface between metabolic balance and reproduction in ruminants: focus on the hypothalamus and pituitary","volume":"66","author":"Clarke","year":"2014","unstructured":"Clarke IJ2014Interface between metabolic balance and reproduction in ruminants: focus on the hypothalamus and pituitary. Hormones and Behavior6615\u201340. (https:\/\/doi.org\/10.1016\/j.yhbeh.2014.02.005)"},{"issue":"Supplement","key":"bib10","series-title":"Domestic Animal Endocrinology","first-page":"165","article-title":"New concepts of the central control of reproduction, integrating influence of stress, metabolic state, and season","volume":"56","author":"Clarke","year":"2016","unstructured":"Clarke IJ & Arbabi L2016New concepts of the central control of reproduction, integrating influence of stress, metabolic state, and season. Domestic Animal Endocrinology56(Supplement) 165\u2013179. (https:\/\/doi.org\/10.1016\/j.domaniend.2016.03.001)"},{"key":"bib11","series-title":"The GnRH Neuron and Its Control 325\u2013356","article-title":"Generation of the GnRH Surge and LH Surge by the positive feedback effect of estrogen","author":"Clarke","year":"2018","unstructured":"Clarke IJ2018Generation of the GnRH Surge and LH Surge by the positive feedback effect of estrogen. In The GnRH Neuron and Its Control 325\u2013356. Chichester, UK: John Wiley & Sons, Ltd."},{"key":"bib12","series-title":"Trends in Endocrinology and Metabolism","first-page":"85","article-title":"Glucagon-like peptide 1 and appetite","volume":"24","author":"Dailey","year":"2013","unstructured":"Dailey MJ & Moran TH2013Glucagon-like peptide 1 and appetite. Trends in Endocrinology and Metabolism2485\u201391. (https:\/\/doi.org\/10.1016\/j.tem.2012.11.008)"},{"key":"bib13","series-title":"Reproduction","first-page":"53","article-title":"Kisspeptin and energy balance in reproduction","volume":"147","author":"De Bond","year":"2014","unstructured":"De Bond JA & Smith JT2014Kisspeptin and energy balance in reproduction. Reproduction14753\u201363. (https:\/\/doi.org\/10.1530\/REP-13-0509)"},{"key":"bib14","series-title":"Molecular and Cellular Endocrinology","first-page":"527","article-title":"Nutritional signals and reproduction","volume":"382","author":"Dupont","year":"2014","unstructured":"Dupont JReverchon MBertoldo MJ & ent P2014Nutritional signals and reproduction. Molecular and Cellular Endocrinology382527\u2013537. (https:\/\/doi.org\/10.1016\/j.mce.2013.09.028)"},{"key":"bib15","series-title":"Endocrinology","first-page":"1828","article-title":"Kisspeptin is a component of the pulse generator for GnRH secretion in female sheep but not THE pulse generator","volume":"156","author":"Ezzat","year":"2015","unstructured":"Ezzat APereira A & Clarke IJ2015Kisspeptin is a component of the pulse generator for GnRH secretion in female sheep but not THE pulse generator. Endocrinology1561828\u20131837. (https:\/\/doi.org\/10.1210\/en.2014-1756)"},{"key":"bib16","series-title":"Frontiers in Cellular Neuroscience","first-page":"214","article-title":"Glucagon-like peptide-1 excites firing and increases GABAergic miniature postsynaptic currents (mPSCs) in gonadotropin-releasing hormone (GnRH) neurons of the male mice via activation of nitric oxide (NO) and suppression of endocannabinoid signaling pathways","volume":"10","author":"Farkas","year":"2016","unstructured":"Farkas IVastagh CFarkas EBalint FSkrapits KHrabovszky EFekete C & Liposits Z2016Glucagon-like peptide-1 excites firing and increases GABAergic miniature postsynaptic currents (mPSCs) in gonadotropin-releasing hormone (GnRH) neurons of the male mice via activation of nitric oxide (NO) and suppression of endocannabinoid signaling pathways. Frontiers in Cellular Neuroscience10214. (https:\/\/doi.org\/10.3389\/fncel.2016.00214)"},{"key":"bib17","series-title":"Frontiers in Physiology","first-page":"555","article-title":"Brain endothelial cells regulate glucagon-like peptide 1 entry into the brain via a receptor-mediated process","volume":"11","author":"Fu","year":"2020","unstructured":"Fu ZGong LLiu JWu JBarrett EJAylor KW & Liu Z2020Brain endothelial cells regulate glucagon-like peptide 1 entry into the brain via a receptor-mediated process. Frontiers in Physiology11555\u2013555. (https:\/\/doi.org\/10.3389\/fphys.2020.00555)"},{"key":"bib18","series-title":"Journal of Neuroendocrinology","first-page":"1138","article-title":"Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep","volume":"20","author":"Grouselle","year":"2008","unstructured":"Grouselle DChaillou ECaraty ABluet-Pajot MTZizzari PTillet Y & Epelbaum J2008Pulsatile cerebrospinal fluid and plasma ghrelin in relation to growth hormone secretion and food intake in the sheep. Journal of Neuroendocrinology201138\u20131146. (https:\/\/doi.org\/10.1111\/j.1365-2826.2008.01770.x)"},{"key":"bib19","series-title":"Domestic Animal Endocrinology","first-page":"17","article-title":"Ghrelin in domestic animals: distribution in stomach and its possible role","volume":"21","author":"Hayashida","year":"2001","unstructured":"Hayashida TMurakami KMogi KNishihara MNakazato MMondal MSHorii YKojima MKangawa K & Murakami N2001Ghrelin in domestic animals: distribution in stomach and its possible role. Domestic Animal Endocrinology2117\u201324. (https:\/\/doi.org\/10.1016\/s0739-7240(0100104-7)"},{"key":"bib20","series-title":"Journal of Neuroendocrinology","first-page":"244","article-title":"Leptin-mediated effects of undernutrition or fasting on luteinizing hormone and growth hormone secretion in ovariectomized ewes depend on the duration of metabolic perturbation","volume":"16","author":"Henry","year":"2004","unstructured":"Henry BAGoding JWTilbrook AJDunshea FRBlache D & Clarke IJ2004Leptin-mediated effects of undernutrition or fasting on luteinizing hormone and growth hormone secretion in ovariectomized ewes depend on the duration of metabolic perturbation. Journal of Neuroendocrinology16244\u2013255. (https:\/\/doi.org\/10.1111\/j.0953-8194.2004.01157.x)"},{"key":"bib21","series-title":"Eneuro","article-title":"GLP-1R signaling directly activates arcuate nucleus kisspeptin action in brain slices but does not rescue luteinizing hormone inhibition in ovariectomized mice during negative energy balance","volume":"4","author":"Heppner","year":"2017","unstructured":"Heppner KMBaquero AFBennett CMLindsley SRKirigiti MABennett BBosch MAMercer AJR\u00f8nnekleiv OKTrue C, 2017GLP-1R signaling directly activates arcuate nucleus kisspeptin action in brain slices but does not rescue luteinizing hormone inhibition in ovariectomized mice during negative energy balance. Eneuro4. (https:\/\/doi.org\/10.1523\/ENEURO.0198-16.2016)"},{"key":"bib22","series-title":"Endocrinology","first-page":"3723","article-title":"The gonadotropin-releasing hormone pulse generator","volume":"159","author":"Herbison","year":"2018","unstructured":"Herbison AE2018The gonadotropin-releasing hormone pulse generator. Endocrinology1593723\u20133736. (https:\/\/doi.org\/10.1210\/en.2018-00653)"},{"key":"bib23","series-title":"Physiological Reviews","first-page":"1409","article-title":"The physiology of glucagon-like peptide 1","volume":"87","author":"Holst","year":"2007","unstructured":"Holst JJ2007The physiology of glucagon-like peptide 1. Physiological Reviews871409\u20131439. (https:\/\/doi.org\/10.1152\/physrev.00034.2006)"},{"key":"bib24","series-title":"Obesity Reviews","first-page":"163","article-title":"Gut peptides and the regulation of appetite","volume":"7","author":"Huda","year":"2006","unstructured":"Huda MSBWilding JPH & Pinkney JH2006Gut peptides and the regulation of appetite. Obesity Reviews7163\u2013182. (https:\/\/doi.org\/10.1111\/j.1467-789X.2006.00245.x)"},{"key":"bib26","series-title":"Endocrinology","first-page":"510","article-title":"Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep","volume":"147","author":"Iqbal","year":"2006","unstructured":"Iqbal JKurose YCanny B & Clarke IJ2006Effects of central infusion of ghrelin on food intake and plasma levels of growth hormone, luteinizing hormone, prolactin, and cortisol secretion in sheep. Endocrinology147510\u2013519. (https:\/\/doi.org\/10.1210\/en.2005-1048)"},{"key":"bib27","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"833","article-title":"Effects of peptide YY on the hypothalamic-pituitary-gonadal axis in healthy men","volume":"105","author":"Izzi-Engbeaya","year":"2020","unstructured":"Izzi-Engbeaya CJones SCrustna YMacenahalli PCPapadopoulou DModi MPanayi CStarikova JEng PCPhylactou M, 2020Effects of peptide YY on the hypothalamic-pituitary-gonadal axis in healthy men. Journal of Clinical Endocrinology and Metabolism105833\u2013838. (https:\/\/doi.org\/10.1210\/clinem\/dgz103)"},{"key":"bib28","series-title":"European Journal of Clinical Investigation","first-page":"565","article-title":"Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males","volume":"35","author":"Jeibmann","year":"2005","unstructured":"Jeibmann AZahedi SSimoni MNieschlag E & Byrne MM2005Glucagon-like peptide-1 reduces the pulsatile component of testosterone secretion in healthy males. European Journal of Clinical Investigation35565\u2013572. (https:\/\/doi.org\/10.1111\/j.1365-2362.2005.01542.x)"},{"key":"bib29","series-title":"Human Reproduction Update","first-page":"504","article-title":"The role of glucagon-like peptide-1 in reproduction: from physiology to therapeutic perspective","volume":"2","author":"Jensterle","year":"2019","unstructured":"Jensterle MJanez AFliers EDeVries JHVrtacnik-Bokal E & Sigelaar SE2019The role of glucagon-like peptide-1 in reproduction: from physiology to therapeutic perspective. Human Reproduction Update2504\u2013517. (https:\/\/doi.org\/10.1093\/humupd\/dmz019)"},{"key":"bib30","series-title":"Journal of Comparative Neurology","first-page":"519","article-title":"Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study","volume":"271","author":"Jin","year":"1988","unstructured":"Jin SLHan VKSimmons JGTowle ACLauder JM & Lund PK1988Distribution of glucagonlike peptide I (GLP-I), glucagon, and glicentin in the rat brain: an immunocytochemical study. Journal of Comparative Neurology271519\u2013532. (https:\/\/doi.org\/10.1002\/cne.902710405)"},{"key":"bib31","series-title":"Peptides","first-page":"55","article-title":"Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats","volume":"90","author":"Johnson","year":"2017","unstructured":"Johnson MLSaffey MJ & Taylor VJ2017Glucagon-like peptide-1 (GLP-1) increases in plasma and colon tissue prior to estrus and circulating levels change with increasing age in reproductively competent Wistar rats. Peptides9055\u201362. (https:\/\/doi.org\/10.1016\/j.peptides.2017.02.010)"},{"key":"bib32","series-title":"International Journal of Obesity and Related Metabolic Disorders","first-page":"313","article-title":"Entry of exendin-4 into brain is rapid but may be limited at high doses","volume":"27","author":"Kastin","year":"2003","unstructured":"Kastin AJ & Akerstrom V2003Entry of exendin-4 into brain is rapid but may be limited at high doses. International Journal of Obesity and Related Metabolic Disorders27313\u2013318. (https:\/\/doi.org\/10.1038\/sj.ijo.0802206)"},{"key":"bib33","series-title":"Biomolecules","first-page":"1","article-title":"Evidence for involvement of GIP and GLP-1 receptors and the gut-gonadal axis in regulating female reproductive function in mice","volume":"12","author":"Khan","year":"2022","unstructured":"Khan DOjo OOWoodward ORMLewis JESridhar AGribble FMReimann FFlatt PR & Moffett RC2022Evidence for involvement of GIP and GLP-1 receptors and the gut-gonadal axis in regulating female reproductive function in mice. Biomolecules121\u201313. (https:\/\/doi.org\/10.3390\/biom12121736)"},{"key":"bib34","series-title":"Peptides","first-page":"52","article-title":"GLP-1 amidation efficiency along the length of the intestine in mice, rats and pigs and in GLP-1 secreting cell lines","volume":"55","author":"Kuhre","year":"2014","unstructured":"Kuhre REAlbrechtsen NWWindel\u00f8v JASvendsen BHartmann B & Holst JJ2014GLP-1 amidation efficiency along the length of the intestine in mice, rats and pigs and in GLP-1 secreting cell lines. Peptides5552\u201357. (https:\/\/doi.org\/10.1016\/j.peptides.2014.01.020)"},{"key":"bib35","series-title":"Expert Review of Clinical Pharmacology","first-page":"401","article-title":"GLP-1 receptor agonists in the treatment of polycystic ovary syndrome","volume":"10","author":"Lamos","year":"2017","unstructured":"Lamos EMMalek R & Davis SN2017GLP-1 receptor agonists in the treatment of polycystic ovary syndrome. Expert Review of Clinical Pharmacology10401\u2013408. (https:\/\/doi.org\/10.1080\/17512433.2017.1292125)"},{"key":"bib36","series-title":"Neuroscience","first-page":"257","article-title":"Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem","volume":"77","author":"Larsen","year":"1997","unstructured":"Larsen PJTang-Christensen MHolst JJ & Orskov C1997Distribution of glucagon-like peptide-1 and other preproglucagon-derived peptides in the rat hypothalamus and brainstem. Neuroscience77257\u2013270. (https:\/\/doi.org\/10.1016\/s0306-4522(9600434-4)"},{"key":"bib53","series-title":"Reproduction","first-page":"1","article-title":"Regulation of gonadotrophin secretion in rams from birth to sexual maturity","volume":"46","year":"1976","unstructured":"Lee VWKCumming IAde Kretser DMFindlay JKHudson B & Keogh EJ1976Regulation of gonadotrophin secretion in rams from birth to sexual maturity. Reproduction461\u20136. (https:\/\/doi.org\/10.1530\/jrf.0.0460001)"},{"key":"bib37","series-title":"Biology of Reproduction","first-page":"240","article-title":"GLP-1 increases Kiss-1 mRNA expression in kisspeptin-expressing neuronal cells","volume":"97","author":"Oride","year":"2017","unstructured":"Oride AAKanasaki HMijiddorj TSukhbaatar UHara TTumurbaatar TKyo S2017GLP-1 increases Kiss-1 mRNA expression in kisspeptin-expressing neuronal cells. Biology of Reproduction97240\u2013248. (https:\/\/doi.org\/10.1093\/biolre\/iox087)"},{"key":"bib38","series-title":"Endocrinology","first-page":"4226","article-title":"GLP-1 increases preovulatory LH source and the number of mature follicles, as well as synchronizing the onset of puberty in female rats","volume":"156","author":"Outeirino-Iglesias","year":"2015","unstructured":"Outeirino-Iglesias VRomani-Perez MGonzalez-Matias LCVigo E & Mallo F2015GLP-1 increases preovulatory LH source and the number of mature follicles, as well as synchronizing the onset of puberty in female rats. Endocrinology1564226\u20134237. (https:\/\/doi.org\/10.1210\/en.2014-1978)"},{"key":"bib39","series-title":"Frontiers in Endocrinology","first-page":"584","article-title":"Dissecting the physiology and pathophysiology of glucagon-like peptide-1","volume":"9","author":"Paternoster","year":"2018","unstructured":"Paternoster S & Falasca M2018Dissecting the physiology and pathophysiology of glucagon-like peptide-1. Frontiers in Endocrinology9584. (https:\/\/doi.org\/10.3389\/fendo.2018.00584)"},{"key":"bib40","series-title":"Journal of Animal Science","first-page":"168","article-title":"Effect of feeding fat or intrajugular infusion of glucagon-like peptide-1 and cholecystokinin on dry matter intake, digestibility, and digesta rate of passage in growing wethers","volume":"89","author":"Relling","year":"2011","unstructured":"Relling AEReynolds CK & Loerch SC2011Effect of feeding fat or intrajugular infusion of glucagon-like peptide-1 and cholecystokinin on dry matter intake, digestibility, and digesta rate of passage in growing wethers. Journal of Animal Science89168\u2013178. (https:\/\/doi.org\/10.2527\/jas.2010-2976)"},{"key":"bib41","series-title":"Animal Reproduction Science","first-page":"25","article-title":"Nutrition and reproduction","volume":"42","author":"Robinson","year":"1996","unstructured":"Robinson JJ1996Nutrition and reproduction. Animal Reproduction Science4225\u201334. (https:\/\/doi.org\/10.1016\/0378-4320(9601526-6)"},{"key":"bib42","series-title":"Animal Feed Science and Technology","first-page":"259","article-title":"Nutrition and fertility in ruminant livestock","volume":"126","author":"Robinson","year":"2006","unstructured":"Robinson JJAshworth CJRooke JAMitchell LM & McEvoy TG2006Nutrition and fertility in ruminant livestock. Animal Feed Science and Technology126259\u2013276. (https:\/\/doi.org\/10.1016\/j.anifeedsci.2005.08.006)"},{"key":"bib43","series-title":"Endocrinology","first-page":"568","article-title":"Levels of Luteinizing Hormone in sera and pituitaries of ewes during the estrous cycle and anestrus","volume":"86","author":"Roche","year":"1970","unstructured":"Roche JFFoster DLKarsch FJCook B & Dziuk PJ1970Levels of Luteinizing Hormone in sera and pituitaries of ewes during the estrous cycle and anestrus. Endocrinology86568\u2013572. (https:\/\/doi.org\/10.1210\/endo-86-3-568)"},{"key":"bib44","series-title":"Physiological Reviews","first-page":"513","article-title":"Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease","volume":"95","author":"Sandoval","year":"2015","unstructured":"Sandoval DA & D'Alessio DA2015Physiology of proglucagon peptides: role of glucagon and GLP-1 in health and disease. Physiological Reviews95513\u2013548. (https:\/\/doi.org\/10.1152\/physrev.00013.2014)."},{"key":"bib45","series-title":"Frontiers in Endocrinology","first-page":"1","article-title":"2017 Central control of feeding behavior by the secretin, pacap, and glucagon family of peptides","volume":"8","author":"Sekar","unstructured":"Sekar RR2017 Central control of feeding behavior by the secretin, pacap, and glucagon family of peptides. Frontiers in Endocrinology81\u201314. (https:\/\/doi.org\/10.3389\/fendo.2017.00018)"},{"key":"bib46","series-title":"Endocrinology","first-page":"1076","article-title":"Identification and localization of glucagon-like peptide-1 and its receptor in rat brain","volume":"121","author":"Shimuzu","year":"1987","unstructured":"Shimuzu IHirota MOhboshi C & Shima K1987Identification and localization of glucagon-like peptide-1 and its receptor in rat brain. Endocrinology1211076\u20131082. (https:\/\/doi.org\/10.1210\/endo-121-3-1076)"},{"key":"bib47","series-title":"International Journal of Environmental Research and Public Health","first-page":"3089","article-title":"Neuroendocrine determinants of polycystic ovary syndrome","volume":"19","year":"2022","unstructured":"Szeliga A, Rudnicka E, Maciejewska-Jeske M, Kucharski M, Kostrzak A, Hajbos M, Niwczyk O, Smolarczyk R, Meczekalski B, Niwczyk O, 2022Neuroendocrine determinants of polycystic ovary syndrome. International Journal of Environmental Research and Public Health193089. (https:\/\/doi.org\/10.3390\/ijerph19053089)"},{"key":"bib48","series-title":"Brain Structure and Function","first-page":"105","article-title":"Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics","volume":"226","author":"Vastagh","year":"2021","unstructured":"Vastagh CFarkas IScott MM & Liposits Z2021Networking of glucagon-like peptide-1 axons with GnRH neurons in the basal forebrain of male mice revealed by 3DISCO-based immunocytochemistry and optogenetics. Brain Structure and Function226105\u2013120. (https:\/\/doi.org\/10.1007\/s00429-020-02167-7)"},{"key":"bib49","series-title":"Signal Transduction and Targeted Therapy","first-page":"1","article-title":"Therapeutic peptides: current applications and future directions","volume":"7","author":"Wang","year":"2022","unstructured":"Wang LNanxi WZhang WCheng XYan ZGang SWang XWang R & Fu C2022Therapeutic peptides: current applications and future directions. Signal Transduction and Targeted Therapy71. (https:\/\/doi.org\/10.1038\/s41392-022-00904-4)"},{"key":"bib50","series-title":"Animal Science","first-page":"41","article-title":"Effects of body condition at calving and feeding level after calving on LH profiles and the duration of the post-partum anoestrous period in beef cows","volume":"55","author":"Wright","year":"1992","unstructured":"Wright IARhind SMWhyte TK & Smith AJ1992Effects of body condition at calving and feeding level after calving on LH profiles and the duration of the post-partum anoestrous period in beef cows. Animal Science5541\u201346. (https:\/\/doi.org\/10.1017\/S0003356100037259)"},{"key":"bib51","series-title":"Journal of Dairy Science","first-page":"6876","article-title":"Effects of prepartum fat supplementation on plasma concentrations of glucagon-like peptide-1, peptide YY, adropin, insulin, and leptin in periparturient dairy cows","volume":"98","author":"Zapata","year":"2015","unstructured":"Zapata RCSalehi RAmbrose DJ & Chelikani PK2015Effects of prepartum fat supplementation on plasma concentrations of glucagon-like peptide-1, peptide YY, adropin, insulin, and leptin in periparturient dairy cows. Journal of Dairy Science986876\u20136885. (https:\/\/doi.org\/10.3168\/jds.2014-9283)"},{"key":"bib52","series-title":"Frontiers in Endocrinology","first-page":"721135","article-title":"GLP-1 receptor agonists: beyond their pancreatic effects","volume":"12","author":"Zhao","year":"2021","unstructured":"Zhao XWang MWen ZLu ZCui LFu CXue HLiu Y & Zhang Y2021GLP-1 receptor agonists: beyond their pancreatic effects. Frontiers in Endocrinology12721135. 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