{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:19Z","timestamp":1784557279757,"version":"3.55.0"},"reference-count":48,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,10,19]]},"abstract":"<jats:p>\n                    Due to the current limited knowledge about the role of filamin A (FLNA) in pituitary tumour progression, we aimed to analyse FLNA expression levels and its impact on aggressive markers of pituitary neuroendocrine tumours (PitNETs), using an integrative approach of\n                    <jats:italic>in vivo<\/jats:italic>\n                    and\n                    <jats:italic>in vitro<\/jats:italic>\n                    models and human samples. An increase in the expression levels of FLNA was observed in the advanced tumoural stages of the hyperplastic adenomatous pituitary model, concomitant with a decrease in cell proliferation and with a modification in the subcellular localisation of this protein. Similarly, overexpression of FLNA in the somatolactotropic GH3 cell line induced a decrease in the cell proliferation, promoted a migratory phenotype, increased invasion activity, and decreased the prolactin secretion. Cyclin D1 (CCND1) and cyclin-dependent kinase 4 (CDK4) expression increased in both models in correlation with the increase observed in FLNA levels. When human tissues were analysed a significant increase of FLNA was observed in PitNETs compared to normal pituitary gland, with heterogeneous intracellular localisation. Higher levels of FLNA expression were observed in tumours with invasive characteristics. These results underline the crucial roles of FLNA as a modulator of pathological markers and as a potential prognostic marker in pituitary tumours.\n                  <\/jats:p>","DOI":"10.1530\/joe-23-0209","type":"journal-article","created":{"date-parts":[[2023,10,19]],"date-time":"2023-10-19T06:58:57Z","timestamp":1697698737000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":3,"title":["FLNA expression modulates pathological markers of pituitary neuroendocrine tumours"],"prefix":"10.1530","volume":"260","author":[{"given":"Jonathan","family":"Toledo","sequence":"first","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), C\u00f3rdoba, Argentina"},{"name":"Centro de Microscopia Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6751-2778","authenticated-orcid":true,"given":"Pablo An\u00edbal","family":"Perez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), C\u00f3rdoba, Argentina"},{"name":"Centro de Microscopia Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mical","family":"Zanetti","sequence":"additional","affiliation":[{"name":"Centro de Microscopia Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7373-6893","authenticated-orcid":true,"given":"Graciela","family":"D\u00edaz-Torga","sequence":"additional","affiliation":[{"name":"Instituto de Biolog\u00eda y Medicina Experimental (IBYME-CONICET), Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge Humberto","family":"Mukdsi","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), C\u00f3rdoba, Argentina"},{"name":"Centro de Microscopia Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0509-5144","authenticated-orcid":true,"given":"Silvina","family":"Gutierrez","sequence":"additional","affiliation":[{"name":"Instituto de Investigaciones en Ciencias de la Salud (INICSA-CONICET), C\u00f3rdoba, Argentina"},{"name":"Centro de Microscopia Electr\u00f3nica, Facultad de Ciencias M\u00e9dicas, Universidad Nacional de C\u00f3rdoba, C\u00f3rdoba, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Molecular and Cellular Endocrinology","first-page":"49","article-title":"Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells","volume":"206","author":"An","year":"2003","unstructured":"An JJCho SRJeong DWPark KWAhn YS & Baik JH2003Anti-proliferative effects and cell death mediated by two isoforms of dopamine D2 receptors in pituitary tumor cells. 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