{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:21Z","timestamp":1784557281156,"version":"3.55.0"},"reference-count":35,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,3,15]]},"abstract":"<jats:p>\n                    Estrogen deficiency is one of the main causes for postmenopausal osteoporosis. Current osteoporotic therapies are of high cost and associated with serious side effects. So there is an urgent need for cost-effective anti-osteoporotic agents. Anti-osteoporotic activity of\n                    <jats:italic>Litsea glutinosa<\/jats:italic>\n                    extract (LGE) is less explored. Moreover, its role in fracture healing and mechanism of action is still unknown. In the present study we explore the osteoprotective potential of LGE in osteoblast cells and fractured and ovariectomized (Ovx) mice models. Alkaline phosphatase (ALP), MTT (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) and mineralization assays revealed that LGE treatment increased osteoblast cell differentiation, viability and mineralization. LGE treatment at 0.01 \u03bcg increased the expression of BMP2, PSMAD, RUNX2 and type 1 col. LGE also mitigated RANKL-induced osteoclastogenesis. Next, drill hole injury Balb\/C mice model was treated with LGE for 12 days. Micro-CT analysis and Calcein labeling at the fracture site showed that LGE (20 mg\/kg) enhanced new bone formation and bone regeneration, also increased expression of BMP2\/SMAD1 signaling genes at fracture site. Ovx mice were treated with LGE for 1 month. \u03bcCT analysis indicated that the treatment of LGE at 20 mg\/kg dose prevented the alteration in bone microarchitecture and maintained bone mineral density and bone mineral content. Treatment also increased bone strength and restored the bone turnover markers. Furthermore, in bone samples, LGE increased osteogenesis by enhancing the expression of BMP2\/SMAD1 signaling components and decreased osteoclast number and surface. We conclude that LGE promotes osteogenesis via modulating the BMP2\/SMAD1 signaling pathway. The study advocates the therapeutic potential of LGE in osteoporosis treatment.\n                  <\/jats:p>","DOI":"10.1530\/joe-23-0351","type":"journal-article","created":{"date-parts":[[2024,3,15]],"date-time":"2024-03-15T12:03:04Z","timestamp":1710504184000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":2,"title":["Litsea glutinosa extract promotes fracture healing and prevents bone loss via BMP2\/SMAD1 signaling"],"prefix":"10.1530","volume":"261","author":[{"given":"Sonu","family":"Khanka","sequence":"first","affiliation":[{"name":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charul","family":"Somani","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mohanlal Sukhadia University, Udaipur-Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kriti","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shivani","family":"Sharma","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akhilesh","family":"Kumar","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"},{"name":"Sophisticated Analytical Instrument Facility & Research, Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naibedya","family":"Chattopadhyay","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2473-0246","authenticated-orcid":true,"given":"Sanjeev K","family":"Kanojiya","sequence":"additional","affiliation":[{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"},{"name":"Sophisticated Analytical Instrument Facility & Research, Division, CSIR-Central Drug Research Institute, Lucknow, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dinesh Kumar","family":"Yadav","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mohanlal Sukhadia University, Udaipur-Rajasthan, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2487-4082","authenticated-orcid":true,"given":"Divya","family":"Singh","sequence":"additional","affiliation":[{"name":"Division of Endocrinology, CSIR-Central Drug Research Institute, Lucknow, India"},{"name":"Academy of Scientific and Innovative Research (AcSIR), Ghaziabad, Uttar Pradesh, India"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Bioorganic and Medicinal Chemistry Letters","first-page":"128340","article-title":"Synthesis and biological evaluation of substituted amide derivatives of C4-ageratochromene dimer analog","volume":"50","author":"Agarwal","year":"2021","unstructured":"Agarwal KGupta KSharma KKhanka SSingh SSingh JTrivedi LVasdev PGLuqman SKhan F, et al.2021Synthesis and biological evaluation of substituted amide derivatives of C4-ageratochromene dimer analog. Bioorganic and Medicinal Chemistry Letters50128340. (https:\/\/doi.org\/10.1016\/j.bmcl.2021.128340)"},{"key":"bib2","series-title":"Journal of Bone and Mineral Research","first-page":"1468","article-title":"Guidelines for assessment of bone microstructure in rodents using micro\u2013computed tomography","volume":"25","author":"Bouxsein","year":"2010","unstructured":"Bouxsein MLBoyd SKChristiansen BAGuldberg REJepsen KJ & M\u00fcller R2010Guidelines for assessment of bone microstructure in rodents using micro\u2013computed tomography. Journal of Bone and Mineral Research251468\u20131486. (https:\/\/doi.org\/10.1002\/jbmr.141)"},{"key":"bib3","series-title":"Journal of Ayurveda and Integrative Medicine","first-page":"100501","article-title":"Molecular insights for an anti-osteoporotic properties of Litsea glutinosa on Saos-2 cells: an in-vitro approach","volume":"13","author":"Changani","year":"2022","unstructured":"Changani H & Parikh P2022Molecular insights for an anti-osteoporotic properties of Litsea glutinosa on Saos-2 cells: an in-vitro approach. Journal of Ayurveda and Integrative Medicine13100501. (https:\/\/doi.org\/10.1016\/j.jaim.2021.07.017)"},{"issue":"Supplement 1","key":"bib4","series-title":"International Journal of Fertility and Menopausal Studies","first-page":"45","article-title":"Prevention and treatment of osteoporosis with hormone replacement therapy","volume":"38","author":"Christiansen","year":"1993","unstructured":"Christiansen C1993Prevention and treatment of osteoporosis with hormone replacement therapy. International Journal of Fertility and Menopausal Studies38(Supplement 1) 45\u201354. (https:\/\/doi.org\/10.1177\/20533691221139902)"},{"key":"bib5","series-title":"Phytochemical Analysis","first-page":"711","article-title":"Rapid structural characterisation of benzylisoquinoline and aporphine alkaloids from Ocotea spixiana acaricide extract by HPTLC\u2010DESI\u2010MSn","volume":"31","author":"Concei\u00e7\u00e3o","year":"2020","unstructured":"Concei\u00e7\u00e3o RSReis IMCerqueira APPerez CJJunior MCBranco AIfa DR & Botura MB2020Rapid structural characterisation of benzylisoquinoline and aporphine alkaloids from Ocotea spixiana acaricide extract by HPTLC\u2010DESI\u2010MSn. Phytochemical Analysis31711\u2013721. (https:\/\/doi.org\/10.1002\/pca.2935)"},{"key":"bib6","series-title":"Bone","first-page":"19","article-title":"Epidemiology of fractures in the United Kingdom 1988\u20132012: variation with age, sex, geography, ethnicity and socioeconomic status","volume":"87","author":"Curtis","year":"2016","unstructured":"Curtis EMvan der Velde RMoon RJvan den Bergh JPGeusens Pde Vries Fvan Staa TPCooper C & Harvey NC2016Epidemiology of fractures in the United Kingdom 1988\u20132012: variation with age, sex, geography, ethnicity and socioeconomic status. Bone8719\u201326. (https:\/\/doi.org\/10.1016\/j.bone.2016.03.006)"},{"key":"bib7","series-title":"Journal of Pharmaceutical Sciences and Research","first-page":"155","article-title":"Study of antioxdant, antiinflammatory and woundhealing activity of extracts of Litsea glutinosa","volume":"2","author":"Devi","year":"2010","unstructured":"Devi P & Meera R2010Study of antioxdant, antiinflammatory and woundhealing activity of extracts of Litsea glutinosa. Journal of Pharmaceutical Sciences and Research2155\u2013163."},{"key":"bib8","series-title":"PLoS One","first-page":"e0144541","article-title":"Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of notch and Wnt canonical signaling pathways","volume":"10","author":"Dixit","year":"2015","unstructured":"Dixit MRaghuvanshi AGupta CPKureel JMansoori MNShukla PJohn AASingh KPurohit DAwasthi P, et al.2015Medicarpin, a natural pterocarpan, heals cortical bone defect by activation of notch and Wnt canonical signaling pathways. PLoS One10e0144541. (https:\/\/doi.org\/10.1371\/journal.pone.0144541)"},{"key":"bib9","series-title":"Journal of Developmental Biology","first-page":"9","article-title":"Bone morphogenetic protein-2 in development and bone homeostasis","volume":"8","author":"Halloran","year":"2020","unstructured":"Halloran DDurbano HW & Nohe A2020Bone morphogenetic protein-2 in development and bone homeostasis. Journal of Developmental Biology89. (https:\/\/doi.org\/10.3390\/jdb8030019)"},{"key":"bib10","series-title":"Clinics","first-page":"e800","article-title":"The effectiveness and safety of parathyroid hormone in fracture healing: a meta-analysis","volume":"74","author":"Hong","year":"2019","unstructured":"Hong HSong TLiu YLi JJiang QSong Q & Deng Z2019The effectiveness and safety of parathyroid hormone in fracture healing: a meta-analysis. Clinics74e800. (https:\/\/doi.org\/10.6061\/clinics\/2019\/e800)"},{"key":"bib11","series-title":"Pharmaceuticals","first-page":"3","article-title":"Ethnomedicinal uses, phytochemistry, and therapeutic potentials of Litsea glutinosa (Lour.) CB Robinson: a literature-based review","volume":"16","author":"Jamaddar","year":"2022","unstructured":"Jamaddar SRaposo ASarkar CRoy UKAra\u00fajo IMCoutinho HDAlkhoshaiban ASAlturki HASaraiva ACarrascosa C, et al.2022Ethnomedicinal uses, phytochemistry, and therapeutic potentials of Litsea glutinosa (Lour.) CB Robinson: a literature-based review. Pharmaceuticals163. (https:\/\/doi.org\/10.3390\/ph16010003)"},{"key":"bib12","series-title":"JAMA","first-page":"785","article-title":"Osteoporosis prevention, diagnosis, and therapy","volume":"285","author":"Klibanski","year":"2001","unstructured":"Klibanski AAdams-Campbell LBassford TBlair SNBoden SDDickersin KGifford DRGlasse LGoldring SRHruska K, et al.2001Osteoporosis prevention, diagnosis, and therapy. JAMA285785\u2013795. (https:\/\/doi.org\/10.1001\/jama.285.6.785)"},{"key":"bib14","series-title":"Osteoporosis International","first-page":"816","article-title":"The effects of synthetic conjugated estrogens, a (Cenestin) on trabecular bone structure and strength in the ovariectomized rat model","volume":"13","author":"Lane","year":"2002","unstructured":"Lane NEKumer JLMajumdar SKhan MLotz JStevens REKlein R & Phelps KV2002The effects of synthetic conjugated estrogens, a (Cenestin) on trabecular bone structure and strength in the ovariectomized rat model. Osteoporosis International13816\u2013823. (https:\/\/doi.org\/10.1007\/s001980200113)"},{"key":"bib15","series-title":"Annals of Biomedical Engineering","first-page":"170","article-title":"Vertebral osteoporosis and trabecular bone quality","volume":"35","author":"Mc Donnell","year":"2007","unstructured":"Mc Donnell PMc Hugh PE & O\u2019mahoney D2007Vertebral osteoporosis and trabecular bone quality. Annals of Biomedical Engineering35170\u2013189. (https:\/\/doi.org\/10.1007\/s10439-006-9239-9)"},{"key":"bib16","series-title":"Therapeutic Advances in Musculoskeletal Disease","first-page":"1759720X19877994","article-title":"Update on the safety and efficacy of teriparatide in the treatment of osteoporosis","volume":"11","author":"Minisola","year":"2019","unstructured":"Minisola SCipriani CGrotta GDColangelo LOcchiuto MBiondi PSonato CVigna ECilli M & Pepe J2019Update on the safety and efficacy of teriparatide in the treatment of osteoporosis. Therapeutic Advances in Musculoskeletal Disease111759720X19877994. (https:\/\/doi.org\/10.1177\/1759720X19877994)"},{"key":"bib17","series-title":"Acta Biomaterialia","first-page":"67","article-title":"In vitro osteogenesis by intracellular uptake of strontium containing bioactive glass nanoparticles","volume":"66","author":"Naruphontjirakul","year":"2018","unstructured":"Naruphontjirakul PPorter AE & Jones JR2018In vitro osteogenesis by intracellular uptake of strontium containing bioactive glass nanoparticles. Acta Biomaterialia6667\u201380. (https:\/\/doi.org\/10.1016\/j.actbio.2017.11.008)"},{"key":"bib13","series-title":"Advances in Osteoporosis","article-title":"Estrogen","author":"Okman-Kilic","year":"2015","unstructured":"Okman-Kilic T2015Estrogen deficiency and osteoporosis. In Advances in Osteoporosis. London, UK: InTechOpen. (https:\/\/doi.org\/10.5772\/59407)"},{"key":"bib18","series-title":"Frontiers in Pharmacology","first-page":"803","article-title":"Pharmacological therapy of osteoporosis: a systematic current review of literature","volume":"8","author":"Pavone","year":"2017","unstructured":"Pavone VTesta GGiardina SMVescio ARestivo DA & Sessa G2017Pharmacological therapy of osteoporosis: a systematic current review of literature. Frontiers in Pharmacology8803. (https:\/\/doi.org\/10.3389\/fphar.2017.00803)"},{"key":"bib19","series-title":"Phytomedicine","first-page":"153750","article-title":"Extract and fraction of Musa paradisiaca flower have osteogenic effect and prevent ovariectomy induced osteopenia","volume":"93","author":"Rai","year":"2021","unstructured":"Rai RKumar SSingh KBSingh YArya KRKanojiya SMaurya R & Singh D2021Extract and fraction of Musa paradisiaca flower have osteogenic effect and prevent ovariectomy induced osteopenia. Phytomedicine93153750. (https:\/\/doi.org\/10.3389\/fphar.2017.00803)"},{"key":"bib20","series-title":"Free Radical Biology and Medicine","first-page":"339","article-title":"Cladrin alleviates dexamethasone-induced apoptosis of osteoblasts and promotes bone formation through autophagy induction via AMPK\/mTOR signaling","volume":"190","author":"Rai","year":"2022","unstructured":"Rai RSingh KBKhanka SMaurya R & Singh D2022Cladrin alleviates dexamethasone-induced apoptosis of osteoblasts and promotes bone formation through autophagy induction via AMPK\/mTOR signaling. Free Radical Biology and Medicine190339\u2013350. (https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.08.028)"},{"key":"bib21","series-title":"Pharmacologyonline","first-page":"675","article-title":"Osteoprotective effect three anti inflammatory plants in ovariectomized Wistar rats","volume":"1","author":"Rangrez","year":"2011","unstructured":"Rangrez AYBalakrishnan S & Parikh PH2011Osteoprotective effect three anti inflammatory plants in ovariectomized Wistar rats. Pharmacologyonline1675\u2013684."},{"key":"bib22","series-title":"Reports of Biochemistry and Molecular Biology","first-page":"73","article-title":"Regulation of bone metabolism","volume":"5","author":"Shahi","year":"2017","unstructured":"Shahi MPeymani A & Sahmani M2017Regulation of bone metabolism. Reports of Biochemistry and Molecular Biology573\u201382."},{"key":"bib23","series-title":"Journal of Drug Delivery and Therapeutics","first-page":"1214","article-title":"Screening of phytochemicals and antioxidant potential of leaves extract of Litsea glutinosa","volume":"9","author":"Sharma","year":"2019","unstructured":"Sharma BKLoksh KR & Jain AP2019Screening of phytochemicals and antioxidant potential of leaves extract of Litsea glutinosa. Journal of Drug Delivery and Therapeutics91214\u20131217. (https:\/\/doi.org\/10.22270\/jddt.v9i4-s.3939)"},{"key":"bib24","series-title":"Journal of Cellular Biochemistry","first-page":"1762","article-title":"Maintenance of increased bone mass after PTH withdrawal by sequential medicarpin treatment via augmentation of cAMP\u2010PKA pathway","volume":"123","author":"Sharma","year":"2022a","unstructured":"Sharma KAwasthi PPrakash RKhanka SBajpai RSahasrabuddhe AAGoel A & Singh D2022aMaintenance of increased bone mass after PTH withdrawal by sequential medicarpin treatment via augmentation of cAMP\u2010PKA pathway. Journal of Cellular Biochemistry1231762\u20131779. (https:\/\/doi.org\/10.1002\/jcb.30313)"},{"key":"bib25","series-title":"Food and Function","first-page":"2184","article-title":"Diosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function","volume":"13","author":"Sharma","year":"2022b","unstructured":"Sharma SPorwal KKulkarni CPal SSihota PKumar STiwari MCKatekar RKumar ASingh P, et al.2022bDiosmin, a citrus fruit-derived phlebotonic bioflavonoid protects rats from chronic kidney disease-induced loss of bone mass and strength without deteriorating the renal function. Food and Function132184\u20132199. (https:\/\/doi.org\/10.1039\/D1FO03867B)"},{"key":"bib26","series-title":"Free Radical Biology and Medicine","first-page":"99","article-title":"Chebulinic acid alleviates LPS-induced inflammatory bone loss by targeting the crosstalk between reactive oxygen species\/NF\u03baB signaling in osteoblast cells","volume":"194","author":"Sharma","year":"2023","unstructured":"Sharma KKumar SPrakash RKhanka SMishra TRathur RBiswas AVerma SKBhatta RSNarender T, et al.2023Chebulinic acid alleviates LPS-induced inflammatory bone loss by targeting the crosstalk between reactive oxygen species\/NF\u03baB signaling in osteoblast cells. Free Radical Biology and Medicine19499\u2013113. (https:\/\/doi.org\/10.1016\/j.freeradbiomed.2022.11.026)"},{"key":"bib27","series-title":"British Journal of Nutrition","first-page":"1511","article-title":"Formononetin, a methoxy isoflavone, enhances bone regeneration in a mouse model of cortical bone defect","volume":"117","author":"Singh","year":"2017","unstructured":"Singh KBDixit MDev KMaurya R & Singh D2017Formononetin, a methoxy isoflavone, enhances bone regeneration in a mouse model of cortical bone defect. British Journal of Nutrition1171511\u20131522. (https:\/\/doi.org\/10.1017\/S0007114517001556)"},{"key":"bib28","series-title":"Biomedicine and Pharmacotherapy","first-page":"112390","article-title":"Discontinuation of PTH therapy amplifies bone loss by increasing oxidative stress: an event ameliorated by sequential IL-17 neutralizing antibody therapy","volume":"145","author":"Singh","year":"2022","unstructured":"Singh KBRai RKhanka S & Singh D2022Discontinuation of PTH therapy amplifies bone loss by increasing oxidative stress: an event ameliorated by sequential IL-17 neutralizing antibody therapy. Biomedicine and Pharmacotherapy145112390. (https:\/\/doi.org\/10.1016\/j.biopha.2021.112390)"},{"key":"bib29","series-title":"Rapid Communications in Mass Spectrometry","first-page":"523","article-title":"Key fragmentation patterns of aporphine alkaloids by electrospray ionization with multistage mass spectrometry","volume":"18","author":"Stevigny","year":"2004","unstructured":"Stevigny CJiwan JLRozenberg Rde Hoffmann E & Quetin\u2010Leclercq J2004Key fragmentation patterns of aporphine alkaloids by electrospray ionization with multistage mass spectrometry. Rapid Communications in Mass Spectrometry18523\u2013528. (https:\/\/doi.org\/10.1002\/rcm.1343)"},{"key":"bib30","series-title":"Pharmaceutical Biology","first-page":"884","article-title":"Study on the pharmacokinetics, tissue distribution and excretion of laurolitsine from Litsea glutinosa in Sprague-Dawley rats","volume":"59","author":"Tan","year":"2021","unstructured":"Tan YFWang RQWang WTWu YMa NLu WYZhang Y & Zhang XP2021Study on the pharmacokinetics, tissue distribution and excretion of laurolitsine from Litsea glutinosa in Sprague-Dawley rats. Pharmaceutical Biology59884\u2013892. (https:\/\/doi.org\/10.1080\/13880209.2021.1944221)"},{"key":"bib31","series-title":"Frontiers in Endocrinology","first-page":"977347","article-title":"MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway","volume":"13","author":"Tripathi","year":"2022","unstructured":"Tripathi AJohn AAKumar DKaushal SKSingh DPHusain NSarkar J & Singh D2022MiR-539-3p impairs osteogenesis by suppressing Wnt interaction with LRP-6 co-receptor and subsequent inhibition of Akap-3 signaling pathway. Frontiers in Endocrinology13977347. (https:\/\/doi.org\/10.3389\/fendo.2022.977347)"},{"key":"bib32","series-title":"Pharmacy and Therapeutics","first-page":"92","article-title":"Osteoporosis: a review of treatment options","volume":"43","author":"Tu","year":"2018","unstructured":"Tu KNLie JDWan CKCameron MAustel AGNguyen JKVan K & Hyun D2018Osteoporosis: a review of treatment options. Pharmacy and Therapeutics4392\u2013104."},{"key":"bib33","series-title":"International Journal of Molecular Sciences","first-page":"41","article-title":"Osteogenic differentiation in healthy and pathological conditions","volume":"18","author":"Valenti","year":"2016","unstructured":"Valenti MTDalle Carbonare L & Mottes M2016Osteogenic differentiation in healthy and pathological conditions. International Journal of Molecular Sciences1841. (https:\/\/doi.org\/10.3390\/ijms18010041)"},{"key":"bib34","series-title":"International Journal of Biological Macromolecules","first-page":"202","article-title":"Runx2: structure, function, and phosphorylation in osteoblast differentiation","volume":"78","author":"Vimalraj","year":"2015","unstructured":"Vimalraj SArumugam BMiranda PJ & Selvamurugan N2015Runx2: structure, function, and phosphorylation in osteoblast differentiation. International Journal of Biological Macromolecules78202\u2013208. (https:\/\/doi.org\/10.1016\/j.ijbiomac.2015.04.008)"},{"key":"bib35","series-title":"Journal of Bone and Mineral Research","first-page":"1582","article-title":"Hymenialdisine: a marine natural product that acts on both osteoblasts and osteoclasts and prevents estrogen\u2010dependent bone loss in mice","volume":"35","author":"Wang","year":"2020","unstructured":"Wang QChen DJin HYe ZWang CChen KKuek VXu KQiu HChen P, et al.2020Hymenialdisine: a marine natural product that acts on both osteoblasts and osteoclasts and prevents estrogen\u2010dependent bone loss in mice. Journal of Bone and Mineral Research351582\u20131596. (https:\/\/doi.org\/10.1002\/jbmr.4025)"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/261\/2\/JOE-23-0351.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/261\/2\/JOE-23-0351.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/261\/2\/JOE-23-0351.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:58:03Z","timestamp":1784555883000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/5668"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,3,15]]},"references-count":35,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/joe-23-0351","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,3,15]]}}}