{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:21:21Z","timestamp":1784557281937,"version":"3.55.0"},"reference-count":86,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,5,28]]},"abstract":"<jats:p>\n                    Polycystic ovary syndrome (PCOS) is a condition resulting from the interaction between environmental factors and hereditary components, profoundly affecting offspring development. Although the etiology of this disease remains unclear, aberrant\n                    <jats:italic>in utero<\/jats:italic>\n                    androgen exposure is considered one of the pivotal pathogenic factors. Herein, we demonstrate the intergenerational inheritance of PCOS-like phenotypes in F2 female offspring through F1 males caused by maternal testosterone exposure in F0 mice. We found impaired serum hormone expression and reproductive system development in prenatal testosterone-treated F1 male and F2 female mice (PTF1 and PTF2). In addition, downregulated N6-methyladenosine (m6A) methyltransferase and binding proteins induced mRNA hypomethylation in the PTF1 testis, including frizzled-6 (Fzd6). In the PTF2 ovary, decreased FZD6 protein expression inhibited the mammalian target of rapamycin (mTOR) signaling pathway and activated Forkhead box O3 (FoxO3) phosphorylation, which led to impaired follicular development. These data indicate that epigenetic modification of the mTOR signaling pathway could be involved in the intergenerational inheritance of maternal testosterone exposure-induced impairments in the PTF2 ovary through male PTF1 mice.\n                  <\/jats:p>","DOI":"10.1530\/joe-23-0368","type":"journal-article","created":{"date-parts":[[2024,5,28]],"date-time":"2024-05-28T13:38:00Z","timestamp":1716903480000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":4,"title":["Maternal androgen exposure induces intergenerational effects via paternal inheritance"],"prefix":"10.1530","volume":"262","author":[{"given":"Yu","family":"Zhou","sequence":"first","affiliation":[{"name":"Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"},{"name":"Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Lian","sequence":"additional","affiliation":[{"name":"Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yingfei","family":"Lu","sequence":"additional","affiliation":[{"name":"Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tianming","family":"Wang","sequence":"additional","affiliation":[{"name":"Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chengcheng","family":"Zhao","sequence":"additional","affiliation":[{"name":"Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cuilan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Min","family":"Gong","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianquan","family":"Chen","sequence":"additional","affiliation":[{"name":"Central Laboratory, Translational Medicine Research Center, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"},{"name":"Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3025-7213","authenticated-orcid":true,"given":"Rong","family":"Ju","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Affiliated Jiangning Hospital of Nanjing Medical University, Nanjing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Clinical Medicine Insights. Endocrinology and Diabetes","first-page":"11795514231196461","article-title":"Prenatal androgen excess induces multigenerational effects on female and male descendants","volume":"16","author":"Abruzzese","year":"2023","unstructured":"Abruzzese GAFerreira SRFerrer MJSilva AF & Motta AB2023Prenatal androgen excess induces multigenerational effects on female and male descendants. Clinical Medicine Insights. Endocrinology and Diabetes1611795514231196461. (https:\/\/doi.org\/10.1177\/11795514231196461)"},{"key":"bib2","series-title":"PLoS Genetics","first-page":"e1006660","article-title":"TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes","volume":"13","author":"Akpinar","year":"2017","unstructured":"Akpinar MLesche MFanourgakis GFu JAnastassiadis KDahl A & Jessberger R2017TDRD6 mediates early steps of spliceosome maturation in primary spermatocytes. PLoS Genetics13e1006660. (https:\/\/doi.org\/10.1371\/journal.pgen.1006660)"},{"key":"bib3","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"2617","article-title":"Evidence for association between polycystic ovary syn2drome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2","volume":"94","author":"Biyasheva","year":"2009","unstructured":"Biyasheva ALegro RSDunaif A & Urbanek M2009Evidence for association between polycystic ovary syn2drome (PCOS) and TCF7L2 and glucose intolerance in women with PCOS and TCF7L2. Journal of Clinical Endocrinology and Metabolism942617\u20132625. (https:\/\/doi.org\/10.1210\/jc.2008-1664)"},{"key":"bib4","series-title":"Molecular Reproduction and Development","first-page":"1064","article-title":"The SCF\/c-KIT system in the male: survival strategies in fertility and cancer","volume":"81","author":"Cardoso","year":"2014","unstructured":"Cardoso HJFigueira MICorreia SVaz CV & Socorro S2014The SCF\/c-KIT system in the male: survival strategies in fertility and cancer. Molecular Reproduction and Development811064\u20131079. (https:\/\/doi.org\/10.1002\/mrd.22430)"},{"key":"bib5","series-title":"Obesity Reviews","first-page":"1148","article-title":"Obesity and male hypogonadism: tales of a vicious cycle","volume":"20","author":"Carrageta","year":"2019","unstructured":"Carrageta DFOliveira PFAlves MG & Monteiro MP2019Obesity and male hypogonadism: tales of a vicious cycle. Obesity Reviews201148\u20131158. (https:\/\/doi.org\/10.1111\/obr.12863)"},{"key":"bib6","series-title":"Autophagy","first-page":"457","article-title":"m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells","volume":"17","author":"Chen","year":"2021","unstructured":"Chen YWang JXu DXiang ZDing JYang XLi D & Han X2021m(6)A mRNA methylation regulates testosterone synthesis through modulating autophagy in Leydig cells. Autophagy17457\u2013475. (https:\/\/doi.org\/10.1080\/15548627.2020.1720431)"},{"key":"bib7","series-title":"Nature","first-page":"761","article-title":"Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency","volume":"605","author":"Chen","year":"2022","unstructured":"Chen BDu YRZhu HSun MLWang CCheng YPang HDing GGao JTan Y, et al.2022Maternal inheritance of glucose intolerance via oocyte TET3 insufficiency. Nature605761\u2013766. (https:\/\/doi.org\/10.1038\/s41586-022-04756-4)"},{"key":"bib8","series-title":"Science","article-title":"LMBR1L regulates lymphopoiesis through Wnt\/beta-catenin signaling","volume":"364","author":"Choi","year":"2019","unstructured":"Choi JHZhong XMcAlpine WLiao TCZhang DFang BRussell JLudwig SNair-Gill EZhang Z, et al.2019LMBR1L regulates lymphopoiesis through Wnt\/beta-catenin signaling. Science364. (https:\/\/doi.org\/10.1126\/science.aau0812)"},{"key":"bib9","series-title":"Reproduction","first-page":"R173","article-title":"The mTOR pathway in reproduction: from gonadal function to developmental coordination","volume":"159","author":"Correia","year":"2020","unstructured":"Correia BSousa MI & Ramalho-Santos J2020The mTOR pathway in reproduction: from gonadal function to developmental coordination. Reproduction159R173\u2013R188. (https:\/\/doi.org\/10.1530\/REP-19-0057)"},{"key":"bib10","series-title":"Fertility and Sterility","first-page":"381","article-title":"Higher luteinizing hormone levels associated with antiMullerian hormone in postmenarchal daughters of women with polycystic ovary syndrome","volume":"111","author":"Crisosto","year":"2019","unstructured":"Crisosto NLadron de Guevara AEchiburu BMaliqueo MCavada GCodner EPaez F & Sir-Petermann T2019Higher luteinizing hormone levels associated with antiMullerian hormone in postmenarchal daughters of women with polycystic ovary syndrome. Fertility and Sterility111381\u2013388. (https:\/\/doi.org\/10.1016\/j.fertnstert.2018.10.011)"},{"key":"bib11","series-title":"Endocrine Reviews","first-page":"927","article-title":"Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification","volume":"43","author":"Dapas","year":"2022","unstructured":"Dapas M & Dunaif A2022Deconstructing a syndrome: genomic insights into PCOS causal mechanisms and classification. Endocrine Reviews43927\u2013965. (https:\/\/doi.org\/10.1210\/endrev\/bnac001)"},{"key":"bib87","series-title":"Human Reproduction Update","first-page":"771","article-title":"Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome","volume":"27","year":"2021","unstructured":"de Medeiros SFRodgers RJ & Norman RJ2021Adipocyte and steroidogenic cell cross-talk in polycystic ovary syndrome. Human Reproduction Update27771\u2013796. (https:\/\/doi.org\/10.1093\/humupd\/dmab004)"},{"key":"bib13","series-title":"Molecular Metabolism","first-page":"1","article-title":"Sperm epigenetics and influence of environmental factors","volume":"14","author":"Donkin","year":"2018","unstructured":"Donkin I & Barres R2018Sperm epigenetics and influence of environmental factors. Molecular Metabolism141\u201311. (https:\/\/doi.org\/10.1016\/j.molmet.2018.02.006)"},{"key":"bib14","series-title":"Reproduction","first-page":"R1","article-title":"Mechanisms of intergenerational transmission of polycystic ovary syndrome","volume":"159","author":"Dumesic","year":"2020","unstructured":"Dumesic DAHoyos LRChazenbalk GDNaik RPadmanabhan V & Abbott DH2020Mechanisms of intergenerational transmission of polycystic ovary syndrome. Reproduction159R1\u2013R13. (https:\/\/doi.org\/10.1530\/REP-19-0197)"},{"key":"bib15","series-title":"Human Reproduction Update","first-page":"421","article-title":"Is foetal hyperexposure to androgens a cause of PCOS?","volume":"23","author":"Filippou","year":"2017","unstructured":"Filippou P & Homburg R2017Is foetal hyperexposure to androgens a cause of PCOS?Human Reproduction Update23421\u2013432. (https:\/\/doi.org\/10.1093\/humupd\/dmx013)"},{"key":"bib16","series-title":"Human Reproduction Update","first-page":"1","article-title":"Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility","volume":"29","author":"Fiorentino","year":"2023","unstructured":"Fiorentino GCimadomo DInnocenti FSoscia DVaiarelli AUbaldi FMGennarelli GGaragna SRienzi L & Zuccotti M2023Biomechanical forces and signals operating in the ovary during folliculogenesis and their dysregulation: implications for fertility. Human Reproduction Update291\u201323. (https:\/\/doi.org\/10.1093\/humupd\/dmac031)"},{"key":"bib17","series-title":"Nature Reviews. Genetics","first-page":"325","article-title":"Molecular mechanisms of transgenerational epigenetic inheritance","volume":"23","author":"Fitz-James","year":"2022","unstructured":"Fitz-James MH & Cavalli G2022Molecular mechanisms of transgenerational epigenetic inheritance. Nature Reviews. Genetics23325\u2013341. (https:\/\/doi.org\/10.1038\/s41576-021-00438-5)"},{"key":"bib18","series-title":"Frontiers in Cell and Developmental Biology","first-page":"754054","article-title":"CEP250 is required for maintaining centrosome cohesion in the germline and fertility in male mice","volume":"9","author":"Floriot","year":"2021","unstructured":"Floriot SBellutti LCastille JMoison PMessiaen SPasset BBoulanger LBoukadiri ATourpin SBeauvallet C, et al.2021CEP250 is required for maintaining centrosome cohesion in the germline and fertility in male mice. Frontiers in Cell and Developmental Biology9754054. (https:\/\/doi.org\/10.3389\/fcell.2021.754054)"},{"key":"bib19","series-title":"Science of the Total Environment","first-page":"160432","article-title":"m6A contributes to a pro-survival state in GC-2 cells by facilitating DNA damage repair: novel perspectives on the mechanism underlying DEHP genotoxicity in male germ cells","volume":"859","author":"Fu","year":"2023","unstructured":"Fu HZhu XDi QSun JJiang Q & Xu Q2023m6A contributes to a pro-survival state in GC-2 cells by facilitating DNA damage repair: novel perspectives on the mechanism underlying DEHP genotoxicity in male germ cells. Science of the Total Environment859160432. (https:\/\/doi.org\/10.1016\/j.scitotenv.2022.160432)"},{"key":"bib20","series-title":"Frontiers in Endocrinology","first-page":"852661","article-title":"The role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency","volume":"13","author":"Grande","year":"2022","unstructured":"Grande GBarrachina FSoler-Ventura AJodar MMancini FMarana RChiloiro SPontecorvi AOliva R & Milardi D2022The role of testosterone in spermatogenesis: lessons from proteome profiling of human spermatozoa in testosterone deficiency. Frontiers in Endocrinology13852661. (https:\/\/doi.org\/10.3389\/fendo.2022.852661)"},{"key":"bib21","series-title":"Cellular and Molecular Life Sciences","first-page":"4893","article-title":"Epigenetic regulations in mammalian spermatogenesis: RNA-m(6)A modification and beyond","volume":"78","author":"Gui","year":"2021","unstructured":"Gui Y & Yuan S2021Epigenetic regulations in mammalian spermatogenesis: RNA-m(6)A modification and beyond. Cellular and Molecular Life Sciences784893\u20134905. (https:\/\/doi.org\/10.1007\/s00018-021-03823-9)"},{"key":"bib22","series-title":"Frontiers in Endocrinology","first-page":"692","article-title":"Role of mTOR signaling in female reproduction","volume":"10","author":"Guo","year":"2019","unstructured":"Guo Z & Yu Q2019Role of mTOR signaling in female reproduction. Frontiers in Endocrinology10692. (https:\/\/doi.org\/10.3389\/fendo.2019.00692)"},{"key":"bib23","series-title":"PNAS","first-page":"E5326","article-title":"Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice","volume":"115","author":"Guo","year":"2018","unstructured":"Guo JZhang TGuo YSun TLi HZhang XYin HCao GYin YWang H, et al.2018Oocyte stage-specific effects of MTOR determine granulosa cell fate and oocyte quality in mice. PNAS115E5326\u2013E5333. (https:\/\/doi.org\/10.1073\/pnas.1800352115)"},{"key":"bib24","series-title":"Molecular and Cellular Endocrinology","first-page":"27","article-title":"Steroidogenic factor 1 (SF-1) is essential for ovarian development and function","volume":"163","author":"Hanley","year":"2000","unstructured":"Hanley NAIkeda YLuo X & Parker KL2000Steroidogenic factor 1 (SF-1) is essential for ovarian development and function. Molecular and Cellular Endocrinology16327\u201332. (https:\/\/doi.org\/10.1016\/s0303-7207(9900237-3)"},{"key":"bib25","series-title":"Nature Communications","first-page":"3184","article-title":"Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis","volume":"12","author":"Horisawa-Takada","year":"2021","unstructured":"Horisawa-Takada YKodera CTakemoto KSakashita AHorisawa KMaeda RShimada RUsuki SFujimura STani N, et al.2021Meiosis-specific ZFP541 repressor complex promotes developmental progression of meiotic prophase towards completion during mouse spermatogenesis. Nature Communications123184. (https:\/\/doi.org\/10.1038\/s41467-021-23378-4)"},{"key":"bib26","series-title":"Cell Research","first-page":"1115","article-title":"Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis","volume":"27","author":"Hsu","year":"2017","unstructured":"Hsu PJZhu YMA HGuo YShi XLiu YQi MLu ZShi HWang J, et al.2017Ythdc2 is an N(6)-methyladenosine binding protein that regulates mammalian spermatogenesis. Cell Research271115\u20131127. (https:\/\/doi.org\/10.1038\/cr.2017.99)"},{"key":"bib27","series-title":"Biology of Reproduction","first-page":"102","article-title":"Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice","volume":"98","author":"Hu","year":"2018","unstructured":"Hu JSun F & Handel MA2018Nuclear localization of EIF4G3 suggests a role for the XY body in translational regulation during spermatogenesis in mice. Biology of Reproduction98102\u2013114. (https:\/\/doi.org\/10.1093\/biolre\/iox150)"},{"key":"bib28","series-title":"Reproductive Sciences","first-page":"119","article-title":"Lipotoxicity impairs granulosa cell function through activated endoplasmic reticulum stress pathway","volume":"27","author":"Hua","year":"2020","unstructured":"Hua DZhou YLu YZhao CQiu WChen J & Ju R2020Lipotoxicity impairs granulosa cell function through activated endoplasmic reticulum stress pathway. Reproductive Sciences27119\u2013131. (https:\/\/doi.org\/10.1007\/s43032-019-00014-7)"},{"key":"bib29","series-title":"Cell Death and Disease","first-page":"37","article-title":"YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m(6)A\/mRNA pathway","volume":"11","author":"Huang","year":"2020","unstructured":"Huang TLiu ZZheng YFeng TGao Q & Zeng W2020YTHDF2 promotes spermagonial adhesion through modulating MMPs decay via m(6)A\/mRNA pathway. Cell Death and Disease1137. (https:\/\/doi.org\/10.1038\/s41419-020-2235-4)"},{"key":"bib30","series-title":"Environmental Pollution","first-page":"118960","article-title":"Perfluorooctane sulfonate induces suppression of testosterone biosynthesis via Sertoli cell-derived exosomal\/miR-9-3p downregulating StAR expression in Leydig cells","volume":"301","author":"Huang","year":"2022","unstructured":"Huang JRen HChen ALi TWang HJiang LZheng SQi HJi BWang X, et al.2022Perfluorooctane sulfonate induces suppression of testosterone biosynthesis via Sertoli cell-derived exosomal\/miR-9-3p downregulating StAR expression in Leydig cells. Environmental Pollution301118960. (https:\/\/doi.org\/10.1016\/j.envpol.2022.118960)"},{"key":"bib31","series-title":"Molecular Cell","first-page":"1059","article-title":"The RNA m(6)A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence","volume":"67","author":"Ivanova","year":"2017","unstructured":"Ivanova IMuch CDi Giacomo MAzzi CMorgan MMoreira PNMonahan JCarrieri CEnright AJ & O\u2019Carroll D2017The RNA m(6)A reader YTHDF2 is essential for the post-transcriptional regulation of the maternal transcriptome and oocyte competence. Molecular Cell671059\u20131067.e4. (https:\/\/doi.org\/10.1016\/j.molcel.2017.08.003)"},{"key":"bib32","series-title":"Critical Reviews in Biochemistry and Molecular Biology","first-page":"235","article-title":"Mammalian target of rapamycin (mTOR): a central regulator of male fertility?","volume":"52","author":"Jesus","year":"2017","unstructured":"Jesus TTOliveira PFSousa MCheng CY & Alves MG2017Mammalian target of rapamycin (mTOR): a central regulator of male fertility?Critical Reviews in Biochemistry and Molecular Biology52235\u2013253. (https:\/\/doi.org\/10.1080\/10409238.2017.1279120)"},{"key":"bib33","series-title":"Signal Transduction and Targeted Therapy","first-page":"74","article-title":"The role of m6A modification in the biological functions and diseases","volume":"6","author":"Jiang","year":"2021","unstructured":"Jiang XLiu BNie ZDuan LXiong QJin ZYang C & Chen Y2021The role of m6A modification in the biological functions and diseases. Signal Transduction and Targeted Therapy674. (https:\/\/doi.org\/10.1038\/s41392-020-00450-x)"},{"key":"bib34","series-title":"Lancet. Diabetes and Endocrinology","first-page":"668","article-title":"Polycystic ovary syndrome","volume":"10","author":"Joham","year":"2022","unstructured":"Joham AENorman RJStener-Victorin ELegro RSFranks SMoran LJBoyle J & Teede HJ2022Polycystic ovary syndrome. Lancet. Diabetes and Endocrinology10668\u2013680. (https:\/\/doi.org\/10.1016\/S2213-8587(2200163-2)"},{"key":"bib35","series-title":"Nature Methods","first-page":"357","article-title":"HISAT: a fast spliced aligner with low memory requirements","volume":"12","author":"Kim","year":"2015","unstructured":"Kim DLangmead B & Salzberg SL2015HISAT: a fast spliced aligner with low memory requirements. Nature Methods12357\u2013360. (https:\/\/doi.org\/10.1038\/nmeth.3317)"},{"key":"bib36","series-title":"Nature Communications","first-page":"414","article-title":"Structural insight into small molecule action on Frizzleds","volume":"11","author":"Kozielewicz","year":"2020","unstructured":"Kozielewicz PTurku ABowin CFPetersen JValnohova JCanizal MCAOno YInoue AHoffmann C & Schulte G2020Structural insight into small molecule action on Frizzleds. Nature Communications11414. (https:\/\/doi.org\/10.1038\/s41467-019-14149-3)"},{"key":"bib37","series-title":"Nature Methods","first-page":"357","article-title":"Fast gapped-read alignment with Bowtie 2","volume":"9","author":"Langmead","year":"2012","unstructured":"Langmead B & Salzberg SL2012Fast gapped-read alignment with Bowtie 2. Nature Methods9357\u2013359. (https:\/\/doi.org\/10.1038\/nmeth.1923)"},{"key":"bib38","series-title":"eLife","article-title":"Intergenerational epigenetic inheritance of cancer susceptibility in mammals","volume":"8","author":"Lesch","year":"2019","unstructured":"Lesch BJTothova ZMorgan EALiao ZBronson RTEbert BL & Page DC2019Intergenerational epigenetic inheritance of cancer susceptibility in mammals. eLife8. (https:\/\/doi.org\/10.7554\/eLife.39380)"},{"key":"bib39","series-title":"BMC Bioinformatics","first-page":"323","article-title":"RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome","volume":"12","author":"Li","year":"2011","unstructured":"Li B & Dewey CN2011RSEM: accurate transcript quantification from RNA-Seq data with or without a reference genome. BMC Bioinformatics12323. (https:\/\/doi.org\/10.1186\/1471-2105-12-323)"},{"key":"bib40","series-title":"Bioinformatics","first-page":"713","article-title":"SOAP: short oligonucleotide alignment program","volume":"24","author":"Li","year":"2008","unstructured":"Li RLi YKristiansen K & Wang J2008SOAP: short oligonucleotide alignment program. Bioinformatics24713\u2013714. (https:\/\/doi.org\/10.1093\/bioinformatics\/btn025)"},{"key":"bib41","series-title":"Signal Transduction and Targeted Therapy","first-page":"216","article-title":"Trends in insulin resistance: insights into mechanisms and therapeutic strategy","volume":"7","author":"Li","year":"2022","unstructured":"Li MChi XWang YSetrerrahmane SXie W & Xu H2022Trends in insulin resistance: insights into mechanisms and therapeutic strategy. Signal Transduction and Targeted Therapy7216. (https:\/\/doi.org\/10.1038\/s41392-022-01073-0)"},{"key":"bib42","series-title":"Nature Methods","first-page":"767","article-title":"Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome","volume":"12","author":"Linder","year":"2015","unstructured":"Linder BGrozhik AVOlarerin-George AOMeydan CMason CE & Jaffrey SR2015Single-nucleotide-resolution mapping of m6A and m6Am throughout the transcriptome. Nature Methods12767\u2013772. (https:\/\/doi.org\/10.1038\/nmeth.3453)"},{"key":"bib43","series-title":"Frontiers in Cell and Developmental Biology","first-page":"676364","article-title":"Role of RNA N6-methyladenosine modification in male infertility and Genital system tumors","volume":"9","author":"Liu","year":"2021","unstructured":"Liu SLao YWang YLi RFang XWang YGao X & Dong Z2021Role of RNA N6-methyladenosine modification in male infertility and Genital system tumors. Frontiers in Cell and Developmental Biology9676364. (https:\/\/doi.org\/10.3389\/fcell.2021.676364)"},{"key":"bib44","series-title":"Genome Biology","first-page":"550","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","unstructured":"Love MIHuber W & Anders S2014Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2. Genome Biology15550. (https:\/\/doi.org\/10.1186\/s13059-014-0550-8)"},{"key":"bib45","series-title":"Endocrine","first-page":"7","article-title":"Role of the steroidogenic acute regulatory protein in health and disease","volume":"51","author":"Manna","year":"2016","unstructured":"Manna PRStetson CLSlominski AT & Pruitt K2016Role of the steroidogenic acute regulatory protein in health and disease. Endocrine517\u201321. (https:\/\/doi.org\/10.1007\/s12020-015-0715-6)"},{"key":"bib46","series-title":"Gynecological Endocrinology","first-page":"289","article-title":"The polycystic ovary syndrome and gynecological cancer risk","volume":"36","author":"Meczekalski","year":"2020","unstructured":"Meczekalski BPerez-Roncero GRLopez-Baena MTChedraui P & Perez-Lopez FR2020The polycystic ovary syndrome and gynecological cancer risk. Gynecological Endocrinology36289\u2013293. (https:\/\/doi.org\/10.1080\/09513590.2020.1730794)"},{"key":"bib47","series-title":"International Journal of Molecular Sciences","article-title":"Role of integrins in sperm activation and fertilization","volume":"22","author":"Merc","year":"2021","unstructured":"Merc VFrolikova M & Komrskova K2021Role of integrins in sperm activation and fertilization. International Journal of Molecular Sciences22. (https:\/\/doi.org\/10.3390\/ijms222111809)"},{"key":"bib48","series-title":"Cell Metabolism","first-page":"513","article-title":"Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process","volume":"33","author":"Mimouni","year":"2021","unstructured":"Mimouni NEHPaiva IBarbotin ALTimzoura FEPlassard DLe Gras STernier GPigny PCatteau-Jonard SSimon V, et al.2021Polycystic ovary syndrome is transmitted via a transgenerational epigenetic process. Cell Metabolism33513\u2013530.e8. (https:\/\/doi.org\/10.1016\/j.cmet.2021.01.004)"},{"key":"bib49","series-title":"International Journal of Molecular Sciences","article-title":"Molecular mechanisms controlled by mTOR in male reproductive system","volume":"20","author":"Moreira","year":"2019","unstructured":"Moreira BPOliveira PF & Alves MG2019Molecular mechanisms controlled by mTOR in male reproductive system. International Journal of Molecular Sciences20. (https:\/\/doi.org\/10.3390\/ijms20071633)"},{"key":"bib50","series-title":"Reproduction","first-page":"569","article-title":"Methods for quantifying follicular numbers within the mouse ovary","volume":"127","author":"Myers","year":"2004","unstructured":"Myers MBritt KLWreford NGEbling FJ & Kerr JB2004Methods for quantifying follicular numbers within the mouse ovary. Reproduction127569\u2013580. (https:\/\/doi.org\/10.1530\/rep.1.00095)"},{"key":"bib51","series-title":"International Journal of Endocrinology","first-page":"6276187","article-title":"From prediabetes to type 2 diabetes mellitus in women with polycystic ovary syndrome: lifestyle and pharmacological management","volume":"2020","author":"Pani","year":"2020","unstructured":"Pani AGironi IDi Vieste GMion EBertuzzi F & Pintaudi B2020From prediabetes to type 2 diabetes mellitus in women with polycystic ovary syndrome: lifestyle and pharmacological management. International Journal of Endocrinology20206276187. (https:\/\/doi.org\/10.1155\/2020\/6276187)"},{"key":"bib52","series-title":"Nature","first-page":"369","article-title":"m(6)A RNA methylation promotes XIST-mediated transcriptional repression","volume":"537","author":"Patil","year":"2016","unstructured":"Patil DPChen CKPickering BFChow AJackson CGuttman M & Jaffrey SR2016m(6)A RNA methylation promotes XIST-mediated transcriptional repression. Nature537369\u2013373. (https:\/\/doi.org\/10.1038\/nature19342)"},{"key":"bib53","series-title":"Nature Cell Biology","first-page":"143","article-title":"Intergenerational and transgenerational epigenetic inheritance in animals","volume":"21","author":"Perez","year":"2019","unstructured":"Perez MF & Lehner B2019Intergenerational and transgenerational epigenetic inheritance in animals. Nature Cell Biology21143\u2013151. (https:\/\/doi.org\/10.1038\/s41556-018-0242-9)"},{"key":"bib54","series-title":"Fertility and Sterility","first-page":"862","article-title":"Higher risk of type 2 diabetes in women with hyperandrogenic polycystic ovary syndrome","volume":"116","author":"Persson","year":"2021","unstructured":"Persson SElenis ETurkmen SKramer MSYong EL & Poromaa IS2021Higher risk of type 2 diabetes in women with hyperandrogenic polycystic ovary syndrome. Fertility and Sterility116862\u2013871. (https:\/\/doi.org\/10.1016\/j.fertnstert.2021.04.018)"},{"key":"bib55","series-title":"Nature Communications","first-page":"226","article-title":"Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling","volume":"8","author":"Petersen","year":"2017","unstructured":"Petersen JWright SCRodriguez DMatricon PLahav NVromen AFriedler AStromqvist JWennmalm SCarlsson J, et al.2017Agonist-induced dimer dissociation as a macromolecular step in G protein-coupled receptor signaling. Nature Communications8226. (https:\/\/doi.org\/10.1038\/s41467-017-00253-9)"},{"key":"bib56","series-title":"Nature Medicine","first-page":"1894","article-title":"Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome","volume":"25","author":"Risal","year":"2019","unstructured":"Risal SPei YLu HManti MFornes RPui HPZhao ZMassart JOhlsson CLindgren E, et al.2019Prenatal androgen exposure and transgenerational susceptibility to polycystic ovary syndrome. Nature Medicine251894\u20131904. (https:\/\/doi.org\/10.1038\/s41591-019-0666-1)"},{"key":"bib57","series-title":"Cell Reports. Medicine","first-page":"101035","article-title":"Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome","volume":"4","author":"Risal","year":"2023","unstructured":"Risal SLi CLuo QFornes RLu HEriksson GManti MOhlsson CLindgren ECrisosto N, et al.2023Transgenerational transmission of reproductive and metabolic dysfunction in the male progeny of polycystic ovary syndrome. Cell Reports. Medicine4101035. (https:\/\/doi.org\/10.1016\/j.xcrm.2023.101035)"},{"key":"bib58","series-title":"Journal of Endocrinology","first-page":"213","article-title":"Prenatal androgen exposure programs metabolic dysfunction in female mice","author":"Roland","year":"2010","unstructured":"Roland AVNunemaker CSKeller SR & Moenter SM2010Prenatal androgen exposure programs metabolic dysfunction in female mice. Journal of Endocrinology 207 213\u2013223. (https:\/\/doi.org\/10.1677\/JOE-10-0217)"},{"key":"bib59","series-title":"Endocrine Reviews","first-page":"467","article-title":"The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited","volume":"37","author":"Rosenfield","year":"2016","unstructured":"Rosenfield RL & Ehrmann DA2016The pathogenesis of polycystic ovary syndrome (PCOS): the hypothesis of PCOS as functional ovarian hyperandrogenism revisited. Endocrine Reviews37467\u2013520. (https:\/\/doi.org\/10.1210\/er.2015-1104)"},{"key":"bib60","series-title":"Journal of Ovarian Research","first-page":"24","article-title":"Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids","volume":"8","author":"Salilew-Wondim","year":"2015","unstructured":"Salilew-Wondim DWang QTesfaye DSchellander KHoelker MHossain MM & Tsang BK2015Polycystic ovarian syndrome is accompanied by repression of gene signatures associated with biosynthesis and metabolism of steroids, cholesterol and lipids. Journal of Ovarian Research824. (https:\/\/doi.org\/10.1186\/s13048-015-0151-5)"},{"key":"bib61","series-title":"Biomolecules","article-title":"Environmental and genetic traffic in the journey from sperm to offspring","volume":"13","author":"Sengupta","year":"2023","unstructured":"Sengupta PDutta SLiew FFDhawan VDas BMottola FSlama PRocco L & Roychoudhury S2023Environmental and genetic traffic in the journey from sperm to offspring. Biomolecules13. (https:\/\/doi.org\/10.3390\/biom13121759)"},{"key":"bib62","series-title":"International Journal of Molecular Sciences","article-title":"The role of promyelocytic leukemia zinc finger (PLZF) and glial-derived neurotrophic factor family receptor alpha 1 (GFRalpha1) in the cryopreservation of spermatogonia stem cells","volume":"24","author":"Shamhari","year":"2023","unstructured":"Shamhari AJefferi NESAbd Hamid ZBudin SBIdris MHM & Taib IS2023The role of promyelocytic leukemia zinc finger (PLZF) and glial-derived neurotrophic factor family receptor alpha 1 (GFRalpha1) in the cryopreservation of spermatogonia stem cells. International Journal of Molecular Sciences24. (https:\/\/doi.org\/10.3390\/ijms24031945)"},{"key":"bib63","series-title":"Metabolic Syndrome and Related Disorders","first-page":"210","article-title":"Relationships between TCF7L2 genetic polymorphisms and polycystic ovary syndrome risk: a meta-analysis","volume":"12","author":"Shen","year":"2014","unstructured":"Shen WJLi TRHu YJLiu HB & Song M2014Relationships between TCF7L2 genetic polymorphisms and polycystic ovary syndrome risk: a meta-analysis. Metabolic Syndrome and Related Disorders12210\u2013219. (https:\/\/doi.org\/10.1089\/met.2014.0004)"},{"key":"bib64","series-title":"Human Reproduction","first-page":"2573","article-title":"Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization","volume":"17","author":"Sir-Petermann","year":"2002","unstructured":"Sir-Petermann TMaliqueo MAngel BLara HEPerez-Bravo F & Recabarren SE2002Maternal serum androgens in pregnant women with polycystic ovarian syndrome: possible implications in prenatal androgenization. Human Reproduction172573\u20132579. (https:\/\/doi.org\/10.1093\/humrep\/17.10.2573)"},{"key":"bib65","series-title":"Nature Reviews. Endocrinology","first-page":"521","article-title":"Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment","volume":"17","author":"Stener-Victorin","year":"2021","unstructured":"Stener-Victorin E & Deng Q2021Epigenetic inheritance of polycystic ovary syndrome - challenges and opportunities for treatment. Nature Reviews. Endocrinology17521\u2013533. (https:\/\/doi.org\/10.1038\/s41574-021-00517-x)"},{"key":"bib66","series-title":"Biology of Reproduction","first-page":"76","article-title":"MTOR-mediated interaction between the oocyte and granulosa cells regulates the development and function of both compartments in micedagger","volume":"107","author":"Su","year":"2022","unstructured":"Su YQYin YGuo JGong XTian Y & Shi L2022MTOR-mediated interaction between the oocyte and granulosa cells regulates the development and function of both compartments in micedagger. Biology of Reproduction10776\u201384. (https:\/\/doi.org\/10.1093\/biolre\/ioac099)"},{"key":"bib67","series-title":"Nature Medicine","first-page":"834","article-title":"Elevated prenatal anti-Mullerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood","volume":"24","author":"Tata","year":"2018","unstructured":"Tata BMimouni NEHBarbotin ALMalone SALoyens APigny PDewailly DCatteau-Jonard SSundstrom-Poromaa IPiltonen TT, et al.2018Elevated prenatal anti-Mullerian hormone reprograms the fetus and induces polycystic ovary syndrome in adulthood. Nature Medicine24834\u2013846. (https:\/\/doi.org\/10.1038\/s41591-018-0035-5)"},{"key":"bib68","series-title":"Science","first-page":"968","article-title":"FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development","volume":"376","author":"Wei","year":"2022","unstructured":"Wei JYu XYang LLiu XGao BHuang BDou XLiu JZou ZCui XL, et al.2022FTO mediates LINE1 m6A demethylation and chromatin regulation in mESCs and mouse development. Science376968\u2013973. (https:\/\/doi.org\/10.1126\/science.abe9582)"},{"key":"bib69","series-title":"BioTechniques","first-page":"75","article-title":"Real-time PCR for mRNA quantitation","volume":"39","author":"Wong","year":"2005","unstructured":"Wong ML & Medrano JF2005Real-time PCR for mRNA quantitation. BioTechniques3975\u201385. (https:\/\/doi.org\/10.2144\/05391RV01)"},{"key":"bib70","series-title":"PNAS","first-page":"4134","article-title":"Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans","volume":"113","author":"Wu","year":"2016","unstructured":"Wu HSun LWen YLiu YYu JMao FWang YTong CGuo XHu Z, et al.2016Major spliceosome defects cause male infertility and are associated with nonobstructive azoospermia in humans. PNAS1134134\u20134139. (https:\/\/doi.org\/10.1073\/pnas.1513682113)"},{"key":"bib71","series-title":"Frontiers in Cell and Developmental Biology","first-page":"882994","article-title":"The maternal microbiome programs the m(6)A epitranscriptome of the mouse fetal brain and intestine","volume":"10","author":"Xiao","year":"2022","unstructured":"Xiao ZLiu SLi ZCui JWang HWang ZRen QXia LWang Z & Li Y2022The maternal microbiome programs the m(6)A epitranscriptome of the mouse fetal brain and intestine. Frontiers in Cell and Developmental Biology10882994. (https:\/\/doi.org\/10.3389\/fcell.2022.882994)"},{"key":"bib72","series-title":"PNAS","first-page":"E2348","article-title":"Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice","volume":"115","author":"Xie","year":"2018","unstructured":"Xie KRyan DPPearson BLHenzel KSNeff FVidal ROHennion MLehmann ISchleif MSchroder S, et al.2018Epigenetic alterations in longevity regulators, reduced life span, and exacerbated aging-related pathology in old father offspring mice. PNAS115E2348\u2013E2357. (https:\/\/doi.org\/10.1073\/pnas.1707337115)"},{"key":"bib73","series-title":"Cell Research","first-page":"1100","article-title":"Mettl3-mediated m(6)A regulates spermatogonial differentiation and meiosis initiation","volume":"27","author":"Xu","year":"2017","unstructured":"Xu KYang YFeng GHSun BFChen JQLi YFChen YSZhang XXWang CXJiang LY, et al.2017Mettl3-mediated m(6)A regulates spermatogonial differentiation and meiosis initiation. Cell Research271100\u20131114. (https:\/\/doi.org\/10.1038\/cr.2017.100)"},{"key":"bib74","series-title":"Cell Research","first-page":"616","article-title":"Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism","volume":"28","author":"Yang","year":"2018","unstructured":"Yang YHsu PJChen YS & Yang YG2018Dynamic transcriptomic m(6)A decoration: writers, erasers, readers and functions in RNA metabolism. Cell Research28616\u2013624. (https:\/\/doi.org\/10.1038\/s41422-018-0040-8)"},{"key":"bib75","series-title":"Endocrinology","article-title":"Cyp17a1 is required for female sex determination and male fertility by regulating sex steroid biosynthesis in fish","volume":"162","author":"Yang","year":"2021","unstructured":"Yang LZhang XLiu SZhao CMiao YJin LWang D & Zhou L2021Cyp17a1 is required for female sex determination and male fertility by regulating sex steroid biosynthesis in fish. Endocrinology162. (https:\/\/doi.org\/10.1210\/endocr\/bqab205)"},{"key":"bib76","series-title":"Reproductive Biology and Endocrinology","first-page":"67","article-title":"Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation","volume":"20","author":"Yang","year":"2022","unstructured":"Yang QXi QWang MLong RHu JLi ZRen XZhu L & Jin L2022Rapamycin improves the quality and developmental competence of mice oocytes by promoting DNA damage repair during in vitro maturation. Reproductive Biology and Endocrinology2067. (https:\/\/doi.org\/10.1186\/s12958-022-00943-0)"},{"key":"bib77","series-title":"Aging","first-page":"3919","article-title":"Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging","volume":"11","author":"Zhang","year":"2019","unstructured":"Zhang MBener MBJiang ZWang TEsencan EScott RHorvath T & Seli E2019Mitofusin 2 plays a role in oocyte and follicle development, and is required to maintain ovarian follicular reserve during reproductive aging. Aging113919\u20133938. (https:\/\/doi.org\/10.18632\/aging.102024)"},{"key":"bib78","series-title":"Frontiers in Physiology","first-page":"595086","article-title":"Expression regulation and physiological role of transcription factor FOXO3a during ovarian follicular development","volume":"11","author":"Zhang","year":"2020a","unstructured":"Zhang HLin FZhao J & Wang Z2020aExpression regulation and physiological role of transcription factor FOXO3a during ovarian follicular development. Frontiers in Physiology11595086. (https:\/\/doi.org\/10.3389\/fphys.2020.595086)"},{"key":"bib79","series-title":"Frontiers in Endocrinology","first-page":"144","article-title":"Transgenerational inheritance of reproductive and metabolic phenotypes in PCOS rats","volume":"11","author":"Zhang","year":"2020b","unstructured":"Zhang HLYi MLi DLi RZhao Y & Qiao J2020bTransgenerational inheritance of reproductive and metabolic phenotypes in PCOS rats. Frontiers in Endocrinology11144. (https:\/\/doi.org\/10.3389\/fendo.2020.00144)"},{"key":"bib80","series-title":"Frontiers in Cardiovascular Medicine","first-page":"552421","article-title":"Risk of cardiovascular and cerebrovascular events in polycystic ovarian syndrome women: a meta-analysis of cohort studies","volume":"7","author":"Zhang","year":"2020c","unstructured":"Zhang JXu JHQu QQ & Zhong GQ2020cRisk of cardiovascular and cerebrovascular events in polycystic ovarian syndrome women: a meta-analysis of cohort studies. Frontiers in Cardiovascular Medicine7552421. (https:\/\/doi.org\/10.3389\/fcvm.2020.552421)"},{"key":"bib81","series-title":"Journal of Pediatrics","first-page":"272","article-title":"Intergenerational influences between maternal polycystic ovary syndrome and offspring: an updated overview","volume":"232","author":"Zhang","year":"2021","unstructured":"Zhang FFZhang QWang YLWang FFHardiman PJ & Qu F2021Intergenerational influences between maternal polycystic ovary syndrome and offspring: an updated overview. Journal of Pediatrics232272\u2013281. (https:\/\/doi.org\/10.1016\/j.jpeds.2021.01.018)"},{"key":"bib82","series-title":"Nature Communications","first-page":"1395","article-title":"CEP128 is involved in spermatogenesis in humans and mice","volume":"13","author":"Zhang","year":"2022","unstructured":"Zhang XWang LMa YWang YLiu HLiu MQin LLi JJiang CZhang X, et al.2022CEP128 is involved in spermatogenesis in humans and mice. Nature Communications131395. (https:\/\/doi.org\/10.1038\/s41467-022-29109-7)"},{"key":"bib83","series-title":"Antioxidants and Redox Signaling","first-page":"962","article-title":"Sirt3 deficiency increased the vulnerability of pancreatic beta cells to oxidative stress-induced dysfunction","volume":"27","author":"Zhou","year":"2017","unstructured":"Zhou YChung ACKFan RLee HMXu GTomlinson BChan JCN & Kong APS2017Sirt3 deficiency increased the vulnerability of pancreatic beta cells to oxidative stress-induced dysfunction. Antioxidants and Redox Signaling27962\u2013976. (https:\/\/doi.org\/10.1089\/ars.2016.6859)"},{"key":"bib84","series-title":"Endocrinology","article-title":"Maternal testosterone excess contributes to reproductive system dysfunction of female offspring mice","volume":"161","author":"Zhou","year":"2020","unstructured":"Zhou YZhang AGong MLu YZhao CShen XZhang XWang LChen J & Ju R2020Maternal testosterone excess contributes to reproductive system dysfunction of female offspring mice. Endocrinology161. (https:\/\/doi.org\/10.1210\/endocr\/bqz011)"},{"key":"bib85","series-title":"Journal of Endocrinology","first-page":"69","article-title":"Prenatal androgen excess impairs beta-cell function by decreased sirtuin 3 expression","volume":"251","author":"Zhou","year":"2021","unstructured":"Zhou YGong MLu YChen J & Ju R2021Prenatal androgen excess impairs beta-cell function by decreased sirtuin 3 expression. Journal of Endocrinology25169\u201381. (https:\/\/doi.org\/10.1530\/JOE-21-0129)"},{"key":"bib86","series-title":"Environmental Pollution","first-page":"115627","article-title":"Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury","volume":"268","author":"Zhao","year":"2021","unstructured":"Zhao TWang JWu YHan LChen JWei YShen LLong CWu S & Wei G2021Increased m6A modification of RNA methylation related to the inhibition of demethylase FTO contributes to MEHP-induced Leydig cell injury. Environmental Pollution268115627. (https:\/\/doi.org\/10.1016\/j.envpol.2020.115627)"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/262\/2\/JOE-23-0368.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/262\/2\/JOE-23-0368.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/262\/2\/JOE-23-0368.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:58:05Z","timestamp":1784555885000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/5693"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,5,28]]},"references-count":86,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/joe-23-0368","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,5,28]]}}}