{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,23]],"date-time":"2026-10-23T00:08:54Z","timestamp":1792714134200,"version":"4.5.0"},"reference-count":122,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,4,25]]},"abstract":"<jats:p>Menopause marks the cessation of fertility and the transition to post-reproductive years. Nearly 1 million US women experience menopause annually, but despite the significant impact it has on their physical and mental health, menopause has been insufficiently studied. Oxytocin is a neurohormone that regulates emotionality, social behaviors, and fundamental physiological systems. Localization of oxytocin receptors in the brain, reproductive tissues, bone, and heart support their role in mental health and potentially sleep, along with reproductive and cardiovascular functions. While experimental data linking oxytocin to behavior and physiology in animals are largely consistent, human data are correlative and inconclusive. As women transition into menopause, oxytocin levels decrease while their susceptibility to mood disorders, poor sleep, osteoporosis, and cardiovascular diseases increases. These concurrent changes highlight oxytocin as a potential influence on the health and mood of women along their reproductive life span. Here, we summarize experimental rodent and non-human primate studies that link oxytocin to reproductive aging and metabolic health and highlight the inconclusive findings in studies of women. Most human studies relied on a single oxytocin assessment in plasma or on intranasal oxytocin administration. The pulsatile release and short half-life of plasma oxytocin limit the validity of these methods. We discuss the need for oxytocin assessments in stable bio-samples, such as urine, and to use valid assays for assessment of associations between changing oxytocin levels and well-being across the reproductive life span. This work has the potential to guide therapeutic strategies that will one day alleviate adverse health outcomes for many women.<\/jats:p>","DOI":"10.1530\/joe-23-0396","type":"journal-article","created":{"date-parts":[[2024,4,25]],"date-time":"2024-04-25T08:58:03Z","timestamp":1714035483000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":7,"title":["Oxytocin and women\u2019s health in midlife"],"prefix":"10.1530","volume":"262","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7240-4923","authenticated-orcid":true,"given":"Galit Levi","family":"Dunietz","sequence":"first","affiliation":[{"name":"Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas J","family":"Tittle","sequence":"additional","affiliation":[{"name":"Department of Psychology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sunni L","family":"Mumford","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise M","family":"O\u2019Brien","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA"},{"name":"Department of Obstetrics and Gynecology, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ana","family":"Baylin","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, School of Public Health, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enrique F","family":"Schisterman","sequence":"additional","affiliation":[{"name":"Department of Biostatistics, Epidemiology and Informatics and Obstetrics and Gynecology, Perelman School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald D","family":"Chervin","sequence":"additional","affiliation":[{"name":"Department of Neurology, Division of Sleep Medicine, University of Michigan, Ann Arbor, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Larry J","family":"Young","sequence":"additional","affiliation":[{"name":"Center for Translational Social Neuroscience, Emory National Primate Research Center, Emory University, Atlanta, Georgia, USA"},{"name":"Department of Psychiatry and Behavioral Sciences, Emory University School of Medicine, Atlanta, Georgia, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Frontiers in Endocrinology","first-page":"160","article-title":"Oxytocin and estrogen receptor \u03b2 in the brain: an overview","volume":"6","author":"Acevedo-Rodriguez","year":"2015","unstructured":"Acevedo-Rodriguez AMani SK & Handa RJ2015Oxytocin and estrogen receptor \u03b2 in the brain: an overview. 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