{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,7]],"date-time":"2026-11-07T18:22:31Z","timestamp":1794075751405,"version":"4.8.0"},"reference-count":93,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,1]]},"abstract":"<jats:p>Osteosarcopenia, which refers to the concomitant presence of osteoporosis and sarcopenia, is expected to increase in the rapidly progressive aging world, with serious clinical implications. However, the pathophysiology of osteosarcopenia has not been fully elucidated, and no optimal treatment specific to osteosarcopenia is available. The RANKL\u2013RANK pathway is widely used as a therapeutic target for osteoporosis. Growing evidence supports the importance of the RANKL\u2013RANK pathway, not only in bone, but also in muscle, and the therapeutic potential of targeting this pathway in muscle diseases has been noted. The muscles and bones closely communicate with each other through various secretory factors called myokines and osteokines. This review covers the roles of the RANKL\u2013RANK pathway in the bone and muscle and their reciprocal interactions. Moreover, we will suggest future directions to move forward for the treatment of osteosarcopenia to prepare for an upcoming aging society.<\/jats:p>","DOI":"10.1530\/joe-24-0093","type":"journal-article","created":{"date-parts":[[2024,6,24]],"date-time":"2024-06-24T12:21:45Z","timestamp":1719231705000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":10,"title":["Bidirectional crosstalk between bone and muscle: the role of RANKL pathway in osteosarcopenia"],"prefix":"10.1530","volume":"262","author":[{"given":"Soo Yeon","family":"Jang","sequence":"first","affiliation":[{"name":"Division of Endocrinology and Metabolism 1","department":["Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6175-0225","authenticated-orcid":true,"given":"Kyung Mook","family":"Choi","sequence":"additional","affiliation":[{"name":"Division of Endocrinology and Metabolism 1","department":["Department of Internal Medicine, Korea University College of Medicine, Seoul, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2024,6,24]]},"reference":[{"key":"2026070806084123600_bib1","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1007\/s41999-020-00355-6","article-title":"Osteosarcopenia: beyond age-related muscle and bone loss","volume":"11","author":"Belchior","year":"2020","journal-title":"European Geriatric Medicine"},{"key":"2026070806084123600_bib2","doi-asserted-by":"crossref","first-page":"202","DOI":"10.1007\/s00774-011-0304-6","article-title":"Physical training increases osteoprotegerin in postmenopausal women","volume":"30","author":"Bergstr\u00f6m","year":"2012","journal-title":"Journal of Bone and Mineral Metabolism"},{"key":"2026070806084123600_bib3","doi-asserted-by":"crossref","first-page":"3214","DOI":"10.1172\/JCI125915","article-title":"RANKL inhibition improves muscle strength and insulin sensitivity and restores bone mass","volume":"129","author":"Bonnet","year":"2019","journal-title":"Journal of Clinical Investigation"},{"key":"2026070806084123600_bib4","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1038\/nature10777","article-title":"A PGC1-alpha-dependent myokine that drives brown-fat-like development of white fat and thermogenesis","volume":"481","author":"Bostrom","year":"2012","journal-title":"Nature"},{"key":"2026070806084123600_bib5","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1016\/j.omtm.2021.03.022","article-title":"Testing the efficacy of a human full-length OPG-Fc analog in a severe model of cardiotoxin-induced skeletal muscle injury and repair","volume":"21","author":"Bouredji","year":"2021","journal-title":"Molecular Therapy. 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