{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T10:21:53Z","timestamp":1783506113227,"version":"3.55.0"},"reference-count":52,"publisher":"Bioscientifica","issue":"1","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:p>The sustained consumption of sucrose-rich diet has deleterious effects on the adrenal cortex, impairing its steroidogenic capacity. As hemin treatment has been shown to exert cytoprotective effects (e.g., by heme oxygenase 1 induction), our main goal was to analyze the adrenocortical function in rats treated with diet and hemin. Male Wistar rats fed standard chow and 30% sucrose in the drinking water (SRD) for 12 weeks ad libitum were injected with hemin for the last 2 weeks of treatment. mRNA and proteins were analyzed by real-time polymerase chain reaction, western blot or immunofluorescence, and corticosterone levels were assessed by radioimmunoassay. A decrease in lipid peroxides and an increase in the activity of catalase were detected in the SRD + H group. Moreover, pro-inflammatory markers (TNF-\u03b1, IL1\u03b2, CXCL10, NOS2, NALP3 and MCP1), IBA1+\/ED1+ cells and NF\u03ba\u03b2 activation were still elevated in tissues from SRD + H-treated rats, whereas an increase in markers of macrophages with the M2-phenotype (ARG1, MRC1 and TGF\u03b2) was also shown. Activation of ER stress in SRD-treated rats (CHOP, XBP1s and P58IPK) and the induction of apoptosis (TUNEL and the BAX\/BCL2 mRNA ratio) were also attenuated by hemin. Finally, ACTH-stimulated glucocorticoid production, significantly decreased in SRD-treated rats, was upregulated by hemin. The consumption of SRD involves exposure of tissues to a higher metabolic load that could generate oxidative stress and a pro-inflammatory state. Deleterious consequences of these processes could account for the significant decrease in the ACTH-induced corticosterone output from the gland. By correcting these effects, hemin treatment was able to restore the hormone-induced adrenocortical response.<\/jats:p>","DOI":"10.1530\/joe-24-0152","type":"journal-article","created":{"date-parts":[[2024,11,19]],"date-time":"2024-11-19T07:25:29Z","timestamp":1732001129000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":0,"title":["Hemin restores ACTH-induced glucocorticoid response in insulin-resistant rats"],"prefix":"10.1530","volume":"264","author":[{"given":"Lilian J","family":"Caldareri","sequence":"first","affiliation":[{"name":"Facultad de Medicina, Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET), Centro de Estudios Farmacol\u00f3gicos y Bot\u00e1nicos (CEFYBO), Universidad de Buenos Aires 1 , ,","place":["Buenos Aires, Argentina"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Morena","family":"Wiszniewski","sequence":"additional","affiliation":[{"name":"Facultad de 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