{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T14:04:04Z","timestamp":1792073044847,"version":"4.4.0"},"reference-count":62,"publisher":"Bioscientifica","issue":"3","content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2024,9,20]]},"abstract":"<jats:p>Liraglutide, an analog of the incretin hormone glucagon-like peptide 1 (GLP-1), is widely used for obesity and type 2 diabetes treatment. However, there is scarce information about its effects on testicular function. Within the testis, Sertoli cells (SCs) provide nutritional support for germ cells; they metabolize glucose to lactate, which is delivered to germ cells to be used as a preferred energy substrate. Besides, SCs use fatty acids (FAs) as an energy source and store them as triacylglycerols (TAGs) within lipid droplets (LDs), which serve as an important energy reserve. In the present study, 20-day-old rat SC cultures were used to assess whether liraglutide affects their metabolic functions related to nutritional support and lipid storage. The results show that liraglutide does not modify glucose consumption or lactate production. However, it increases TAG levels and LD content. These effects are accompanied by an increase in the mRNA levels of the fatty acid transporter FAT\/CD36, glycerol-3-phosphate-acyltransferase 3, and perilipins 1 and 4. The participation of the cAMP\/PKA signaling pathway was explored. We observed that H89 (a PKA inhibitor) decreases the LD upregulation elicited by liraglutide, and that dibutyryl cAMP increases LD content and the expression of related genes. In summary, liraglutide promotes lipid storage in SCs through the regulation of key regulatory genes involved in FA transport, TAG synthesis, and LD formation. Considering the importance of lipid storage in SC energetic homeostasis maintenance, we postulate that liraglutide might improve the overall energetic status of the seminiferous tubule.<\/jats:p>","DOI":"10.1530\/joe-24-0274","type":"journal-article","created":{"date-parts":[[2024,9,20]],"date-time":"2024-09-20T18:44:57Z","timestamp":1726857897000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":9,"title":["Glucagon-like peptide-1 analog, liraglutide, regulates Sertoli cell energy metabolism"],"prefix":"10.1530","volume":"263","author":[{"given":"Marina Ercilia","family":"Dasso","sequence":"first","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE) \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cecilia Lucia","family":"Centola","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE) \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2678-622X","authenticated-orcid":true,"given":"Mar\u00eda Noel","family":"Galardo","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE) \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0313-7075","authenticated-orcid":true,"given":"Silvina Beatriz","family":"Meroni","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE) \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0762-1662","authenticated-orcid":true,"given":"Mar\u00eda Fernanda","family":"Riera","sequence":"additional","affiliation":[{"name":"Centro de Investigaciones Endocrinol\u00f3gicas \u201cDr. C\u00e9sar Bergad\u00e1\u201d (CEDIE) \u2013 Consejo Nacional de Investigaciones Cient\u00edficas y T\u00e9cnicas (CONICET) \u2013 FEI \u2013 Divisi\u00f3n de Endocrinolog\u00eda, Hospital de Ni\u00f1os Ricardo Guti\u00e9rrez, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Peptides","first-page":"170711","article-title":"Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1-PPAR-\u03b1-Kisspeptin-Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model","volume":"149","author":"Abdullah","year":"2022","unstructured":"Abdullah DMAlsemeh AE & Khamis T 2022 Semaglutide early intervention attenuated testicular dysfunction by targeting the GLP-1-PPAR-\u03b1-Kisspeptin-Steroidogenesis signaling pathway in a testicular ischemia-reperfusion rat model. Peptides 149 170711. (https:\/\/doi.org\/10.1016\/j.peptides.2021.170711)"},{"key":"bib2","series-title":"British Journal of Pharmacology","first-page":"1033","article-title":"Metformin and male reproduction: effects on Sertoli cell metabolism","volume":"171","author":"Alves","year":"2014","unstructured":"Alves MGMartins ADVaz CVCorreia SMoreira PIOliveira PF & Socorro S 2014 Metformin and male reproduction: effects on Sertoli cell metabolism. British Journal of Pharmacology 171 1033\u20131042. (https:\/\/doi.org\/10.1111\/bph.12522)"},{"key":"bib3","series-title":"Journal of Translational Medicine","first-page":"229","article-title":"The GLP-1 receptor agonists exenatide and liraglutide activate glucose transport by an AMPK-dependent mechanism","volume":"14","author":"Andreozzi","year":"2016","unstructured":"Andreozzi FRaciti GANigro CMannino GCProcopio TDavalli AMBeguinot FSesti GMiele C & Folli F 2016 The GLP-1 receptor agonists exenatide and liraglutide activate glucose transport by an AMPK-dependent mechanism. Journal of Translational Medicine 14 229. (https:\/\/doi.org\/10.1186\/s12967-016-0985-7)"},{"key":"bib4","series-title":"Journal of Biological Chemistry","first-page":"10070","article-title":"The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes","volume":"279","author":"Arimura","year":"2004","unstructured":"Arimura NHoriba TImagawa MShimizu M & Sato R 2004 The peroxisome proliferator-activated receptor gamma regulates expression of the perilipin gene in adipocytes. Journal of Biological Chemistry 279 10070\u201310076. (https:\/\/doi.org\/10.1074\/jbc.M308522200)"},{"key":"bib5","series-title":"Trends in Endocrinology and Metabolism","first-page":"345","article-title":"Lactate and energy metabolism in male germ cells","volume":"15","author":"Boussouar","year":"2004","unstructured":"Boussouar F & Benahmed M 2004 Lactate and energy metabolism in male germ cells. Trends in Endocrinology and Metabolism 15 345\u2013350. (https:\/\/doi.org\/10.1016\/j.tem.2004.07.003)"},{"key":"bib6","series-title":"Andrology","first-page":"1935","article-title":"Glucagon-like peptide-1 receptor is expressed in human and rodent testis","volume":"8","author":"Caltabiano","year":"2020","unstructured":"Caltabiano RCondorelli DPanza SBoitani CMusso NJe\u017eek DMemeo LColarossi LRago VMularoni V, et al. 2020 Glucagon-like peptide-1 receptor is expressed in human and rodent testis. Andrology 8 1935\u20131945. (https:\/\/doi.org\/10.1111\/andr.12871)"},{"key":"bib7","series-title":"Molecular and Cellular Endocrinology","first-page":"43","article-title":"Effect of liraglutide on proliferation and differentiation of human adipose stem cells","volume":"402","author":"Cantini","year":"2015","unstructured":"Cantini GDi Franco ASamavat JForti GMannucci E & Luconi M 2015 Effect of liraglutide on proliferation and differentiation of human adipose stem cells. Molecular and Cellular Endocrinology 402 43\u201350. (https:\/\/doi.org\/10.1016\/j.mce.2014.12.021)"},{"key":"bib8","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"19695","article-title":"Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis","volume":"103","author":"Cao","year":"2006","unstructured":"Cao JLi JLLi DTobin JF & Gimeno RE 2006 Molecular identification of microsomal acyl-CoA:glycerol-3-phosphate acyltransferase, a key enzyme in de novo triacylglycerol synthesis. Proceedings of the National Academy of Sciences of the United States of America 103 19695\u201319700. (https:\/\/doi.org\/10.1073\/pnas.0609140103)"},{"key":"bib9","series-title":"Cellular Physiology and Biochemistry","first-page":"1165","article-title":"GLP-1\/GLP-1R signaling in regulation of adipocyte differentiation and lipogenesis","volume":"42","author":"Chen","year":"2017","unstructured":"Chen JZhao HMa XZhang YLu SWang YZong CQin DWang YYingfeng Yang Y, et al. 2017 GLP-1\/GLP-1R signaling in regulation of adipocyte differentiation and lipogenesis. Cellular Physiology and Biochemistry 42 1165\u20131176. (https:\/\/doi.org\/10.1159\/000478872)"},{"key":"bib10","series-title":"Biology of Reproduction","first-page":"154","article-title":"Improvement of spermatogenesis in adult cryptorchid rat testis by intratesticular infusion of lactate","volume":"61","author":"Courtens","year":"1999","unstructured":"Courtens JL & Pl\u00f6en L 1999 Improvement of spermatogenesis in adult cryptorchid rat testis by intratesticular infusion of lactate. Biology of Reproduction 61 154\u2013161. (https:\/\/doi.org\/10.1095\/biolreprod61.1.154)"},{"key":"bib11","series-title":"Molecular Human Reproduction","first-page":"109","article-title":"Lactate inhibits germ cell apoptosis in the human testis","volume":"8","author":"Erkkil\u00e4","year":"2002","unstructured":"Erkkil\u00e4 KAito HAalto KPentik\u00e4inen V & Dunkel L 2002 Lactate inhibits germ cell apoptosis in the human testis. Molecular Human Reproduction 8 109\u2013117. (https:\/\/doi.org\/10.1093\/molehr\/8.2.109)"},{"key":"bib12","series-title":"Acta Biochimica et Biophysica Sinica","first-page":"612","article-title":"Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP\/PKA\/RhoA\/ROCK2 signaling","volume":"52","author":"Fan","year":"2020","unstructured":"Fan SXiong QZhang XZhang L & Shi Y 2020 Glucagon-like peptide 1 reverses myocardial hypertrophy through cAMP\/PKA\/RhoA\/ROCK2 signaling. Acta Biochimica et Biophysica Sinica 52 612\u2013619. (https:\/\/doi.org\/10.1093\/abbs\/gmaa038)"},{"key":"bib13","series-title":"Reproduction","first-page":"527","article-title":"The insulin sensitiser metformin regulates chicken Sertoli and germ cell populations","volume":"151","author":"Faure","year":"2016","unstructured":"Faure MGuibert EAlves SPain BRam\u00e9 CDupont JBrillard JP & ent P 2016 The insulin sensitiser metformin regulates chicken Sertoli and germ cell populations. Reproduction 151 527\u2013538. (https:\/\/doi.org\/10.1530\/REP-15-0565)"},{"key":"bib14","series-title":"Biochemical Society Transactions","first-page":"582","article-title":"The complexity of signaling mediated by the glucagon-like peptide-1 receptor","volume":"44","author":"Fletcher","year":"2016","unstructured":"Fletcher MMHalls MLChristopoulos ASexton PM & Wootten D 2016 The complexity of signaling mediated by the glucagon-like peptide-1 receptor. Biochemical Society Transactions 44 582\u2013588. (https:\/\/doi.org\/10.1042\/BST20150244)"},{"key":"bib15","series-title":"Reproductive Biomedicine Online","first-page":"644","article-title":"The effects of liraglutide on male fertility: a case report","volume":"29","author":"Fontoura","year":"2014","unstructured":"Fontoura PCardoso MCAErthal-Martins MCWerneck CSartorio C & Ramos CF 2014 The effects of liraglutide on male fertility: a case report. Reproductive Biomedicine Online 29 644\u2013646. (https:\/\/doi.org\/10.1016\/j.rbmo.2014.07.009)"},{"key":"bib16","series-title":"PLoS One","first-page":"e88024","article-title":"Lactate regulates rat male germ cell function through reactive oxygen species","volume":"9","author":"Galardo","year":"2014","unstructured":"Galardo MNRegueira MRiera MFPellizzari EHCigorraga SB & Meroni SB 2014 Lactate regulates rat male germ cell function through reactive oxygen species. PLoS One 9 e88024. (https:\/\/doi.org\/10.1371\/journal.pone.0088024)"},{"key":"bib17","series-title":"Journal of Cell Science","first-page":"3027","article-title":"Germ cells and fatty acids induce translocation of CD36 scavenger receptor to the plasma membrane of Sertoli cells","volume":"118","author":"Gillot","year":"2005","unstructured":"Gillot IJehl-Pietri CGounon PLuquet SRassoulzadegan MGrimaldi P & Vidal F 2005 Germ cells and fatty acids induce translocation of CD36 scavenger receptor to the plasma membrane of Sertoli cells. Journal of Cell Science 118 3027\u20133035. (https:\/\/doi.org\/10.1242\/jcs.02430)"},{"key":"bib18","series-title":"Cell and Tissue Research","first-page":"611","article-title":"PPAR\u03b3 activation regulates lipid droplet formation and lactate production in rat Sertoli cells","volume":"369","author":"Gorga","year":"2017","unstructured":"Gorga ARindone GMRegueira MPellizzari EHCamberos MCCigorraga SBRiera MFGalardo MN & Meroni SB 2017 PPAR\u03b3 activation regulates lipid droplet formation and lactate production in rat Sertoli cells. Cell and Tissue Research 369 611\u2013624. (https:\/\/doi.org\/10.1007\/s00441-017-2615-y)"},{"key":"bib19","series-title":"Systems Biology in Reproductive Medicine","first-page":"368","article-title":"Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis","volume":"64","author":"Hu","year":"2018","unstructured":"Hu XGe XLiang WShao YJing JWang CZeng R & Yao B 2018 Effects of saturated palmitic acid and omega-3 polyunsaturated fatty acids on Sertoli cell apoptosis. Systems Biology in Reproductive Medicine 64 368\u2013380. (https:\/\/doi.org\/10.1080\/19396368.2018.1471554)"},{"key":"bib20","series-title":"Lipids in Health and Disease","first-page":"83","article-title":"Perilipins: a diversity of intracellular lipid droplet proteins","volume":"16","author":"Itabe","year":"2017","unstructured":"Itabe HYamaguchi TNimura S & Sasabe N 2017 Perilipins: a diversity of intracellular lipid droplet proteins. Lipids in Health and Disease 16 83. (https:\/\/doi.org\/10.1186\/s12944-017-0473-y)"},{"key":"bib21","series-title":"Journal of Clinical Pharmacology","first-page":"1620","article-title":"The pharmacokinetics, pharmacodynamics, and tolerability of liraglutide, a once-daily human GLP-1 analogue, after multiple subcutaneous administration in healthy Chinese male subjects","volume":"51","author":"Jiang","year":"2011","unstructured":"Jiang JZhang JJacobsen LV & Hu P 2011 The pharmacokinetics, pharmacodynamics, and tolerability of liraglutide, a once-daily human GLP-1 analogue, after multiple subcutaneous administration in healthy Chinese male subjects. Journal of Clinical Pharmacology 51 1620\u20131627. (https:\/\/doi.org\/10.1177\/0091270010389468)"},{"key":"bib22","series-title":"Journal of Reproduction and Fertility","first-page":"497","article-title":"Metabolism of palmitate in cultured rat Sertoli cells","volume":"73","author":"Jutte","year":"1985","unstructured":"Jutte NHEikvar LLevy FO & Hansson V 1985 Metabolism of palmitate in cultured rat Sertoli cells. Journal of Reproduction and Fertility 73 497\u2013503. (https:\/\/doi.org\/10.1530\/jrf.0.0730497)"},{"key":"bib23","series-title":"Journal of Reproduction and Fertility","first-page":"1","article-title":"Cyclic variations in Sertoli cell lipid content throughout the spermatogenic cycle in the rat","volume":"43","author":"Kerr","year":"1975","unstructured":"Kerr JB & De Kretser DM 1975 Cyclic variations in Sertoli cell lipid content throughout the spermatogenic cycle in the rat. Journal of Reproduction and Fertility 43 1\u20138. (https:\/\/doi.org\/10.1530\/jrf.0.0430001)"},{"key":"bib24","series-title":"Cell and Tissue Research","first-page":"699","article-title":"Morphometric studies on lipid inclusions in Sertoli cell during the spermatogenic cycle in the rat","volume":"236","author":"Kerr","year":"1984","unstructured":"Kerr JBMayberry RA & Irby DC 1984 Morphometric studies on lipid inclusions in Sertoli cell during the spermatogenic cycle in the rat. Cell and Tissue Research 236 699\u2013709. (https:\/\/doi.org\/10.1007\/BF00217241)"},{"key":"bib25","series-title":"Diabetes","first-page":"2863","article-title":"Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity","volume":"56","author":"Koonen","year":"2007","unstructured":"Koonen DPYJacobs RLFebbraio MYoung MESoltys CLMOng HVance DE & Dyck JRB 2007 Increased hepatic CD36 expression contributes to dyslipidemia associated with diet-induced obesity. Diabetes 56 2863\u20132871. (https:\/\/doi.org\/10.2337\/db07-0907)"},{"key":"bib26","series-title":"Journal of Clinical Medicine","first-page":"672","article-title":"Sexual and reproductive outcomes in obese fertile men with functional hypogonadism after treatment with liraglutide: preliminary results","volume":"12","author":"La Vignera","year":"2023","unstructured":"La Vignera SCondorelli RACalogero AECannarella R & Aversa A 2023 Sexual and reproductive outcomes in obese fertile men with functional hypogonadism after treatment with liraglutide: preliminary results. Journal of Clinical Medicine 12 672. (https:\/\/doi.org\/10.3390\/jcm12020672)"},{"key":"bib27","series-title":"Metabolism: Clinical and Experimental","first-page":"1022","article-title":"Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells","volume":"63","author":"Li","year":"2014","unstructured":"Li ZNi CLYao ZChen LM & Niu WY 2014 Liraglutide enhances glucose transporter 4 translocation via regulation of AMP-activated protein kinase signaling pathways in mouse skeletal muscle cells. Metabolism: Clinical and Experimental 63 1022\u20131030. (https:\/\/doi.org\/10.1016\/j.metabol.2014.05.008)"},{"key":"bib28","series-title":"Expert Opinion on Pharmacotherapy","first-page":"275","article-title":"An evaluation of liraglutide including its efficacy and safety for the treatment of obesity","volume":"21","author":"Lin","year":"2020","unstructured":"Lin CHShao LZhang YMTu YJZhang YTomlinson BChan P & Liu Z 2020 An evaluation of liraglutide including its efficacy and safety for the treatment of obesity. Expert Opinion on Pharmacotherapy 21 275\u2013285. (https:\/\/doi.org\/10.1080\/14656566.2019.1695779)"},{"key":"bib29","series-title":"Scientific Reports","first-page":"7633","article-title":"Thyrotropin and obesity: increased adipose triglyceride content through glycerol-3-phosphate acyltransferase 3","volume":"5","author":"Ma","year":"2015","unstructured":"Ma SJing FXu CZhou LSong YYu CJiang DGao LLi YGuan Q, et al. 2015 Thyrotropin and obesity: increased adipose triglyceride content through glycerol-3-phosphate acyltransferase 3. Scientific Reports 5 7633. (https:\/\/doi.org\/10.1038\/srep07633)"},{"key":"bib30","series-title":"Toxicology and Applied Pharmacology","first-page":"1","article-title":"Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1","volume":"362","author":"Martins","year":"2019","unstructured":"Martins ADMonteiro MPSilva BMBarros ASousa MCarvalho RAOliveira PF & Alves MG 2019 Metabolic dynamics of human Sertoli cells are differentially modulated by physiological and pharmacological concentrations of GLP-1. Toxicology and Applied Pharmacology 362 1\u20138. (https:\/\/doi.org\/10.1016\/j.taap.2018.10.009)"},{"key":"bib31","series-title":"Journal of Endocrinology","first-page":"195","article-title":"Regulation of rat Sertoli cell function by FSH: possible role of phosphatidylinositol 3-kinase\/protein kinase B pathway","volume":"174","author":"Meroni","year":"2002","unstructured":"Meroni SBRiera MFPellizzari EH & Cigorraga SB 2002 Regulation of rat Sertoli cell function by FSH: possible role of phosphatidylinositol 3-kinase\/protein kinase B pathway. Journal of Endocrinology 174 195\u2013204. (https:\/\/doi.org\/10.1677\/joe.0.1740195)"},{"key":"bib32","series-title":"Biology of Reproduction","first-page":"445","article-title":"Metabolism of round spermatids from rats: lactate as the preferred substrate","volume":"26","author":"Mita","year":"1982","unstructured":"Mita M & Hall PF 1982 Metabolism of round spermatids from rats: lactate as the preferred substrate. Biology of Reproduction 26 445\u2013455. (https:\/\/doi.org\/10.1095\/biolreprod26.3.445)"},{"key":"bib33","series-title":"Molecular Metabolism","first-page":"72","article-title":"Glucagon-like peptide 1 (GLP-1)","volume":"30","author":"M\u00fcller","year":"2019","unstructured":"M\u00fcller TDFinan BBloom SRD'Alessio DDrucker DJFlatt PRFritsche AGribble FGrill HJHabener JF, et al. 2019 Glucagon-like peptide 1 (GLP-1). Molecular Metabolism 30 72\u2013130. (https:\/\/doi.org\/10.1016\/j.molmet.2019.09.010)"},{"key":"bib34","series-title":"Current Obesity Reports","first-page":"284","article-title":"Mechanism of glucagon-like peptide 1 improvements in type 2 diabetes mellitus and obesity","volume":"8","author":"Nolen-Doerr","year":"2019","unstructured":"Nolen-Doerr EStockman MC & Rizo I 2019 Mechanism of glucagon-like peptide 1 improvements in type 2 diabetes mellitus and obesity. Current Obesity Reports 8 284\u2013291. (https:\/\/doi.org\/10.1007\/s13679-019-00350-4)"},{"key":"bib35","series-title":"FEBS Letters","first-page":"1207","article-title":"Lipid droplets and fatty acid-induced lipotoxicity: in a nutshell","volume":"598","author":"Obaseki","year":"2024","unstructured":"Obaseki EAdebayo DBandyopadhyay S & Hariri H 2024 Lipid droplets and fatty acid-induced lipotoxicity: in a nutshell. FEBS Letters 598 1207\u20131214. (https:\/\/doi.org\/10.1002\/1873-3468.14808)"},{"key":"bib36","series-title":"Reproduction","first-page":"471","article-title":"2013 cell-type-specific regulation of genes involved in testicular lipid metabolism: fatty acid-binding proteins, diacylglycerol acyltransferases, and perilipin 2","volume":"146","author":"Oresti","year":"2013","unstructured":"Oresti GMGarcia-Lopez JAveldano MI & Del Mazo J 2013 2013 cell-type-specific regulation of genes involved in testicular lipid metabolism: fatty acid-binding proteins, diacylglycerol acyltransferases, and perilipin 2. Reproduction 146 471\u2013480. (https:\/\/doi.org\/10.1530\/REP-13-0199)"},{"key":"bib37","series-title":"Cell and Tissue Research","first-page":"589","article-title":"Study in vitro of the phagocytic function of Sertoli cells in the rat","volume":"264","author":"Pineau","year":"1991","unstructured":"Pineau CLe Magueresse BCourtens JL & J\u00e9gou B 1991 Study in vitro of the phagocytic function of Sertoli cells in the rat. Cell and Tissue Research 264 589\u2013598."},{"key":"bib38","series-title":"Reproduction","first-page":"311","article-title":"Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells","volume":"150","author":"Regueira","year":"2015","unstructured":"Regueira MArtagaveytia SLGalardo MNPellizzari EHCigorraga SBMeroni SB & Riera MF 2015 Novel molecular mechanisms involved in hormonal regulation of lactate production in Sertoli cells. Reproduction 150 311\u2013321. (https:\/\/doi.org\/10.1530\/REP-15-0093)"},{"key":"bib39","series-title":"Reproduction","first-page":"515","article-title":"Apoptotic germ cells regulate Sertoli cell lipid storage and fatty acid oxidation","volume":"156","author":"Regueira","year":"2018","unstructured":"Regueira MGorga ARindone GMPellizzari EHCigorraga SBGalardo MNRiera MF & Meroni SB 2018 Apoptotic germ cells regulate Sertoli cell lipid storage and fatty acid oxidation. Reproduction 156 515\u2013525. (https:\/\/doi.org\/10.1530\/REP-18-0181)"},{"key":"bib40","series-title":"Journal of Applied Toxicology","first-page":"870","article-title":"Sertoli cell as a model in male reproductive toxicology: advantages and disadvantages","volume":"35","author":"Reis","year":"2015","unstructured":"Reis MMSMoreira ACSousa MMathur PPOliveira PF & Alves MG 2015 Sertoli cell as a model in male reproductive toxicology: advantages and disadvantages. Journal of Applied Toxicology 35 870\u2013883. (https:\/\/doi.org\/10.1002\/jat.3122)"},{"key":"bib41","series-title":"Biomedicines","first-page":"1115","article-title":"Exenatide and dapagliflozin combination enhances Sertoli cell secretion of key metabolites for spermatogenesis","volume":"10","author":"Ribeiro","year":"2022","unstructured":"Ribeiro JCMartins ADJarak ICarvalho RAAlves MG & Oliveira PF 2022 Exenatide and dapagliflozin combination enhances Sertoli cell secretion of key metabolites for spermatogenesis. Biomedicines 10 1115. (https:\/\/doi.org\/10.3390\/biomedicines10051115)"},{"key":"bib43","series-title":"Reproduction","first-page":"93","article-title":"Metformin counteracts the effects of FSH on rat Sertoli cell proliferation","volume":"156","author":"Rindone","year":"2018","unstructured":"Rindone GMGorga ARegueira MPellizzari EHCigorraga SBGalardo MNMeroni SB & Riera MF 2018 Metformin counteracts the effects of FSH on rat Sertoli cell proliferation. Reproduction 156 93\u2013101. (https:\/\/doi.org\/10.1530\/REP-18-0233)"},{"key":"bib42","series-title":"Journal of Cellular Biochemistry","first-page":"716","article-title":"Sertoli cell adaptation to glucose deprivation: potential role of AMPK in the regulation of lipid metabolism","volume":"124","author":"Rindone","year":"2023","unstructured":"Rindone GMDasso MECentola CLPellizzari EHCamberos MDCToneatto JGalardo MNMeroni SB & Riera MF 2023 Sertoli cell adaptation to glucose deprivation: potential role of AMPK in the regulation of lipid metabolism. Journal of Cellular Biochemistry 124 716\u2013730. (https:\/\/doi.org\/10.1002\/jcb.30399)"},{"key":"bib44","series-title":"Biology of Reproduction","first-page":"1032","article-title":"Metabolism of glucose by Sertoli cells in culture","volume":"24","author":"Robinson","year":"1981","unstructured":"Robinson R & Fritz IB 1981 Metabolism of glucose by Sertoli cells in culture. Biology of Reproduction 24 1032\u20131041. (https:\/\/doi.org\/10.1095\/biolreprod24.5.1032)"},{"key":"bib45","series-title":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences","first-page":"1501","article-title":"Male germ cell apoptosis: regulation and biology","volume":"365","author":"Shaha","year":"2010","unstructured":"Shaha CTripathi R & Mishra DP 2010 Male germ cell apoptosis: regulation and biology. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 365 1501\u20131515. (https:\/\/doi.org\/10.1098\/rstb.2009.0124)"},{"key":"bib46","series-title":"Journal of Lipid Research","first-page":"1971","article-title":"GPAT3, and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis","volume":"51","author":"Shan","year":"2010","unstructured":"Shan DLi JLWu LLi DHurov JTobin JFGimeno RE & Cao J 2010 GPAT3, and GPAT4 are regulated by insulin-stimulated phosphorylation and play distinct roles in adipogenesis. Journal of Lipid Research 51 1971\u20131981. (https:\/\/doi.org\/10.1194\/jlr.M006304)"},{"key":"bib47","series-title":"Pharmacological Research","first-page":"104778","article-title":"Liraglutide attenuates renal tubular ectopic lipid deposition in rats with diabetic nephropathy by inhibiting lipid synthesis and promoting lipolysis","volume":"156","author":"Su","year":"2020","unstructured":"Su KYi BYao BQXia TYang YFZhang ZH & Chen C 2020 Liraglutide attenuates renal tubular ectopic lipid deposition in rats with diabetic nephropathy by inhibiting lipid synthesis and promoting lipolysis. Pharmacological Research 156 104778. (https:\/\/doi.org\/10.1016\/j.phrs.2020.104778)"},{"key":"bib48","series-title":"Journal of Molecular Endocrinology","first-page":"469","article-title":"Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10\/glycerol-3-phosphate acyltransferase isoform 3","volume":"42","author":"Sukumaran","year":"2009","unstructured":"Sukumaran SBarnes RIGarg A & Agarwal AK 2009 Functional characterization of the human 1-acylglycerol-3-phosphate-O-acyltransferase isoform 10\/glycerol-3-phosphate acyltransferase isoform 3. Journal of Molecular Endocrinology 42 469\u2013478. (https:\/\/doi.org\/10.1677\/JME-09-0010)"},{"key":"bib49","series-title":"Frontiers in Cell and Developmental Biology","first-page":"349","article-title":"RXR\u03b1 positively regulates expression of the chicken PLIN1 gene in a PPAR\u03b3-independent manner and promotes adipogenesis","volume":"8","author":"Sun","year":"2020","unstructured":"Sun YZhai GLi RZhou WLi YCao ZWang NLi H & Wang Y 2020 RXR\u03b1 positively regulates expression of the chicken PLIN1 gene in a PPAR\u03b3-independent manner and promotes adipogenesis. Frontiers in Cell and Developmental Biology 8 349. (https:\/\/doi.org\/10.3389\/fcell.2020.00349)"},{"key":"bib50","series-title":"Proceedings of the National Academy of Sciences of the United States of America","first-page":"6494","article-title":"Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity","volume":"98","author":"Tansey","year":"2001","unstructured":"Tansey JTSztalryd CGruia-Gray JRoush DLZee JVGavrilova OReitman MLDeng CXLi CKimmel AR, et al. 2001 Perilipin ablation results in a lean mouse with aberrant adipocyte lipolysis, enhanced leptin production, and resistance to diet-induced obesity. Proceedings of the National Academy of Sciences of the United States of America 98 6494\u20136499. (https:\/\/doi.org\/10.1073\/pnas.101042998)"},{"key":"bib51","series-title":"Human Reproduction","first-page":"3304","article-title":"Metformin exposure affects human and mouse fetal testicular cells","volume":"27","author":"Tartarin","year":"2012","unstructured":"Tartarin PMoison DGuibert EDupont JHabert RRouiller-Fabre VFrydman NPozzi SFrydman RLecureuil C, et al. 2012 Metformin exposure affects human and mouse fetal testicular cells. Human Reproduction 27 3304\u20133314. (https:\/\/doi.org\/10.1093\/humrep\/des264)"},{"key":"bib52","series-title":"Biology of Reproduction","first-page":"769","article-title":"Morphometrical analysis of Sertoli cell ultrastructure during the seminiferous epitelial cycle in rats","volume":"43","author":"Ueno","year":"1990","unstructured":"Ueno H & Mori H 1990 Morphometrical analysis of Sertoli cell ultrastructure during the seminiferous epitelial cycle in rats. Biology of Reproduction 43 769\u2013776. (https:\/\/doi.org\/10.1095\/biolreprod43.5.769)"},{"key":"bib53","series-title":"Molecular Human Reproduction","first-page":"gaad004","article-title":"Multiomics approach to profiling Sertoli cell maturation during development of the spermatogonial stem cell niche","volume":"29","author":"Voigt","year":"2023","unstructured":"Voigt ALDardari RLara NLMHe TSteele HDufour AOrwig KE & Dobrinski I 2023 Multiomics approach to profiling Sertoli cell maturation during development of the spermatogonial stem cell niche. Molecular Human Reproduction 29 gaad004. (https:\/\/doi.org\/10.1093\/molehr\/gaad004)"},{"key":"bib54","series-title":"Endocrinology","first-page":"3817","article-title":"GLP-1 analog liraglutide enhances proinsulin processing in pancreatic \u03b2-cells via a PKA-dependent pathway","volume":"155","author":"Wang","year":"2014","unstructured":"Wang LLiu YYang JZhao HKe JTian QZhang LWen JWei R & Hong T 2014 GLP-1 analog liraglutide enhances proinsulin processing in pancreatic \u03b2-cells via a PKA-dependent pathway. Endocrinology 155 3817\u20133828. (https:\/\/doi.org\/10.1210\/en.2014-1218)"},{"key":"bib55","series-title":"Biochemical and Biophysical Research Communications","first-page":"976","article-title":"GLP-1RA promotes brown adipogenesis of C3H10T1\/2 mesenchymal stem cells via the PI3K-AKT-mTOR signaling pathway","volume":"506","author":"Wang","year":"2018","unstructured":"Wang XChen JRong CPan FZhao X & Hu Y 2018 GLP-1RA promotes brown adipogenesis of C3H10T1\/2 mesenchymal stem cells via the PI3K-AKT-mTOR signaling pathway. Biochemical and Biophysical Research Communications 506 976\u2013982. (https:\/\/doi.org\/10.1016\/j.bbrc.2018.10.197)"},{"key":"bib56","series-title":"Journal of Clinical Pharmacology","first-page":"886","article-title":"Population pharmacokinetics of liraglutide, a once-daily human glucagon-like peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide","volume":"50","author":"Watson","year":"2010","unstructured":"Watson EJonker DMJacobsen LV & Ingwersen SH 2010 Population pharmacokinetics of liraglutide, a once-daily human glucagon-like peptide-1 analog, in healthy volunteers and subjects with type 2 diabetes, and comparison to twice-daily exenatide. Journal of Clinical Pharmacology 50 886\u2013894. (https:\/\/doi.org\/10.1177\/0091270009354996)"},{"key":"bib57","series-title":"Journal of Biological Chemistry","first-page":"37713","article-title":"Adipocyte protein S3-12 coats nascent lipid droplets","volume":"278","author":"Wolins","year":"2003","unstructured":"Wolins NESkinner JRSchoenfish MJTzekov ABensch KG & Bickel PE 2003 Adipocyte protein S3-12 coats nascent lipid droplets. Journal of Biological Chemistry 278 37713\u201337721. (https:\/\/doi.org\/10.1074\/jbc.M304025200)"},{"key":"bib58","series-title":"Reproduction","first-page":"469","article-title":"Apoptotic spermatogenic cells can be energy sources for Sertoli cells","volume":"137","author":"Xiong","year":"2009","unstructured":"Xiong WWang HWu HChen Y & Han D 2009 Apoptotic spermatogenic cells can be energy sources for Sertoli cells. Reproduction 137 469\u2013479. (https:\/\/doi.org\/10.1530\/REP-08-0343)"},{"key":"bib59","series-title":"Pediatric Surgery International","first-page":"675","article-title":"Regulation of FAT\/CD36 mRNA gene expression by long chain fatty acids in the differentiated 3T3-L1 cells","volume":"23","author":"Yang","year":"2007","unstructured":"Yang YChen MLoux TJ & Harmon CM 2007 Regulation of FAT\/CD36 mRNA gene expression by long chain fatty acids in the differentiated 3T3-L1 cells. Pediatric Surgery International 23 675\u2013683. (https:\/\/doi.org\/10.1007\/s00383-007-1942-6)"},{"key":"bib60","series-title":"BioMed Research International","first-page":"2947549","article-title":"Liraglutide attenuates nonalcoholic fatty liver disease by modulating gut microbiota in rats administered a high-fat diet","volume":"2020","author":"Zhang","year":"2020","unstructured":"Zhang NTao JGao LBi YLi PWang HZhu D & Feng W 2020 Liraglutide attenuates nonalcoholic fatty liver disease by modulating gut microbiota in rats administered a high-fat diet. BioMed Research International 2020 2947549. (https:\/\/doi.org\/10.1155\/2020\/2947549)"},{"key":"bib62","series-title":"Molecular Metabolism","first-page":"101180","article-title":"GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease","volume":"47","author":"Zheng","year":"2021","unstructured":"Zheng JXie YRen LQi LWu LPan XZhou JChen Z & Liu L 2021 GLP-1 improves the supportive ability of astrocytes to neurons by promoting aerobic glycolysis in Alzheimer's disease. Molecular Metabolism 47 101180. (https:\/\/doi.org\/10.1016\/j.molmet.2021.101180)"},{"key":"bib61","series-title":"Biology (Basel)","first-page":"1791","article-title":"Ldha-dependent metabolic programs in Sertoli cells regulate spermiogenesis in mouse testis","volume":"11","author":"Zhang","year":"2022","unstructured":"Zhang XNTao HPLi SWang YJWu SXPan B & Yang QE 2022 Ldha-dependent metabolic programs in Sertoli cells regulate spermiogenesis in mouse testis. Biology (Basel) 11 1791. (https:\/\/doi.org\/10.3390\/biology11121791)"}],"container-title":["Journal of Endocrinology"],"original-title":[],"link":[{"URL":"https:\/\/joe.bioscientifica.com\/view\/journals\/joe\/263\/3\/JOE-24-0274.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/263\/3\/JOE-24-0274.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/joe.bioscientifica.com\/downloadpdf\/journals\/joe\/263\/3\/JOE-24-0274.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:58:12Z","timestamp":1784555892000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/joe\/article\/5688"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,9,20]]},"references-count":62,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/joe-24-0274","relation":{},"ISSN":["0022-0795","1479-6805"],"issn-type":[{"value":"0022-0795","type":"print"},{"value":"1479-6805","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,9,20]]}}}