{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,4]],"date-time":"2026-05-04T06:09:43Z","timestamp":1777874983745,"version":"3.51.4"},"reference-count":78,"publisher":"Bioscientifica","issue":"1","funder":[{"DOI":"10.13039\/501100021171","name":"Basic and Applied Basic Research Foundation of Guangdong Province","doi-asserted-by":"crossref","award":["2024A1515010480"],"award-info":[{"award-number":["2024A1515010480"]}],"id":[{"id":"10.13039\/501100021171","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["joe.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:p>\n                    Trefoil factor 3 (TFF3) is a small peptide with complex activities in different diseases. Our previous studies have indicated that TFF3 can mediate gut\u2013kidney crosstalk in diabetic kidney disease (DKD), but the underlying mechanism remains unclear. To investigate the role of TFF3 in regulating lipotoxicity in DKD, male\n                    <jats:italic>Tff3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    C57BL\/6J mice were used in our study. The mice were divided into four groups: WT (wild type), WT-\n                    <jats:italic>Tff3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    , Mod-WT (DKD model), and Mod-\n                    <jats:italic>Tff3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    . The DKD model was established using a combination of high-fat diet and streptozotocin (STZ). Basic physiological parameters, including body weight and fasting blood glucose (FBG), were monitored biweekly. Glucolipid metabolism and renal functional parameters, including TC, TG, LDL-c, HDL-c, OGTT, ITT, UACR, and BUN, were detected by biochemical detection kits. Renal pathological examination methods including H&amp;E and Oil Red O staining were used. Western blot analysis was performed to quantify the protein levels of SCAP, SREBP, AMPK, p-AMPK, ACC, and p-ACC in renal tissues. Our findings indicate that\n                    <jats:italic>Tff3<\/jats:italic>\n                    deficiency in the kidney significantly alters renal lipid metabolism but not glucose metabolism.\n                    <jats:italic>Tff3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice exhibited elevated levels of TC, TG, and LDL-c, but with no significant changes in HDL or the AUC of OGTT and ITT; additionally,\n                    <jats:italic>Tff3<\/jats:italic>\n                    deficiency accelerates renal pathological changes, including lipid accumulation. Furthermore,\n                    <jats:italic>Tff3<\/jats:italic>\n                    <jats:sup>\n                      <jats:italic>\u2212\/\u2212<\/jats:italic>\n                    <\/jats:sup>\n                    mice showed up-regulation of SCAP and SREBP expression and down-regulation of p-AMPK and p-ACC in the context of DKD. In conclusion,\n                    <jats:italic>Tff3<\/jats:italic>\n                    knockout could accelerate renal lipotoxicity by the AMPK\/ACC and SCAP\/SREBP signaling pathways in DKD progression, which provides a new perspective of DKD investigation.\n                  <\/jats:p>","DOI":"10.1530\/joe-25-0303","type":"journal-article","created":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T18:00:48Z","timestamp":1775066448000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":0,"title":["TFF3 in renal pathobiology: a novel lipotoxicity regulator in male mice with diabetic kidney disease"],"prefix":"10.1530","volume":"269","author":[{"given":"Jinyuan","family":"Zhang","sequence":"first","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of The Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Li","family":"Lai","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of The Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei-Lan","family":"Huang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of The Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yang","family":"Mei","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of The Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiao-Fen","family":"Wan","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of The Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0116-3827","authenticated-orcid":true,"given":"Yi-Qi","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Glucolipid Metabolic Diseases of The Ministry of Education, Guangdong Metabolic Diseases Research Center of Integrated Chinese and Western Medicine, Guangdong Pharmaceutical University, Guangzhou, PR China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Clinical J Am Soc Nephrol","first-page":"2032","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic RZ","year":"2017","unstructured":"Alicic RZ\n, \nRooney MT\n & \nTuttle KR\n\n. Diabetic kidney disease: challenges, progress, and possibilities. Clinical J Am Soc Nephrol 2017 12 2032\u20132045. (https:\/\/doi.org\/10.2215\/cjn.11491116)"},{"key":"bib2","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"412","article-title":"Reported cases of end-stage kidney disease \u2013 united States, 2000\u20132019","volume":"71","author":"Burrows NR","year":"2022","unstructured":"Burrows NR\n, \nKoyama A\n & \nPavkov ME\n\n. Reported cases of end-stage kidney disease \u2013 united States, 2000\u20132019. MMWR Morb Mortal Wkly Rep 2022 71 412\u2013415. (https:\/\/doi.org\/10.15585\/mmwr.mm7111a3)"},{"key":"bib3","series-title":"World J Diabetes","first-page":"1111","article-title":"Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies","volume":"15","author":"Zhou T","year":"2024","unstructured":"Zhou T\n, \nFang YL\n, \nTian TT\n, et al.\n Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies. World J Diabetes 2024 15 1111\u20131121. (https:\/\/doi.org\/10.4239\/wjd.v15.i6.1111)"},{"key":"bib4","series-title":"J Biol Chem","first-page":"32317","article-title":"Diet-induced obesity in C57BL\/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway","volume":"280","author":"Jiang T","year":"2005","unstructured":"Jiang T\n, \nWang Z\n, \nProctor G\n, et al.\n Diet-induced obesity in C57BL\/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. J Biol Chem 2005 280 32317\u201332325. (https:\/\/doi.org\/10.1074\/jbc.m500801200)"},{"key":"bib5","series-title":"Cell Mol Life Sci","first-page":"1350","article-title":"The trefoil factor family \u2013 small peptides with multiple functionalities","volume":"66","author":"Kjellev S","year":"2009","unstructured":"Kjellev S\n\n. The trefoil factor family \u2013 small peptides with multiple functionalities. Cell Mol Life Sci 2009 66 1350\u20131369. (https:\/\/doi.org\/10.1007\/s00018-008-8646-5)"},{"key":"bib6","series-title":"Cell Death Dis","first-page":"62","article-title":"Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective","volume":"13","author":"Yang Y","year":"2022","unstructured":"Yang Y\n, \nLin Z\n, \nLin Q\n, et al.\n Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective. Cell Death Dis 2022 13 62. (https:\/\/doi.org\/10.1038\/s41419-022-04504-6)"},{"key":"bib7","series-title":"Int J Nephrol Renovascular Dis","first-page":"255","article-title":"Low-intensity shockwave therapy (LI-ESWT) in diabetic kidney disease: results from an open-label interventional clinical trial","volume":"14","author":"Skov-Jeppesen SM","year":"2021","unstructured":"Skov-Jeppesen SM\n, \nYderstraede KB\n, \nJensen BL\n, et al.\n Low-intensity shockwave therapy (LI-ESWT) in diabetic kidney disease: results from an open-label interventional clinical trial. Int J Nephrol Renovascular Dis 2021 14 255\u2013266. (https:\/\/doi.org\/10.2147\/ijnrd.s315143)"},{"key":"bib8","series-title":"PLoS One","article-title":"Tff3, as a novel peptide, regulates hepatic glucose metabolism","volume":"8","author":"Xue Y","year":"2013","unstructured":"Xue Y\n, \nShen L\n, \nCui Y\n, et al.\n Tff3, as a novel peptide, regulates hepatic glucose metabolism. PLoS One 2013 8 e75240. (https:\/\/doi.org\/10.1371\/journal.pone.0075240)"},{"key":"bib9","series-title":"Life","first-page":"1288","article-title":"Tff3 deficiency protects against hepatic fat accumulation after prolonged high-fat diet","volume":"12","author":"\u0160e\u0161elja K","year":"2022","unstructured":"\u0160e\u0161elja K\n, \nBazina I\n, \nVrecl M\n, et al.\n Tff3 deficiency protects against hepatic fat accumulation after prolonged high-fat diet. Life 2022 12 1288. (https:\/\/doi.org\/10.3390\/life12081288)"},{"key":"bib10","series-title":"Biochem Pharmacol","first-page":"42","article-title":"Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation","volume":"122","author":"Zheng ZG","year":"2016","unstructured":"Zheng ZG\n, \nZhou YP\n, \nZhang X\n, et al.\n Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. Biochem Pharmacol 2016 122 42\u201361. (https:\/\/doi.org\/10.1016\/j.bcp.2016.10.016)"},{"key":"bib11","series-title":"Life Sci","article-title":"AMPK allostery: a therapeutic target for the management\/treatment of diabetic nephropathy","volume":"261","author":"Ayinde KS","year":"2020","unstructured":"Ayinde KS\n, \nOlaoba OT\n, \nIbrahim B\n, et al.\n AMPK allostery: a therapeutic target for the management\/treatment of diabetic nephropathy. Life Sci 2020 261 118455. (https:\/\/doi.org\/10.1016\/j.lfs.2020.118455)"},{"key":"bib12","series-title":"J Orthop Surg Res","first-page":"386","article-title":"L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway","volume":"18","author":"Liao T","year":"2023","unstructured":"Liao T\n, \nMei W\n, \nZhang L\n, et al.\n L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway. J Orthop Surg Res 2023 18 386. (https:\/\/doi.org\/10.1186\/s13018-023-03872-9)"},{"key":"bib13","series-title":"J Food Biochem","article-title":"Chrysin improves diabetic nephropathy by regulating the AMPK-mediated lipid metabolism in HFD\/STZ-induced DN mice","volume":"46","author":"Zhou Y","year":"2022","unstructured":"Zhou Y\n, \nTao H\n, \nXu N\n, et al.\n Chrysin improves diabetic nephropathy by regulating the AMPK-mediated lipid metabolism in HFD\/STZ-induced DN mice. J Food Biochem 2022 46 e14379. (https:\/\/doi.org\/10.1111\/jfbc.14379)"},{"key":"bib14","series-title":"Diabetes Metab Syndr Obes","first-page":"227","article-title":"Empagliflozin regulates the AdipoR1\/p-AMPK\/p-ACC pathway to alleviate lipid deposition in diabetic nephropathy","volume":"14","author":"Zhang Z","year":"2021","unstructured":"Zhang Z\n, \nNi L\n, \nZhang L\n, et al.\n Empagliflozin regulates the AdipoR1\/p-AMPK\/p-ACC pathway to alleviate lipid deposition in diabetic nephropathy. Diabetes Metab Syndr Obes 2021 14 227\u2013240. (https:\/\/doi.org\/10.2147\/dmso.s289712)"},{"key":"bib15","series-title":"Biosci Biotechnol Biochem","first-page":"1183","article-title":"Vitexin, a fenugreek glycoside, ameliorated obesity-induced diabetic nephropathy via modulation of NF-\u03baB\/IkB\u03b1 and AMPK\/ACC pathways in mice","volume":"85","author":"Zhou G","year":"2021","unstructured":"Zhou G\n, \nCui J\n, \nXie S\n, et al.\n Vitexin, a fenugreek glycoside, ameliorated obesity-induced diabetic nephropathy via modulation of NF-\u03baB\/IkB\u03b1 and AMPK\/ACC pathways in mice. Biosci Biotechnol Biochem 2021 85 1183\u20131193. (https:\/\/doi.org\/10.1093\/bbb\/zbab012)"},{"key":"bib16","series-title":"Int J Endocrinol","article-title":"Cholesterol contributes to diabetic nephropathy through SCAP-SREBP-2 pathway","volume":"2013","author":"Sun H","year":"2013","unstructured":"Sun H\n, \nYuan Y\n & \nSun ZL\n\n. Cholesterol contributes to diabetic nephropathy through SCAP-SREBP-2 pathway. Int J Endocrinol 2013 2013 592576. (https:\/\/doi.org\/10.1155\/2013\/592576)"},{"key":"bib17","series-title":"Neurosci Lett","first-page":"121","article-title":"Depletion of norepinephrine of the central nervous system down-regulates the blood glucose level in d-glucose-fed and restraint stress models","volume":"620","author":"Park SH","year":"2016","unstructured":"Park SH\n, \nKim SS\n, \nLee JR\n, et al.\n Depletion of norepinephrine of the central nervous system down-regulates the blood glucose level in d-glucose-fed and restraint stress models. Neurosci Lett 2016 620 121\u2013126. (https:\/\/doi.org\/10.1016\/j.neulet.2016.02.055)"},{"key":"bib18","series-title":"Cell Commun Signal","first-page":"519","article-title":"DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1","volume":"22","author":"Hu Y","year":"2024","unstructured":"Hu Y\n, \nYe S\n, \nKong J\n, et al.\n DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1. Cell Commun Signal 2024 22 519. (https:\/\/doi.org\/10.1186\/s12964-024-01895-1)"},{"key":"bib19","series-title":"Nat Commun","first-page":"2693","article-title":"An RFC4\/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness","volume":"12","author":"Liu L","year":"2021","unstructured":"Liu L\n, \nTao T\n, \nLiu S\n, et al.\n An RFC4\/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness. Nat Commun 2021 12 2693. (https:\/\/doi.org\/10.1038\/s41467-021-22971-x)"},{"key":"bib20","series-title":"Int J Mol Sci","first-page":"2806","article-title":"Macrophage phenotype and fibrosis in diabetic nephropathy","volume":"21","author":"Calle P","year":"2020","unstructured":"Calle P\n & \nHotter G\n\n. Macrophage phenotype and fibrosis in diabetic nephropathy. Int J Mol Sci 2020 21 2806. (https:\/\/doi.org\/10.3390\/ijms21082806)"},{"key":"bib21","series-title":"Rev Diabet Stud","first-page":"110","article-title":"Diabetic nephropathy: new risk factors and improvements in diagnosis","volume":"12","author":"Tziomalos K","year":"2015","unstructured":"Tziomalos K\n & \nAthyros VG\n\n. Diabetic nephropathy: new risk factors and improvements in diagnosis. Rev Diabet Stud 2015 12 110\u2013118. (https:\/\/doi.org\/10.1900\/rds.2015.12.110)"},{"key":"bib22","series-title":"Biomed Pharmacother","article-title":"Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects","volume":"168","author":"Li X","year":"2023","unstructured":"Li X\n, \nZhang Y\n, \nXing X\n, et al.\n Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects. Biomed Pharmacother 2023 168 115670. (https:\/\/doi.org\/10.1016\/j.biopha.2023.115670)"},{"key":"bib23","series-title":"Int J Mol Sci","first-page":"2632","article-title":"Lipotoxicity and diabetic nephropathy: novel mechanistic insights and therapeutic opportunities","volume":"21","author":"Opazo-R\u00edos L","year":"2020","unstructured":"Opazo-R\u00edos L\n, \nMas S\n, \nMar\u00edn-Royo G\n, et al.\n Lipotoxicity and diabetic nephropathy: novel mechanistic insights and therapeutic opportunities. Int J Mol Sci 2020 21 2632. (https:\/\/doi.org\/10.3390\/ijms21072632)"},{"key":"bib24","series-title":"Cell Physiol Biochem","first-page":"827","article-title":"Trefoil factor 3 deficiency affects liver lipid metabolism","volume":"47","author":"Bujak M","year":"2018","unstructured":"Bujak M\n, \nBujak IT\n, \nSobo\u010danec S\n, et al.\n Trefoil factor 3 deficiency affects liver lipid metabolism. Cell Physiol Biochem 2018 47 827\u2013841. (https:\/\/doi.org\/10.1159\/000490039)"},{"key":"bib25","series-title":"Food Funct","first-page":"2970","article-title":"Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation","volume":"10","author":"Ge C","year":"2019","unstructured":"Ge C\n, \nXu M\n, \nQin Y\n, et al.\n Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation. Food Funct 2019 10 2970\u20132985. (https:\/\/doi.org\/10.1039\/c8fo01653d)"},{"key":"bib26","series-title":"Biochem Pharmacol","article-title":"FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism","volume":"235","author":"Chang K","year":"2025","unstructured":"Chang K\n, \nHong F\n, \nLiu H\n, et al.\n FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism. Biochem Pharmacol 2025 235 116819. (https:\/\/doi.org\/10.1016\/j.bcp.2025.116819)"},{"key":"bib27","series-title":"Am J Physiol Ren Physiol","first-page":"F1138","article-title":"Diabetic kidney disease in the db\/db mouse","volume":"284","author":"Sharma K","year":"2003","unstructured":"Sharma K\n, \nMcCue P\n & \nDunn SR\n\n. Diabetic kidney disease in the db\/db mouse. Am J Physiol Ren Physiol 2003 284 F1138\u2013F1144. (https:\/\/doi.org\/10.1152\/ajprenal.00315.2002)"},{"key":"bib28","series-title":"Cytokine","article-title":"Association of serum trefoil factor 3 and leptin levels with obesity: a case-control study","volume":"181","author":"Said NM","year":"2024","unstructured":"Said NM\n & \nEl-Shaer NH\n\n. Association of serum trefoil factor 3 and leptin levels with obesity: a case-control study. Cytokine 2024 181 156690. (https:\/\/doi.org\/10.1016\/j.cyto.2024.156690)"},{"key":"bib29","series-title":"PLoS One","article-title":"Trefoil factor 3 (TFF3) is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia","volume":"10","author":"Ge H","year":"2015","unstructured":"Ge H\n, \nGardner J\n, \nWu X\n, et al.\n Trefoil factor 3 (TFF3) is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia. PLoS One 2015 10 e0126924. (https:\/\/doi.org\/10.1371\/journal.pone.0126924)"},{"key":"bib30","series-title":"Cell Signal","article-title":"Trefoil factor 3: new highlights in chronic kidney disease research","volume":"100","author":"Lin Z","year":"2022","unstructured":"Lin Z\n, \nWan X\n, \nZhang T\n, et al.\n Trefoil factor 3: new highlights in chronic kidney disease research. Cell Signal 2022 100 110470. (https:\/\/doi.org\/10.1016\/j.cellsig.2022.110470)"},{"key":"bib31","series-title":"Physiol Genom","first-page":"187","article-title":"Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver","volume":"37","author":"Guill\u00e9n N","year":"2009","unstructured":"Guill\u00e9n N\n, \nNavarro MA\n, \nArnal C\n, et al.\n Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Physiol Genom 2009 37 187\u2013198. (https:\/\/doi.org\/10.1152\/physiolgenomics.90339.2008)"},{"key":"bib32","series-title":"Int J Mol Sci","first-page":"4389","article-title":"Effect of Tff3 deficiency and ER stress in the liver","volume":"20","author":"\u0160e\u0161elja K","year":"2019","unstructured":"\u0160e\u0161elja K\n, \nBazina I\n, \nWelss J\n, et al.\n Effect of Tff3 deficiency and ER stress in the liver. Int J Mol Sci 2019 20 4389. (https:\/\/doi.org\/10.3390\/ijms20184389)"},{"key":"bib33","series-title":"Acta Biochim Biophys Sin","first-page":"1406","article-title":"Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota","volume":"54","author":"Ni Y","year":"2022","unstructured":"Ni Y\n, \nZheng L\n, \nNan S\n, et al.\n Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota. Acta Biochim Biophys Sin 2022 54 1406\u20131420. (https:\/\/doi.org\/10.3724\/abbs.2022140)"},{"key":"bib34","series-title":"Science","first-page":"262","article-title":"Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor","volume":"274","author":"Mashimo H","year":"1996","unstructured":"Mashimo H\n, \nWu DC\n, \nPodolsky DK\n, et al.\n Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996 274 262\u2013265. (https:\/\/doi.org\/10.1126\/science.274.5285.262)"},{"key":"bib35","series-title":"Diseases","first-page":"21","article-title":"Impact of gut dysbiosis on neurohormonal pathways in chronic kidney disease","volume":"7","author":"Jazani NH","year":"2019","unstructured":"Jazani NH\n, \nSavoj J\n, \nLustgarten M\n, et al.\n Impact of gut dysbiosis on neurohormonal pathways in chronic kidney disease. Diseases 2019 7 21. (https:\/\/doi.org\/10.3390\/diseases7010021)"},{"key":"bib36","series-title":"Am J Physiol Cell Physiol","first-page":"C1085","article-title":"TFF3 modulates NF-\u03baB and a novel negative regulatory molecule of NF-\u03baB in intestinal epithelial cells via a mechanism distinct from TNF-\u03b1","volume":"289","author":"Zhu YQ","year":"2005","unstructured":"Zhu YQ\n & \nTan XD\n\n. TFF3 modulates NF-\u03baB and a novel negative regulatory molecule of NF-\u03baB in intestinal epithelial cells via a mechanism distinct from TNF-\u03b1. Am J Physiol Cell Physiol 2005 289 C1085\u2013C1093. (https:\/\/doi.org\/10.1152\/ajpcell.00185.2005)"},{"key":"bib37","series-title":"Cell Tissue Res","first-page":"3","article-title":"Trefoil factor 3 shows anti-inflammatory effects on activated microglia","volume":"365","author":"Arnold P","year":"2016","unstructured":"Arnold P\n, \nRickert U\n, \nHelmers AK\n, et al.\n Trefoil factor 3 shows anti-inflammatory effects on activated microglia. Cell Tissue Res 2016 365 3\u201311. (https:\/\/doi.org\/10.1007\/s00441-016-2370-5)"},{"key":"bib38","series-title":"J Neuroinflammation","first-page":"34","article-title":"AMPK activation attenuates inflammatory pain through inhibiting NF-\u03baB activation and IL-1\u03b2 expression","volume":"16","author":"Xiang HC","year":"2019","unstructured":"Xiang HC\n, \nLin LX\n, \nHu XF\n, et al.\n AMPK activation attenuates inflammatory pain through inhibiting NF-\u03baB activation and IL-1\u03b2 expression. J Neuroinflammation 2019 16 34. (https:\/\/doi.org\/10.1186\/s12974-019-1411-x)"},{"key":"bib39","series-title":"Cell Metab","first-page":"376","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice","volume":"13","author":"Li Y","year":"2011","unstructured":"Li Y\n, \nXu S\n, \nMihaylova MM\n, et al.\n AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011 13 376\u2013388. (https:\/\/doi.org\/10.1016\/j.cmet.2011.03.009)"},{"key":"bib1","series-title":"Clinical J Am Soc Nephrol","first-page":"2032","article-title":"Diabetic kidney disease: challenges, progress, and possibilities","volume":"12","author":"Alicic RZ","year":"2017","unstructured":"Alicic RZ\n, \nRooney MT\n & \nTuttle KR\n\n. Diabetic kidney disease: challenges, progress, and possibilities. Clinical J Am Soc Nephrol 2017 12 2032\u20132045. (https:\/\/doi.org\/10.2215\/cjn.11491116)"},{"key":"bib2","series-title":"MMWR Morb Mortal Wkly Rep","first-page":"412","article-title":"Reported cases of end-stage kidney disease \u2013 united States, 2000\u20132019","volume":"71","author":"Burrows NR","year":"2022","unstructured":"Burrows NR\n, \nKoyama A\n & \nPavkov ME\n\n. Reported cases of end-stage kidney disease \u2013 united States, 2000\u20132019. MMWR Morb Mortal Wkly Rep 2022 71 412\u2013415. (https:\/\/doi.org\/10.15585\/mmwr.mm7111a3)"},{"key":"bib3","series-title":"World J Diabetes","first-page":"1111","article-title":"Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies","volume":"15","author":"Zhou T","year":"2024","unstructured":"Zhou T\n, \nFang YL\n, \nTian TT\n, et al.\n Pathological mechanism of immune disorders in diabetic kidney disease and intervention strategies. World J Diabetes 2024 15 1111\u20131121. (https:\/\/doi.org\/10.4239\/wjd.v15.i6.1111)"},{"key":"bib4","series-title":"J Biol Chem","first-page":"32317","article-title":"Diet-induced obesity in C57BL\/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway","volume":"280","author":"Jiang T","year":"2005","unstructured":"Jiang T\n, \nWang Z\n, \nProctor G\n, et al.\n Diet-induced obesity in C57BL\/6J mice causes increased renal lipid accumulation and glomerulosclerosis via a sterol regulatory element-binding protein-1c-dependent pathway. J Biol Chem 2005 280 32317\u201332325. (https:\/\/doi.org\/10.1074\/jbc.m500801200)"},{"key":"bib5","series-title":"Cell Mol Life Sci","first-page":"1350","article-title":"The trefoil factor family \u2013 small peptides with multiple functionalities","volume":"66","author":"Kjellev S","year":"2009","unstructured":"Kjellev S\n\n. The trefoil factor family \u2013 small peptides with multiple functionalities. Cell Mol Life Sci 2009 66 1350\u20131369. (https:\/\/doi.org\/10.1007\/s00018-008-8646-5)"},{"key":"bib6","series-title":"Cell Death Dis","first-page":"62","article-title":"Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective","volume":"13","author":"Yang Y","year":"2022","unstructured":"Yang Y\n, \nLin Z\n, \nLin Q\n, et al.\n Pathological and therapeutic roles of bioactive peptide trefoil factor 3 in diverse diseases: recent progress and perspective. Cell Death Dis 2022 13 62. (https:\/\/doi.org\/10.1038\/s41419-022-04504-6)"},{"key":"bib7","series-title":"Int J Nephrol Renovascular Dis","first-page":"255","article-title":"Low-intensity shockwave therapy (LI-ESWT) in diabetic kidney disease: results from an open-label interventional clinical trial","volume":"14","author":"Skov-Jeppesen SM","year":"2021","unstructured":"Skov-Jeppesen SM\n, \nYderstraede KB\n, \nJensen BL\n, et al.\n Low-intensity shockwave therapy (LI-ESWT) in diabetic kidney disease: results from an open-label interventional clinical trial. Int J Nephrol Renovascular Dis 2021 14 255\u2013266. (https:\/\/doi.org\/10.2147\/ijnrd.s315143)"},{"key":"bib8","series-title":"PLoS One","article-title":"Tff3, as a novel peptide, regulates hepatic glucose metabolism","volume":"8","author":"Xue Y","year":"2013","unstructured":"Xue Y\n, \nShen L\n, \nCui Y\n, et al.\n Tff3, as a novel peptide, regulates hepatic glucose metabolism. PLoS One 2013 8 e75240. (https:\/\/doi.org\/10.1371\/journal.pone.0075240)"},{"key":"bib9","series-title":"Life","first-page":"1288","article-title":"Tff3 deficiency protects against hepatic fat accumulation after prolonged high-fat diet","volume":"12","author":"\u0160e\u0161elja K","year":"2022","unstructured":"\u0160e\u0161elja K\n, \nBazina I\n, \nVrecl M\n, et al.\n Tff3 deficiency protects against hepatic fat accumulation after prolonged high-fat diet. Life 2022 12 1288. (https:\/\/doi.org\/10.3390\/life12081288)"},{"key":"bib10","series-title":"Biochem Pharmacol","first-page":"42","article-title":"Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation","volume":"122","author":"Zheng ZG","year":"2016","unstructured":"Zheng ZG\n, \nZhou YP\n, \nZhang X\n, et al.\n Anhydroicaritin improves diet-induced obesity and hyperlipidemia and alleviates insulin resistance by suppressing SREBPs activation. Biochem Pharmacol 2016 122 42\u201361. (https:\/\/doi.org\/10.1016\/j.bcp.2016.10.016)"},{"key":"bib11","series-title":"Life Sci","article-title":"AMPK allostery: a therapeutic target for the management\/treatment of diabetic nephropathy","volume":"261","author":"Ayinde KS","year":"2020","unstructured":"Ayinde KS\n, \nOlaoba OT\n, \nIbrahim B\n, et al.\n AMPK allostery: a therapeutic target for the management\/treatment of diabetic nephropathy. Life Sci 2020 261 118455. (https:\/\/doi.org\/10.1016\/j.lfs.2020.118455)"},{"key":"bib12","series-title":"J Orthop Surg Res","first-page":"386","article-title":"L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway","volume":"18","author":"Liao T","year":"2023","unstructured":"Liao T\n, \nMei W\n, \nZhang L\n, et al.\n L-carnitine alleviates synovitis in knee osteoarthritis by regulating lipid accumulation and mitochondrial function through the AMPK-ACC-CPT1 signaling pathway. J Orthop Surg Res 2023 18 386. (https:\/\/doi.org\/10.1186\/s13018-023-03872-9)"},{"key":"bib13","series-title":"J Food Biochem","article-title":"Chrysin improves diabetic nephropathy by regulating the AMPK-mediated lipid metabolism in HFD\/STZ-induced DN mice","volume":"46","author":"Zhou Y","year":"2022","unstructured":"Zhou Y\n, \nTao H\n, \nXu N\n, et al.\n Chrysin improves diabetic nephropathy by regulating the AMPK-mediated lipid metabolism in HFD\/STZ-induced DN mice. J Food Biochem 2022 46 e14379. (https:\/\/doi.org\/10.1111\/jfbc.14379)"},{"key":"bib14","series-title":"Diabetes Metab Syndr Obes","first-page":"227","article-title":"Empagliflozin regulates the AdipoR1\/p-AMPK\/p-ACC pathway to alleviate lipid deposition in diabetic nephropathy","volume":"14","author":"Zhang Z","year":"2021","unstructured":"Zhang Z\n, \nNi L\n, \nZhang L\n, et al.\n Empagliflozin regulates the AdipoR1\/p-AMPK\/p-ACC pathway to alleviate lipid deposition in diabetic nephropathy. Diabetes Metab Syndr Obes 2021 14 227\u2013240. (https:\/\/doi.org\/10.2147\/dmso.s289712)"},{"key":"bib15","series-title":"Biosci Biotechnol Biochem","first-page":"1183","article-title":"Vitexin, a fenugreek glycoside, ameliorated obesity-induced diabetic nephropathy via modulation of NF-\u03baB\/IkB\u03b1 and AMPK\/ACC pathways in mice","volume":"85","author":"Zhou G","year":"2021","unstructured":"Zhou G\n, \nCui J\n, \nXie S\n, et al.\n Vitexin, a fenugreek glycoside, ameliorated obesity-induced diabetic nephropathy via modulation of NF-\u03baB\/IkB\u03b1 and AMPK\/ACC pathways in mice. Biosci Biotechnol Biochem 2021 85 1183\u20131193. (https:\/\/doi.org\/10.1093\/bbb\/zbab012)"},{"key":"bib16","series-title":"Int J Endocrinol","article-title":"Cholesterol contributes to diabetic nephropathy through SCAP-SREBP-2 pathway","volume":"2013","author":"Sun H","year":"2013","unstructured":"Sun H\n, \nYuan Y\n & \nSun ZL\n\n. Cholesterol contributes to diabetic nephropathy through SCAP-SREBP-2 pathway. Int J Endocrinol 2013 2013 592576. (https:\/\/doi.org\/10.1155\/2013\/592576)"},{"key":"bib17","series-title":"Neurosci Lett","first-page":"121","article-title":"Depletion of norepinephrine of the central nervous system down-regulates the blood glucose level in d-glucose-fed and restraint stress models","volume":"620","author":"Park SH","year":"2016","unstructured":"Park SH\n, \nKim SS\n, \nLee JR\n, et al.\n Depletion of norepinephrine of the central nervous system down-regulates the blood glucose level in d-glucose-fed and restraint stress models. Neurosci Lett 2016 620 121\u2013126. (https:\/\/doi.org\/10.1016\/j.neulet.2016.02.055)"},{"key":"bib18","series-title":"Cell Commun Signal","first-page":"519","article-title":"DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1","volume":"22","author":"Hu Y","year":"2024","unstructured":"Hu Y\n, \nYe S\n, \nKong J\n, et al.\n DOT1L protects against podocyte injury in diabetic kidney disease through phospholipase C-like 1. Cell Commun Signal 2024 22 519. (https:\/\/doi.org\/10.1186\/s12964-024-01895-1)"},{"key":"bib19","series-title":"Nat Commun","first-page":"2693","article-title":"An RFC4\/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness","volume":"12","author":"Liu L","year":"2021","unstructured":"Liu L\n, \nTao T\n, \nLiu S\n, et al.\n An RFC4\/Notch1 signaling feedback loop promotes NSCLC metastasis and stemness. Nat Commun 2021 12 2693. (https:\/\/doi.org\/10.1038\/s41467-021-22971-x)"},{"key":"bib20","series-title":"Int J Mol Sci","first-page":"2806","article-title":"Macrophage phenotype and fibrosis in diabetic nephropathy","volume":"21","author":"Calle P","year":"2020","unstructured":"Calle P\n & \nHotter G\n\n. Macrophage phenotype and fibrosis in diabetic nephropathy. Int J Mol Sci 2020 21 2806. (https:\/\/doi.org\/10.3390\/ijms21082806)"},{"key":"bib21","series-title":"Rev Diabet Stud","first-page":"110","article-title":"Diabetic nephropathy: new risk factors and improvements in diagnosis","volume":"12","author":"Tziomalos K","year":"2015","unstructured":"Tziomalos K\n & \nAthyros VG\n\n. Diabetic nephropathy: new risk factors and improvements in diagnosis. Rev Diabet Stud 2015 12 110\u2013118. (https:\/\/doi.org\/10.1900\/rds.2015.12.110)"},{"key":"bib22","series-title":"Biomed Pharmacother","article-title":"Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects","volume":"168","author":"Li X","year":"2023","unstructured":"Li X\n, \nZhang Y\n, \nXing X\n, et al.\n Podocyte injury of diabetic nephropathy: novel mechanism discovery and therapeutic prospects. Biomed Pharmacother 2023 168 115670. (https:\/\/doi.org\/10.1016\/j.biopha.2023.115670)"},{"key":"bib23","series-title":"Int J Mol Sci","first-page":"2632","article-title":"Lipotoxicity and diabetic nephropathy: novel mechanistic insights and therapeutic opportunities","volume":"21","author":"Opazo-R\u00edos L","year":"2020","unstructured":"Opazo-R\u00edos L\n, \nMas S\n, \nMar\u00edn-Royo G\n, et al.\n Lipotoxicity and diabetic nephropathy: novel mechanistic insights and therapeutic opportunities. Int J Mol Sci 2020 21 2632. (https:\/\/doi.org\/10.3390\/ijms21072632)"},{"key":"bib24","series-title":"Cell Physiol Biochem","first-page":"827","article-title":"Trefoil factor 3 deficiency affects liver lipid metabolism","volume":"47","author":"Bujak M","year":"2018","unstructured":"Bujak M\n, \nBujak IT\n, \nSobo\u010danec S\n, et al.\n Trefoil factor 3 deficiency affects liver lipid metabolism. Cell Physiol Biochem 2018 47 827\u2013841. (https:\/\/doi.org\/10.1159\/000490039)"},{"key":"bib25","series-title":"Food Funct","first-page":"2970","article-title":"Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation","volume":"10","author":"Ge C","year":"2019","unstructured":"Ge C\n, \nXu M\n, \nQin Y\n, et al.\n Fisetin supplementation prevents high fat diet-induced diabetic nephropathy by repressing insulin resistance and RIP3-regulated inflammation. Food Funct 2019 10 2970\u20132985. (https:\/\/doi.org\/10.1039\/c8fo01653d)"},{"key":"bib26","series-title":"Biochem Pharmacol","article-title":"FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism","volume":"235","author":"Chang K","year":"2025","unstructured":"Chang K\n, \nHong F\n, \nLiu H\n, et al.\n FTO aggravates podocyte injury and diabetic nephropathy progression via m6A-dependent stabilization of ACC1 mRNA and promoting fatty acid metabolism. Biochem Pharmacol 2025 235 116819. (https:\/\/doi.org\/10.1016\/j.bcp.2025.116819)"},{"key":"bib27","series-title":"Am J Physiol Ren Physiol","first-page":"F1138","article-title":"Diabetic kidney disease in the db\/db mouse","volume":"284","author":"Sharma K","year":"2003","unstructured":"Sharma K\n, \nMcCue P\n & \nDunn SR\n\n. Diabetic kidney disease in the db\/db mouse. Am J Physiol Ren Physiol 2003 284 F1138\u2013F1144. (https:\/\/doi.org\/10.1152\/ajprenal.00315.2002)"},{"key":"bib28","series-title":"Cytokine","article-title":"Association of serum trefoil factor 3 and leptin levels with obesity: a case-control study","volume":"181","author":"Said NM","year":"2024","unstructured":"Said NM\n & \nEl-Shaer NH\n\n. Association of serum trefoil factor 3 and leptin levels with obesity: a case-control study. Cytokine 2024 181 156690. (https:\/\/doi.org\/10.1016\/j.cyto.2024.156690)"},{"key":"bib29","series-title":"PLoS One","article-title":"Trefoil factor 3 (TFF3) is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia","volume":"10","author":"Ge H","year":"2015","unstructured":"Ge H\n, \nGardner J\n, \nWu X\n, et al.\n Trefoil factor 3 (TFF3) is regulated by food intake, improves glucose tolerance and induces mucinous metaplasia. PLoS One 2015 10 e0126924. (https:\/\/doi.org\/10.1371\/journal.pone.0126924)"},{"key":"bib30","series-title":"Cell Signal","article-title":"Trefoil factor 3: new highlights in chronic kidney disease research","volume":"100","author":"Lin Z","year":"2022","unstructured":"Lin Z\n, \nWan X\n, \nZhang T\n, et al.\n Trefoil factor 3: new highlights in chronic kidney disease research. Cell Signal 2022 100 110470. (https:\/\/doi.org\/10.1016\/j.cellsig.2022.110470)"},{"key":"bib31","series-title":"Physiol Genom","first-page":"187","article-title":"Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver","volume":"37","author":"Guill\u00e9n N","year":"2009","unstructured":"Guill\u00e9n N\n, \nNavarro MA\n, \nArnal C\n, et al.\n Microarray analysis of hepatic gene expression identifies new genes involved in steatotic liver. Physiol Genom 2009 37 187\u2013198. (https:\/\/doi.org\/10.1152\/physiolgenomics.90339.2008)"},{"key":"bib32","series-title":"Int J Mol Sci","first-page":"4389","article-title":"Effect of Tff3 deficiency and ER stress in the liver","volume":"20","author":"\u0160e\u0161elja K","year":"2019","unstructured":"\u0160e\u0161elja K\n, \nBazina I\n, \nWelss J\n, et al.\n Effect of Tff3 deficiency and ER stress in the liver. Int J Mol Sci 2019 20 4389. (https:\/\/doi.org\/10.3390\/ijms20184389)"},{"key":"bib33","series-title":"Acta Biochim Biophys Sin","first-page":"1406","article-title":"Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota","volume":"54","author":"Ni Y","year":"2022","unstructured":"Ni Y\n, \nZheng L\n, \nNan S\n, et al.\n Enterorenal crosstalks in diabetic nephropathy and novel therapeutics targeting the gut microbiota. Acta Biochim Biophys Sin 2022 54 1406\u20131420. (https:\/\/doi.org\/10.3724\/abbs.2022140)"},{"key":"bib34","series-title":"Science","first-page":"262","article-title":"Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor","volume":"274","author":"Mashimo H","year":"1996","unstructured":"Mashimo H\n, \nWu DC\n, \nPodolsky DK\n, et al.\n Impaired defense of intestinal mucosa in mice lacking intestinal trefoil factor. Science 1996 274 262\u2013265. (https:\/\/doi.org\/10.1126\/science.274.5285.262)"},{"key":"bib35","series-title":"Diseases","first-page":"21","article-title":"Impact of gut dysbiosis on neurohormonal pathways in chronic kidney disease","volume":"7","author":"Jazani NH","year":"2019","unstructured":"Jazani NH\n, \nSavoj J\n, \nLustgarten M\n, et al.\n Impact of gut dysbiosis on neurohormonal pathways in chronic kidney disease. Diseases 2019 7 21. (https:\/\/doi.org\/10.3390\/diseases7010021)"},{"key":"bib36","series-title":"Am J Physiol Cell Physiol","first-page":"C1085","article-title":"TFF3 modulates NF-\u03baB and a novel negative regulatory molecule of NF-\u03baB in intestinal epithelial cells via a mechanism distinct from TNF-\u03b1","volume":"289","author":"Zhu YQ","year":"2005","unstructured":"Zhu YQ\n & \nTan XD\n\n. TFF3 modulates NF-\u03baB and a novel negative regulatory molecule of NF-\u03baB in intestinal epithelial cells via a mechanism distinct from TNF-\u03b1. Am J Physiol Cell Physiol 2005 289 C1085\u2013C1093. (https:\/\/doi.org\/10.1152\/ajpcell.00185.2005)"},{"key":"bib37","series-title":"Cell Tissue Res","first-page":"3","article-title":"Trefoil factor 3 shows anti-inflammatory effects on activated microglia","volume":"365","author":"Arnold P","year":"2016","unstructured":"Arnold P\n, \nRickert U\n, \nHelmers AK\n, et al.\n Trefoil factor 3 shows anti-inflammatory effects on activated microglia. Cell Tissue Res 2016 365 3\u201311. (https:\/\/doi.org\/10.1007\/s00441-016-2370-5)"},{"key":"bib38","series-title":"J Neuroinflammation","first-page":"34","article-title":"AMPK activation attenuates inflammatory pain through inhibiting NF-\u03baB activation and IL-1\u03b2 expression","volume":"16","author":"Xiang HC","year":"2019","unstructured":"Xiang HC\n, \nLin LX\n, \nHu XF\n, et al.\n AMPK activation attenuates inflammatory pain through inhibiting NF-\u03baB activation and IL-1\u03b2 expression. J Neuroinflammation 2019 16 34. (https:\/\/doi.org\/10.1186\/s12974-019-1411-x)"},{"key":"bib39","series-title":"Cell Metab","first-page":"376","article-title":"AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice","volume":"13","author":"Li Y","year":"2011","unstructured":"Li Y\n, \nXu S\n, \nMihaylova MM\n, et al.\n AMPK phosphorylates and inhibits SREBP activity to attenuate hepatic steatosis and atherosclerosis in diet-induced insulin-resistant mice. Cell Metab 2011 13 376\u2013388. 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