{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:18:42Z","timestamp":1787678322095,"version":"build-2784847793"},"reference-count":40,"publisher":"Bioscientifica","issue":"2","content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,8,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Obesity is characterized by chronic inflammation and impaired glucose homeostasis. Regulatory T cells (Tregs) preserve immunometabolic balance, and their reduction contributes to metabolic disturbances. Although IL-2\/anti-IL-2 complex (IL-2C) and hyperbaric oxygen (HBO) therapy expand Tregs, their combined effects on obesity remain unclear. Male C57BL\/6 mice were fed a low-fat diet (LFD) or a high-fat diet (HFD) for 16 weeks and treated with IL-2C and\/or HBO. Both interventions significantly reduced HFD-induced body weight (9\u201322%, P &amp;lt; 0.05) independent of caloric intake, with no significant changes in LFD groups. Glucose tolerance and insulin sensitivity improved, showing significant reductions in IPGTT and IPITT area-under-the-curve values (20\u201325% and 30\u201335%, respectively; P &amp;lt; 0.05) compared with the HFD control. Combination therapy produced the most consistent metabolic improvements. Histological analysis demonstrated reduced adipocyte hypertrophy and crown-like structures in epididymal adipose tissue (P &amp;lt; 0.05). Treatments restored CD4+FoxP3+ Tregs, suppressed pro-inflammatory M1 macrophages, and decreased hypoxia-inducible factor-1\u03b1 expression (P &amp;lt; 0.05). Consistent with these findings, histological examination revealed tissue-specific structural remodeling, characterized by restored multilocular adipocytes in iBAT and reduced adipocyte hypertrophy in iWAT under HFD conditions. These findings suggest that IL-2C and HBO improve immunometabolic dysfunction associated with obesity, in parallel with favorable adipose tissue remodeling and metabolic adaptation. Thus, IL-2C and HBO may represent complementary therapeutic strategies for enhancing metabolic health.<\/jats:p>","DOI":"10.1530\/joe-25-0474","type":"journal-article","created":{"date-parts":[[2026,8,6]],"date-time":"2026-08-06T15:47:56Z","timestamp":1786031276000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-5","source":"Crossref","is-referenced-by-count":0,"title":["Attenuation of diet-induced obesity and impaired glucose homeostasis by the IL-2\/anti-IL-2 complex and hyperbaric oxygen"],"prefix":"10.1530","volume":"270","author":[{"given":"Eun-Jeong","family":"Choi","sequence":"first","affiliation":[{"name":"Department of Microbiology, Ewha Womans University Graduate School of Medicine, Seoul, Korea 1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung-Ran","family":"Kim","sequence":"additional","affiliation":[{"name":"Central Research Laboratory, GI Longevity 2 , ,","place":["Seongnam, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Hae","family":"Kie","sequence":"additional","affiliation":[{"name":"Department of Pathology, National Health Insurance Cooperation Ilsan Hospital 3 , ,","place":["Koyang, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ju-Young","family":"Seoh","sequence":"additional","affiliation":[{"name":"Department of Microbiology, CHA University 4 , ,","place":["Pocheon, Korea"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8499-664X","authenticated-orcid":true,"given":"Joo-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Nowon Eulji Medical Center, Eulji University 5 , ,","place":["Seoul, 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