{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,20]],"date-time":"2026-09-20T00:09:01Z","timestamp":1789862941745,"version":"4.0.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1974,6,1]],"date-time":"1974-06-01T00:00:00Z","timestamp":139276800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1974,6,1]]},"abstract":"<jats:title>Summary.<\/jats:title>\n                  <jats:p>The antifertility effects and histopathological changes in the reproductive tract of male rats following administration of \u03b1-chlorohydrin, \u03b1-bromohydrin, epi-chlorohydrin and glycidol were compared. Contrary to earlier reports, \u03b1-bromohydrin induced bilateral spermatocoeles and permanent sterility in rats but did not produce the functional epididymal sterilizing effect of \u03b1-chlorohydrin. Glycidol reproduced the primary sterilizing effect of \u03b1-chlorohydrin but not the lesions in the proximal caput epididymidis. Epi-chlorohydrin showed activities resembling those of \u03b1-chlorohydrin. The primary lesion in the proximal caput epididymidis was seen specifically to involve the `conus' and adjacent regions with sloughing of the epithelium. This may impair the secretory\/absorptive function of this region with ensuing severe damage to the thin-walled ductuli efferentes. Except where granulomata were formed, restoration of the epithelium occurred. The apical region of the proximal caput remained undamaged throughout.<\/jats:p>","DOI":"10.1530\/jrf.0.0380379","type":"journal-article","created":{"date-parts":[[2007,5,15]],"date-time":"2007-05-15T17:27:02Z","timestamp":1179250022000},"page":"379-386","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":77,"title":["EFFECTS OF \u03b1-CHLOROHYDRIN AND RELATED COMPOUNDS ON THE REPRODUCTIVE ORGANS AND FERTILITY OF THE MALE RAT"],"prefix":"10.1093","volume":"38","author":[{"given":"E. R. A.","family":"COOPER","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"A. R.","family":"JONES","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H.","family":"JACKSON","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[1974,6,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/38\/2\/379\/64928925\/jrf_38_2_013.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/38\/2\/379\/64928925\/jrf_38_2_013.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T21:09:28Z","timestamp":1767820168000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/38\/2\/379\/8288427"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1974,6,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1974,6,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0380379","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1974,6,1]]},"published":{"date-parts":[[1974,6,1]]}}}