{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T04:18:52Z","timestamp":1767845932649,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1977,7,1]],"date-time":"1977-07-01T00:00:00Z","timestamp":236563200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1977,7,1]]},"abstract":"<jats:p>Summary. The effects of altering the dietary level of vitamin A on cyclic ovarian activity, and serum and hepatic vitamin A concentrations were studied in female rats. High but non-toxic oral doses of retinyl palmitate (5000 i.u., 3 times\/week) significantly advanced the age at vaginal opening but had no effect on vaginal and ovarian cycles after 15 weeks of treatment. Hepatic stores of vitamin A were significantly elevated but serum levels were unchanged. Retinol-deficient rats given a supplement of retinoic acid had a normal vaginal opening age but displayed cornified vaginal cells for many of the days that smears were taken. Hepatic and serum vitamin A concentrations were markedly reduced. When treatment with high doses of retinyl palmitate was continued for 9 months, animals developed polycystic anovulatory ovaries which were significantly lighter than those of controls. Retinol-deficient rats given retinoic acid and demonstrating depleted hepatic vitamin A reserves had ovaries of normal weight and containing corpora lutea, indicating that retinol is not necessary for ovulatory activity. Short-term treatment (16 days) of rats with toxic doses of retinyl palmitate (50,000 i.u. daily) sufficient to raise serum and hepatic retinol levels significantly did not alter ovarian cyclicity; corpora lutea were present and ovarian weight was normal.<\/jats:p>\n                  <jats:p>These data indicate that long-term treatment with high but non-toxic doses of vitamin A inhibits cyclic ovulatory activity, perhaps via alteration of a steroidogenic mechanism in the ovary or adrenal since other studies indirectly support the existence of such a relationship. Furthermore, retinoic acid is a sufficient form of vitamin A replacement to maintain cyclic ovarian activity.<\/jats:p>","DOI":"10.1530\/jrf.0.0500223","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T03:12:46Z","timestamp":1079752366000},"page":"223-229","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":6,"title":["Inhibition of cyclic ovarian activity in rats treated chronically with vitamin A"],"prefix":"10.1093","volume":"50","author":[{"given":"R. J.","family":"Gellert","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1977,7,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/50\/2\/223\/64931013\/jrf_50_2_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/50\/2\/223\/64931013\/jrf_50_2_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T22:08:50Z","timestamp":1767823730000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/50\/2\/223\/8289368"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1977,7,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1977,7,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0500223","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1977,7,1]]},"published":{"date-parts":[[1977,7,1]]}}}