{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,23]],"date-time":"2026-04-23T06:28:25Z","timestamp":1776925705182,"version":"3.51.2"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1983,11,1]],"date-time":"1983-11-01T00:00:00Z","timestamp":436492800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1983,11,1]]},"abstract":"<jats:title>Summary.<\/jats:title>\n                  <jats:p>Non-pregnant heifers (4\/group) received intrauterine infusions of vehicle, oestradiol-17\u03b2 (150 ng), PGE-2 (250 \u03bcg), or oestradiol + PGE-2 every 6 h from 12:00 h on Day 13 to 06:00 h on the day of subsequent oestrus or 06:00 h on Day 21 (day of oestrus = Day 0). Ten of 12 heifers receiving vehicle, oestradiol or PGE-2 returned to oestrus by Day 21, whereas none of the heifers receiving oestradiol + PGE-2 returned to oestrus by Day 21. Jugular venous progesterone concentrations of vehicle- and PGE-2-treated heifers declined rapidly after Day 15 and were basal (&amp;lt; 1 ng\/ml) by Day 20. For heifers receiving oestradiol infusions, systemic progesterone levels did not decline until after Day 18, but were again basal by Day 20. Heifers treated with oestradiol + PGE-2 maintained elevated systemic progesterone levels until Day 21 after oestrus. In addition, the corpora lutea of the heifers treated with oestradiol + PGE-2 were heavier (P &amp;lt; 0\u00b701) and contained more (P &amp;lt; 0\u00b705) progesterone than did corpora lutea of the heifers in the other 3 groups on Day 21 (3\u00b74 g and 19\u00b752 \u03bcg\/g and 1\u00b72 g and 1\u00b765 \u03bcg\/g, respectively). It is concluded that oestradiol-17\u03b2 and PGE-2, both of which are produced by the bovine conceptus and secreted from the gravid uterus, may act synergistically to maintain luteal function during early pregnancy in the cow.<\/jats:p>","DOI":"10.1530\/jrf.0.0690703","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"703-709","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":46,"title":["Effects of intrauterine infusion of oestradiol-17\u03b2 and prostaglandin E-2 on luteal function in non-pregnant heifers"],"prefix":"10.1093","volume":"69","author":[{"given":"L. P.","family":"Reynolds","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. A.","family":"Robertson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S. P.","family":"Ford","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1983,11,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/69\/2\/703\/64850895\/jrf_69_2_039.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/69\/2\/703\/64850895\/jrf_69_2_039.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T20:15:23Z","timestamp":1767816923000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/69\/2\/703\/8282565"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1983,11,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1983,11,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0690703","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1983,11,1]]},"published":{"date-parts":[[1983,11,1]]}}}