{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T21:15:14Z","timestamp":1767820514877,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1984,9,1]],"date-time":"1984-09-01T00:00:00Z","timestamp":462844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1984,9,1]]},"abstract":"<jats:title>Summary.<\/jats:title>\n                  <jats:p>The outputs of prostaglandin (PG) F-2\u03b1 and PGE-2, but not of 6-oxo-PGF-1\u03b1, from the guinea-pig uterus were significantly lower on Days 7 and 15 of pregnancy than on the corresponding days of the cycle. Uterine PGF-2\u03b1 output increased 28-fold between Days 7 and 15 of the cycle but only 4- to 5-fold between these same days of pregnancy. Uterine PGE-2 and 6-oxo-PGF-1\u03b1 outputs increased 2- to 3-fold between Days 7 and 15 of the cycle and of pregnancy. Endometrial PGF-2\u03b1 synthesizing capacity was 60\u201370% lower on Days 7 and 15 of pregnancy than on the corresponding days of the cycle, although it increased 2-fold and 2\u00b75-fold between these days of pregnancy and of the cycle, respectively. Endometrial PGE-2 and 6-oxo-PGF-1\u03b1 synthesizing capacities showed no significant variation amongst Days 7 and 15 of the cycle and of pregnancy, except that endometrial PGE-2 synthesizing capacity was lower on Day 7 of the cycle.<\/jats:p>\n                  <jats:p>Oestradiol treatment (10 \u03bcg s.c. daily from Days 10 to 14 of pregnancy) did not affect plasma progesterone concentrations, uterine 6-oxo-PGF-1\u03b1 output, and endometrial PGF-2\u03b1, PGE-2 and 6-oxo-PGF-1\u03b1 synthesizing capacities in 9\/12 guinea-pigs when examined on Day 15. Uterine PGF-2\u03b1 and PGE-2 outputs increased 3- and 1\u00b75-fold, respectively, in these guinea-pigs, but were still much lower than the outputs from the Day-15 non-pregnant uterus. The pregnancies appeared unaffected in these oestradiol-treated guinea-pigs. In the other 3 oestradiol-treated animals, uterine PGF-2\u03b1 output was 20- to 30-fold higher than in untreated, pregnant guinea-pigs on Day 15, and 2- to 3-fold higher than in Day-15 non-pregnant guinea-pigs. Uterine PGE-2 and 6-oxo-PGF-1\u03b1 outputs also tended to be higher in these treated guinea-pigs. In these 3 guinea-pigs, endometrial PGF-2\u03b1, PGE-2 and 6-oxe-PGF-1\u03b1 synthesizing capacities were 4\u00b70-, 3\u00b74- and 2\u00b75-fold higher, respectively, than in untreated, pregnant guinea-pigs on Day 15, and tended to be higher than in Day-15 non-pregnant guinea-pigs. Plasma progesterone concentrations were much lower in these 3 animals than in the other 9 treated with oestradiol, and also much lower than in untreated, pregnant guinea-pigs on Day 15. However, only 1 of these 3 guinea-pigs was in the process of aborting, and this had the lowest progesterone concentration (0\u00b75 ng\/ml).<\/jats:p>\n                  <jats:p>In the pregnant guinea-pig a large increase in output of PGF-2\u03b1 from the uterus after Day 11 does not occur, uterine PGE-2 does not appear to be involved in luteal maintenance and general uterine PG production is not increased at the time of implantation.<\/jats:p>","DOI":"10.1530\/jrf.0.0720117","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"117-127","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":9,"title":["Prostaglandin production by the early pregnant guineapig uterus in relation to implantation and luteal maintenance, and the effect of oestradiol"],"prefix":"10.1093","volume":"72","author":[{"given":"N. L.","family":"Poyser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1984,9,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/72\/1\/117\/64851860\/jrf_72_1_015.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/72\/1\/117\/64851860\/jrf_72_1_015.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T20:16:58Z","timestamp":1767817018000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/72\/1\/117\/8282699"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1984,9,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1984,9,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0720117","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1984,9,1]]},"published":{"date-parts":[[1984,9,1]]}}}