{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T06:32:21Z","timestamp":1767853941697,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1985,5,1]],"date-time":"1985-05-01T00:00:00Z","timestamp":483753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,5,1]]},"abstract":"<jats:title>Summary.<\/jats:title>\n                  <jats:p>The outputs of prostaglandin (PG) E-2 and 6-oxo-PGF-1\u03b1 from the early pregnant rat uterus superfused in vitro were significantly higher (P &amp;lt; 0\u00b705) on Day 4 (09:00\u201310:00 h) and Day 5 (14:00\u201315:00 h) than on Day 2 (09:00\u201310:00 h) and Day 5 (14:00\u201315:00 h). PGF-2\u03b1 output was significantly higher (P &amp;lt; 0\u00b705) only on Day 5 (09:00\u201310:00 h). PGE-2 was the major PG released at all times, although the amounts of PGF-2\u03b1 and\/or 6-oxo-PGF-1\u03b1 released were often only slightly less. These findings are consistent with uterine PGs having a role in implantation in the rat.<\/jats:p>\n                  <jats:p>A23187 stimulated 6-oxo-PGF-1\u03b1 output and, except on Day 4 (09:00\u201310:00 h), PGF-2\u03b1 output at all times studied. A23187 had little effect on PGE-2 output. The greatest stimulatory effect of A23187 on 6-oxo-PGF-1\u03b1 and PGF-2\u03b1 outputs occurred on Day 5 (09:00\u201310:00 h), which is the day of highest uterine PGH-2 synthetase activity. These increases in response to A23187 were prevented by trifluoperazine (100 \u03bcm), a calmodulin antagonist. Trifluoperazine had no inhibitory effect on the high basal output of PGs on Day 5 (09:00\u201310:00 h), but caused a small increase in uterine PG output.<\/jats:p>","DOI":"10.1530\/jrf.0.0740271","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"271-277","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Prostaglandin output from the early pregnant rat uterus superfused\n                    <i>in vitro<\/i>\n                    , and the effect of A23187 and trifluoperazine"],"prefix":"10.1093","volume":"74","author":[{"given":"N. L.","family":"Poyser","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,5,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/74\/1\/271\/64852340\/jrf_74_1_032.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/74\/1\/271\/64852340\/jrf_74_1_032.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T20:19:53Z","timestamp":1767817193000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/74\/1\/271\/8282933"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,5,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0740271","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1985,5,1]]},"published":{"date-parts":[[1985,5,1]]}}}