{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T02:17:41Z","timestamp":1767925061389,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1985,5,1]],"date-time":"1985-05-01T00:00:00Z","timestamp":483753600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1985,5,1]]},"abstract":"<jats:title>Summary.<\/jats:title>\n                  <jats:p>Testicular descent was prevented unilaterally in newborn rats by cutting the gubernaculum testis. At 100 days of age, the number of Leydig and Sertoli cells per testis, the concentration of receptors for LH, FSH, prolactin and GnRH, and endogenous concentrations of progesterone and testosterone were determined. The weight of the abdominal testes was reduced by 80%, but in spite of this they contained as many Sertoli (32\u00b78 \u00b1 1\u00b73 \u00d7 106, mean \u00b1 s.e.m., n = 6) and Leydig (28\u00b72 \u00b1 1\u00b77 \u00d7 106) cells as did scrotal testes (32\u00b71 \u00b1 2\u00b75 \u00d7 106 and 24\u00b73 \u00b1 1\u00b72 \u00d7 106 respectively). The numbers of receptors for LH (3\u00b72 \u00b1 0\u00b72 and 1\u00b70 \u00b1 0\u00b72 pmol\/testis, mean \u00b1 s.e.m., n = 11), FSH (358 \u00b1 11\u00b70 and 96\u00b73 \u00b1 12\u00b76 fmol\/testis) and prolactin (535 \u00b1 32\u00b77 and 92\u00b74 \u00b1 13\u00b72 fmol\/testis) were reduced (P &amp;lt; 0\u00b7001) in abdominal testes, but the number of GnRH receptors was unaffected (8\u00b79 \u00b1 1\u00b74 and 12\u00b71 \u00b1 1\u00b78 fmol\/testis, n = 6). Testicular testosterone concentration (30\u00b79 \u00b1 4\u00b74 vs 15\u00b74 \u00b1 3\u00b72 ng\/g, n = 11, P &amp;lt; 0\u00b7001), but not that of progesterone (0\u00b787 \u00b1 0\u00b710 vs 1\u00b701 \u00b1 0\u00b721 ng\/g), was decreased in abdominal testes. The decreased receptor and androgen values reflect functional disturbances in the abdominal testes. The changed local milieu within abdominal testes may reduce hormone receptor concentrations which are then involved in the observed Leydig cell dysfunction.<\/jats:p>","DOI":"10.1530\/jrf.0.0740279","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"279-286","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":18,"title":["Altered concentrations of gonadotrophin, prolactin and GnRH receptors, and endogenous steroids in the abdominal testes of adult unilaterally cryptorchid rats"],"prefix":"10.1093","volume":"74","author":[{"given":"A.","family":"Bergh","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"H.","family":"Nikula","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"J.-E.","family":"Damber","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R.","family":"Clayton","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"I.","family":"Huhtaniemi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1985,5,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/74\/1\/279\/64852084\/jrf_74_1_033.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/74\/1\/279\/64852084\/jrf_74_1_033.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T20:19:43Z","timestamp":1767817183000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/74\/1\/279\/8282927"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1985,5,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1985,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0740279","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1985,5,1]]},"published":{"date-parts":[[1985,5,1]]}}}