{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T09:53:29Z","timestamp":1770976409186,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1988,9,1]],"date-time":"1988-09-01T00:00:00Z","timestamp":589075200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1988,9,1]]},"abstract":"<jats:p>Summary. The activities of DNA polymerase \u03b1 (EC 2.7.7.7) and topoisomerase I did not fluctuate up to 7 days after surgery to induce cryptorchidism and showed no significant difference from those in control testes (sham-operated). In contrast, the activity of DNA polymerase \u03b2 decreased by 43% at 5 days (P &amp;lt; 0\u00b701) and by 47% at 7 days (P &amp;lt; 0\u00b7001). The activity of DNA polymerase \u03b3 also decreased by 46% at 3 days (P &amp;lt; 0\u00b702) and by 78% at 7 days (P &amp;lt; 0\u00b701) after surgery. The amount of mRNA for DNA polymerase \u03b2 decreased in parallel with enzyme activity. Since the sensitivity to heat inactivation of testicular DNA polymerase \u03b2 was exactly the same as that from liver, the decrease in DNA polymerase \u03b2 activity may be, at least in part, due to reduced biosynthesis of enzyme protein. The morphological changes in cryptorchid testes suggested that the decrease in DNA polymerase \u03b2 and \u03b3 activities might be related to the deleterious effects of elevated temperature on spermatogenesis.<\/jats:p>\n                  <jats:p>Keywords: DNA polymerase \u03b1, \u03b2, \u03b3; topoisomerase I; rat; cryptorchid testes<\/jats:p>","DOI":"10.1530\/jrf.0.0840123","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"123-130","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":20,"title":["Changes of enzymes involved in DNA synthesis in the testes of cryptorchid rats"],"prefix":"10.1093","volume":"84","author":[{"given":"M.","family":"Fujisawa","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"O.","family":"Matsumoto","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Kamidono","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F.","family":"Hirose","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Kojima","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"S.","family":"Yoshida","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1988,9,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/84\/1\/123\/64812493\/jrf_84_1_017.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/84\/1\/123\/64812493\/jrf_84_1_017.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:21:17Z","timestamp":1767813677000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/84\/1\/123\/8279132"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1988,9,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1988,9,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0840123","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1988,9,1]]},"published":{"date-parts":[[1988,9,1]]}}}