{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T21:05:53Z","timestamp":1767819953621,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1990,7,1]],"date-time":"1990-07-01T00:00:00Z","timestamp":646790400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1990,7,1]]},"abstract":"<jats:p>Summary. Sodium fluoride (10 mm) caused a slow increase in the outputs of PGF-2\u03b1, 6-keto-PGF-1\u03b1 and, to a lesser extent, PGE-2 from the Day-7 and Day-15 guinea-pig uterus superfused in vitro. This stimulatory action of sodium fluoride was not prevented by using calcium-free Krebs' solution. There was also a faster stimulation of 6-keto-PGF-1\u03b1 output from the Day-7 guinea-pig uterus produced by sodium fluoride, and this quicker response was abolished by using calcium-free Krebs' solution. TMB-8 (an intracellular calcium antagonist) inhibited the stimulatory action of sodium fluoride on the outputs of PGF-2\u03b1, PGE-2 and 6-keto-PGF-1\u03b1 from the Day-7 guineapig uterus. W-7 and trifluoperazine (calmodulin antagonists) and neomycin (an inhibitor of phospholipase C) had no inhibitory effect on the increases in outputs of PGF-2\u03b1, PGE-2 and 6-keto-PGF-1\u03b1 from the Day-7 guinea-pig uterus produced by sodium fluoride. These results indicate that sodium fluoride slowly stimulates uterine PGF-2\u03b1, PGE-2 and 6-keto-PGF-1\u03b1 synthesis in the guinea-pig uterus by mobilizing intracellular calcium by a mechanism which apparently does not involve the activation of phospholipase C or the participation of calmodulin (or a related compound). The initial, faster stimulation of 6-keto-PGF-1\u03b1 synthesis in the Day-7 guinea-pig uterus by sodium fluoride is dependent upon extracellular calcium.<\/jats:p>\n                  <jats:p>Keywords: sodium fluoride; TMB-8; W-7; trifluoperazine; neomycin; uterus; guinea-pig; prostaglandins<\/jats:p>","DOI":"10.1530\/jrf.0.0890753","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"753-759","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":4,"title":["Investigations into the mechanism by which sodium fluoride stimulates prostaglandin production in guinea-pig uterus"],"prefix":"10.1093","volume":"89","author":[{"given":"Caroline M.","family":"Leckie","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N. L.","family":"Poyser","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1990,7,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/89\/2\/753\/64816803\/jrf_89_2_045.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/89\/2\/753\/64816803\/jrf_89_2_045.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T20:04:58Z","timestamp":1767816298000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/89\/2\/753\/8279467"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1990,7,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1990,7,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0890753","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1990,7,1]]},"published":{"date-parts":[[1990,7,1]]}}}