{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T20:19:49Z","timestamp":1767817189135,"version":"3.49.0"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[1991,5,1]],"date-time":"1991-05-01T00:00:00Z","timestamp":673056000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,5,1]]},"abstract":"<jats:p>Summary. Pregnant pony mares in Group A (n = 4) received i.m. injections at 07:00 and 17:00 h of 0\u00b78 mg bromocriptine\/kg body weight0\u00b775 per day beginning on Day 295 of gestation and continuing until parturition. Group B (n = 4) was treated similarly, but perphenazine was administered orally at 0\u00b7375 mg\/kg body weight twice a day beginning on Day 305 of gestation and continuing until parturition. Mares in Group C (n = 3) received i.m. injections of saline. Mean plasma prolactin and progesterone concentrations were greater (P &amp;lt; 0\u00b705) for mares in Group C than in Groups A and B from 295 to 309 days of gestation. From 305 days of gestation, plasma prolactin and progesterone concentrations were greater (P &amp;lt; 0\u00b705) in Group B and C than in Group A mares. Progesterone and prolactin concentrations increased over this period for Group B and Group C mares, but remained constant in Group A mares. From 10 days pre partum through foaling, mares in Group A had lower progesterone (P &amp;lt; 0\u00b705) and prolactin (P &amp;lt; 0\u00b701) concentrations than Group B and C mares. All mares in Group A were agalactic at foaling, while all mares in Groups B and C had normal milk secretion. Gestation was longer (P &amp;lt; 0\u00b705) in Group A than in Group C mares. In Group A, 2 mares retained the placenta for &amp;gt; 3 h, 3 mares had dystocia and all 4 mares had thickened, haemorrhagic placentae. There was no incidence of dystocia, thickened or retained placentae in Groups B or C. Bromocriptine appears to produce clinical signs in mares in late pregnancy similar to those in mares affected by tall fescue (Festuca arundinacea) pasture infected with the fungus Acremonium coenophialum. Perphenazine, administered orally, may be useful in treatment of mares affected by ergot alkaloids.<\/jats:p>\n                  <jats:p>Keywords: bromocriptine; perphenazine; prolactin; mare<\/jats:p>","DOI":"10.1530\/jrf.0.0920179","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"179-186","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":40,"title":["Effects of bromocriptine and perphenazine on prolactin and progesterone concentrations in pregnant pony mares during late gestation"],"prefix":"10.1093","volume":"92","author":[{"given":"F. A.","family":"Ireland","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W. E.","family":"Loch","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Worthy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"R. V.","family":"Anthony","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,5,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/92\/1\/179\/64814088\/jrf_92_1_022.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/92\/1\/179\/64814088\/jrf_92_1_022.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T19:14:16Z","timestamp":1767813256000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/92\/1\/179\/8278653"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,5,1]]},"references-count":0,"journal-issue":{"issue":"1","published-print":{"date-parts":[[1991,5,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0920179","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,5,1]]},"published":{"date-parts":[[1991,5,1]]}}}