{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,3]],"date-time":"2026-03-03T23:35:53Z","timestamp":1772580953877,"version":"3.50.1"},"reference-count":0,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[1991,11,1]],"date-time":"1991-11-01T00:00:00Z","timestamp":688953600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[1991,11,1]]},"abstract":"<jats:p>Summary. The effect of the mutation for white belly spot controlled by the dominant gene W on spermatogenesis in mice was examined by experimental cryptorchidism and its surgical reversal. The course of spermatogenesis from spermatogonia to spermatid was normal in intact testes of W\/+ mice. In cryptorchid testes, there was no difference in the number and activity of Type A spermatogonia between the testes of W\/+ and +\/+ mice, in mitotic and labelling indices. Although surgical reversal of the cryptorchid testis resulted in regenerative differentiation of germ cells in both genotypes, the recovery of cell differentiation in the W\/+ testis was slower than in the +\/+ testis. There were fewer germ cells, such as intermediate\u2013Type B spermatogonia or more advanced ones, in W\/+ testes. On Day 17 after surgical reversal, cell associations in W\/+ testes were abnormal and the numbers of intermediate\u2013Type B spermatogonia, spermatocytes and spermatids were approximately \u223c70, 50 and 15%, respectively, of those in +\/+ testes. These results indicate that the W gene affects spermatogenic cell differentiation in adult mice.<\/jats:p>\n                  <jats:p>Keywords: \u00a0W mutation; spermatogenesis; cryptorchidism; orchidopexy; mouse<\/jats:p>","DOI":"10.1530\/jrf.0.0930287","type":"journal-article","created":{"date-parts":[[2004,3,20]],"date-time":"2004-03-20T01:55:52Z","timestamp":1079747752000},"page":"287-294","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":17,"title":["Effect of the\n                    <i>W<\/i>\n                    mutation, for white belly spot, on testicular germ cell differentiation in mice"],"prefix":"10.1093","volume":"93","author":[{"given":"K.","family":"Sawada","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"K.","family":"Sakamaki","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Y.","family":"Nishimune","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"286","published-online":{"date-parts":[[1991,11,1]]},"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/93\/2\/287\/64565469\/jrf_93_2_005.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/93\/2\/287\/64565469\/jrf_93_2_005.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T17:03:51Z","timestamp":1767805431000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/93\/2\/287\/8211550"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[1991,11,1]]},"references-count":0,"journal-issue":{"issue":"2","published-print":{"date-parts":[[1991,11,1]]}},"URL":"https:\/\/doi.org\/10.1530\/jrf.0.0930287","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[1991,11,1]]},"published":{"date-parts":[[1991,11,1]]}}}