{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:19:05Z","timestamp":1783448345607,"version":"3.55.0"},"reference-count":243,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":499,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Heart, Lung and Blood Institute of National Institutes of Health","award":["R01HL152162"],"award-info":[{"award-number":["R01HL152162"]}]}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,2,1]]},"abstract":"<jats:p>Background: The global rise in the prevalence and incidence of cardiometabolic disorders\u00a0\u2013\u00a0such as obesity, hypertension, and insulin resistance\u00a0\u2013\u00a0has reached alarming levels and poses a significant public health concern. Dietary patterns characterized by excessive consumption of sodium, refined carbohydrates, and unhealthy fats are primary contributors to this trend. Emerging evidence suggests that dietary interventions can improve metabolic health, in part by modulating gut microbiota.<\/jats:p>\n                  <jats:p>Objective:This review aims to synthesize current understanding of diet\u2013microbiota\u2013host interactions and identify key areas for developing sustainable, physiology-based interventions for cardiometabolic disease management.<\/jats:p>\n                  <jats:p>Methods:For this narrative review, a comprehensive literature search was conducted across major biomedical sciences databases, including PubMed and Web of Science, supplemented by Google Scholar. Literature published up to June of 2025 was included, with emphasis on most recent findings and supported by seminal works. Studies were evaluated for relevance and methodological rigor.<\/jats:p>\n                  <jats:p>Results:Current evidence supports a triadic relationship among diet, gut dysbiosis, and cardiometabolic dysfunction, underscoring the complex interplay between nutrition and host physiology. The Western diet, high in sodium and carbohydrates, can disrupt gut microbial communities, thereby altering intestinal nutrient absorption leading to an increased incidence of cardiometabolic diseases. Targeted manipulation of the gut microbiota,\u00a0through probiotics or other modulators, may\u00a0offer novel avenues to regulate metabolism and maintain nutrient homeostasis.<\/jats:p>\n                  <jats:p>Conclusion:The integration of nutritional, microbial, and physiological perspectives offers a promising framework for cardiometabolic disease prevention and treatment. To move beyond associative findings, future research should prioritize mechanistic studies to clarify the pathways by which gut microbiota influence host nutrient and micronutrient handling. This will be critical to unlocking the therapeutic potential of both dietary modulation and microbiota-targeted strategies in maintaining homeostasis.<\/jats:p>","DOI":"10.1530\/mah-25-0008","type":"journal-article","created":{"date-parts":[[2025,10,22]],"date-time":"2025-10-22T11:06:42Z","timestamp":1761131202000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-19","source":"Crossref","is-referenced-by-count":1,"title":["Diet\u2013microbiota\u2013host interactions in regulation of cardiometabolic homeostasis: emerging mechanisms and therapeutic potential"],"prefix":"10.1530","volume":"3","author":[{"given":"Adriana","family":"Alviter Plata","sequence":"first","affiliation":[{"name":"1"},{"name":"2"},{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily 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