{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:11Z","timestamp":1784557211105,"version":"3.55.0"},"reference-count":15,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2021,6,1]],"date-time":"2021-06-01T00:00:00Z","timestamp":1622505600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["raf.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2021,6]]},"abstract":"<jats:sec>\n                    <jats:title>Objective<\/jats:title>\n                    <jats:p>\n                      Oocyte pick-up (OPU) is a painful but essential part of\n                      <jats:italic>in-vitro<\/jats:italic>\n                      fertilization (IVF) that is usually performed under sedation and analgesia (SaA). Our aim was to study that why some women decide to undergo OPU without SaA?\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>This was a prospective study using patient questionnaires and the standardized 7-item generalized anxiety disorder (GAD-7) score. The patients were asked to assess the pain experienced during OPU using a visual analog scale (VAS). The study sample was a convenience sample of 100 healthy women undergoing OPU at our unit with or without SaA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Women who chose to undergo OPU without SaA were significantly more likely to express the fear of anesthesia. A high pain score (VAS \u2265 6) was reported by significantly more patients who underwent OPU without SaA than with SaA. Yet, 98% of the patients who underwent OPU without SaA stated that in future IVF cycles, they would still choose to undergo OPU without SaA. More patients had high anxiety scores among those who underwent OPU with than without SaA.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Women who chose to undergo OPU without SaA reported more often fear of anesthesia. Although these women experienced significantly more pain during OPU, almost all of them suggested that they would still choose to undergo OPU without SaA. Increased anxiety, as expressed by higher GAD-7 scores, was not associated with a tendency to choose SaA during OPU. The option of OPU without SaA seems to be an acceptable option for selected women.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>\n                      Egg retrieval from the ovaries is a painful part of\n                      <jats:italic>in vitro<\/jats:italic>\n                      fertilization (IVF). It is, therefore, usually performed under sedation and pain relief (analgesia). The aim of this study was to investigate: Why some women decide to undergo egg retrieval without sedation? We prospectively studied 100 women using patient questionnaires and standardized scores in order to measure patient's pain and anxiety levels. We found that women who chose to undergo egg retrieval without sedation were significantly more likely to express fear of anesthesia. As expected, women who decided to forgo sedation experienced more pain during egg retrieval, yet, 98% of them decided that in future IVF cycles, they would still choose to undergo egg retrieval without sedation. Surprisingly, women who had high anxiety scores were not more likely to ask for sedation during egg retrieval. The option to undergo egg retrieval without sedation during IVF seems to be acceptable for some women.\n                    <\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-20-0064","type":"journal-article","created":{"date-parts":[[2021,3,2]],"date-time":"2021-03-02T13:06:51Z","timestamp":1614690411000},"page":"89-94","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":10,"title":["Why do women choose to undergo oocyte aspiration without sedation or analgesia?"],"prefix":"10.1530","volume":"2","author":[{"given":"Daniella","family":"Gilboa","sequence":"first","affiliation":[{"name":"IVF Unit, Assuta Medical Center, Tel Aviv, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liron","family":"Seidman","sequence":"additional","affiliation":[{"name":"The Goldman Medical School at the Faculty of Health Sciences, Ben-Gurion University of the Negev, Beer-Sheva, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Polina","family":"Kimiagarov","sequence":"additional","affiliation":[{"name":"Department of Nursing, The Academic College of Tel-Aviv \u2013 Yaffo, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Avia","family":"Noni","sequence":"additional","affiliation":[{"name":"Department of Nursing, The Academic College of Tel-Aviv \u2013 Yaffo, Tel-Aviv, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ravid","family":"Doron","sequence":"additional","affiliation":[{"name":"Department of Nursing, The Academic College of Tel-Aviv \u2013 Yaffo, Tel-Aviv, Israel"},{"name":"Department of Education and Psychology, The Open University, Raanana, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S","family":"Seidman","sequence":"additional","affiliation":[{"name":"IVF Unit, Assuta Medical Center, Tel Aviv, Tel-Aviv, Israel"},{"name":"Department of Obstetrics and Gynecology, Chaim Sheba Medical Center, affiliated to the Sackler Faculty of Medicine, Tel Aviv University, Tel Hashomer, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Internet Journal of Anesthesiology","first-page":"1","article-title":"Assisted reproductive technology and anesthetic considerations: review of literature","volume":"18","author":"Garg","year":"2007","unstructured":"Garg RDali J2007 Assisted reproductive technology and anesthetic considerations: review of literature. Internet Journal of Anesthesiology 18 1\u20138."},{"key":"bib2","series-title":"Fertility and Sterility","first-page":"354","article-title":"High level of satisfaction among women who underwent oocyte retrieval without anesthesia","volume":"114","author":"Greenberger","year":"2020","unstructured":"Greenberger CMatot IArtsi HSamara NAzem F2020 High level of satisfaction among women who underwent oocyte retrieval without anesthesia. Fertility and Sterility 114 354\u2013360. (https:\/\/doi.org\/10.1016\/j.fertnstert.2020.03.033)"},{"key":"bib3","series-title":"Fertility and Sterility","first-page":"683","article-title":"Effect of needle diameter on pain during oocyte retrieval-a randomized controlled trial","volume":"115","author":"Iduna Antigoni Buisman","year":"2020","unstructured":"Iduna Antigoni Buisman ETde Bruin JPMaria Braat DDvan der Steeg JW2020 Effect of needle diameter on pain during oocyte retrieval-a randomized controlled trial. Fertility and Sterility 115 683\u2013691. (https:\/\/doi.org\/10.1016\/j.fertnstert.2020.06.040)"},{"key":"bib4","series-title":"Cochrane Database of Systematic Reviews","article-title":"Pain relief for women undergoing oocyte retrieval for assisted reproduction","volume":"5","author":"Kwan","year":"2018","unstructured":"Kwan IWang RPearce EBhattacharya S2018 Pain relief for women undergoing oocyte retrieval for assisted reproduction. Cochrane Database of Systematic Reviews 5 CD004829. (https:\/\/doi.org\/10.1002\/14651858.CD004829.pub4)"},{"key":"bib5","series-title":"BioMed Research International","article-title":"Anesthesia related toxic effects on in vitro fertilization outcome: burden of proof","volume":"2015","author":"Matsota","year":"2015","unstructured":"Matsota PKaminioti EKostopanagiotou G2015 Anesthesia related toxic effects on in vitro fertilization outcome: burden of proof. BioMed Research International 2015 article ID 475362. (https:\/\/doi.org\/10.1155\/2015\/475362)"},{"key":"bib6","series-title":"Journal of Reproduction and Infertility","first-page":"207","article-title":"The effect of a newly designed needle on the pain and bleeding of patients during oocyte retrieval of a single follicle","volume":"16","author":"Nakagawa","year":"2015","unstructured":"Nakagawa KNishi YKaneyama MSugiyama RMotoyama HSugiyama R2015 The effect of a newly designed needle on the pain and bleeding of patients during oocyte retrieval of a single follicle. Journal of Reproduction and Infertility 16 207\u2013211."},{"key":"bib7","series-title":"Fertility and Sterility","first-page":"711","article-title":"Paracervical block with and without conscious sedation: a comparison of the pain levels during egg collection and the postoperative side effects","volume":"75","author":"Ng","year":"2001","unstructured":"Ng EHChui DKTang OSHo PC2001 Paracervical block with and without conscious sedation: a comparison of the pain levels during egg collection and the postoperative side effects. Fertility and Sterility 75 711\u2013717. (https:\/\/doi.org\/10.1016\/s0015-0282(0101693-4)"},{"key":"bib8","series-title":"Journal of Assisted Reproduction and Genetics","first-page":"1523","article-title":"IVF oocyte retrieval: prospective evaluation of the type of anesthesia on live birth rate, pain, and patient satisfaction","volume":"34","author":"Rolland","year":"2017","unstructured":"Rolland LPerrin JVilles VPellegrin VBoubli LCourbiere B2017 IVF oocyte retrieval: prospective evaluation of the type of anesthesia on live birth rate, pain, and patient satisfaction. Journal of Assisted Reproduction and Genetics 34 1523\u20131528. (https:\/\/doi.org\/10.1007\/s10815-017-1002-7)"},{"key":"bib9","series-title":"Archives of Gynecology and Obstetrics","first-page":"1137","article-title":"Women show a higher level of anxiety during IVF treatment than men and hold different concerns: a cohort study","volume":"293","author":"Schaller","year":"2016","unstructured":"Schaller MAGriesinger GBanz-Jansen C2016 Women show a higher level of anxiety during IVF treatment than men and hold different concerns: a cohort study. Archives of Gynecology and Obstetrics 293 1137\u20131145. (https:\/\/doi.org\/10.1007\/s00404-016-4033-x)"},{"key":"bib10","series-title":"Journal of Obstetric Anaesthesia and Critical Care","first-page":"62","article-title":"Anesthesia for in vitro fertilization","volume":"5","author":"Sharma","year":"2015","unstructured":"Sharma ABorle ATrikha A2015 Anesthesia for in vitro fertilization. Journal of Obstetric Anaesthesia and Critical Care 5 62\u201372. (https:\/\/doi.org\/10.4103\/2249-4472.165132)"},{"key":"bib11","series-title":"Archives of Internal Medicine","first-page":"1092","article-title":"A brief measure for assessing generalized anxiety disorder: the GAD-7","volume":"166","author":"Spitzer","year":"2006","unstructured":"Spitzer RLKroenke KWilliams JBL\u00f6we B2006 A brief measure for assessing generalized anxiety disorder: the GAD-7. Archives of Internal Medicine 166 1092\u20131097. (https:\/\/doi.org\/10.1001\/archinte.166.10.1092)"},{"key":"bib12","series-title":"Journal of Pain","first-page":"459","article-title":"Influence of estrogen levels on thermal perception, pain thresholds, and pain tolerance: studies on women undergoing in vitro fertilization","volume":"13","author":"Stening","year":"2012","unstructured":"Stening KDBerg GHammar MVoster HEriksson OAmandusson ABlomqvist A2012 Influence of estrogen levels on thermal perception, pain thresholds, and pain tolerance: studies on women undergoing in vitro fertilization. Journal of Pain 13 459\u2013466. (https:\/\/doi.org\/10.1016\/j.jpain.2012.01.446)"},{"key":"bib13","series-title":"Journal of Clinical and Analytical Medicine","first-page":"840","article-title":"Effect of anesthetics During oocyte pick-up procedure on oocyte quality and pregnancy","volume":"7","author":"Urfalio\u011flu","year":"2016","unstructured":"Urfalio\u011flu AYaylali A2016 Effect of anesthetics During oocyte pick-up procedure on oocyte quality and pregnancy. Journal of Clinical and Analytical Medicine 7 840\u2013843. (https:\/\/doi.org\/10.4328\/JCAM.4617)"},{"key":"bib14","series-title":"Human Reproduction","first-page":"1377","article-title":"A randomized controlled study comparing pain experience between a newly designed needle with a thin tip and a standard needle for oocyte aspiration","volume":"26","author":"Wikland","year":"2011","unstructured":"Wikland MBlad SBungum LHillensj\u00f6 TKarlstr\u00f6m PONilsson S2011 A randomized controlled study comparing pain experience between a newly designed needle with a thin tip and a standard needle for oocyte aspiration. Human Reproduction 26 1377\u20131383. (https:\/\/doi.org\/10.1093\/humrep\/der100)"},{"key":"bib15","series-title":"Fertility and Sterility","first-page":"393","article-title":"The international glossary on infertility and fertility care, 2017","volume":"108","author":"Zegers-Hochschild","year":"2017","unstructured":"Zegers-Hochschild FAdamson GDDyer SRacowsky Cde Mouzon JSokol RRienzi LSunde ASchmidt LCooke ID 2017 The international glossary on infertility and fertility care, 2017. Fertility and Sterility 108 393\u2013406. 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