{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:34:24Z","timestamp":1787168064083,"version":"build-2736575974"},"reference-count":106,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["raf.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>Graphical abstract<\/jats:title>\n                    <jats:p>\n                      <jats:inline-graphic xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" xlink:href=\"images\/RAF-22-0015inf1.jpeg\"\/>\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The phenomenal extracellular matrix (ECM) remodelling of the cervix that precedes the myometrial contraction of labour at term or preterm appears to share some common mechanisms with the occurrence, growth, invasion and metastasis of cervical carcinoma. Matrix metalloproteinases (MMPs) are zinc-dependent endopeptidases that are pivotal to the complex extracellular tissue modulation that includes degradation, remodelling and exchange of ECM components, which contribute to homeostasis under normal physiological conditions such as cervical remodelling during pregnancy and puerperium. However, in cancer such as that of the uterine cervix, this extensive network of extracellular tissue modulation is altered leading to disrupted cell\u2013cell and cell\u2013basement membrane adhesion, abnormal tissue growth, neovascularization and metastasis that disrupt homeostasis. Cervical ECM remodelling during pregnancy and puerperium could be a physiological albeit benign neoplasm. In this review, we examined the pathophysiologic differences and similarities in the role of MMPs in cervical remodelling and cervical carcinoma.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>During pregnancy and childbirth, the cervix, which is the barrel-shaped lower portion of the womb that connects to the vagina, gradually softens, shortens and opens to allow birth of the baby. This process requires structural and biochemical changes in the cervix that are stimulated by enzymes known as matrix metalloproteinases. Interestingly, these enzymes also affect the structural and biochemical framework of the cervix during cervical cancer, although cervical cancers usually occur after infection by human papillomavirus. This review is intended to identify and explain the similarities and differences between the structural and chemical changes in the cervix during pregnancy and childbirth and the changes seen in cervical cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-22-0015","type":"journal-article","created":{"date-parts":[[2022,7,22]],"date-time":"2022-07-22T11:06:13Z","timestamp":1658487973000},"page":"R177-R191","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":26,"title":["Matrix metalloproteinase-induced cervical extracellular matrix remodelling in pregnancy and cervical cancer"],"prefix":"10.1530","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3924-5270","authenticated-orcid":true,"given":"Emmanuel","family":"Amabebe","sequence":"first","affiliation":[{"name":"Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Henry","family":"Ogidi","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynaecology, Glan Clwyd Hospital North Wales, Gwynedd, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dilly O","family":"Anumba","sequence":"additional","affiliation":[{"name":"Department of Oncology and Metabolism, University of Sheffield, Sheffield, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Biology of Reproduction","doi-asserted-by":"publisher","first-page":"1053","DOI":"10.1095\/biolreprod.110.089599","article-title":"Cervical softening during pregnancy: regulated changes in collagen cross-linking and composition of matricellular proteins in the mouse","volume":"84","author":"Akins","year":"2011","unstructured":"Akins MLLuby-Phelps KBank RAMahendroo M2011Cervical softening during pregnancy: regulated changes in collagen cross-linking and composition of matricellular proteins in the mouse. Biology of Reproduction841053\u20131062. (https:\/\/doi.org\/10.1095\/biolreprod.110.089599)10.1095\/biolreprod.110.089599"},{"key":"bib2","series-title":"Frontiers in Medicine","doi-asserted-by":"publisher","first-page":"181","DOI":"10.3389\/fmed.2018.00181","article-title":"The vaginal microenvironment: the physiologic role of lactobacilli","volume":"5","author":"Amabebe","year":"2018","unstructured":"Amabebe EAnumba DOC2018The vaginal microenvironment: the physiologic role of lactobacilli. Frontiers in Medicine5181. (https:\/\/doi.org\/10.3389\/fmed.2018.00181)10.3389\/fmed.2018.00181"},{"key":"bib3","series-title":"Frontiers in Immunology","doi-asserted-by":"publisher","first-page":"2184","DOI":"10.3389\/fimmu.2020.02184","article-title":"Female gut and genital tract microbiota-induced crosstalk and differential effects of short-chain fatty acids on immune sequelae","volume":"11","author":"Amabebe","year":"2020","unstructured":"Amabebe EAnumba DOC2020Female gut and genital tract microbiota-induced crosstalk and differential effects of short-chain fatty acids on immune sequelae. Frontiers in Immunology112184. (https:\/\/doi.org\/10.3389\/fimmu.2020.02184)10.3389\/fimmu.2020.02184"},{"key":"bib4","series-title":"Current Microbiology","article-title":"Mechanistic insights into immune suppression and evasion in bacterial vaginosis","volume":"79","author":"Amabebe","year":"2022","unstructured":"Amabebe EAnumba DOC2022Mechanistic insights into immune suppression and evasion in bacterial vaginosis. Current Microbiology79 84. (https:\/\/doi.org\/10.1007\/s00284-022-02771-2)"},{"key":"bib5","series-title":"Romanian Journal of Morphology and Embryology","first-page":"323","article-title":"Biology of metalloproteinases","volume":"48","author":"Am\u0103linei","year":"2007","unstructured":"Am\u0103linei CC\u0103runtu IDB\u0103lan RA2007Biology of metalloproteinases. Romanian Journal of Morphology and Embryology48323\u2013334."},{"key":"bib6","series-title":"Reproductive Biology and Endocrinology","article-title":"Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss","volume":"8","author":"Anumba","year":"2010","unstructured":"Anumba DOEl Gelany SElliott SLLi TC2010Circulating levels of matrix proteases and their inhibitors in pregnant women with and without a history of recurrent pregnancy loss. Reproductive Biology and Endocrinology8 62. (https:\/\/doi.org\/10.1186\/1477-7827-8-62)"},{"key":"bib7","series-title":"Matrix Biology","first-page":"247","article-title":"The role of TIMPs in regulation of extracellular matrix proteolysis","volume":"44\u201346","author":"Arpino","year":"2015","unstructured":"Arpino VBrock MGill SE2015The role of TIMPs in regulation of extracellular matrix proteolysis. Matrix Biology44\u201346247\u2013254. (https:\/\/doi.org\/10.1016\/j.matbio.2015.03.005)"},{"key":"bib8","series-title":"Journal of Maternal-Fetal Medicine","first-page":"213","article-title":"Matrix metalloproteinases-9 in preterm and term human parturition","volume":"8","author":"Athayde","year":"1999","unstructured":"Athayde NRomero RGomez RMaymon EPacora PMazor MYoon BHFortunato SMenon RGhezzi F1999Matrix metalloproteinases-9 in preterm and term human parturition. Journal of Maternal-Fetal Medicine8213\u2013219. (https:\/\/doi.org\/10.1002\/(SICI)1520-6661(199909\/10)8:5<213::AID-MFM3>3.0.CO;2-R)"},{"key":"bib9","series-title":"BMC Cancer","article-title":"Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis","volume":"20","author":"Azevedo Martins","year":"2020","unstructured":"Azevedo Martins JMRabelo-Santos SHdo Amaral Westin MCZeferino LC2020Tumoral and stromal expression of MMP-2, MMP-9, MMP-14, TIMP-1, TIMP-2, and VEGF-A in cervical cancer patient survival: a competing risk analysis. BMC Cancer20 660. (https:\/\/doi.org\/10.1186\/s12885-020-07150-3)"},{"key":"bib10","series-title":"Current Opinion in Oncology","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/01.cco.0000143682.45316.ae","article-title":"Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter","volume":"17","author":"Bachman","year":"2005","unstructured":"Bachman KEPark BH2005Duel nature of TGF-beta signaling: tumor suppressor vs. tumor promoter. Current Opinion in Oncology1749\u201354. (https:\/\/doi.org\/10.1097\/01.cco.0000143682.45316.ae)10.1097\/01.cco.0000143682.45316.ae"},{"key":"bib11","series-title":"Reproductive Biology and Endocrinology","article-title":"Matrix metalloproteinases in the cervical mucus plug in relation to gestational age, plug compartment, and preterm labor","volume":"8","author":"Becher","year":"2010","unstructured":"Becher NHein MDanielsen CCUldbjerg N2010Matrix metalloproteinases in the cervical mucus plug in relation to gestational age, plug compartment, and preterm labor. Reproductive Biology and Endocrinology8 113. (https:\/\/doi.org\/10.1186\/1477-7827-8-113)"},{"key":"bib12","series-title":"Cancer Journal","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/PPO.0000000000000138","article-title":"The contribution of angiogenesis to the process of metastasis","volume":"21","author":"Bielenberg","year":"2015","unstructured":"Bielenberg DRZetter BR2015The contribution of angiogenesis to the process of metastasis. Cancer Journal21267\u2013273. (https:\/\/doi.org\/10.1097\/PPO.0000000000000138)10.1097\/PPO.0000000000000138"},{"key":"bib13","series-title":"Biochimica et Biophysica Acta","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1016\/j.bbamcr.2010.01.003","article-title":"The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity","volume":"1803","author":"Brew","year":"2010","unstructured":"Brew KNagase H2010The tissue inhibitors of metalloproteinases (TIMPs): an ancient family with structural and functional diversity. Biochimica et Biophysica Acta180355\u201371. (https:\/\/doi.org\/10.1016\/j.bbamcr.2010.01.003)10.1016\/j.bbamcr.2010.01.003"},{"key":"bib14","series-title":"Breast Cancer Research and Treatment","doi-asserted-by":"publisher","first-page":"39","DOI":"10.1007\/s10549-007-9684-7","article-title":"Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study","volume":"110","author":"Casey","year":"2008","unstructured":"Casey TMEneman JCrocker AWhite JTessitore JStanley MHarlow SBunn JYWeaver DMuss H2008Cancer associated fibroblasts stimulated by transforming growth factor beta1 (TGF-beta 1) increase invasion rate of tumor cells: a population study. Breast Cancer Research and Treatment11039\u201349. (https:\/\/doi.org\/10.1007\/s10549-007-9684-7)10.1007\/s10549-007-9684-7"},{"key":"bib15","series-title":"Pathobiology","doi-asserted-by":"publisher","first-page":"187","DOI":"10.1159\/000511477","article-title":"Microbiome and cervical cancer","volume":"88","author":"Castanheira","year":"2021","unstructured":"Castanheira CPSallas MLNunes RALLorenzi NPCTermin L2021Microbiome and cervical cancer. Pathobiology88187\u2013197. (https:\/\/doi.org\/10.1159\/000511477)10.1159\/000511477"},{"key":"bib16","series-title":"Frontiers in Cell and Developmental Biology","doi-asserted-by":"publisher","first-page":"593269","DOI":"10.3389\/fcell.2020.593269","article-title":"Connective tissue growth factor: from molecular understandings to drug discovery","volume":"8","author":"Chen","year":"2020","unstructured":"Chen ZZhang NChu HYYu YZhang ZKZhang GZhang BT2020Connective tissue growth factor: from molecular understandings to drug discovery. Frontiers in Cell and Developmental Biology8593269. (https:\/\/doi.org\/10.3389\/fcell.2020.593269)10.3389\/fcell.2020.593269"},{"key":"bib17","series-title":"Cancer Control","first-page":"10732748211033743","article-title":"Prognostic role of matrix metalloproteinases in cervical cancer: a meta-analysis","volume":"28","author":"Chen","year":"2021","unstructured":"Chen WHuang SShi KYi LLiu YLiu W2021Prognostic role of matrix metalloproteinases in cervical cancer: a meta-analysis. Cancer Control2810732748211033743. (https:\/\/doi.org\/10.1177\/10732748211033743)"},{"key":"bib18","series-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology","doi-asserted-by":"publisher","first-page":"182","DOI":"10.1016\/j.ejogrb.2006.07.024","article-title":"Changes of nuclear factor kappa B (NF-kappaB), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor","volume":"132","author":"Choi","year":"2007","unstructured":"Choi SJOh SYKim JHRoh CR2007Changes of nuclear factor kappa B (NF-kappaB), cyclooxygenase-2 (COX-2) and matrix metalloproteinase-9 (MMP-9) in human myometrium before and during term labor. European Journal of Obstetrics, Gynecology, and Reproductive Biology132182\u2013188. (https:\/\/doi.org\/10.1016\/j.ejogrb.2006.07.024)10.1016\/j.ejogrb.2006.07.024"},{"key":"bib19","series-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology","doi-asserted-by":"publisher","first-page":"43","DOI":"10.1016\/j.ejogrb.2008.08.009","article-title":"Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition","volume":"142","author":"Choi","year":"2009","unstructured":"Choi SJJung KLOh SYKim JHRoh CR2009Cervicovaginal matrix metalloproteinase-9 and cervical ripening in human term parturition. European Journal of Obstetrics, Gynecology, and Reproductive Biology14243\u201347. (https:\/\/doi.org\/10.1016\/j.ejogrb.2008.08.009)10.1016\/j.ejogrb.2008.08.009"},{"key":"bib20","series-title":"Endocrine Reviews","doi-asserted-by":"publisher","first-page":"428","DOI":"10.1210\/er.2002-0005","article-title":"The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle","volume":"24","author":"Curry","year":"2003","unstructured":"Curry Jr TE& Osteen KG2003The matrix metalloproteinase system: changes, regulation, and impact throughout the ovarian and uterine reproductive cycle. Endocrine Reviews24428\u2013465. (https:\/\/doi.org\/10.1210\/er.2002-0005)10.1210\/er.2002-0005"},{"key":"bib21","series-title":"American Journal of Obstetrics and Gynecology","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1016\/0002-9378(74)90608-5","article-title":"The effect of pregnancy and labor on the human cervix: changes in collagen, glycoproteins, and glycosaminoglycans","volume":"120","author":"Danforth","year":"1974","unstructured":"Danforth DNVeis ABreen MWeinstein HGBuckingham JCManalo P1974The effect of pregnancy and labor on the human cervix: changes in collagen, glycoproteins, and glycosaminoglycans. American Journal of Obstetrics and Gynecology120641\u2013651. (https:\/\/doi.org\/10.1016\/0002-9378(7490608-5)10.1016\/0002-9378(74)90608-5"},{"key":"bib22","series-title":"Developmental Cell","doi-asserted-by":"publisher","first-page":"884","DOI":"10.1016\/j.devcel.2010.05.012","article-title":"Tumors as organs: complex tissues that interface with the entire organism","volume":"18","author":"Egeblad","year":"2010","unstructured":"Egeblad MNakasone ESWerb Z2010Tumors as organs: complex tissues that interface with the entire organism. Developmental Cell18884\u2013901. (https:\/\/doi.org\/10.1016\/j.devcel.2010.05.012)10.1016\/j.devcel.2010.05.012"},{"key":"bib23","series-title":"BMC Cancer","article-title":"Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression","volume":"15","author":"Full\u00e1r","year":"2015","unstructured":"Full\u00e1r ADud\u00e1s JOl\u00e1h LHoll\u00f3si PPapp ZSobel GKar\u00e1szi KPaku SBaghy KKovalszky I2015Remodeling of extracellular matrix by normal and tumor-associated fibroblasts promotes cervical cancer progression. BMC Cancer15 256. (https:\/\/doi.org\/10.1186\/s12885-015-1272-3)"},{"key":"bib24","series-title":"Molecular Reproduction and Development","doi-asserted-by":"publisher","first-page":"276","DOI":"10.1002\/mrd.22626","article-title":"Roles and regulation of the matrix metalloproteinase system in parturition","volume":"83","author":"Geng","year":"2016","unstructured":"Geng JHuang CJiang S2016Roles and regulation of the matrix metalloproteinase system in parturition. Molecular Reproduction and Development83276\u2013286. (https:\/\/doi.org\/10.1002\/mrd.22626)10.1002\/mrd.22626"},{"key":"bib25","series-title":"European Journal of Cell Biology","first-page":"111","article-title":"Tissue inhibitors of metalloproteinases: structure, regulation and biological functions","volume":"74","author":"Gomez","year":"1997","unstructured":"Gomez DEAlonso DFYoshiji HThorgeirsson UP1997Tissue inhibitors of metalloproteinases: structure, regulation and biological functions. European Journal of Cell Biology74111\u2013122."},{"key":"bib26","series-title":"Journal of Leukocyte Biology","doi-asserted-by":"publisher","first-page":"625","DOI":"10.1189\/jlb.1209796","article-title":"Invasion of the leukocytes into the fetal-maternal interface during pregnancy","volume":"88","author":"Gomez-Lopez","year":"2010","unstructured":"Gomez-Lopez NGuilbert LJOlson DM2010Invasion of the leukocytes into the fetal-maternal interface during pregnancy. Journal of Leukocyte Biology88625\u2013633. (https:\/\/doi.org\/10.1189\/jlb.1209796)10.1189\/jlb.1209796"},{"key":"bib27","series-title":"PLoS ONE","article-title":"Cervical remodeling\/ripening at term and preterm delivery: the same mechanism initiated by different mediators and different effector cells","volume":"6","author":"Gonzalez","year":"2011a","unstructured":"Gonzalez JMDong ZRomero RGirardi G2011aCervical remodeling\/ripening at term and preterm delivery: the same mechanism initiated by different mediators and different effector cells. PLoS ONE6 e26877. (https:\/\/doi.org\/10.1371\/journal.pone.0026877)"},{"key":"bib28","series-title":"American Journal of Pathology","doi-asserted-by":"publisher","first-page":"838","DOI":"10.1016\/j.ajpath.2011.04.024","article-title":"Complement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice","volume":"179","author":"Gonzalez","year":"2011b","unstructured":"Gonzalez JMFranzke CWYang FRomero RGirardi G2011bComplement activation triggers metalloproteinases release inducing cervical remodeling and preterm birth in mice. American Journal of Pathology179838\u2013849. (https:\/\/doi.org\/10.1016\/j.ajpath.2011.04.024)10.1016\/j.ajpath.2011.04.024"},{"key":"bib29","series-title":"Journal of Reproductive Immunology","doi-asserted-by":"publisher","first-page":"112","DOI":"10.1016\/j.jri.2012.07.008","article-title":"Comparison of the mechanisms responsible for cervical remodeling in preterm and term labor","volume":"97","author":"Gonzalez","year":"2013","unstructured":"Gonzalez JMRomero RGirardi G2013Comparison of the mechanisms responsible for cervical remodeling in preterm and term labor. Journal of Reproductive Immunology97112\u2013119. (https:\/\/doi.org\/10.1016\/j.jri.2012.07.008)10.1016\/j.jri.2012.07.008"},{"key":"bib30","series-title":"Reproductive Sciences","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1177\/1933719111413299","article-title":"Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid in late pregnancy and labor","volume":"19","author":"Heng","year":"2012","unstructured":"Heng YJDi Quinzio MKLiong SPermezel MRice GEGeorgiou HM2012Temporal investigation of matrix metalloproteinases and their inhibitors in human cervicovaginal fluid in late pregnancy and labor. Reproductive Sciences1955\u201363. (https:\/\/doi.org\/10.1177\/1933719111413299)10.1177\/1933719111413299"},{"key":"bib31","series-title":"Mayo Clinic Proceedings","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1016\/S0025-6196(11)60669-1","article-title":"Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents","volume":"84","author":"Holtan","year":"2009","unstructured":"Holtan SGCreedon DJHaluska PMarkovic SN2009Cancer and pregnancy: parallels in growth, invasion, and immune modulation and implications for cancer therapeutic agents. Mayo Clinic Proceedings84985\u20131000. (https:\/\/doi.org\/10.1016\/S0025-6196(1160669-1)10.1016\/S0025-6196(11)60669-1"},{"key":"bib32","series-title":"Seminars in Perinatology","doi-asserted-by":"publisher","first-page":"300","DOI":"10.1053\/j.semperi.2009.06.002","article-title":"Relationships between mechanical properties and extracellular matrix constituents of the cervical stroma during pregnancy","volume":"33","author":"House","year":"2009","unstructured":"House MKaplan DLSocrate S2009Relationships between mechanical properties and extracellular matrix constituents of the cervical stroma during pregnancy. Seminars in Perinatology33300\u2013307. (https:\/\/doi.org\/10.1053\/j.semperi.2009.06.002)10.1053\/j.semperi.2009.06.002"},{"key":"bib33","series-title":"Journal of Biological Chemistry","doi-asserted-by":"publisher","first-page":"13070","DOI":"10.1016\/S0021-9258(18)98804-6","article-title":"Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2","volume":"266","author":"Howard","year":"1991","unstructured":"Howard EWBullen ECBanda MJ1991Preferential inhibition of 72- and 92-kDa gelatinases by tissue inhibitor of metalloproteinases-2. Journal of Biological Chemistry26613070\u201313075. (https:\/\/doi.org\/10.1016\/S0021-9258(1898804-6)10.1016\/S0021-9258(18)98804-6"},{"key":"bib34","series-title":"Oncogene","doi-asserted-by":"publisher","first-page":"7194","DOI":"10.1038\/sj.onc.1210535","article-title":"The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells","volume":"26","author":"Ito","year":"2007","unstructured":"Ito TKIshii GChiba HOchiai A2007The VEGF angiogenic switch of fibroblasts is regulated by MMP-7 from cancer cells. Oncogene267194\u20137203. (https:\/\/doi.org\/10.1038\/sj.onc.1210535)10.1038\/sj.onc.1210535"},{"key":"bib35","series-title":"Cancer Metastasis Reviews","doi-asserted-by":"publisher","first-page":"35","DOI":"10.1007\/s10555-006-7887-8","article-title":"Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression","volume":"25","author":"Jodele","year":"2006","unstructured":"Jodele SBlavier LYoon JMDeClerck YA2006Modifying the soil to affect the seed: role of stromal-derived matrix metalloproteinases in cancer progression. Cancer Metastasis Reviews2535\u201343. (https:\/\/doi.org\/10.1007\/s10555-006-7887-8)10.1007\/s10555-006-7887-8"},{"key":"bib36","series-title":"Scientific Reports","article-title":"Changes to the cervicovaginal microbiota and cervical cytokine profile following surgery for cervical intraepithelial neoplasia","volume":"11","author":"Kawahara","year":"2021","unstructured":"Kawahara RFujii TKukimoto INomura HKawasaki RNishio EIchikawa RTsukamoto TIwata A2021Changes to the cervicovaginal microbiota and cervical cytokine profile following surgery for cervical intraepithelial neoplasia. Scientific Reports11 2156. (https:\/\/doi.org\/10.1038\/s41598-020-80176-6)"},{"key":"bib37","series-title":"BMC Clinical Pathology","doi-asserted-by":"publisher","first-page":"9","DOI":"10.1186\/1472-6890-12-9","article-title":"Cell culture model predicts human disease: altered expression of junction proteins and matrix metalloproteinases in cervical dysplasia","volume":"12","author":"Kivi","year":"2012","unstructured":"Kivi NR\u00f6nty MTarkkanen JAuvinen PAuvinen E2012Cell culture model predicts human disease: altered expression of junction proteins and matrix metalloproteinases in cervical dysplasia. BMC Clinical Pathology129\u20139. (https:\/\/doi.org\/10.1186\/1472-6890-12-9)10.1186\/1472-6890-12-9"},{"key":"bib38","series-title":"Journal of Periodontology","doi-asserted-by":"publisher","first-page":"166","DOI":"10.1902\/jop.2008.070159","article-title":"Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue","volume":"79","author":"Kubota","year":"2008","unstructured":"Kubota TItagaki MHoshino CNagata MMorozumi TKobayashi TTakagi RYoshie H2008Altered gene expression levels of matrix metalloproteinases and their inhibitors in periodontitis-affected gingival tissue. Journal of Periodontology79166\u2013173. (https:\/\/doi.org\/10.1902\/jop.2008.070159)10.1902\/jop.2008.070159"},{"key":"bib39","series-title":"Anticancer Research","first-page":"1589","article-title":"Matrix metalloproteinases and their inhibitors","volume":"19","author":"Kugler","year":"1999","unstructured":"Kugler A1999Matrix metalloproteinases and their inhibitors. Anticancer Research191589\u20131592. (https:\/\/doi.org\/10.1385\/1-59259-144-2:139)"},{"key":"bib40","series-title":"Seminars in Cancer Biology","first-page":"In press","article-title":"Vaginal microbiome and cervical cancer","author":"Kyrgiou","year":"2022","unstructured":"Kyrgiou MMoscicki AB2022Vaginal microbiome and cervical cancer. Seminars in Cancer BiologyIn press. (https:\/\/doi.org\/10.1016\/j.semcancer.2022.03.005)"},{"key":"bib41","series-title":"Biochemical and Biophysical Research Communications","doi-asserted-by":"publisher","first-page":"232","DOI":"10.1016\/j.bbrc.2013.06.046","article-title":"MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells","volume":"437","author":"Lee","year":"2013","unstructured":"Lee HChang KWYang HYLin PWChen SUHuang YL2013MT1-MMP regulates MMP-2 expression and angiogenesis-related functions in human umbilical vein endothelial cells. Biochemical and Biophysical Research Communications437232\u2013238. (https:\/\/doi.org\/10.1016\/j.bbrc.2013.06.046)10.1016\/j.bbrc.2013.06.046"},{"key":"bib42","series-title":"Clinical Obstetrics and Gynecology","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1097\/00003081-199506000-00009","article-title":"Anatomy and physiology of cervical ripening","volume":"38","author":"Leppert","year":"1995","unstructured":"Leppert PC1995Anatomy and physiology of cervical ripening. Clinical Obstetrics and Gynecology38267\u2013279. (https:\/\/doi.org\/10.1097\/00003081-199506000-00009)10.1097\/00003081-199506000-00009"},{"key":"bib43","series-title":"International Journal of Oncology","first-page":"897","article-title":"Uterine cervical carcinoma: role of matrix metalloproteinases (review)","volume":"34","author":"Libra","year":"2009","unstructured":"Libra MScalisi AVella NClementi SSorio RStivala FSpandidos DAMazzarino C2009Uterine cervical carcinoma: role of matrix metalloproteinases (review). International Journal of Oncology34897\u2013903. (https:\/\/doi.org\/10.3892\/ijo_00000215)"},{"key":"bib44","series-title":"Scientific Reports","article-title":"Changes of the vaginal microbiota in HPV infection and cervical intraepithelial neoplasia: a cross-sectional analysis","volume":"12","author":"Lin","year":"2022","unstructured":"Lin WZhang QChen YDong BXue HLei HLu YWei XSun P2022Changes of the vaginal microbiota in HPV infection and cervical intraepithelial neoplasia: a cross-sectional analysis. Scientific Reports12 2812. (https:\/\/doi.org\/10.1038\/s41598-022-06731-5)"},{"key":"bib45","series-title":"Reproduction","doi-asserted-by":"publisher","first-page":"429","DOI":"10.1530\/REP-11-0466","article-title":"Cervical remodeling in term and preterm birth: insights from an animal model","volume":"143","author":"Mahendroo","year":"2012","unstructured":"Mahendroo M2012Cervical remodeling in term and preterm birth: insights from an animal model. Reproduction143429\u2013438. (https:\/\/doi.org\/10.1530\/REP-11-0466)10.1530\/REP-11-0466"},{"key":"bib46","series-title":"FASEB Journal","first-page":"234","article-title":"Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes","volume":"19","author":"Masson","year":"2005","unstructured":"Masson VDe La Ballina LRMunaut CWielockx BJost MMaillard CBlacher SBajou KItoh TItohara S2005Contribution of host MMP-2 and MMP-9 to promote tumor vascularization and invasion of malignant keratinocytes. FASEB Journal19234\u2013236. (https:\/\/doi.org\/10.1096\/fj.04-2140fje)"},{"key":"bib47","series-title":"American Journal of Obstetrics and Gynecology","doi-asserted-by":"publisher","first-page":"887","DOI":"10.1067\/mob.2000.108878","article-title":"Evidence of in vivo differential bioavailability of the active forms of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra-amniotic infection","volume":"183","author":"Maymon","year":"2000a","unstructured":"Maymon ERomero RPacora PGervasi MTGomez REdwin SSYoon BH2000aEvidence of in vivo differential bioavailability of the active forms of matrix metalloproteinases 9 and 2 in parturition, spontaneous rupture of membranes, and intra-amniotic infection. American Journal of Obstetrics and Gynecology183887\u2013894. (https:\/\/doi.org\/10.1067\/mob.2000.108878)10.1067\/mob.2000.108878"},{"key":"bib48","series-title":"American Journal of Obstetrics and Gynecology","doi-asserted-by":"publisher","first-page":"94","DOI":"10.1016\/S0002-9378(00)99072-0","article-title":"Human neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection","volume":"183","author":"Maymon","year":"2000b","unstructured":"Maymon ERomero RPacora PGomez RAthayde NEdwin SYoon BH2000bHuman neutrophil collagenase (matrix metalloproteinase 8) in parturition, premature rupture of the membranes, and intrauterine infection. American Journal of Obstetrics and Gynecology18394\u201399. (https:\/\/doi.org\/10.1067\/mob.2000.105344)10.1016\/S0002-9378(00)99072-0"},{"key":"bib49","series-title":"Journal of Perinatal Medicine","first-page":"308","article-title":"A role for the 72 kDa gelatinase (MMP-2) and its inhibitor (TIMP-2) in human parturition, premature rupture of membranes and intraamniotic infection","volume":"29","author":"Maymon","year":"2001","unstructured":"Maymon ERomero RPacora PGomez RMazor MEdwin SChaiworapongsa TKim JCYoon BHMenon R2001A role for the 72 kDa gelatinase (MMP-2) and its inhibitor (TIMP-2) in human parturition, premature rupture of membranes and intraamniotic infection. Journal of Perinatal Medicine29308\u2013316. (https:\/\/doi.org\/10.1515\/JPM.2001.044)"},{"key":"bib50","series-title":"Nature Communications","doi-asserted-by":"publisher","first-page":"1999","DOI":"10.1038\/s41467-020-15856-y","article-title":"The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions","volume":"11","author":"Mitra","year":"2020","unstructured":"Mitra AMacIntyre DANtritsos GSmith ATsilidis KKMarchesi JRBennett PRMoscicki ABKyrgiou M2020The vaginal microbiota associates with the regression of untreated cervical intraepithelial neoplasia 2 lesions. Nature Communications111999. (https:\/\/doi.org\/10.1038\/s41467-020-15856-y)10.1038\/s41467-020-15856-y"},{"key":"bib51","series-title":"Genome Medicine","article-title":"The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia","volume":"13","author":"Mitra","year":"2021","unstructured":"Mitra AMacIntyre DAParaskevaidi MMoscicki ABMahajan VSmith ALee YSLyons DParaskevaidis EMarchesi JR2021The vaginal microbiota and innate immunity after local excisional treatment for cervical intraepithelial neoplasia. Genome Medicine13 176. (https:\/\/doi.org\/10.1186\/s13073-021-00977-w)"},{"key":"bib52","series-title":"Clinical Biochemistry","doi-asserted-by":"publisher","first-page":"837","DOI":"10.1016\/j.clinbiochem.2007.03.023","article-title":"Relationship between matrix metalloproteinases\/tissue inhibitors of matrix metalloproteinases systems and autoantibody patterns in systemic sclerosis","volume":"40","author":"Montagnana","year":"2007","unstructured":"Montagnana MVolpe ALippi GCaramaschi PSalvagno GLBiasi DBambara LMGuidi GC2007Relationship between matrix metalloproteinases\/tissue inhibitors of matrix metalloproteinases systems and autoantibody patterns in systemic sclerosis. Clinical Biochemistry40837\u2013842. (https:\/\/doi.org\/10.1016\/j.clinbiochem.2007.03.023)10.1016\/j.clinbiochem.2007.03.023"},{"key":"bib53","series-title":"Journal of Critical Care","doi-asserted-by":"publisher","first-page":"550","DOI":"10.1016\/j.jcrc.2011.02.011","article-title":"Dynamic changes of matrix metalloproteinases and their tissue inhibitors in severe sepsis","volume":"26","author":"M\u00fchl","year":"2011","unstructured":"M\u00fchl DNagy BWoth GFalusi BBog\u00e1r LWeber GLantos J2011Dynamic changes of matrix metalloproteinases and their tissue inhibitors in severe sepsis. Journal of Critical Care26550\u2013555. (https:\/\/doi.org\/10.1016\/j.jcrc.2011.02.011)10.1016\/j.jcrc.2011.02.011"},{"key":"bib54","series-title":"Acta Biomaterialia","doi-asserted-by":"publisher","first-page":"104","DOI":"10.1016\/j.actbio.2007.04.009","article-title":"Mechanical and biochemical properties of human cervical tissue","volume":"4","author":"Myers","year":"2008","unstructured":"Myers KMPaskaleva APHouse MSocrate S2008Mechanical and biochemical properties of human cervical tissue. Acta Biomaterialia4104\u2013116. (https:\/\/doi.org\/10.1016\/j.actbio.2007.04.009)10.1016\/j.actbio.2007.04.009"},{"key":"bib55","series-title":"Cardiovascular Research","doi-asserted-by":"publisher","first-page":"562","DOI":"10.1016\/j.cardiores.2005.12.002","article-title":"Structure and function of matrix metalloproteinases and TIMPs","volume":"69","author":"Nagase","year":"2006","unstructured":"Nagase HVisse RMurphy G2006Structure and function of matrix metalloproteinases and TIMPs. Cardiovascular Research69562\u2013573. (https:\/\/doi.org\/10.1016\/j.cardiores.2005.12.002)10.1016\/j.cardiores.2005.12.002"},{"key":"bib56","series-title":"Respirology","doi-asserted-by":"publisher","first-page":"1006","DOI":"10.1111\/j.1440-1843.2012.02197.x","article-title":"Simultaneous up-regulation of matrix metalloproteinases 1, 2, 3, 7, 8, 9 and tissue inhibitors of metalloproteinases 1, 4 in serum of patients with chronic obstructive pulmonary disease","volume":"17","author":"Navratilova","year":"2012","unstructured":"Navratilova ZZatloukal JKriegova EKolek VPetrek M2012Simultaneous up-regulation of matrix metalloproteinases 1, 2, 3, 7, 8, 9 and tissue inhibitors of metalloproteinases 1, 4 in serum of patients with chronic obstructive pulmonary disease. Respirology171006\u20131012. (https:\/\/doi.org\/10.1111\/j.1440-1843.2012.02197.x)10.1111\/j.1440-1843.2012.02197.x"},{"key":"bib57","series-title":"BMC Ophthalmology","article-title":"Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma \u2013 a quantitative study","volume":"14","author":"Nga","year":"2014","unstructured":"Nga ADYap SLSamsudin AAbdul-Rahman PSHashim OHMimiwati Z2014Matrix metalloproteinases and tissue inhibitors of metalloproteinases in the aqueous humour of patients with primary angle closure glaucoma \u2013 a quantitative study. BMC Ophthalmology14 33. (https:\/\/doi.org\/10.1186\/1471-2415-14-33)"},{"key":"bib58","series-title":"European Journal of Neurology","doi-asserted-by":"publisher","first-page":"226","DOI":"10.1111\/j.1468-1331.2009.02775.x","article-title":"Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis","volume":"17","author":"Niebroj-Dobosz","year":"2010","unstructured":"Niebroj-Dobosz IJanik PSoko\u0142owska BKwiecinski H2010Matrix metalloproteinases and their tissue inhibitors in serum and cerebrospinal fluid of patients with amyotrophic lateral sclerosis. European Journal of Neurology17226\u2013231. (https:\/\/doi.org\/10.1111\/j.1468-1331.2009.02775.x)10.1111\/j.1468-1331.2009.02775.x"},{"key":"bib59","series-title":"Reproductive Biology and Endocrinology","article-title":"Circulating matrix metalloproteinase MMP-9 and MMP-2\/TIMP-2 complex are associated with spontaneous early pregnancy failure","volume":"11","author":"Nissi","year":"2013","unstructured":"Nissi RTalvensaari-Mattila AKotila VNiinim\u00e4ki MJ\u00e4rvel\u00e4 ITurpeenniemi-Hujanen T2013Circulating matrix metalloproteinase MMP-9 and MMP-2\/TIMP-2 complex are associated with spontaneous early pregnancy failure. Reproductive Biology and Endocrinology11 2. (https:\/\/doi.org\/10.1186\/1477-7827-11-2)"},{"key":"bib60","series-title":"BJOG","doi-asserted-by":"publisher","first-page":"171","DOI":"10.1111\/1471-0528.15854","article-title":"The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis","volume":"127","author":"Norenhag","year":"2020","unstructured":"Norenhag JDu JOlovsson MVerstraelen HEngstrand LBrusselaers N2020The vaginal microbiota, human papillomavirus and cervical dysplasia: a systematic review and network meta-analysis. BJOG127171\u2013180. (https:\/\/doi.org\/10.1111\/1471-0528.15854)10.1111\/1471-0528.15854"},{"key":"bib61","series-title":"International Journal of Oncology","first-page":"531","article-title":"Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women","volume":"31","author":"Noriyuki","year":"2007","unstructured":"Noriyuki MSumi TZhi XMisugi FNobeyama HYoshida HMatsumoto YYasui THonda KIshiko O2007Vascular endothelial growth factor, matrix metalloproteinases, and cyclooxygenase-2 influence prognosis of uterine cervical cancer in young women. International Journal of Oncology31531\u2013536. (https:\/\/doi.org\/10.3892\/ijo.31.3.531)"},{"key":"bib62","series-title":"Nature Reviews: Cancer","first-page":"227","article-title":"Tumour microenvironment \u2013 opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy","volume":"6","author":"Overall","year":"2006","unstructured":"Overall CMKleifeld O2006Tumour microenvironment \u2013 opinion: validating matrix metalloproteinases as drug targets and anti-targets for cancer therapy. Nature Reviews: Cancer6227\u2013239. (https:\/\/doi.org\/10.1038\/nrc1821)"},{"key":"bib63","series-title":"Journal of Perinatal Medicine","first-page":"12","article-title":"Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity","volume":"31","author":"Park","year":"2003","unstructured":"Park KHChaiworapongsa TKim YMEspinoza JYoshimatsu JEdwin SGomez RYoon BHRomero R2003Matrix metalloproteinase 3 in parturition, premature rupture of the membranes, and microbial invasion of the amniotic cavity. Journal of Perinatal Medicine3112\u201322. (https:\/\/doi.org\/10.1515\/JPM.2003.002)"},{"key":"bib64","series-title":"Frontiers in Oncology","doi-asserted-by":"publisher","first-page":"1370","DOI":"10.3389\/fonc.2019.01370","article-title":"Role of matrix metalloproteinases in angiogenesis and cancer","volume":"9","author":"Quintero-Fabi\u00e1n","year":"2019","unstructured":"Quintero-Fabi\u00e1n SArreola RBecerril-Villanueva ETorres-Romero JCArana-Arg\u00e1ez VLara-Riegos JRam\u00edrez-Camacho MAAlvarez-S\u00e1nchez ME2019Role of matrix metalloproteinases in angiogenesis and cancer. Frontiers in Oncology91370. (https:\/\/doi.org\/10.3389\/fonc.2019.01370)10.3389\/fonc.2019.01370"},{"key":"bib65","series-title":"Biochemical Pharmacology","doi-asserted-by":"publisher","first-page":"346","DOI":"10.1016\/j.bcp.2007.07.004","article-title":"Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease","volume":"75","author":"Raffetto","year":"2008","unstructured":"Raffetto JDKhalil RA2008Matrix metalloproteinases and their inhibitors in vascular remodeling and vascular disease. Biochemical Pharmacology75346\u2013359. (https:\/\/doi.org\/10.1016\/j.bcp.2007.07.004)10.1016\/j.bcp.2007.07.004"},{"key":"bib66","series-title":"International Journal of Gynecological Cancer","doi-asserted-by":"publisher","first-page":"1297","DOI":"10.1136\/ijgc-00009577-200605000-00052","article-title":"Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression","volume":"16","author":"Rauvala","year":"2006","unstructured":"Rauvala MAglund KPuistola UTurpeenniemi-Hujanen THorvath GWill\u00e9n RStendahl U2006Matrix metalloproteinases-2 and -9 in cervical cancer: different roles in tumor progression. International Journal of Gynecological Cancer161297\u20131302. (https:\/\/doi.org\/10.1111\/j.1525-1438.2006.00448.x)10.1136\/ijgc-00009577-200605000-00052"},{"key":"bib67","series-title":"Reproduction","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1530\/REP-07-0032","article-title":"Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice","volume":"134","author":"Read","year":"2007","unstructured":"Read CPWord RARuscheinsky MATimmons BCMahendroo MS2007Cervical remodeling during pregnancy and parturition: molecular characterization of the softening phase in mice. Reproduction134327\u2013340. (https:\/\/doi.org\/10.1530\/REP-07-0032)10.1530\/REP-07-0032"},{"key":"bib68","series-title":"Madame Curie Bioscience Database","article-title":"Matrix metalloproteinases in cancer cell invasion","author":"Reunanen","year":"2000","unstructured":"Reunanen NK\u00e4h\u00e4ri V2000\u20132013 Matrix metalloproteinases in cancer cell invasion. In Madame Curie Bioscience Database [Internet]. TX,Austin: Landes Bioscience. (available at: https:\/\/www.ncbi.nlm.nih.gov\/books\/NBK6598\/)"},{"key":"bib69","series-title":"Molecular Human Reproduction","doi-asserted-by":"publisher","first-page":"96","DOI":"10.1093\/molehr\/6.1.96","article-title":"Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells","volume":"6","author":"Roh","year":"2000","unstructured":"Roh CROh WJYoon BKLee JH2000Up-regulation of matrix metalloproteinase-9 in human myometrium during labour: a cytokine-mediated process in uterine smooth muscle cells. Molecular Human Reproduction696\u2013102. (https:\/\/doi.org\/10.1093\/molehr\/6.1.96)10.1093\/molehr\/6.1.96"},{"key":"bib70","series-title":"PLoS Medicine","article-title":"MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis","volume":"5","author":"Rosas","year":"2008","unstructured":"Rosas IORichards TJKonishi KZhang YGibson KLokshin AELindell KOCisneros JMacdonald SDPardo A2008MMP1 and MMP7 as potential peripheral blood biomarkers in idiopathic pulmonary fibrosis. PLoS Medicine5 e93. (https:\/\/doi.org\/10.1371\/journal.pmed.0050093)"},{"key":"bib71","series-title":"Experimental Cell Research","doi-asserted-by":"publisher","first-page":"608","DOI":"10.1016\/j.yexcr.2005.11.022","article-title":"Making the cut: protease-mediated regulation of angiogenesis","volume":"312","author":"Roy","year":"2006","unstructured":"Roy RZhang BMoses MA2006Making the cut: protease-mediated regulation of angiogenesis. Experimental Cell Research312608\u2013622. (https:\/\/doi.org\/10.1016\/j.yexcr.2005.11.022)10.1016\/j.yexcr.2005.11.022"},{"key":"bib72","series-title":"Journal of Cellular and Molecular Medicine","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1111\/j.1582-4934.2005.tb00355.x","article-title":"Matrix metalloproteinases and angiogenesis","volume":"9","author":"Rundhaug","year":"2005","unstructured":"Rundhaug JE2005Matrix metalloproteinases and angiogenesis. Journal of Cellular and Molecular Medicine9267\u2013285. (https:\/\/doi.org\/10.1111\/j.1582-4934.2005.tb00355.x)10.1111\/j.1582-4934.2005.tb00355.x"},{"key":"bib73","series-title":"Journal of Nephrology","first-page":"444","article-title":"Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy","volume":"20","author":"Rysz","year":"2007","unstructured":"Rysz JBanach MStolarek RAPasnik JCialkowska-Rysz AKoktysz RPiechota MBaj Z2007Serum matrix metalloproteinases MMP-2 and MMP-9 and metalloproteinase tissue inhibitors TIMP-1 and TIMP-2 in diabetic nephropathy. Journal of Nephrology20444\u2013452."},{"key":"bib74","series-title":"Gynecologic Oncology","doi-asserted-by":"publisher","first-page":"47","DOI":"10.1016\/j.ygyno.2003.09.012","article-title":"Tumor\u2013stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases","volume":"92","author":"Sato","year":"2004","unstructured":"Sato TSakai TNoguchi YTakita MHirakawa SIto A2004Tumor\u2013stromal cell contact promotes invasion of human uterine cervical carcinoma cells by augmenting the expression and activation of stromal matrix metalloproteinases. Gynecologic Oncology9247\u201356. (https:\/\/doi.org\/10.1016\/j.ygyno.2003.09.012)10.1016\/j.ygyno.2003.09.012"},{"key":"bib75","series-title":"Gynecologic Oncology","doi-asserted-by":"publisher","first-page":"337","DOI":"10.1016\/j.ygyno.2009.04.004","article-title":"Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts","volume":"114","author":"Sato","year":"2009","unstructured":"Sato TOta TWatanabe MImada KNomizu MIto A2009Identification of an active site of EMMPRIN for the augmentation of matrix metalloproteinase-1 and -3 expression in a co-culture of human uterine cervical carcinoma cells and fibroblasts. Gynecologic Oncology114337\u2013342. (https:\/\/doi.org\/10.1016\/j.ygyno.2009.04.004)10.1016\/j.ygyno.2009.04.004"},{"key":"bib76","series-title":"Cancer Research","first-page":"6537","article-title":"Increased expression and activation of gelatinolytic matrix metalloproteinases is associated with the progression and recurrence of human cervical cancer","volume":"63","author":"Sheu","year":"2003","unstructured":"Sheu BCLien HCHo HNLin HHChow SNHuang SCHsu SM2003Increased expression and activation of gelatinolytic matrix metalloproteinases is associated with the progression and recurrence of human cervical cancer. Cancer Research636537\u20136542."},{"key":"bib77","series-title":"Frontiers in Cellular and Infection Microbiology","doi-asserted-by":"publisher","first-page":"750103","DOI":"10.3389\/fcimb.2021.750103","article-title":"Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration","volume":"11","author":"Short","year":"2021","unstructured":"Short C-ESQuinlan RAWang XPreda VGSmith AMarchesi JRLee YSMacIntyre DABennett PRTaylor GP2021Vaginal microbiota, genital inflammation and extracellular matrix remodelling collagenase: MMP-9 in pregnant women with HIV, a potential preterm birth mechanism warranting further exploration. Frontiers in Cellular and Infection Microbiology11750103. (https:\/\/doi.org\/10.3389\/fcimb.2021.750103)10.3389\/fcimb.2021.750103"},{"key":"bib78","series-title":"CA: A Cancer Journal for Clinicians","first-page":"7","article-title":"Cancer statistics, 2018","volume":"68","author":"Siegel","year":"2018","unstructured":"Siegel RLMiller KDJemal A2018Cancer statistics, 2018. CA: A Cancer Journal for Clinicians687\u201330. (https:\/\/doi.org\/10.3322\/caac.21442)"},{"key":"bib79","series-title":"International Journal of Cancer","doi-asserted-by":"publisher","first-page":"2991","DOI":"10.1002\/ijc.21778","article-title":"EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma","volume":"118","author":"Sier","year":"2006","unstructured":"Sier CFZuidwijk KZijlmans HJHanemaaijer RMulder-Stapel AAPrins FADreef EJKenter GGFleuren GJGorter A2006EMMPRIN-induced MMP-2 activation cascade in human cervical squamous cell carcinoma. International Journal of Cancer1182991\u20132998. (https:\/\/doi.org\/10.1002\/ijc.21778)10.1002\/ijc.21778"},{"key":"bib80","series-title":"Biology of Reproduction","doi-asserted-by":"publisher","first-page":"772","DOI":"10.1095\/biolreprod46.5.772","article-title":"Tumor necrosis factor-alpha stimulates the biosynthesis of matrix metalloproteinases and plasminogen activator in cultured human chorionic cells","volume":"46","author":"So","year":"1992","unstructured":"So TIto ASato TMori YHirakawa S1992Tumor necrosis factor-alpha stimulates the biosynthesis of matrix metalloproteinases and plasminogen activator in cultured human chorionic cells. Biology of Reproduction46772\u2013778. (https:\/\/doi.org\/10.1095\/biolreprod46.5.772)10.1095\/biolreprod46.5.772"},{"key":"bib81","series-title":"PLoS ONE","article-title":"Changes of vaginal microbiota during cervical carcinogenesis in women with human papillomavirus infection","volume":"15","author":"So","year":"2020","unstructured":"So KAYang EJKim NRHong SRLee JHHwang CSShim SHLee SJKim TJ2020Changes of vaginal microbiota during cervical carcinogenesis in women with human papillomavirus infection. PLoS ONE15 e0238705. (https:\/\/doi.org\/10.1371\/journal.pone.0238705)"},{"key":"bib82","series-title":"Gynecological Endocrinology","doi-asserted-by":"publisher","first-page":"201","DOI":"10.3109\/09513590902972026","article-title":"Serum levels of matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors in women with glucose intolerance in pregnancy and normal controls","volume":"26","author":"Stojanovic","year":"2010","unstructured":"Stojanovic NLewandowski KSalata IBienkiewicz MTuck SPrelevic GPress M2010Serum levels of matrix metalloproteinases MMP-2 and MMP-9 and their inhibitors in women with glucose intolerance in pregnancy and normal controls. Gynecological Endocrinology26201\u2013207. (https:\/\/doi.org\/10.1080\/09513590902972026)10.3109\/09513590902972026"},{"key":"bib83","series-title":"IUBMB Life","doi-asserted-by":"publisher","first-page":"985","DOI":"10.1002\/iub.1687","article-title":"Investigating the expression of MMPs and TIMPs in preterm placenta and role of CpG methylation in regulating MMP-9 expression","volume":"69","author":"Sundrani","year":"2017","unstructured":"Sundrani DNarang AMehendale SJoshi SChavan-Gautam P2017Investigating the expression of MMPs and TIMPs in preterm placenta and role of CpG methylation in regulating MMP-9 expression. IUBMB Life69985\u2013993. (https:\/\/doi.org\/10.1002\/iub.1687)10.1002\/iub.1687"},{"key":"bib84","series-title":"American Journal of Pathology","doi-asserted-by":"publisher","first-page":"673","DOI":"10.1016\/S0002-9440(10)64887-0","article-title":"Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells","volume":"160","author":"Taraboletti","year":"2002","unstructured":"Taraboletti GD\u2019Ascenzo SBorsotti PGiavazzi RPavan ADolo V2002Shedding of the matrix metalloproteinases MMP-2, MMP-9, and MT1-MMP as membrane vesicle-associated components by endothelial cells. American Journal of Pathology160673\u2013680. (https:\/\/doi.org\/10.1016\/S0002-9440(1064887-0)10.1016\/S0002-9440(10)64887-0"},{"key":"bib85","series-title":"American Journal of Hypertension","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1016\/j.amjhyper.2004.09.014","article-title":"Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and -2 levels in gestational hypertension","volume":"18","author":"Tayebjee","year":"2005","unstructured":"Tayebjee MHKaralis INadar SKBeevers DGMacFadyen RJLip GY2005Circulating matrix metalloproteinase-9 and tissue inhibitors of metalloproteinases-1 and -2 levels in gestational hypertension. American Journal of Hypertension18325\u2013329. (https:\/\/doi.org\/10.1016\/j.amjhyper.2004.09.014)10.1016\/j.amjhyper.2004.09.014"},{"key":"bib86","series-title":"PLoS ONE","article-title":"Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor","volume":"7","author":"Tency","year":"2012","unstructured":"Tency IVerstraelen HKroes IHoltappels GVerhasselt BVaneechoutte MVerhelst RTemmerman M2012Imbalances between matrix metalloproteinases (MMPs) and tissue inhibitor of metalloproteinases (TIMPs) in maternal serum during preterm labor. PLoS ONE7 e49042. (https:\/\/doi.org\/10.1371\/journal.pone.0049042)"},{"key":"bib87","series-title":"New England Journal of Medicine","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1056\/NEJMoa1309748","article-title":"Improved survival with bevacizumab in advanced cervical cancer","volume":"370","author":"Tewari","year":"2014","unstructured":"Tewari KSSill MWLong 3rd HJPenson RTHuang HRamondetta LMLandrum LMOaknin AReid TJLeitao MM2014Improved survival with bevacizumab in advanced cervical cancer. New England Journal of Medicine370734\u2013743. (https:\/\/doi.org\/10.1056\/NEJMoa1309748)10.1056\/NEJMoa1309748"},{"key":"bib88","series-title":"Human Reproduction","doi-asserted-by":"publisher","first-page":"229","DOI":"10.1093\/humrep\/14.1.229","article-title":"Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process","volume":"14","author":"Thomson","year":"1999","unstructured":"Thomson AJTelfer JFYoung ACampbell SStewart CJCameron ITGreer IANorman JE1999Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process. Human Reproduction14229\u2013236. (https:\/\/doi.org\/10.1093\/humrep\/14.1.229)10.1093\/humrep\/14.1.229"},{"key":"bib89","series-title":"International Journal of Oncology","first-page":"1198","article-title":"Identification and validation of the role of matrix metalloproteinase-1 in cervical cancer","volume":"52","author":"Tian","year":"2018","unstructured":"Tian RLi XGao YLi YYang PWang K2018Identification and validation of the role of matrix metalloproteinase-1 in cervical cancer. International Journal of Oncology521198\u20131208. (https:\/\/doi.org\/10.3892\/ijo.2018.4267)"},{"key":"bib90","series-title":"Trends in Endocrinology and Metabolism","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1016\/j.tem.2010.01.011","article-title":"Cervical remodeling during pregnancy and parturition","volume":"21","author":"Timmons","year":"2010","unstructured":"Timmons BAkins MMahendroo M2010Cervical remodeling during pregnancy and parturition. Trends in Endocrinology and Metabolism21353\u2013361. (https:\/\/doi.org\/10.1016\/j.tem.2010.01.011)10.1016\/j.tem.2010.01.011"},{"key":"bib91","series-title":"BMC Cancer","article-title":"Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer","volume":"5","author":"Vazquez-Ortiz","year":"2005","unstructured":"Vazquez-Ortiz GPina-Sanchez PVazquez KDuenas ATaja LMendoza PGarcia JASalcedo M2005Overexpression of cathepsin F, matrix metalloproteinases 11 and 12 in cervical cancer. BMC Cancer5 68. (https:\/\/doi.org\/10.1186\/1471-2407-5-68)"},{"key":"bib92","series-title":"Seminars in Perinatology","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1053\/j.semperi.2017.07.014","article-title":"The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: where are we now?","volume":"41","author":"Vink","year":"2017","unstructured":"Vink JMourad M2017The pathophysiology of human premature cervical remodeling resulting in spontaneous preterm birth: where are we now?Seminars in Perinatology41427\u2013437. (https:\/\/doi.org\/10.1053\/j.semperi.2017.07.014)10.1053\/j.semperi.2017.07.014"},{"key":"bib93","series-title":"Seminars in Reproductive Medicine","doi-asserted-by":"publisher","first-page":"69","DOI":"10.1055\/s-2006-956777","article-title":"Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts","volume":"25","author":"Word","year":"2007","unstructured":"Word RALi XHHnat MCarrick K2007Dynamics of cervical remodeling during pregnancy and parturition: mechanisms and current concepts. Seminars in Reproductive Medicine2569\u201379. (https:\/\/doi.org\/10.1055\/s-2006-956777)10.1055\/s-2006-956777"},{"key":"bib94","series-title":"Ai Zheng","first-page":"315","article-title":"Expression of ETV5 and MMP-7 in early stage cervical squamous cell carcinoma and its role in lymphatic metastasis","volume":"25","author":"Wu","year":"2006","unstructured":"Wu SHZhang JLi YLi JM2006Expression of ETV5 and MMP-7 in early stage cervical squamous cell carcinoma and its role in lymphatic metastasis. Ai Zheng25315\u2013319."},{"key":"bib95","series-title":"Frontiers in Cellular and Infection Microbiology","doi-asserted-by":"publisher","first-page":"538336","DOI":"10.3389\/fcimb.2020.538336","article-title":"Revealing the disturbed vaginal Micobiota caused by cervical cancer using high-throughput sequencing technology","volume":"10","author":"Xie","year":"2020","unstructured":"Xie YFeng YLi WZhan FHuang GHu HXiong YTan BChen T2020Revealing the disturbed vaginal Micobiota caused by cervical cancer using high-throughput sequencing technology. Frontiers in Cellular and Infection Microbiology10538336. (https:\/\/doi.org\/10.3389\/fcimb.2020.538336)10.3389\/fcimb.2020.538336"},{"key":"bib96","series-title":"Brain, Behavior, and Immunity","doi-asserted-by":"publisher","first-page":"161","DOI":"10.1016\/j.bbi.2017.04.024","article-title":"MMPs\/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders","volume":"65","author":"Xing","year":"2017","unstructured":"Xing YShepherd NLan JLi WRane SGupta SKZhang SDong JYu Q2017MMPs\/TIMPs imbalances in the peripheral blood and cerebrospinal fluid are associated with the pathogenesis of HIV-1-associated neurocognitive disorders. Brain, Behavior, and Immunity65161\u2013172. (https:\/\/doi.org\/10.1016\/j.bbi.2017.04.024)10.1016\/j.bbi.2017.04.024"},{"key":"bib97","series-title":"Pharmacology and Therapeutics","doi-asserted-by":"publisher","first-page":"111","DOI":"10.1016\/j.pharmthera.2014.11.007","article-title":"Putative targeting of matrix metalloproteinase-8 in atherosclerosis","volume":"147","author":"Ye","year":"2015","unstructured":"Ye S2015Putative targeting of matrix metalloproteinase-8 in atherosclerosis. Pharmacology and Therapeutics147111\u2013122. (https:\/\/doi.org\/10.1016\/j.pharmthera.2014.11.007)10.1016\/j.pharmthera.2014.11.007"},{"key":"bib98","series-title":"Biology of Reproduction","doi-asserted-by":"publisher","first-page":"13","DOI":"10.1095\/biolreprod.116.142844","article-title":"Contributions to the dynamics of cervix remodeling prior to term and preterm birth","volume":"96","author":"Yellon","year":"2017","unstructured":"Yellon SM2017Contributions to the dynamics of cervix remodeling prior to term and preterm birth. Biology of Reproduction9613\u201323. (https:\/\/doi.org\/10.1095\/biolreprod.116.142844)10.1095\/biolreprod.116.142844"},{"key":"bib99","series-title":"Frontiers in Immunology","first-page":"3156","article-title":"Immunobiology of cervix ripening","volume":"10","author":"Yellon","year":"2019","unstructured":"Yellon SM2019Immunobiology of cervix ripening. Frontiers in Immunology103156. (https:\/\/doi.org\/10.3389\/fimmu.2019.03156)"},{"key":"bib100","series-title":"Interface Focus","article-title":"Mechanics of cervical remodelling: insights from rodent models of pregnancy","volume":"9","author":"Yoshida","year":"2019","unstructured":"Yoshida KJayyosi CLee NMahendroo MMyers KM2019Mechanics of cervical remodelling: insights from rodent models of pregnancy. Interface Focus9 20190026. (https:\/\/doi.org\/10.1098\/rsfs.2019.0026)"},{"key":"bib101","series-title":"Genes and Development","doi-asserted-by":"publisher","first-page":"163","DOI":"10.1101\/gad.14.2.163","article-title":"2000 cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis","volume":"14","author":"Yu","year":"2000","unstructured":"Yu QStamenkovic I20002000 cell surface-localized matrix metalloproteinase-9 proteolytically activates TGF-beta and promotes tumor invasion and angiogenesis. Genes and Development14163\u2013176. (https:\/\/doi.org\/10.1101\/gad.14.2.163)10.1101\/gad.14.2.163"},{"key":"bib102","series-title":"Scientific Reports","article-title":"HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6\/E7 viral oncogenes","volume":"7","author":"Yuan","year":"2017","unstructured":"Yuan HKrawczyk EBlancato JAlbanese CZhou DWang NPaul SAlkhilaiwi FPalechor-Ceron NDakic A2017HPV positive neuroendocrine cervical cancer cells are dependent on Myc but not E6\/E7 viral oncogenes. Scientific Reports7 45617. (https:\/\/doi.org\/10.1038\/srep45617)"},{"key":"bib103","series-title":"Cancer Research","doi-asserted-by":"publisher","first-page":"6543","DOI":"10.1158\/0008-5472.CAN-05-0231","article-title":"Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion","volume":"65","author":"Zhai","year":"2005","unstructured":"Zhai YHotary KBNan BBosch FXMu\u00f1oz NWeiss SJCho KR2005Expression of membrane type 1 matrix metalloproteinase is associated with cervical carcinoma progression and invasion. Cancer Research656543\u20136550. (https:\/\/doi.org\/10.1158\/0008-5472.CAN-05-0231)10.1158\/0008-5472.CAN-05-0231"},{"key":"bib104","series-title":"Frontiers in Bioscience","doi-asserted-by":"publisher","first-page":"353","DOI":"10.2741\/1533","article-title":"The role and regulation of the uterine matrix metalloproteinase system in menstruating and non-menstruating species","volume":"10","author":"Zhang","year":"2005","unstructured":"Zhang XNothnick WB2005The role and regulation of the uterine matrix metalloproteinase system in menstruating and non-menstruating species. Frontiers in Bioscience10353\u2013366. (https:\/\/doi.org\/10.2741\/1533)10.2741\/1533"},{"key":"bib105","series-title":"BMC Cancer","article-title":"Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors","volume":"14","author":"Zhang","year":"2014","unstructured":"Zhang GMiyake MLawton AGoodison SRosser CJ2014Matrix metalloproteinase-10 promotes tumor progression through regulation of angiogenic and apoptotic pathways in cervical tumors. BMC Cancer14 310. (https:\/\/doi.org\/10.1186\/1471-2407-14-310)"},{"key":"bib106","series-title":"OncoTargets and Therapy","doi-asserted-by":"publisher","first-page":"4207","DOI":"10.2147\/OTT.S160998","article-title":"Matrix metalloproteinase-7 may serve as a novel biomarker for cervical cancer","volume":"11","author":"Zhu","year":"2018","unstructured":"Zhu LZheng XDu YXing YXu KCui L2018Matrix metalloproteinase-7 may serve as a novel biomarker for cervical cancer. OncoTargets and Therapy114207\u20134220. (https:\/\/doi.org\/10.2147\/OTT.S160998)10.2147\/OTT.S160998"}],"container-title":["Reproduction and Fertility"],"original-title":[],"link":[{"URL":"https:\/\/raf.bioscientifica.com\/view\/journals\/raf\/3\/3\/RAF-22-0015.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/raf.bioscientifica.com\/downloadpdf\/journals\/raf\/3\/3\/RAF-22-0015.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/raf.bioscientifica.com\/downloadpdf\/journals\/raf\/3\/3\/RAF-22-0015.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T13:53:39Z","timestamp":1784555619000},"score":1,"resource":{"primary":{"URL":"http:\/\/journals.bioscientifica.com\/raf\/article\/3\/3\/R177-R191\/26126"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2022,7,1]]},"references-count":106,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.1530\/raf-22-0015","relation":{},"ISSN":["2633-8386"],"issn-type":[{"value":"2633-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2022,7,1]]}}}