{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:20:15Z","timestamp":1784557215153,"version":"3.55.0"},"reference-count":29,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2022,7,1]],"date-time":"2022-07-01T00:00:00Z","timestamp":1656633600000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["raf.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2022,7,1]]},"abstract":"<jats:sec>\n                    <jats:title>In vitro<\/jats:title>\n                    <jats:p>\n                      culturing of endometrial cells obtained from the uterine mucosa or ectopic sites is used to study molecular and cellular signalling relevant to physiologic and pathologic reproductive conditions. However, the lack of consensus on standard operating procedures for deriving, characterising and maintaining primary cells in two- or three-dimensional cultures from eutopic or ectopic endometrium may be hindering progress in this area of research. Guidance for unbiased\n                      <jats:italic>in vitro<\/jats:italic>\n                      research methodologies in the field of reproductive science remains essential to increase confidence in the reliability of\n                      <jats:italic>in vitro<\/jats:italic>\n                      models. We present herein the protocol for a Delphi process to develop a consensus on\n                      <jats:italic>in vitro<\/jats:italic>\n                      methodologies using endometrial cells (ENDOCELL-Seud Project). A steering committee composed of leading scientists will select critical methodologies, topics and items that need to be harmonised and that will be included in a survey. An enlarged panel of experts (ENDOCELL-Seud Working Group) will be invited to participate in the survey and provide their ratings to the items to be harmonised. According to Delphi, an iterative investigation method will be adopted. Recommended measures will be finalised by the steering committee. The study received full ethical approval from the Ethical Committee of the Maastricht University (ref. FHML-REC\/2021\/103). The study findings will be available in both peer-reviewed articles and will also be disseminated to appropriate audiences at relevant conferences.\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Patient-derived cells cultured in the lab are simple and cost-effective methods used to study biological and dysfunctional or disease processes. These tools are frequently used in the field of reproductive medicine. However, the lack of clear recommendations and standardised methodology to guide the laboratory work of researchers can produce results that are not always reproducible and sometimes are incorrect. To remedy this situation, we define here a method to ascertain if researchers who routinely culture cells in the lab agree or disagree on the optimal laboratory techniques. This method will be used to make recommendations for future researchers working in the field of reproductive biology to reproducibly culture endometrial cells in the laboratory.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-22-0041","type":"journal-article","created":{"date-parts":[[2022,7,28]],"date-time":"2022-07-28T11:24:03Z","timestamp":1659007443000},"page":"G1-G8","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":2,"title":["ENDOCELL-Seud: a Delphi protocol to harmonise methods in endometrial cell culturing"],"prefix":"10.1530","volume":"3","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5900-6883","authenticated-orcid":true,"given":"Andrea","family":"Romano","sequence":"first","affiliation":[{"name":"Department Obstetrics and Gynecology, GROW \u2013 School for Oncology and Reproduction, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8511-7624","authenticated-orcid":true,"given":"Sun-Wei","family":"Guo","sequence":"additional","affiliation":[{"name":"Shanghai Ob\/Gyn Hospital, Fudan University, Shanghai, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jan","family":"Brosens","sequence":"additional","affiliation":[{"name":"Division of Biomedical Sciences, Warwick Medical School University of Warwick, Coventry, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Asgerally","family":"Fazlebas","sequence":"additional","affiliation":[{"name":"Department of Obstetrics, Gynecology & Reproductive Biology, Michigan State University, Grand Rapids, Michigan, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline E","family":"Gargett","sequence":"additional","affiliation":[{"name":"The Ritchie Centre, Hudson Institute of Medical Research and Department of Obstetrics and Gynecology, Monash University, Melbourne, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"Giselbrecht","sequence":"additional","affiliation":[{"name":"Department of Instructive Biomaterials Engineering, MERLN Institute for Technology-Inspired Regenerative Medicine, Maastricht University, Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Gotte","sequence":"additional","affiliation":[{"name":"Department of Gynecology and Obstetrics, M\u00fcnster University Hospital, M\u00fcnster, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda","family":"Griffith","sequence":"additional","affiliation":[{"name":"MIT, Cambridge, Massachusetts, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugh S","family":"Taylor","sequence":"additional","affiliation":[{"name":"Yale University, New Haven, Connecticut, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert N","family":"Taylor","sequence":"additional","affiliation":[{"name":"University at Buffalo, Buffalo, New York, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hugo","family":"Vankelecom","sequence":"additional","affiliation":[{"name":"University of Leuven, Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Charles","family":"Chapron","sequence":"additional","affiliation":[{"name":"Universit\u00e9 Paris Cit\u00e9, Assistance Publique H\u00f4pitaux de Paris, Centre Hospitalier Universitaire Cochin, Department of Gynecology Obstetrics II and Reproductive Medicine, Paris, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9713-9134","authenticated-orcid":true,"given":"Xiao-Hong","family":"Chang","sequence":"additional","affiliation":[{"name":"Peking University People\u2019s Hospital, Beijing, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khaleque N","family":"Khan","sequence":"additional","affiliation":[{"name":"Department of Obstetrics and Gynecology, The Clinical and Translational Research Center, Graduate School of Medical Science, Kyoto Prefectural University of Medicine, Kyoto, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paola","family":"Vigano\u2019","sequence":"additional","affiliation":[{"name":"Fondazione IRCCS Ca\u2019 Granda, Ospedale Maggiore Policlinico, Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"BMC Medical Research Methodology","article-title":"Stability of response characteristics of a Delphi panel: application of bootstrap data expansion","volume":"5","author":"Akins","year":"2005","unstructured":"Akins RBTolson HCole BR2005Stability of response characteristics of a Delphi panel: application of bootstrap data expansion. 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