{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,20]],"date-time":"2026-07-20T14:19:35Z","timestamp":1784557175074,"version":"3.55.0"},"reference-count":7,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2023,1,1]],"date-time":"2023-01-01T00:00:00Z","timestamp":1672531200000},"content-version":"unspecified","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["raf.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2023,2,16]]},"abstract":"<jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Men and boys with cancer treated with chemotherapy are known to have reduced fertility following their treatment. This is because some chemotherapy drugs can damage the cells in the testicles that make sperm. This study found there is limited information available on the effect of one group of chemotherapy drugs, called taxanes, on testicular function and fertility. More studies are needed to aid clinicians in advising patients on how this taxane-based chemotherapy may affect their future fertility.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-22-0134","type":"journal-article","created":{"date-parts":[[2023,2,16]],"date-time":"2023-02-16T13:26:31Z","timestamp":1676553991000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":2,"title":["Impact of taxane-based chemotherapeutics on male reproductive function"],"prefix":"10.1530","volume":"4","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2187-516X","authenticated-orcid":true,"given":"Charvi","family":"Kanodia","sequence":"first","affiliation":[{"name":"Edinburgh Medical School, University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3295-8753","authenticated-orcid":true,"given":"Michael P","family":"Rimmer","sequence":"additional","affiliation":[{"name":"MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0039-8525","authenticated-orcid":true,"given":"Kathleen","family":"Duffin","sequence":"additional","affiliation":[{"name":"Biomedical Sciences, University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4650-3765","authenticated-orcid":true,"given":"Rod T","family":"Mitchell","sequence":"additional","affiliation":[{"name":"MRC Centre for Reproductive Health, Institute of Regeneration and Repair, University of Edinburgh, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Journal of Clinical Endocrinology and Metabolism","first-page":"E700","article-title":"Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia","volume":"97","author":"Burney","year":"2012","unstructured":"Burney BOHayes TGSmiechowska JCardwell GPapusha VBhargava PKonda BAuchus RJ & Garcia JM2012Low testosterone levels and increased inflammatory markers in patients with cancer and relationship with cachexia. 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(https:\/\/doi.org\/10.1016\/j.fertnstert.2009.03.068)"},{"key":"bib3","series-title":"Science","first-page":"1314","article-title":"Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring","volume":"363","author":"Fayomi","year":"2019","unstructured":"Fayomi APPeters KSukhwani MValli-Pulaski HShetty GMeistrich MLHouser LRobertson NRoberts VRamsey C, 2019Autologous grafting of cryopreserved prepubertal rhesus testis produces sperm and offspring. Science3631314\u20131319. (https:\/\/doi.org\/10.1126\/science.aav2914)"},{"key":"bib4","series-title":"Journal of Andrology","first-page":"280","article-title":"Testicular function in poor-risk nonseminomatous germ cell tumors treated with methotrexate, paclitaxel, ifosfamide, and cisplatin combination chemotherapy","volume":"30","author":"Pectasides","year":"2009","unstructured":"Pectasides DPectasides EPapaxoinis GSkondra MGerostathou MKarageorgopoulou SKamposioras CTountas NKoumarianou APsyrri A, 2009Testicular function in poor-risk nonseminomatous germ cell tumors treated with methotrexate, paclitaxel, ifosfamide, and cisplatin combination chemotherapy. Journal of Andrology30280\u2013286. 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