{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:45Z","timestamp":1787022825938,"version":"build-2736575974"},"reference-count":26,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":423,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Major Science and Technology Program of Yunnan Province","award":["202302AA310044"],"award-info":[{"award-number":["202302AA310044"]}]},{"name":"Major Science and Technology Program of Yunnan Province","award":["202105AC160012"],"award-info":[{"award-number":["202105AC160012"]}]},{"name":"Major Science and Technology Program of Yunnan Province","award":["202401AS070008"],"award-info":[{"award-number":["202401AS070008"]}]},{"name":"Major Science and Technology Program of Yunnan Province","award":["202301AY070001-227"],"award-info":[{"award-number":["202301AY070001-227"]}]}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>This study reveals the association between gene copy number variants (CNVs) and integrin expression in endometrial tissue, especially focusing on patients with repeated implantation failure and unexplained infertility. CNV expression, integrin \u03b1V\u03b23 (by real-time quantitative polymerase chain reaction and protein immunoblotting), and related clinical indicators were investigated by analyzing endometrial samples from 48 patients with repeated implantation failure and ten patients with infertility who had no history of implantation issues. The results revealed the presence of CNVs in approximately 31.04% of patients with infertility, mainly affecting chromosomes 2, 5, 6, 7, 10, 11, 15, 19 and X. Age was associated with CNV occurrence. Integrin \u03b23 expression was significantly higher in the CNV group than in the non-CNV group among patients with repeated implantation failure. Clinical indicators related to coagulation were significantly different between the CNV and non-CNV groups. The study indicated a potential association between CNVs, increased integrin \u03b23 expression and recurrent implantation failure. The study provides new information for understanding the complex interactions between genetic variants, integrin function and coagulation factors by integrating advanced molecular diagnostic techniques, thereby emphasizing the need for a personalized approach in reproductive medicine. These results may redefine the diagnostic paradigm for recurrent implantation failure, laying the foundation for future translational applications.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Our research has found a link between certain genetic changes and problems with embryo implantation in women struggling with infertility. Specifically, we looked at variations in the number of copies of certain genes, CNVs, and how they relate to a protein called integrin \u03b23 in the lining of the uterus. About one-third of the women we studied had these genetic variations, which were mostly found on chromosomes. We discovered that older women were more likely to have these CNVs, especially those with repeated implantation failure. Furthermore, women with these genetic changes had higher levels of integrin \u03b23 in their uterine lining compared to those without the changes. We also found that these genetic variations were linked to differences in blood platelet counts and blood clotting times, suggesting a possible impact on blood coagulation. Our findings shed light on how genetic changes might influence both the uterine environment and blood clotting, potentially affecting a woman\u2019s ability to conceive. This knowledge could help in developing personalized treatments for women facing recurrent implantation failure, improving their chances of successful pregnancy.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-24-0088","type":"journal-article","created":{"date-parts":[[2025,2,27]],"date-time":"2025-02-27T11:52:12Z","timestamp":1740657132000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":2,"title":["Repeated implantation failures and infertility in patients are strongly associated with elevated integrin B3 caused by endometrial copy number variation"],"prefix":"10.1530","volume":"6","author":[{"given":"Hong-Xia","family":"Xu","sequence":"first","affiliation":[{"name":"Department of Reproductive Medicine, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, First People\u2019s Hospital of Yunnan Province 1 , , ,","place":["Kunming, Yunnan, China"]},{"name":"The Affiliated Hospital 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Kunming University of Science and Technology 2 , , ,","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiang-Jing","family":"Tang","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, First People\u2019s Hospital of Yunnan Province 1 , , ,","place":["Kunming, Yunnan, China"]},{"name":"The Affiliated Hospital of Kunming University of Science and Technology 2 , , ,","place":["Kunming, Yunnan, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian-Mei","family":"Yu","sequence":"additional","affiliation":[{"name":"Department of Reproductive Medicine, NHC Key Laboratory of Healthy Birth and Birth Defect Prevention in Western China, First People\u2019s Hospital of Yunnan Province 1 , , ,","place":["Kunming, Yunnan, China"]},{"name":"The Affiliated Hospital of Kunming University of Science and Technology 2 , , 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