{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,21]],"date-time":"2026-07-21T22:42:39Z","timestamp":1784673759124,"version":"3.55.0"},"reference-count":81,"publisher":"Bioscientifica","issue":"1","license":[{"start":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T00:00:00Z","timestamp":1772236800000},"content-version":"vor","delay-in-days":436,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,1,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>The inability of animals to get pregnant, pregnancy loss and weak or stillborn offspring are significant economic burdens to livestock producers worldwide. Progesterone, the hormone of pregnancy, has a crucial role in the establishment of pregnancy, and it has been suggested that progesterone supplementation may be a promising strategy to improve pregnancy outcomes and conceptus development. This review article describes the existing literature on progesterone supplementation in sheep and pigs in relation to pregnancy outcomes and conceptus development.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>Pregnancy loss and weak offspring are significant problems both in humans and in agriculturally relevant species. Progesterone (the hormone of pregnancy) is important for establishing pregnancy and regulating fetal and placental growth, and it is speculated that progesterone supplementation could be a promising method to improve pregnancy outcomes and both fetal and placental growth. This review article describes the existing literature on progesterone supplementation in sheep and pigs in relation to pregnancy outcomes and fetal and placental development.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-24-0092","type":"journal-article","created":{"date-parts":[[2024,12,19]],"date-time":"2024-12-19T12:33:21Z","timestamp":1734611601000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":2,"title":["Exogenous progesterone supplementation: a strategy to enhance conceptus development in sheep and pigs?"],"prefix":"10.1530","volume":"6","author":[{"given":"Maria F","family":"Tyree","sequence":"first","affiliation":[{"name":"Department of Animal Science, Pennsylvania State University , , ,","place":["University Park, Pennsylvania, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8302-7900","authenticated-orcid":true,"given":"Claire","family":"Stenhouse","sequence":"additional","affiliation":[{"name":"Department of Animal Science, Pennsylvania State University , , ,","place":["University Park, Pennsylvania, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2024,12,19]]},"reference":[{"key":"2026070713180759500_bib1","doi-asserted-by":"crossref","first-page":"106656","DOI":"10.1016\/j.domaniend.2021.106656","article-title":"Pregnancy in pigs: the journey of an early life","volume":"78","author":"Almeida","year":"2022","journal-title":"Domest Anim Endocrinol"},{"key":"2026070713180759500_bib2","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/0378-4320(91)90056-6","article-title":"Effect of pre-mating nutritional status and post-mating progesterone supplementation on embryo survival and conceptus growth in gilts","volume":"26","author":"Ashworth","year":"1991","journal-title":"Anim Reprod Sci"},{"key":"2026070713180759500_bib3","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1530\/REP-10-0170","article-title":"Effects of long-term progesterone on developmental and functional aspects of porcine uterine epithelia and vasculature: progesterone alone does not support development of uterine glands comparable to that of pregnancy","volume":"140","author":"Bailey","year":"2010","journal-title":"Reproduction"},{"key":"2026070713180759500_bib4","doi-asserted-by":"crossref","first-page":"1376","DOI":"10.2527\/jas1975.4151376x","article-title":"Uterine protein secretions: relationship to development of the conceptus","volume":"41","author":"Bazer","year":"1975","journal-title":"J Anim Sci"},{"key":"2026070713180759500_bib5","first-page":"39","article-title":"Physiological mechanisms of pregnancy recognition in ruminants","volume":"43","author":"Bazer","year":"1991","journal-title":"J Reprod Fert"},{"key":"2026070713180759500_bib6","first-page":"1","volume-title":"Endocrinology of Pregnancy. 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