{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:19:38Z","timestamp":1783448378940,"version":"3.55.0"},"reference-count":40,"publisher":"Bioscientifica","issue":"4","license":[{"start":{"date-parts":[[2026,6,15]],"date-time":"2026-06-15T00:00:00Z","timestamp":1781481600000},"content-version":"vor","delay-in-days":257,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2025,10,1]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>In this study, we aimed to uncover the perspectives of male childhood cancer survivors on parenthood, fertility preservation, and potential fertility restoration using their own cryopreserved testicular biopsy. We invited all young men eligible for this study, 27 male cancer survivors over the age of 16 who had undergone a testicular tissue biopsy in the past in Amsterdam, of whom five men (18.5% response rate) decided to participate. In semi-structured interviews, we discussed their views on parenthood, testicular cryopreservation, and potential fertility restoration, specifically through spermatogonial stem cell transplantation (SSCT). All data were pseudonymized before analysis via open coding using MAXQDA software. We found that all five participants (ages 17\u201324) had actively thought about family planning, and some expressed a very strong wish to experience parenthood, although they were aware of potential fertility issues related to their treatments. However, these participants reported that fertility issues had been minimally discussed at the late effects clinic during checkups, and they therefore had a limited understanding of the potential and restrictions of fertility restoration techniques such as SSCT. Overall, these participants displayed a high willingness to undertake additional steps to achieve biological parenthood and low levels of concern regarding the safety of SSCT. Autonomy and the opportunity of choice were determining factors in their underlying views. Perspectives and needs of these survivors, for whom a testicular biopsy was cryopreserved as a child, predominantly revolved around the importance of having autonomy over their fertility choices and being adequately informed to make those choices.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Treatments for childhood cancer may lead to infertility. To safeguard the fertility of young male cancer patients, a testicular biopsy can be frozen that contains spermatogonial stem cells (SSCs), the basis for spermatogenesis. This study focused on SSCT, a new fertility restoration treatment. Through interviews with five male survivors (aged 17\u201324), we explored their experiences and opinions on fertility preservation and restoration. In general, participants were happy with their parents\u2019 decision to freeze a biopsy. The freedom to choose was a key topic for them. They were willing to take the required steps to reach parenthood if desired. They had few concerns about the safety of SSCT but had questions about the chances of success. Their trust in science and healthcare was strong. However, in their experience, fertility was not sufficiently discussed during follow-up care. The results support doctors, former childhood cancer patients, and their parents concerning fertility after childhood cancer.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-25-0071","type":"journal-article","created":{"date-parts":[[2025,11,7]],"date-time":"2025-11-07T11:37:50Z","timestamp":1762515470000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":1,"title":["Views of male childhood cancer survivors on fertility preservation and restoration"],"prefix":"10.1530","volume":"6","author":[{"given":"Jillis","family":"van Maaren","sequence":"first","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nienke","family":"de Graeff","sequence":"additional","affiliation":[{"name":"3"},{"name":"4"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jaap G","family":"den Hartogh","sequence":"additional","affiliation":[{"name":"5"},{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alied M","family":"van der Aa\u2013van Delden","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marianne D","family":"van de Wetering","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Heleen J H","family":"van der Pal","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leontien C M","family":"Kremer","sequence":"additional","affiliation":[{"name":"6"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ans M M","family":"van Pelt","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9160-7585","authenticated-orcid":true,"given":"Callista L","family":"Mulder","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2025,11,6]]},"reference":[{"key":"2026070714101863700_bib1","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1089\/jayao.2015.0024","article-title":"Fertility issues in adolescent and young adult cancer survivors","volume":"5","author":"Benedict","year":"2016","journal-title":"J Adolesc Young Adult Oncol"},{"key":"2026070714101863700_bib2","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.28507","article-title":"A prospective study on the long-term outcome of prepubertal and pubertal boys undergoing testicular biopsy for fertility preservation prior to hematologic stem cell transplantation","volume":"67","author":"Borgstr\u00f6m","year":"2020","journal-title":"Pediatr Blood Cancer"},{"key":"2026070714101863700_bib3","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1016\/S1470-2045(22)00637-4","article-title":"Long-term survival and cure fraction estimates for childhood cancer in Europe (EUROCARE-6): results from a population-based study","volume":"23","author":"Botta","year":"2022","journal-title":"Lancet Oncol"},{"key":"2026070714101863700_bib4","doi-asserted-by":"crossref","DOI":"10.1177\/1179558119886342","article-title":"Setting up a cryopreservation programme for immature testicular tissue: lessons learned after more than 15 years of experience","volume":"13","author":"Braye","year":"2019","journal-title":"Clin Med Insights Reprod Health"},{"key":"2026070714101863700_bib5","doi-asserted-by":"crossref","DOI":"10.1002\/pbc.30370","article-title":"Gonadal development and function after immature testicular tissue banking as part of high-risk gonadotoxic treatment","volume":"70","author":"Braye","year":"2023","journal-title":"Pediatr Blood Cancer"},{"key":"2026070714101863700_bib6","doi-asserted-by":"crossref","first-page":"11303","DOI":"10.1073\/pnas.91.24.11303","article-title":"Germline transmission of donor haplotype following spermatogonial transplantation","volume":"91","author":"Brinster","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070714101863700_bib7","doi-asserted-by":"crossref","first-page":"11298","DOI":"10.1073\/pnas.91.24.11298","article-title":"Spermatogenesis following male germ-cell transplantation","volume":"91","author":"Brinster","year":"1994","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026070714101863700_bib8","first-page":"428","article-title":"The long-term psychosocial impact of cancer: the views of young adult survivors of childhood cancer","volume":"25","author":"Brown","year":"2016","journal-title":"Eur J Cancer Care"},{"key":"2026070714101863700_bib9","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1080\/17460751.2024.2386214","article-title":"Patient, parent and professional expert perspectives on personalized regenerative implants: a qualitative focus group study","volume":"19","author":"Daal","year":"2024","journal-title":"Regen Med"},{"key":"2026070714101863700_bib10","doi-asserted-by":"crossref","DOI":"10.1515\/med-2025-1144","article-title":"The era of increasing cancer survivorship: trends in fertility preservation, medico-legal implications, and ethical challenges","volume":"20","author":"De Paola","year":"2025","journal-title":"Open Med"},{"key":"2026070714101863700_bib11","doi-asserted-by":"crossref","first-page":"2109","DOI":"10.3390\/cancers16112109","article-title":"Fertility-preserving treatments and patient- and parental satisfaction on fertility counseling in a cohort of newly diagnosed boys and girls with childhood hodgkin lymphoma","volume":"16","author":"Drechsel","year":"2024","journal-title":"Cancers"},{"key":"2026070714101863700_bib12","doi-asserted-by":"crossref","first-page":"hoae010","DOI":"10.1093\/hropen\/hoae010","article-title":"A 20-year overview of fertility preservation in boys: new insights gained through a comprehensive international survey","volume":"2024","author":"Duffin","year":"2024","journal-title":"Hum Reprod Open"},{"key":"2026070714101863700_bib14","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1002\/pbc.21257","article-title":"Sperm banking for adolescent and young adult cancer patients: sperm quality, patient, and parent perspectives","volume":"50","author":"Ginsberg","year":"2008","journal-title":"Pediatr Blood Cancer"},{"key":"2026070714101863700_bib13","first-page":"1391","article-title":"ESHRE good practice recommendations on fertility preservation involving testicular tissue cryopreservation in children receiving gonadotoxic therapies","volume":"40","author":"ESHRE FP for Boys Working Group","year":"2025","journal-title":"Hum Reprod"},{"key":"2026070714101863700_bib15","doi-asserted-by":"crossref","first-page":"1673","DOI":"10.1002\/pbc.25078","article-title":"Testicular tissue cryopreservation in prepubertal male children: an analysis of parental decision-making","volume":"61","author":"Ginsberg","year":"2014","journal-title":"Pediatr Blood Cancer"},{"key":"2026070714101863700_bib16","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1002\/pon.622","article-title":"The psycho-social impact of infertility on young male cancer survivors: a qualitative investigation","volume":"12","author":"Green","year":"2003","journal-title":"Psychooncology"},{"key":"2026070714101863700_bib17","doi-asserted-by":"crossref","first-page":"715","DOI":"10.1016\/j.stem.2012.07.017","article-title":"Spermatogonial stem cell transplantation into rhesus testes regenerates spermatogenesis producing functional sperm","volume":"11","author":"Hermann","year":"2012","journal-title":"Cell Stem Cell"},{"key":"2026070714101863700_bib18","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1095\/biolreprod.103.017012","article-title":"Long-term proliferation in culture and germline transmission of mouse male germline stem cells","volume":"69","author":"Kanatsu-Shinohara","year":"2003","journal-title":"Biol Reprod"},{"key":"2026070714101863700_bib19","first-page":"26","article-title":"Long-term follow-up of boys who have undergone a testicular biopsy for fertility preservation","volume":"36","author":"Kanbar","year":"2021","journal-title":"Hum Reprod"},{"key":"2026070714101863700_bib20","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1080\/07347332.2011.644396","article-title":"\u201cYou\u2019re too young for this\u201d: adolescent and young adults\u2019 perspectives on cancer survivorship","volume":"30","author":"Kent","year":"2012","journal-title":"J Psychosoc Oncol"},{"key":"2026070714101863700_bib21","doi-asserted-by":"crossref","first-page":"726","DOI":"10.1089\/jayao.2023.0191","article-title":"Determinants of decision regret regarding fertility preservation in adolescent and young adult cancer survivors: a systematic review","volume":"13","author":"Kuntz","year":"2024","journal-title":"J Adolesc Young Adult Oncol"},{"key":"2026070714101863700_bib22","doi-asserted-by":"crossref","first-page":"598","DOI":"10.1111\/aogs.13551","article-title":"Oncologists\u2019 and pediatric oncologists\u2019 perspectives and challenges for fertility preservation","volume":"98","author":"Lampic","year":"2019","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2026070714101863700_bib23","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1002\/pon.4927","article-title":"Systematic review of fertility-related psychological distress in cancer patients: informing on an improved model of care","volume":"28","author":"Logan","year":"2019","journal-title":"Psychooncology"},{"key":"2026070714101863700_bib24","doi-asserted-by":"crossref","DOI":"10.1002\/pon.9313","article-title":"Risk and protective factors of psychosocial functioning in survivors of childhood cancer: results of the DCCSS-LATER study","volume":"33","author":"Maas","year":"2024","journal-title":"Psychooncology"},{"key":"2026070714101863700_bib25","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1093\/humrep\/dex348","article-title":"Long-term health in recipients of transplanted in vitro propagated spermatogonial stem cells","volume":"33","author":"Mulder","year":"2018","journal-title":"Hum Reprod"},{"key":"2026070714101863700_bib26","doi-asserted-by":"crossref","first-page":"e57","DOI":"10.1016\/S1470-2045(20)30582-9","article-title":"Fertility preservation for male patients with childhood, adolescent, and young adult cancer: recommendations from the PanCareLIFE consortium and the international late effects of childhood cancer guideline harmonization group","volume":"22","author":"Mulder","year":"2021","journal-title":"Lancet Oncol"},{"key":"2026070714101863700_bib27","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1111\/1467-9566.13581","article-title":"Patient informed choice in the age of evidence-based medicine: IVF patients\u2019 approaches to biomedical evidence and fertility treatment add-ons","volume":"45","author":"Perrotta","year":"2023","journal-title":"Sociol Health Illn"},{"key":"2026070714101863700_bib28","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1001\/jama.2009.1689","article-title":"Propagation of human spermatogonial stem cells in vitro","volume":"302","author":"Sadri-Ardekani","year":"2009","journal-title":"JAMA"},{"key":"2026070714101863700_bib29","doi-asserted-by":"crossref","first-page":"2416","DOI":"10.1001\/jama.2011.791","article-title":"In vitro propagation of human prepubertal spermatogonial stem cells","volume":"305","author":"Sadri-Ardekani","year":"2011","journal-title":"JAMA"},{"key":"2026070714101863700_bib30","doi-asserted-by":"crossref","DOI":"10.3389\/fendo.2022.850219","article-title":"Spermatogonial stem cell-based therapies: taking preclinical research to the next level","volume":"13","author":"Sanou","year":"2022","journal-title":"Front Endocrinol"},{"key":"2026070714101863700_bib31","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1093\/jncimonographs\/lgi010","article-title":"Motivation for parenthood after cancer: a review","volume":"34","author":"Schover","year":"2005","journal-title":"J Natl Cancer Inst Monogr"},{"key":"2026070714101863700_bib32","doi-asserted-by":"crossref","DOI":"10.1002\/ctm2.531","article-title":"Impact of restoring male fertility with transplantation of in vitro propagated spermatogonial stem cells on the health of their offspring throughout life","volume":"11","author":"Serrano","year":"2021","journal-title":"Clin Transl Med"},{"key":"2026070714101863700_bib33","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1186\/s13148-023-01469-x","article-title":"Sperm DNA methylation is predominantly stable in mice offspring born after transplantation of long-term cultured spermatogonial stem cells","volume":"15","author":"Serrano","year":"2023","journal-title":"Clin Epigenetics"},{"key":"2026070714101863700_bib34","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1089\/jayao.2014.0007","article-title":"Fertility preservation preferences and perspectives among adult Male survivors of pediatric cancer and their parents","volume":"3","author":"Stein","year":"2014","journal-title":"J Adolesc Young Adult Oncol"},{"key":"2026070714101863700_bib35","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1089\/jayao.2014.0036","article-title":"A qualitative study of the impact of cancer on romantic relationships, sexual relationships, and fertility: perspectives of Canadian adolescents and parents during and after treatment","volume":"4","author":"Stinson","year":"2015","journal-title":"J Adolesc Young Adult Oncol"},{"key":"2026070714101863700_bib36","volume-title":"Basics of Qualitative Research: Grounded Theory Procedures and Techniques","author":"Strauss","year":"1990"},{"key":"2026070714101863700_bib37","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1016\/j.jpag.2016.04.005","article-title":"Fertility preservation after a cancer diagnosis: a systematic review of adolescents\u2019, parents\u2019, and providers\u2019 perspectives, experiences, and preferences","volume":"29","author":"Taylor","year":"2016","journal-title":"J Pediatr Adolesc Gynecol"},{"key":"2026070714101863700_bib38","doi-asserted-by":"crossref","first-page":"2366","DOI":"10.1093\/humrep\/dex306","article-title":"Development of the testis in pre-pubertal boys with cancer after biopsy for fertility preservation","volume":"32","author":"Uijldert","year":"2017","journal-title":"Hum Reprod"},{"key":"2026070714101863700_bib39","doi-asserted-by":"crossref","first-page":"2022","DOI":"10.1093\/humrep\/dev161","article-title":"Fertility preservation in the male pediatric population: factors influencing the decision of parents and children","volume":"30","author":"Wyns","year":"2015","journal-title":"Hum Reprod"},{"key":"2026070714101863700_bib40","doi-asserted-by":"crossref","first-page":"255","DOI":"10.5534\/wjmh.220102","article-title":"Long-term fertility function sequelae in young male cancer survivors","volume":"41","author":"Yumura","year":"2023","journal-title":"World J Mens Health"}],"container-title":["Reproduction and Fertility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/raf.bioscientifica.com\/view\/journals\/raf\/6\/4\/RAF-25-0071.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/raf.bioscientifica.com\/downloadpdf\/journals\/raf\/6\/4\/RAF-25-0071.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-25-0071\/508556\/raf-25-0071.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-25-0071\/508556\/raf-25-0071.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:10:28Z","timestamp":1783447828000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article\/6\/4\/e250071\/76008\/Views-of-male-childhood-cancer-survivors-on"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2025,10,1]]},"references-count":40,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2025,10,1]]}},"URL":"https:\/\/doi.org\/10.1530\/raf-25-0071","relation":{},"ISSN":["2633-8386"],"issn-type":[{"value":"2633-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2025,10,1]]},"article-number":"e250071"}}