{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T19:44:21Z","timestamp":1782848661172,"version":"3.54.5"},"reference-count":172,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T00:00:00Z","timestamp":1775001600000},"content-version":"unspecified","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["raf.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,9]]},"abstract":"<jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Moderate and high levels of anticardiolipin antibodies (aCL) are associated with pregnancy-related complications, thrombosis, and other cardiovascular diseases. However, the clinical impact of isolated low IgM aCL levels on pregnancy outcomes has not yet been demonstrated in large-scale analyses. This study aimed to evaluate whether isolated low aCL levels induce epigenetic changes at early stages of gestation in otherwise normally ongoing pregnancies. The expression of 29 microRNAs linked to adverse obstetric outcomes and cardiovascular risk was assessed in 40 singleton normal term pregnancies with isolated low IgM aCL levels (IgM aCL &lt;40 MPL units, IgG aCL negative) and 75 gestational-age-matched aCL-negative controls, using reverse transcription real-time polymerase chain reaction. Two microRNAs (miR-100-5p and miR-199a-5p) were upregulated, and seven (miR-130b-3p, miR-133a-3p, miR-145-5p, miR-155-5p, miR-210-3p, miR-342-3p, and miR-574-3p) were downregulated in normal term pregnancies with isolated low IgM aCL levels. After adjusting for maternal age, pre-pregnancy BMI, smoking, autoimmune disease, inherited thrombophilia, history of precancerosis, and ART conception, dysregulation of miR-133a-3p, miR-145-5p, and miR-574-3p remained statistically significant. Logistic regression (enter and backward methods) achieved very good performance in differentiating between cases and controls (areas under curve 0.917 and 0.908, respectively; 77.50% sensitivities at 10% false-positive rate; 86.96% accuracies). Using the multilayer perceptron, a type of artificial neural network, multiple models based on nine microRNAs were constructed. Some of them had better overall performance than the logistic regression approach. Isolated low IgM aCL positivity can adversely modify the epigenetic profile, which under additional unfavorable conditions may lead to pregnancy complications and increased cardiovascular risk.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Some women have certain antibodies in their blood called aCL (anticardiolipin antibodies). These antibodies can sometimes be linked to pregnancy complications or a higher risk of heart disease. This study explored whether low levels of one type of these antibodies (called IgM aCL) early in pregnancy might still affect the body in ways that might matter later. We compared pregnant women with low levels of these antibodies to those without the antibodies and examined microRNAs \u2013 tiny molecules that help control cell activity \u2013 in their blood. Even low antibody levels were linked to small changes in microRNAs during the first trimester. Some of these changes resembled patterns seen in pregnancies that later develop complications or in people with increased cardiovascular risk. These findings do not mean that low antibody levels always cause problems. Instead, they suggest that such antibodies may slightly increase vulnerability, especially when combined with other risk factors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-25-0101","type":"journal-article","created":{"date-parts":[[2026,4,10]],"date-time":"2026-04-10T17:41:22Z","timestamp":1775842882000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":0,"title":["MicroRNA profile in normal pregnancies with isolated low IgM anticardiolipin levels"],"prefix":"10.1530","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0003-9897-4259","authenticated-orcid":true,"given":"Veronika V","family":"Matraszek","sequence":"first","affiliation":[{"name":"Department of Molecular Biology and Cell Pathology, Clinic of Obstetrics and Gynaecology, Institute for the Care of Mother and Child, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katerina","family":"Kotlabova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Cell Pathology, Clinic of Obstetrics and Gynaecology, Institute for the Care of Mother and Child, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ladislav","family":"Krofta","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Cell Pathology, Clinic of Obstetrics and Gynaecology, Institute for the Care of Mother and Child, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ilona","family":"Hromadnikova","sequence":"additional","affiliation":[{"name":"Department of Molecular Biology and Cell Pathology, Clinic of Obstetrics and Gynaecology, Institute for the Care of Mother and Child, Third Faculty of Medicine, Charles University, Prague, Czech Republic"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","reference":[{"key":"bib1","series-title":"Thromb Res","first-page":"77","article-title":"The association between antiphospholipid antibodies and placenta mediated complications: a systematic review and meta analysis","volume":"128","author":"Abou Nassar K","year":"2011","unstructured":"Abou Nassar K\n, \nCarrier M\n, \nRamsay T\n, et al.\n 2011 The association between antiphospholipid antibodies and placenta mediated complications: a systematic review and meta analysis. Thromb Res 128 77\u201385. (https:\/\/doi.org\/10.1016\/j.thromres.2011.02.006)"},{"key":"bib2","series-title":"Diabetes Res Clin Pract","first-page":"35","article-title":"MicroRNA expression profile in plasma from type 1 diabetic patients","volume":"141","author":"Assmann TS","year":"2018","unstructured":"Assmann TS\n, \nRecamonde Mendoza M\n, \nPu\u00f1ales M\n, et al.\n 2018 MicroRNA expression profile in plasma from type 1 diabetic patients. Diabetes Res Clin Pract 141 35\u201346. (https:\/\/doi.org\/10.1016\/j.diabres.2018.03.044)"},{"key":"bib3","series-title":"Diabetol Metab Syndr","first-page":"6","article-title":"Study on inflammation related genes and microRNAs in T2D","volume":"8","author":"Balde\u00f3n Rojas L","year":"2016","unstructured":"Balde\u00f3n Rojas L\n, \nWeigelt K\n, \nde Wit H\n, et al.\n 2016 Study on inflammation related genes and microRNAs in T2D. Diabetol Metab Syndr 8 6. (https:\/\/doi.org\/10.1186\/s13098-015-0113-5)"},{"key":"bib4","series-title":"Arthritis Rheumatol","first-page":"1687","article-title":"The 2023 ACR\/EULAR antiphospholipid syndrome classification criteria","volume":"75","author":"Barbhaiya M","year":"2023","unstructured":"Barbhaiya M\n, \nZuily S\n, \nNaden R\n, et al.\n 2023 The 2023 ACR\/EULAR antiphospholipid syndrome classification criteria. Arthritis Rheumatol 75 1687\u20131702. (https:\/\/doi.org\/10.1002\/art.42624)"},{"key":"bib5","series-title":"ESC Heart Fail","first-page":"835","article-title":"Cardiac peripheral microRNA gradients in systolic heart failure","volume":"7","author":"Ben Zvi I","year":"2020","unstructured":"Ben Zvi I\n, \nVolinsky N\n, \nGrosman Rimon L\n, et al.\n 2020 Cardiac peripheral microRNA gradients in systolic heart failure. ESC Heart Fail 7 835\u2013843. (https:\/\/doi.org\/10.1002\/ehf2.12597)"},{"key":"bib6","series-title":"J Roy Stat Soc B","first-page":"289","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Benjamini Y\n & \nHochberg Y\n\n 1995 Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 57 289\u2013300. (https:\/\/doi.org\/10.1111\/j.2517-6161.1995.tb02031.x)"},{"key":"bib7","series-title":"Blood","first-page":"404","article-title":"Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH APS observational study","volume":"123","author":"Bouvier S","year":"2014","unstructured":"Bouvier S\n, \nCochery Nouvellon E\n, \nLavigne Lissalde G\n, et al.\n 2014 Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH APS observational study. Blood 123 404\u2013413. (https:\/\/doi.org\/10.1182\/blood-2013-08-522623)"},{"key":"bib8","series-title":"Sci Rep","first-page":"7517","article-title":"Plasma microRNA profile in dilated cardiomyopathy","volume":"11","author":"Calderon Dominguez M","year":"2021","unstructured":"Calderon Dominguez M\n, \nBelmonte T\n, \nQuezada Feijoo M\n, et al.\n 2021 Plasma microRNA profile in dilated cardiomyopathy. Sci Rep 11 7517. (https:\/\/doi.org\/10.1038\/s41598-021-87086-1)"},{"key":"bib9","series-title":"J Am Heart Assoc","article-title":"Transpulmonary expression of exosomal microRNAs in PAH","volume":"12","author":"Chang WT","year":"2023","unstructured":"Chang WT\n, \nLee WC\n, \nLin YW\n, et al.\n 2023 Transpulmonary expression of exosomal microRNAs in PAH. J Am Heart Assoc 12 031435. (https:\/\/doi.org\/10.1161\/jaha.123.031435)"},{"key":"bib10","series-title":"J Thromb Haemostasis","first-page":"169","article-title":"The (non-)sense of detecting anticardiolipin and anti \u03b22 glycoprotein I IgM antibodies in the antiphospholipid syndrome","volume":"18","author":"Chayoua W","year":"2020","unstructured":"Chayoua W\n, \nKelchtermans H\n, \nGris JC\n, et al.\n 2020 The (non-)sense of detecting anticardiolipin and anti \u03b22 glycoprotein I IgM antibodies in the antiphospholipid syndrome. J Thromb Haemostasis 18 169\u2013179. (https:\/\/doi.org\/10.1111\/jth.14633)"},{"key":"bib11","series-title":"Eur Rev Med Pharmacol Sci","first-page":"2223","article-title":"miR 155 5p inhibits VSMC and HUVEC proliferation in atherosclerosis","volume":"23","author":"Chen L","year":"2019","unstructured":"Chen L\n, \nZheng SY\n, \nYang CQ\n, et al.\n 2019 miR 155 5p inhibits VSMC and HUVEC proliferation in atherosclerosis. Eur Rev Med Pharmacol Sci 23 2223\u20132233. (https:\/\/doi.org\/10.26355\/eurrev_201903_17270)"},{"key":"bib12","series-title":"Nat Rev Genet","first-page":"704","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce CM","year":"2009","unstructured":"Croce CM\n\n 2009 Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 10 704\u2013714. (https:\/\/doi.org\/10.1038\/nrg2634)"},{"key":"bib13","series-title":"Angiology","first-page":"357","article-title":"Anticardiolipin antibodies as a risk factor of atherosclerosis in intermittent claudication","volume":"55","author":"de Godoy JM","year":"2004","unstructured":"de Godoy JM\n, \nBatig\u00e1lia F\n, \nde Godoy MR\n, et al.\n 2004 Anticardiolipin antibodies as a risk factor of atherosclerosis in intermittent claudication. Angiology 55 357\u2013359. (https:\/\/doi.org\/10.1177\/000331970405500402)"},{"key":"bib14","series-title":"Med Sci Monit","first-page":"CR430","article-title":"Vascular dementia and anticardiolipin antibodies","volume":"11","author":"de Godoy JM","year":"2005","unstructured":"de Godoy JM\n, \nde Godoy MR\n, \nCipulo JP\n, et al.\n 2005 Vascular dementia and anticardiolipin antibodies. Med Sci Monit 11 CR430\u2013CR433."},{"key":"bib15","series-title":"Angiology","first-page":"79","article-title":"Recurrent thrombosis in patients with deep vein thrombosis and\/or venous thromboembolism associated with anticardiolipin antibodies","volume":"57","author":"de Godoy JM","year":"2006","unstructured":"de Godoy JM\n, \nde Godoy MF\n & \nBraile DM\n\n 2006 Recurrent thrombosis in patients with deep vein thrombosis and\/or venous thromboembolism associated with anticardiolipin antibodies. Angiology 57 79\u201383. (https:\/\/doi.org\/10.1177\/000331970605700111)"},{"key":"bib16","series-title":"Thromb Res","first-page":"883","article-title":"The clinical relevance of the IgM isotype of antiphospholipid antibodies in the vascular antiphospholipid syndrome","volume":"136","author":"Del Ross T","year":"2015","unstructured":"Del Ross T\n, \nRuffatti A\n, \nCuffaro S\n, et al.\n 2015 The clinical relevance of the IgM isotype of antiphospholipid antibodies in the vascular antiphospholipid syndrome. Thromb Res 136 883\u2013886. (https:\/\/doi.org\/10.1016\/j.thromres.2015.08.019)"},{"key":"bib17","series-title":"Biosci Rep","article-title":"Combined detection of multiple microRNAs for early heart failure","volume":"40","author":"Ding H","year":"2020","unstructured":"Ding H\n, \nWang Y\n, \nHu L\n, et al.\n 2020 Combined detection of multiple microRNAs for early heart failure. Biosci Rep 40 BSR20191653. (https:\/\/doi.org\/10.1042\/bsr20191653)"},{"key":"bib18","series-title":"Obstet Gynecol","first-page":"1433","article-title":"Association of anticardiolipin antibodies with preeclampsia: a systematic review and meta analysis","volume":"116","author":"do Prado AD","year":"2010","unstructured":"do Prado AD\n, \nPiovesan DM\n, \nStaub HL\n, et al.\n 2010 Association of anticardiolipin antibodies with preeclampsia: a systematic review and meta analysis. Obstet Gynecol 116 1433\u20131443. (https:\/\/doi.org\/10.1097\/aog.0b013e3181fe02ec)"},{"key":"bib19","series-title":"JCI Insight","article-title":"Profiling circulating microRNAs in children with recent onset type 1 diabetes","volume":"2","author":"Erener S","year":"2017","unstructured":"Erener S\n, \nMarwaha A\n, \nTan R\n, et al.\n 2017 Profiling circulating microRNAs in children with recent onset type 1 diabetes. JCI Insight 2 e89656. (https:\/\/doi.org\/10.1172\/jci.insight.89656)"},{"key":"bib20","series-title":"Genome Res","first-page":"92","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman RC","year":"2009","unstructured":"Friedman RC\n, \nFarh KK\n, \nBurge CB\n, et al.\n 2009 Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19 92\u2013105. (https:\/\/doi.org\/10.1101\/gr.082701.108)"},{"key":"bib21","series-title":"Blood","first-page":"1827","article-title":"Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature","volume":"101","author":"Galli M","year":"2003","unstructured":"Galli M\n, \nLuciani D\n, \nBertolini G\n, et al.\n 2003 Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 101 1827\u20131832. (https:\/\/doi.org\/10.1182\/blood-2002-02-0441)"},{"key":"bib22","series-title":"Rheumatol","first-page":"24","article-title":"Epidemiology of antiphospholipid syndrome: macro and microvascular manifestations","volume":"63","author":"Gaspar P","year":"2024","unstructured":"Gaspar P\n, \nSciascia S\n & \nTektonidou MG\n\n 2024 Epidemiology of antiphospholipid syndrome: macro and microvascular manifestations. Rheumatol 63 24\u201336. (https:\/\/doi.org\/10.1093\/rheumatology\/kead571)"},{"key":"bib23","series-title":"J Personalized Med","first-page":"770","article-title":"Dysregulated miRNAs as biomarkers and therapeutic targets in neurodegenerative diseases","volume":"12","author":"Gentile G","year":"2022","unstructured":"Gentile G\n, \nMorello G\n, \nLa Cognata V\n, et al.\n 2022 Dysregulated miRNAs as biomarkers and therapeutic targets in neurodegenerative diseases. J Personalized Med 12 770. (https:\/\/doi.org\/10.3390\/jpm12050770)"},{"key":"bib24","series-title":"Mol Hum Reprod","first-page":"465","article-title":"Antiphospholipid antibody induced miR 146a 3p drives trophoblast interleukin 8 secretion through activation of toll like receptor 8","volume":"22","author":"Gysler SM","year":"2016","unstructured":"Gysler SM\n, \nMulla MJ\n, \nGuerra M\n, et al.\n 2016 Antiphospholipid antibody induced miR 146a 3p drives trophoblast interleukin 8 secretion through activation of toll like receptor 8. Mol Hum Reprod 22 465\u2013474. (https:\/\/doi.org\/10.1093\/molehr\/gaw027)"},{"key":"bib25","series-title":"J Transl Med","first-page":"407","article-title":"Atrial myocyte derived exosomal microRNA in atrial fibrosis","volume":"20","author":"Hao H","year":"2022","unstructured":"Hao H\n, \nYan S\n, \nZhao X\n, et al.\n 2022 Atrial myocyte derived exosomal microRNA in atrial fibrosis. J Transl Med 20 407. (https:\/\/doi.org\/10.1186\/s12967-022-03617-y)"},{"key":"bib26","series-title":"Cell Immunol","first-page":"70","article-title":"microRNA 342, microRNA 191 and microRNA 510 are differentially expressed in T regulatory cells of type 1 diabetic patients","volume":"260","author":"Hezova R","year":"2010","unstructured":"Hezova R\n, \nSlaby O\n, \nFaltejskova P\n, et al.\n 2010 microRNA 342, microRNA 191 and microRNA 510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell Immunol 260 70\u201374. (https:\/\/doi.org\/10.1016\/j.cellimm.2009.10.012)"},{"key":"bib27","series-title":"Thromb Res","first-page":"126","article-title":"Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood","volume":"137","author":"Hromadnikova I","year":"2016","unstructured":"Hromadnikova I\n, \nKotlabova K\n, \nHympanova L\n, et al.\n 2016 Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood. Thromb Res 137 126\u2013140. (https:\/\/doi.org\/10.1016\/j.thromres.2015.11.032)"},{"key":"bib28","series-title":"Int J Mol Sci","article-title":"Cardiovascular disease associated microRNAs as novel biomarkers of first trimester screening for gestational diabetes mellitus","volume":"23","author":"Hromadnikova I","year":"2022a","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022a Cardiovascular disease associated microRNAs as novel biomarkers of first trimester screening for gestational diabetes mellitus. Int J Mol Sci 23 10635. (https:\/\/doi.org\/10.3390\/ijms231810635)"},{"key":"bib29","series-title":"Biomedicines","first-page":"256","article-title":"Cardiovascular disease associated microRNA dysregulation during the first trimester in women with chronic hypertension or those developing gestational hypertension or preeclampsia","volume":"10","author":"Hromadnikova I","year":"2022b","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022b Cardiovascular disease associated microRNA dysregulation during the first trimester in women with chronic hypertension or those developing gestational hypertension or preeclampsia. Biomedicines 10 256. (https:\/\/doi.org\/10.3390\/biomedicines10020256)"},{"key":"bib30","series-title":"Biomedicines","first-page":"718","article-title":"First trimester screening for fetal growth restriction and small for gestational age pregnancies using cardiovascular disease associated microRNA biomarkers","volume":"10","author":"Hromadnikova I","year":"2022c","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022c First trimester screening for fetal growth restriction and small for gestational age pregnancies using cardiovascular disease associated microRNA biomarkers. Biomedicines 10 718. (https:\/\/doi.org\/10.3390\/biomedicines10030718)"},{"key":"bib31","series-title":"Int J Mol Sci","first-page":"3951","article-title":"First trimester prediction of preterm delivery using cardiovascular disease associated microRNA biomarkers","volume":"23","author":"Hromadnikova I","year":"2022d","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022d First trimester prediction of preterm delivery using cardiovascular disease associated microRNA biomarkers. Int J Mol Sci 23 3951. (https:\/\/doi.org\/10.3390\/ijms23073951)"},{"key":"bib32","series-title":"Int J Mol Sci","article-title":"First trimester screening for miscarriage or stillbirth using microRNA biomarkers","volume":"24","author":"Hromadnikova I","year":"2023a","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2023a First trimester screening for miscarriage or stillbirth using microRNA biomarkers. Int J Mol Sci 24 10137. (https:\/\/doi.org\/10.3390\/ijms241210137)"},{"key":"bib33","series-title":"Int J Mol Sci","first-page":"5177","article-title":"First trimester screening for HELLP syndrome using microRNA biomarkers and maternal clinical characteristics","volume":"24","author":"Hromadnikova I","year":"2023b","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2023b First trimester screening for HELLP syndrome using microRNA biomarkers and maternal clinical characteristics. Int J Mol Sci 24 5177. (https:\/\/doi.org\/10.3390\/ijms24065177)"},{"key":"bib34","series-title":"Nucleic Acids Res","first-page":"222","article-title":"miRTarBase update 2022: an informative resource for experimentally validated miRNA target interactions","volume":"50","author":"Huang HY","year":"2022","unstructured":"Huang HY\n, \nLin YC\n, \nCui S\n, et al.\n 2022 miRTarBase update 2022: an informative resource for experimentally validated miRNA target interactions. Nucleic Acids Res 50 222\u2013230. (https:\/\/doi.org\/10.1093\/nar\/gkab1079)"},{"key":"bib35","series-title":"Rheumatol Int","first-page":"1329","article-title":"miR 19b 3p and miR 20a 5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome","volume":"41","author":"Ju\u00e1rez Vicu\u00f1a Y","year":"2021","unstructured":"Ju\u00e1rez Vicu\u00f1a Y\n, \nGuzm\u00e1n Mart\u00edn CA\n, \nMart\u00ednez Mart\u00ednez LA\n, et al.\n 2021 miR 19b 3p and miR 20a 5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome. Rheumatol Int 41 1329\u20131335. (https:\/\/doi.org\/10.1007\/s00296-021-04864-w)"},{"key":"bib36","series-title":"Noncoding RNA","first-page":"64","article-title":"Machine learning model based on microRNAs for essential hypertension","volume":"9","author":"Jusic A","year":"2023","unstructured":"Jusic A\n, \nJunuzovic I\n, \nHujdurovic A\n, et al.\n 2023 Machine learning model based on microRNAs for essential hypertension. Noncoding RNA 9 64. (https:\/\/doi.org\/10.3390\/ncrna9060064)"},{"key":"bib37","series-title":"J Thromb Haemostasis","first-page":"1530","article-title":"IgG\/IgM antiphospholipid antibodies present in the classification criteria for the antiphospholipid syndrome: a critical review of their association with thrombosis","volume":"14","author":"Kelchtermans H","year":"2016","unstructured":"Kelchtermans H\n, \nPelkmans L\n, \nde Laat B\n, et al.\n 2016 IgG\/IgM antiphospholipid antibodies present in the classification criteria for the antiphospholipid syndrome: a critical review of their association with thrombosis. J Thromb Haemostasis 14 1530\u20131548. (https:\/\/doi.org\/10.1111\/jth.13379)"},{"key":"bib38","series-title":"Endocrine","first-page":"226","article-title":"Decreased expression of microRNAs targeting T2D susceptibility genes","volume":"66","author":"Kokkinopoulou I","year":"2019","unstructured":"Kokkinopoulou I\n, \nMaratou E\n, \nMitrou P\n, et al.\n 2019 Decreased expression of microRNAs targeting T2D susceptibility genes. Endocrine 66 226\u2013239. (https:\/\/doi.org\/10.1007\/s12020-019-02062-0)"},{"key":"bib39","series-title":"Front Immunol","first-page":"941","article-title":"Cardiac manifestations of antiphospholipid syndrome with focus on its primary form","volume":"10","author":"Kolitz T","year":"2019","unstructured":"Kolitz T\n, \nShiber S\n, \nSharabi I\n, et al.\n 2019 Cardiac manifestations of antiphospholipid syndrome with focus on its primary form. Front Immunol 10 941. (https:\/\/doi.org\/10.3389\/fimmu.2019.00941)"},{"key":"bib40","series-title":"J Am Heart Assoc","article-title":"Circulating microRNAs serve as novel biological markers for intracranial aneurysms","volume":"3","author":"Li P","year":"2014","unstructured":"Li P\n, \nZhang Q\n, \nWu X\n, et al.\n 2014 Circulating microRNAs serve as novel biological markers for intracranial aneurysms. J Am Heart Assoc 3 e000972. (https:\/\/doi.org\/10.1161\/jaha.114.000972)"},{"key":"bib41","series-title":"J Assist Reprod Genet","first-page":"3","article-title":"MicroRNAs: key regulators of trophoblast function in pregnancy disorders","volume":"40","author":"Liang L","year":"2023","unstructured":"Liang L\n, \nChen Y\n, \nWu C\n, et al.\n 2023 MicroRNAs: key regulators of trophoblast function in pregnancy disorders. J Assist Reprod Genet 40 3\u201317. (https:\/\/doi.org\/10.1007\/s10815-022-02677-9)"},{"key":"bib42","series-title":"Sci Rep","article-title":"Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients","volume":"5","author":"Liu W","year":"2015","unstructured":"Liu W\n, \nLing S\n, \nSun W\n, et al.\n 2015 Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients. Sci Rep 5 16099. (https:\/\/doi.org\/10.1038\/srep16099)"},{"key":"bib43","series-title":"Methods","first-page":"402","article-title":"Analysis of relative gene expression data using real time quantitative PCR and the 2(\u2212\u0394\u0394C(T)) method","volume":"25","author":"Livak KJ","year":"2001","unstructured":"Livak KJ\n & \nSchmittgen TD\n\n 2001 Analysis of relative gene expression data using real time quantitative PCR and the 2(\u2212\u0394\u0394C(T)) method. Methods 25 402\u2013408. (https:\/\/doi.org\/10.1006\/meth.2001.1262)"},{"key":"bib44","series-title":"Cancer Lett","first-page":"90","article-title":"Dysregulation of microRNAs in autoimmune diseases: pathogenesis, biomarkers and potential therapeutic targets","volume":"428","author":"Long H","year":"2018","unstructured":"Long H\n, \nWang X\n, \nChen Y\n, et al.\n 2018 Dysregulation of microRNAs in autoimmune diseases: pathogenesis, biomarkers and potential therapeutic targets. Cancer Lett 428 90\u2013103. (https:\/\/doi.org\/10.1016\/j.canlet.2018.04.016)"},{"key":"bib45","series-title":"Inflamm Res","first-page":"919","article-title":"Antiphospholipid antibodies and sub clinical atherosclerosis in the CARDIA cohort","volume":"62","author":"Majka DS","year":"2013","unstructured":"Majka DS\n, \nLiu K\n, \nPope RM\n, et al.\n 2013 Antiphospholipid antibodies and sub clinical atherosclerosis in the CARDIA cohort. Inflamm Res 62 919\u2013927. (https:\/\/doi.org\/10.1007\/s00011-013-0652-x)"},{"key":"bib46","series-title":"J Thromb Haemostasis","first-page":"502","article-title":"Thrombophilic risk factors in patients with severe carotid atherosclerosis","volume":"3","author":"Marcucci R","year":"2005","unstructured":"Marcucci R\n, \nSofi F\n, \nFedi S\n, et al.\n 2005 Thrombophilic risk factors in patients with severe carotid atherosclerosis. J Thromb Haemostasis 3 502\u2013507. (https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01173.x)"},{"key":"bib47","series-title":"Acta Obstet Gynecol Scand","first-page":"897","article-title":"Even low levels of anticardiolipin antibodies are associated with pregnancy related complications: a monocentric cohort study","volume":"104","author":"Matraszek VV","year":"2025","unstructured":"Matraszek VV\n, \nKrofta L\n & \nHromadnikova I\n\n 2025 Even low levels of anticardiolipin antibodies are associated with pregnancy related complications: a monocentric cohort study. Acta Obstet Gynecol Scand 104 897\u2013905. (https:\/\/doi.org\/10.1111\/aogs.15096)"},{"key":"bib48","series-title":"Clin Immunol","article-title":"Clinical presentation and outcomes in patients with antiphospholipid syndrome associated adrenal hemorrhage: a multicenter cohort study and systematic literature review","volume":"260","author":"Meade Aguilar JA","year":"2024","unstructured":"Meade Aguilar JA\n, \nFigueroa Parra G\n, \nYang JX\n, et al.\n 2024 Clinical presentation and outcomes in patients with antiphospholipid syndrome associated adrenal hemorrhage: a multicenter cohort study and systematic literature review. Clin Immunol 260 109906. (https:\/\/doi.org\/10.1016\/j.clim.2024.109906)"},{"key":"bib49","series-title":"Front Genet","first-page":"110","article-title":"MicroRNAs associated with cardiometabolic traits","volume":"11","author":"Mens MMJ","year":"2020","unstructured":"Mens MMJ\n, \nMaas SCE\n, \nKlap J\n, et al.\n 2020 MicroRNAs associated with cardiometabolic traits. Front Genet 11 110. (https:\/\/doi.org\/10.3389\/fgene.2020.00110)"},{"key":"bib50","series-title":"J Thromb Haemostasis","first-page":"295","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis S","year":"2006","unstructured":"Miyakis S\n, \nLockshin MD\n, \nAtsumi T\n, et al.\n 2006 International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemostasis 4 295\u2013306. (https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01753.x)"},{"key":"bib51","series-title":"Front Endocrinol","first-page":"402","article-title":"Overview of microRNA biogenesis, mechanisms of action, and circulation","volume":"9","author":"O\u2019Brien J","year":"2018","unstructured":"O\u2019Brien J\n, \nHayder H\n, \nZayed Y\n, et al.\n 2018 Overview of microRNA biogenesis, mechanisms of action, and circulation. Front Endocrinol 9 402. (https:\/\/doi.org\/10.3389\/fendo.2018.00402)"},{"key":"bib52","series-title":"Genet Test Mol Biomark","first-page":"644","article-title":"Genetic determination of ischemic vs idiopathic dilated cardiomyopathy","volume":"22","author":"Onrat ST","year":"2018","unstructured":"Onrat ST\n, \nOnrat E\n, \nErcan Onay E\n, et al.\n 2018 Genetic determination of ischemic vs idiopathic dilated cardiomyopathy. Genet Test Mol Biomark 22 644\u2013651. (https:\/\/doi.org\/10.1089\/gtmb.2018.0188)"},{"key":"bib53","series-title":"J Rheumatol","first-page":"2214","article-title":"Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a meta analysis","volume":"33","author":"Opatrny L","year":"2006","unstructured":"Opatrny L\n, \nDavid M\n, \nKahn SR\n, et al.\n 2006 Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a meta analysis. J Rheumatol 33 2214\u20132221."},{"key":"bib54","series-title":"Lab Med","first-page":"361","article-title":"Circulating miRNAs in myocardial infarction and lipid levels","volume":"55","author":"Ozuynuk Ertugrul AS","year":"2024","unstructured":"Ozuynuk Ertugrul AS\n, \nEkici B\n, \nErkan AF\n, et al.\n 2024 Circulating miRNAs in myocardial infarction and lipid levels. Lab Med 55 361\u2013372. (https:\/\/doi.org\/10.1093\/labmed\/lmad094)"},{"key":"bib55","series-title":"Clin Appl Thromb Hemost","first-page":"89","article-title":"Current debates in antiphospholipid syndrome: the acquired antibody mediated thrombophilia","volume":"10","author":"\u00d6zt\u00fcrk MA","year":"2004","unstructured":"\u00d6zt\u00fcrk MA\n, \nHaznedaro\u011flu IC\n, \nTurgut M\n, et al.\n 2004 Current debates in antiphospholipid syndrome: the acquired antibody mediated thrombophilia. Clin Appl Thromb Hemost 10 89\u2013126. (https:\/\/doi.org\/10.1177\/107602960401000201)"},{"key":"bib56","series-title":"J Biol Chem","article-title":"miR 210 3p from adipose macrophages disrupts insulin sensitivity","volume":"300","author":"Patra D","year":"2024","unstructured":"Patra D\n, \nRamprasad P\n, \nSharma S\n, et al.\n 2024 miR 210 3p from adipose macrophages disrupts insulin sensitivity. J Biol Chem 300 107328. (https:\/\/doi.org\/10.1016\/j.jbc.2024.107328)"},{"key":"bib57","series-title":"Sci Rep","article-title":"Atherothrombosis associated microRNAs in antiphospholipid syndrome and systemic lupus erythematosus patients","volume":"6","author":"P\u00e9rez S\u00e1nchez C","year":"2016","unstructured":"P\u00e9rez S\u00e1nchez C\n, \nAguirre MA\n, \nRuiz Lim\u00f3n P\n, et al.\n 2016 Atherothrombosis associated microRNAs in antiphospholipid syndrome and systemic lupus erythematosus patients. Sci Rep 6 31375. (https:\/\/doi.org\/10.1038\/srep31375)"},{"key":"bib58","series-title":"Haematologica","first-page":"908","article-title":"Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome","volume":"103","author":"P\u00e9rez S\u00e1nchez C","year":"2018","unstructured":"P\u00e9rez S\u00e1nchez C\n, \nArias de la Rosa I\n, \nAguirre M\u00c1\n, et al.\n 2018 Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome. Haematologica 103 908\u2013918. (https:\/\/doi.org\/10.3324\/haematol.2017.184416)"},{"key":"bib59","series-title":"PLoS One","article-title":"Circulating miRNAs of the \u2018Asian Indian phenotype\u2019 in impaired glucose tolerance and type 2 diabetes","volume":"10","author":"Prabu P","year":"2018","unstructured":"Prabu P\n, \nRome S\n, \nSathishkumar C\n, et al.\n 2018 Circulating miRNAs of the \u2018Asian Indian phenotype\u2019 in impaired glucose tolerance and type 2 diabetes. PLoS One 10 e0128372. (https:\/\/doi.org\/10.1371\/journal.pone.0128372)"},{"key":"bib60","series-title":"Cureus","article-title":"Unraveling the association between myocardial infarction of nonobstructive coronary arteries and antiphospholipid syndrome","volume":"13","author":"Ramjas V","year":"2021","unstructured":"Ramjas V\n, \nJain A\n, \nLee RDM\n, et al.\n 2021 Unraveling the association between myocardial infarction of nonobstructive coronary arteries and antiphospholipid syndrome. Cureus 13 17002. (https:\/\/doi.org\/10.7759\/cureus.17002)"},{"key":"bib61","series-title":"J Am Coll Cardiol","first-page":"920","article-title":"Circulating miR 29a, among other up regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy","volume":"63","author":"Roncarati R","year":"2014","unstructured":"Roncarati R\n, \nViviani Anselmi C\n, \nLosi MA\n, et al.\n 2014 Circulating miR 29a, among other up regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 63 920\u2013927. (https:\/\/doi.org\/10.1016\/j.jacc.2013.09.041)"},{"key":"bib62","series-title":"PLoS One","article-title":"Whole blood microRNA expression associated with stroke","volume":"14","author":"Salinas J","year":"2019","unstructured":"Salinas J\n, \nLin H\n, \nAparico HJ\n, et al.\n 2019 Whole blood microRNA expression associated with stroke. PLoS One 14 e0219261. (https:\/\/doi.org\/10.1371\/journal.pone.0219261)"},{"key":"bib63","series-title":"Thromb Res","first-page":"213","article-title":"Thrombotic antiphospholipid syndrome: a practical guide to diagnosis and management","volume":"198","author":"Sayar Z","year":"2021","unstructured":"Sayar Z\n, \nMoll R\n, \nIsenberg D\n, et al.\n 2021 Thrombotic antiphospholipid syndrome: a practical guide to diagnosis and management. Thromb Res 198 213\u2013221. (https:\/\/doi.org\/10.1016\/j.thromres.2020.10.010)"},{"key":"bib64","series-title":"Ann Rheum Dis","first-page":"2028","article-title":"The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review","volume":"74","author":"Sciascia S","year":"2015","unstructured":"Sciascia S\n, \nSanna G\n, \nKhamashta MA\n, et al.\n 2015 The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review. Ann Rheum Dis 74 2028\u20132033. (https:\/\/doi.org\/10.1136\/annrheumdis-2014-205663)"},{"key":"bib65","series-title":"Int J Cardiol","first-page":"209","article-title":"Anti phospholipid antibody prevalence and association with subclinical atherosclerosis and atherothrombosis in the general population","volume":"300","author":"Selmi C","year":"2020","unstructured":"Selmi C\n, \nDe Santis M\n, \nBattezzati PM\n, et al.\n 2020 Anti phospholipid antibody prevalence and association with subclinical atherosclerosis and atherothrombosis in the general population. Int J Cardiol 300 209\u2013213. (https:\/\/doi.org\/10.1016\/j.ijcard.2019.10.042)"},{"key":"bib66","series-title":"Arthritis Care Res","first-page":"324","article-title":"Characteristics of patients with antiphospholipid antibody positivity in the APS ACTION international clinical database and repository","volume":"74","author":"Sevim E","year":"2022","unstructured":"Sevim E\n, \nZisa D\n, \nAndrade D\n, et al.\n 2022 Characteristics of patients with antiphospholipid antibody positivity in the APS ACTION international clinical database and repository. Arthritis Care Res 74 324\u2013335. (https:\/\/doi.org\/10.1002\/acr.24468)"},{"key":"bib67","series-title":"Exp Ther Med","first-page":"4356","article-title":"Effect of microRNA 133a 3p\/MMP 9 axis on atherosclerotic VSMCs","volume":"18","author":"Shi L","year":"2019","unstructured":"Shi L\n, \nYu C\n, \nTian X\n, et al.\n 2019 Effect of microRNA 133a 3p\/MMP 9 axis on atherosclerotic VSMCs. Exp Ther Med 18 4356\u20134362. (https:\/\/doi.org\/10.3892\/etm.2019.8070)"},{"key":"bib68","series-title":"Obstet Gynecol","first-page":"641","article-title":"Antiphospholipid antibodies in stillbirth","volume":"122","author":"Silver RM","year":"2013","unstructured":"Silver RM\n, \nParker CB\n, \nReddy UM\n, et al.\n 2013 Antiphospholipid antibodies in stillbirth. Obstet Gynecol 122 641\u2013657. (https:\/\/doi.org\/10.1097\/aog.0b013e3182a1060e)"},{"key":"bib69","series-title":"Int J Mol Sci","article-title":"Small extracellular vesicle derived miRNA profile identifies miR 483 3p and miR 326 as regulators in the pathogenesis of antiphospholipid syndrome","volume":"24","author":"Sol\u00e9 C","year":"2023","unstructured":"Sol\u00e9 C\n, \nRoyo M\n, \nSandoval S\n, et al.\n 2023 Small extracellular vesicle derived miRNA profile identifies miR 483 3p and miR 326 as regulators in the pathogenesis of antiphospholipid syndrome. Int J Mol Sci 24 11607. (https:\/\/doi.org\/10.3390\/ijms241411607)"},{"key":"bib70","series-title":"Sci Rep","first-page":"8419","article-title":"Differential gene expression and miRNA network in coronary slow flow","volume":"14","author":"Sun L","year":"2024","unstructured":"Sun L\n, \nWang J\n, \nLei J\n, et al.\n 2024 Differential gene expression and miRNA network in coronary slow flow. Sci Rep 14 8419. (https:\/\/doi.org\/10.1038\/s41598-024-58745-w)"},{"key":"bib71","series-title":"Cells","first-page":"3526","article-title":"Platelet miR 142 3p as biomarker for acute coronary syndrome","volume":"10","author":"Szelenberger R","year":"2021","unstructured":"Szelenberger R\n, \nKarbownik MS\n, \nKacprzak M\n, et al.\n 2021 Platelet miR 142 3p as biomarker for acute coronary syndrome. Cells 10 3526. (https:\/\/doi.org\/10.3390\/cells10123526)"},{"key":"bib72","series-title":"Gene","first-page":"213","article-title":"MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus","volume":"539","author":"Takahashi P","year":"2014","unstructured":"Takahashi P\n, \nXavier DJ\n, \nEvangelista AF\n, et al.\n 2014 MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus. Gene 539 213\u2013223. (https:\/\/doi.org\/10.1016\/j.gene.2014.01.075)"},{"key":"bib73","series-title":"Clin Exp Hypertens","first-page":"281","article-title":"Hsa_circ_0037897 and hypertension via miR 145 5p","volume":"43","author":"Tao Z","year":"2021","unstructured":"Tao Z\n, \nZheng S\n, \nHe X\n, et al.\n 2021 Hsa_circ_0037897 and hypertension via miR 145 5p. Clin Exp Hypertens 43 281\u2013286. (https:\/\/doi.org\/10.1080\/10641963.2020.1860081)"},{"key":"bib74","series-title":"J Thromb Haemostasis","first-page":"1985","article-title":"Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome","volume":"9","author":"Teruel R","year":"2011","unstructured":"Teruel R\n, \nP\u00e9rez S\u00e1nchez C\n, \nCorral J\n, et al.\n 2011 Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome. J Thromb Haemostasis 9 1985\u20131992. (https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04451.x)"},{"key":"bib75","series-title":"PLoS One","article-title":"Plasma microRNA 16 as a biomarker for hyperacute cerebral infarction","volume":"11","author":"Tian C","year":"2016","unstructured":"Tian C\n, \nLi Z\n, \nYang Z\n, et al.\n 2016 Plasma microRNA 16 as a biomarker for hyperacute cerebral infarction. PLoS One 11 e0166688. (https:\/\/doi.org\/10.1371\/journal.pone.0166688)"},{"key":"bib76","series-title":"Exp Ther Med","first-page":"595","article-title":"MicroRNA 199a 5p aggravates primary hypertension by damaging vascular endothelial cells","volume":"16","author":"Tian X","year":"2018","unstructured":"Tian X\n, \nYu C\n, \nShi L\n, et al.\n 2018 MicroRNA 199a 5p aggravates primary hypertension by damaging vascular endothelial cells. Exp Ther Med 16 595\u2013602. (https:\/\/doi.org\/10.3892\/etm.2018.6252)"},{"key":"bib77","series-title":"J Mol Med","first-page":"845","article-title":"Plasma microRNAs as biomarkers for Lamin A\/C related dilated cardiomyopathy","volume":"96","author":"Toro R","year":"2018","unstructured":"Toro R\n, \nBlasco-Turri\u00f3n S\n, \nMorales Ponce FJ\n, et al.\n 2018 Plasma microRNAs as biomarkers for Lamin A\/C related dilated cardiomyopathy. J Mol Med 96 845\u2013856. (https:\/\/doi.org\/10.1007\/s00109-018-1666-1)"},{"key":"bib78","series-title":"Genome Biol","article-title":"Accurate normalization of real time quantitative RT PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele J","year":"2002","unstructured":"Vandesompele J\n, \nDe Preter K\n, \nPattyn F\n, et al.\n 2002 Accurate normalization of real time quantitative RT PCR data by geometric averaging of multiple internal control genes. Genome Biol 3 research0034.1. (https:\/\/doi.org\/10.1186\/gb-2002-3-7-research0034)"},{"key":"bib79","series-title":"Adv Clin Exp Med","first-page":"865","article-title":"MicroRNA in cardiovascular biology and disease","volume":"26","author":"Wojciechowska A","year":"2017","unstructured":"Wojciechowska A\n, \nBraniewska A\n & \nKozar Kami\u0144ska K\n\n 2017 MicroRNA in cardiovascular biology and disease. Adv Clin Exp Med 26 865\u2013874. (https:\/\/doi.org\/10.17219\/acem\/62915)"},{"key":"bib80","series-title":"Noncoding RNA Res","first-page":"471","article-title":"Integrative analysis of miRNA\u2013mRNA networks in intracranial aneurysms","volume":"9","author":"Xu D","year":"2024","unstructured":"Xu D\n, \nGareev I\n, \nBeylerli O\n, et al.\n 2024 Integrative analysis of miRNA\u2013mRNA networks in intracranial aneurysms. Noncoding RNA Res 9 471\u2013485. (https:\/\/doi.org\/10.1016\/j.ncrna.2024.01.004)"},{"key":"bib81","series-title":"Mol Biol Rep","first-page":"2605","article-title":"MIAT\/miR 133a 3p axis in atrial fibrillation","volume":"47","author":"Yao L","year":"2020","unstructured":"Yao L\n, \nZhou B\n, \nYou L\n, et al.\n 2020 MIAT\/miR 133a 3p axis in atrial fibrillation. Mol Biol Rep 47 2605\u20132617. (https:\/\/doi.org\/10.1007\/s11033-020-05347-0)"},{"key":"bib82","series-title":"J Cell Mol Med","first-page":"1146","article-title":"Circulating microRNAs as diagnostic biomarkers for coronary artery disease","volume":"24","author":"Zhang L","year":"2020","unstructured":"Zhang L\n, \nZhang Y\n, \nXue S\n, et al.\n 2020 Circulating microRNAs as diagnostic biomarkers for coronary artery disease. J Cell Mol Med 24 1146\u20131150. (https:\/\/doi.org\/10.1111\/jcmm.14802)"},{"key":"bib83","series-title":"Int J Cardiol","first-page":"68","article-title":"miR 145 5p affects autophagy via CaMKII\u03b4 in atherosclerosis","volume":"360","author":"Zhang X","year":"2022","unstructured":"Zhang X\n, \nZai L\n, \nTao Z\n, et al.\n 2022 miR 145 5p affects autophagy via CaMKII\u03b4 in atherosclerosis. Int J Cardiol 360 68\u201375. (https:\/\/doi.org\/10.1016\/j.ijcard.2022.05.039)"},{"key":"bib84","series-title":"J Stroke Cerebrovasc Dis","article-title":"Machine learning analysis of microRNAs for ischemic stroke","volume":"30","author":"Zhao X","year":"2021","unstructured":"Zhao X\n, \nChen X\n, \nWu X\n, et al.\n 2021 Machine learning analysis of microRNAs for ischemic stroke. J Stroke Cerebrovasc Dis 30 105825. (https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2021.105825)"},{"key":"bib85","series-title":"PeerJ","article-title":"The association between antiphospholipid syndrome and atrial fibrillation: a single center retrospective case control study","volume":"12","author":"Zhou Z","year":"2024","unstructured":"Zhou Z\n & \nLiu Y\n\n 2024 The association between antiphospholipid syndrome and atrial fibrillation: a single center retrospective case control study. PeerJ 12 17617. (https:\/\/doi.org\/10.7717\/peerj.17617)"},{"key":"bib86","series-title":"JAMA Netw Open","article-title":"Prevalence of antiphospholipid antibodies and association with incident cardiovascular events","volume":"6","author":"Zuo Y","year":"2023","unstructured":"Zuo Y\n, \nNavaz S\n, \nLiang W\n, et al.\n 2023 Prevalence of antiphospholipid antibodies and association with incident cardiovascular events. JAMA Netw Open 6 236530. (https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.6530)"},{"key":"bib1","series-title":"Thromb Res","first-page":"77","article-title":"The association between antiphospholipid antibodies and placenta mediated complications: a systematic review and meta analysis","volume":"128","author":"Abou Nassar K","year":"2011","unstructured":"Abou Nassar K\n, \nCarrier M\n, \nRamsay T\n, et al.\n 2011 The association between antiphospholipid antibodies and placenta mediated complications: a systematic review and meta analysis. Thromb Res 128 77\u201385. (https:\/\/doi.org\/10.1016\/j.thromres.2011.02.006)"},{"key":"bib2","series-title":"Diabetes Res Clin Pract","first-page":"35","article-title":"MicroRNA expression profile in plasma from type 1 diabetic patients","volume":"141","author":"Assmann TS","year":"2018","unstructured":"Assmann TS\n, \nRecamonde Mendoza M\n, \nPu\u00f1ales M\n, et al.\n 2018 MicroRNA expression profile in plasma from type 1 diabetic patients. Diabetes Res Clin Pract 141 35\u201346. (https:\/\/doi.org\/10.1016\/j.diabres.2018.03.044)"},{"key":"bib3","series-title":"Diabetol Metab Syndr","first-page":"6","article-title":"Study on inflammation related genes and microRNAs in T2D","volume":"8","author":"Balde\u00f3n Rojas L","year":"2016","unstructured":"Balde\u00f3n Rojas L\n, \nWeigelt K\n, \nde Wit H\n, et al.\n 2016 Study on inflammation related genes and microRNAs in T2D. Diabetol Metab Syndr 8 6. (https:\/\/doi.org\/10.1186\/s13098-015-0113-5)"},{"key":"bib4","series-title":"Arthritis Rheumatol","first-page":"1687","article-title":"The 2023 ACR\/EULAR antiphospholipid syndrome classification criteria","volume":"75","author":"Barbhaiya M","year":"2023","unstructured":"Barbhaiya M\n, \nZuily S\n, \nNaden R\n, et al.\n 2023 The 2023 ACR\/EULAR antiphospholipid syndrome classification criteria. Arthritis Rheumatol 75 1687\u20131702. (https:\/\/doi.org\/10.1002\/art.42624)"},{"key":"bib5","series-title":"ESC Heart Fail","first-page":"835","article-title":"Cardiac peripheral microRNA gradients in systolic heart failure","volume":"7","author":"Ben Zvi I","year":"2020","unstructured":"Ben Zvi I\n, \nVolinsky N\n, \nGrosman Rimon L\n, et al.\n 2020 Cardiac peripheral microRNA gradients in systolic heart failure. ESC Heart Fail 7 835\u2013843. (https:\/\/doi.org\/10.1002\/ehf2.12597)"},{"key":"bib6","series-title":"J Roy Stat Soc B","first-page":"289","article-title":"Controlling the false discovery rate: a practical and powerful approach to multiple testing","volume":"57","author":"Benjamini Y","year":"1995","unstructured":"Benjamini Y\n & \nHochberg Y\n\n 1995 Controlling the false discovery rate: a practical and powerful approach to multiple testing. J Roy Stat Soc B 57 289\u2013300. (https:\/\/doi.org\/10.1111\/j.2517-6161.1995.tb02031.x)"},{"key":"bib7","series-title":"Blood","first-page":"404","article-title":"Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH APS observational study","volume":"123","author":"Bouvier S","year":"2014","unstructured":"Bouvier S\n, \nCochery Nouvellon E\n, \nLavigne Lissalde G\n, et al.\n 2014 Comparative incidence of pregnancy outcomes in treated obstetric antiphospholipid syndrome: the NOH APS observational study. Blood 123 404\u2013413. (https:\/\/doi.org\/10.1182\/blood-2013-08-522623)"},{"key":"bib8","series-title":"Sci Rep","first-page":"7517","article-title":"Plasma microRNA profile in dilated cardiomyopathy","volume":"11","author":"Calderon Dominguez M","year":"2021","unstructured":"Calderon Dominguez M\n, \nBelmonte T\n, \nQuezada Feijoo M\n, et al.\n 2021 Plasma microRNA profile in dilated cardiomyopathy. Sci Rep 11 7517. (https:\/\/doi.org\/10.1038\/s41598-021-87086-1)"},{"key":"bib9","series-title":"J Am Heart Assoc","article-title":"Transpulmonary expression of exosomal microRNAs in PAH","volume":"12","author":"Chang WT","year":"2023","unstructured":"Chang WT\n, \nLee WC\n, \nLin YW\n, et al.\n 2023 Transpulmonary expression of exosomal microRNAs in PAH. J Am Heart Assoc 12 031435. (https:\/\/doi.org\/10.1161\/jaha.123.031435)"},{"key":"bib10","series-title":"J Thromb Haemostasis","first-page":"169","article-title":"The (non-)sense of detecting anticardiolipin and anti \u03b22 glycoprotein I IgM antibodies in the antiphospholipid syndrome","volume":"18","author":"Chayoua W","year":"2020","unstructured":"Chayoua W\n, \nKelchtermans H\n, \nGris JC\n, et al.\n 2020 The (non-)sense of detecting anticardiolipin and anti \u03b22 glycoprotein I IgM antibodies in the antiphospholipid syndrome. J Thromb Haemostasis 18 169\u2013179. (https:\/\/doi.org\/10.1111\/jth.14633)"},{"key":"bib11","series-title":"Eur Rev Med Pharmacol Sci","first-page":"2223","article-title":"miR 155 5p inhibits VSMC and HUVEC proliferation in atherosclerosis","volume":"23","author":"Chen L","year":"2019","unstructured":"Chen L\n, \nZheng SY\n, \nYang CQ\n, et al.\n 2019 miR 155 5p inhibits VSMC and HUVEC proliferation in atherosclerosis. Eur Rev Med Pharmacol Sci 23 2223\u20132233. (https:\/\/doi.org\/10.26355\/eurrev_201903_17270)"},{"key":"bib12","series-title":"Nat Rev Genet","first-page":"704","article-title":"Causes and consequences of microRNA dysregulation in cancer","volume":"10","author":"Croce CM","year":"2009","unstructured":"Croce CM\n\n 2009 Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet 10 704\u2013714. (https:\/\/doi.org\/10.1038\/nrg2634)"},{"key":"bib13","series-title":"Angiology","first-page":"357","article-title":"Anticardiolipin antibodies as a risk factor of atherosclerosis in intermittent claudication","volume":"55","author":"de Godoy JM","year":"2004","unstructured":"de Godoy JM\n, \nBatig\u00e1lia F\n, \nde Godoy MR\n, et al.\n 2004 Anticardiolipin antibodies as a risk factor of atherosclerosis in intermittent claudication. Angiology 55 357\u2013359. (https:\/\/doi.org\/10.1177\/000331970405500402)"},{"key":"bib14","series-title":"Med Sci Monit","first-page":"CR430","article-title":"Vascular dementia and anticardiolipin antibodies","volume":"11","author":"de Godoy JM","year":"2005","unstructured":"de Godoy JM\n, \nde Godoy MR\n, \nCipulo JP\n, et al.\n 2005 Vascular dementia and anticardiolipin antibodies. Med Sci Monit 11 CR430\u2013CR433."},{"key":"bib15","series-title":"Angiology","first-page":"79","article-title":"Recurrent thrombosis in patients with deep vein thrombosis and\/or venous thromboembolism associated with anticardiolipin antibodies","volume":"57","author":"de Godoy JM","year":"2006","unstructured":"de Godoy JM\n, \nde Godoy MF\n & \nBraile DM\n\n 2006 Recurrent thrombosis in patients with deep vein thrombosis and\/or venous thromboembolism associated with anticardiolipin antibodies. Angiology 57 79\u201383. (https:\/\/doi.org\/10.1177\/000331970605700111)"},{"key":"bib16","series-title":"Thromb Res","first-page":"883","article-title":"The clinical relevance of the IgM isotype of antiphospholipid antibodies in the vascular antiphospholipid syndrome","volume":"136","author":"Del Ross T","year":"2015","unstructured":"Del Ross T\n, \nRuffatti A\n, \nCuffaro S\n, et al.\n 2015 The clinical relevance of the IgM isotype of antiphospholipid antibodies in the vascular antiphospholipid syndrome. Thromb Res 136 883\u2013886. (https:\/\/doi.org\/10.1016\/j.thromres.2015.08.019)"},{"key":"bib17","series-title":"Biosci Rep","article-title":"Combined detection of multiple microRNAs for early heart failure","volume":"40","author":"Ding H","year":"2020","unstructured":"Ding H\n, \nWang Y\n, \nHu L\n, et al.\n 2020 Combined detection of multiple microRNAs for early heart failure. Biosci Rep 40 BSR20191653. (https:\/\/doi.org\/10.1042\/bsr20191653)"},{"key":"bib18","series-title":"Obstet Gynecol","first-page":"1433","article-title":"Association of anticardiolipin antibodies with preeclampsia: a systematic review and meta analysis","volume":"116","author":"do Prado AD","year":"2010","unstructured":"do Prado AD\n, \nPiovesan DM\n, \nStaub HL\n, et al.\n 2010 Association of anticardiolipin antibodies with preeclampsia: a systematic review and meta analysis. Obstet Gynecol 116 1433\u20131443. (https:\/\/doi.org\/10.1097\/aog.0b013e3181fe02ec)"},{"key":"bib19","series-title":"JCI Insight","article-title":"Profiling circulating microRNAs in children with recent onset type 1 diabetes","volume":"2","author":"Erener S","year":"2017","unstructured":"Erener S\n, \nMarwaha A\n, \nTan R\n, et al.\n 2017 Profiling circulating microRNAs in children with recent onset type 1 diabetes. JCI Insight 2 e89656. (https:\/\/doi.org\/10.1172\/jci.insight.89656)"},{"key":"bib20","series-title":"Genome Res","first-page":"92","article-title":"Most mammalian mRNAs are conserved targets of microRNAs","volume":"19","author":"Friedman RC","year":"2009","unstructured":"Friedman RC\n, \nFarh KK\n, \nBurge CB\n, et al.\n 2009 Most mammalian mRNAs are conserved targets of microRNAs. Genome Res 19 92\u2013105. (https:\/\/doi.org\/10.1101\/gr.082701.108)"},{"key":"bib21","series-title":"Blood","first-page":"1827","article-title":"Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature","volume":"101","author":"Galli M","year":"2003","unstructured":"Galli M\n, \nLuciani D\n, \nBertolini G\n, et al.\n 2003 Lupus anticoagulants are stronger risk factors for thrombosis than anticardiolipin antibodies in the antiphospholipid syndrome: a systematic review of the literature. Blood 101 1827\u20131832. (https:\/\/doi.org\/10.1182\/blood-2002-02-0441)"},{"key":"bib22","series-title":"Rheumatol","first-page":"24","article-title":"Epidemiology of antiphospholipid syndrome: macro and microvascular manifestations","volume":"63","author":"Gaspar P","year":"2024","unstructured":"Gaspar P\n, \nSciascia S\n & \nTektonidou MG\n\n 2024 Epidemiology of antiphospholipid syndrome: macro and microvascular manifestations. Rheumatol 63 24\u201336. (https:\/\/doi.org\/10.1093\/rheumatology\/kead571)"},{"key":"bib23","series-title":"J Personalized Med","first-page":"770","article-title":"Dysregulated miRNAs as biomarkers and therapeutic targets in neurodegenerative diseases","volume":"12","author":"Gentile G","year":"2022","unstructured":"Gentile G\n, \nMorello G\n, \nLa Cognata V\n, et al.\n 2022 Dysregulated miRNAs as biomarkers and therapeutic targets in neurodegenerative diseases. J Personalized Med 12 770. (https:\/\/doi.org\/10.3390\/jpm12050770)"},{"key":"bib24","series-title":"Mol Hum Reprod","first-page":"465","article-title":"Antiphospholipid antibody induced miR 146a 3p drives trophoblast interleukin 8 secretion through activation of toll like receptor 8","volume":"22","author":"Gysler SM","year":"2016","unstructured":"Gysler SM\n, \nMulla MJ\n, \nGuerra M\n, et al.\n 2016 Antiphospholipid antibody induced miR 146a 3p drives trophoblast interleukin 8 secretion through activation of toll like receptor 8. Mol Hum Reprod 22 465\u2013474. (https:\/\/doi.org\/10.1093\/molehr\/gaw027)"},{"key":"bib25","series-title":"J Transl Med","first-page":"407","article-title":"Atrial myocyte derived exosomal microRNA in atrial fibrosis","volume":"20","author":"Hao H","year":"2022","unstructured":"Hao H\n, \nYan S\n, \nZhao X\n, et al.\n 2022 Atrial myocyte derived exosomal microRNA in atrial fibrosis. J Transl Med 20 407. (https:\/\/doi.org\/10.1186\/s12967-022-03617-y)"},{"key":"bib26","series-title":"Cell Immunol","first-page":"70","article-title":"microRNA 342, microRNA 191 and microRNA 510 are differentially expressed in T regulatory cells of type 1 diabetic patients","volume":"260","author":"Hezova R","year":"2010","unstructured":"Hezova R\n, \nSlaby O\n, \nFaltejskova P\n, et al.\n 2010 microRNA 342, microRNA 191 and microRNA 510 are differentially expressed in T regulatory cells of type 1 diabetic patients. Cell Immunol 260 70\u201374. (https:\/\/doi.org\/10.1016\/j.cellimm.2009.10.012)"},{"key":"bib27","series-title":"Thromb Res","first-page":"126","article-title":"Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood","volume":"137","author":"Hromadnikova I","year":"2016","unstructured":"Hromadnikova I\n, \nKotlabova K\n, \nHympanova L\n, et al.\n 2016 Gestational hypertension, preeclampsia and intrauterine growth restriction induce dysregulation of cardiovascular and cerebrovascular disease associated microRNAs in maternal whole peripheral blood. Thromb Res 137 126\u2013140. (https:\/\/doi.org\/10.1016\/j.thromres.2015.11.032)"},{"key":"bib28","series-title":"Int J Mol Sci","article-title":"Cardiovascular disease associated microRNAs as novel biomarkers of first trimester screening for gestational diabetes mellitus","volume":"23","author":"Hromadnikova I","year":"2022a","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022a Cardiovascular disease associated microRNAs as novel biomarkers of first trimester screening for gestational diabetes mellitus. Int J Mol Sci 23 10635. (https:\/\/doi.org\/10.3390\/ijms231810635)"},{"key":"bib29","series-title":"Biomedicines","first-page":"256","article-title":"Cardiovascular disease associated microRNA dysregulation during the first trimester in women with chronic hypertension or those developing gestational hypertension or preeclampsia","volume":"10","author":"Hromadnikova I","year":"2022b","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022b Cardiovascular disease associated microRNA dysregulation during the first trimester in women with chronic hypertension or those developing gestational hypertension or preeclampsia. Biomedicines 10 256. (https:\/\/doi.org\/10.3390\/biomedicines10020256)"},{"key":"bib30","series-title":"Biomedicines","first-page":"718","article-title":"First trimester screening for fetal growth restriction and small for gestational age pregnancies using cardiovascular disease associated microRNA biomarkers","volume":"10","author":"Hromadnikova I","year":"2022c","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022c First trimester screening for fetal growth restriction and small for gestational age pregnancies using cardiovascular disease associated microRNA biomarkers. Biomedicines 10 718. (https:\/\/doi.org\/10.3390\/biomedicines10030718)"},{"key":"bib31","series-title":"Int J Mol Sci","first-page":"3951","article-title":"First trimester prediction of preterm delivery using cardiovascular disease associated microRNA biomarkers","volume":"23","author":"Hromadnikova I","year":"2022d","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2022d First trimester prediction of preterm delivery using cardiovascular disease associated microRNA biomarkers. Int J Mol Sci 23 3951. (https:\/\/doi.org\/10.3390\/ijms23073951)"},{"key":"bib32","series-title":"Int J Mol Sci","article-title":"First trimester screening for miscarriage or stillbirth using microRNA biomarkers","volume":"24","author":"Hromadnikova I","year":"2023a","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2023a First trimester screening for miscarriage or stillbirth using microRNA biomarkers. Int J Mol Sci 24 10137. (https:\/\/doi.org\/10.3390\/ijms241210137)"},{"key":"bib33","series-title":"Int J Mol Sci","first-page":"5177","article-title":"First trimester screening for HELLP syndrome using microRNA biomarkers and maternal clinical characteristics","volume":"24","author":"Hromadnikova I","year":"2023b","unstructured":"Hromadnikova I\n, \nKotlabova K\n & \nKrofta L\n\n 2023b First trimester screening for HELLP syndrome using microRNA biomarkers and maternal clinical characteristics. Int J Mol Sci 24 5177. (https:\/\/doi.org\/10.3390\/ijms24065177)"},{"key":"bib34","series-title":"Nucleic Acids Res","first-page":"222","article-title":"miRTarBase update 2022: an informative resource for experimentally validated miRNA target interactions","volume":"50","author":"Huang HY","year":"2022","unstructured":"Huang HY\n, \nLin YC\n, \nCui S\n, et al.\n 2022 miRTarBase update 2022: an informative resource for experimentally validated miRNA target interactions. Nucleic Acids Res 50 222\u2013230. (https:\/\/doi.org\/10.1093\/nar\/gkab1079)"},{"key":"bib35","series-title":"Rheumatol Int","first-page":"1329","article-title":"miR 19b 3p and miR 20a 5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome","volume":"41","author":"Ju\u00e1rez Vicu\u00f1a Y","year":"2021","unstructured":"Ju\u00e1rez Vicu\u00f1a Y\n, \nGuzm\u00e1n Mart\u00edn CA\n, \nMart\u00ednez Mart\u00ednez LA\n, et al.\n 2021 miR 19b 3p and miR 20a 5p are associated with the levels of antiphospholipid antibodies in patients with antiphospholipid syndrome. Rheumatol Int 41 1329\u20131335. (https:\/\/doi.org\/10.1007\/s00296-021-04864-w)"},{"key":"bib36","series-title":"Noncoding RNA","first-page":"64","article-title":"Machine learning model based on microRNAs for essential hypertension","volume":"9","author":"Jusic A","year":"2023","unstructured":"Jusic A\n, \nJunuzovic I\n, \nHujdurovic A\n, et al.\n 2023 Machine learning model based on microRNAs for essential hypertension. Noncoding RNA 9 64. (https:\/\/doi.org\/10.3390\/ncrna9060064)"},{"key":"bib37","series-title":"J Thromb Haemostasis","first-page":"1530","article-title":"IgG\/IgM antiphospholipid antibodies present in the classification criteria for the antiphospholipid syndrome: a critical review of their association with thrombosis","volume":"14","author":"Kelchtermans H","year":"2016","unstructured":"Kelchtermans H\n, \nPelkmans L\n, \nde Laat B\n, et al.\n 2016 IgG\/IgM antiphospholipid antibodies present in the classification criteria for the antiphospholipid syndrome: a critical review of their association with thrombosis. J Thromb Haemostasis 14 1530\u20131548. (https:\/\/doi.org\/10.1111\/jth.13379)"},{"key":"bib38","series-title":"Endocrine","first-page":"226","article-title":"Decreased expression of microRNAs targeting T2D susceptibility genes","volume":"66","author":"Kokkinopoulou I","year":"2019","unstructured":"Kokkinopoulou I\n, \nMaratou E\n, \nMitrou P\n, et al.\n 2019 Decreased expression of microRNAs targeting T2D susceptibility genes. Endocrine 66 226\u2013239. (https:\/\/doi.org\/10.1007\/s12020-019-02062-0)"},{"key":"bib39","series-title":"Front Immunol","first-page":"941","article-title":"Cardiac manifestations of antiphospholipid syndrome with focus on its primary form","volume":"10","author":"Kolitz T","year":"2019","unstructured":"Kolitz T\n, \nShiber S\n, \nSharabi I\n, et al.\n 2019 Cardiac manifestations of antiphospholipid syndrome with focus on its primary form. Front Immunol 10 941. (https:\/\/doi.org\/10.3389\/fimmu.2019.00941)"},{"key":"bib40","series-title":"J Am Heart Assoc","article-title":"Circulating microRNAs serve as novel biological markers for intracranial aneurysms","volume":"3","author":"Li P","year":"2014","unstructured":"Li P\n, \nZhang Q\n, \nWu X\n, et al.\n 2014 Circulating microRNAs serve as novel biological markers for intracranial aneurysms. J Am Heart Assoc 3 e000972. (https:\/\/doi.org\/10.1161\/jaha.114.000972)"},{"key":"bib41","series-title":"J Assist Reprod Genet","first-page":"3","article-title":"MicroRNAs: key regulators of trophoblast function in pregnancy disorders","volume":"40","author":"Liang L","year":"2023","unstructured":"Liang L\n, \nChen Y\n, \nWu C\n, et al.\n 2023 MicroRNAs: key regulators of trophoblast function in pregnancy disorders. J Assist Reprod Genet 40 3\u201317. (https:\/\/doi.org\/10.1007\/s10815-022-02677-9)"},{"key":"bib42","series-title":"Sci Rep","article-title":"Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients","volume":"5","author":"Liu W","year":"2015","unstructured":"Liu W\n, \nLing S\n, \nSun W\n, et al.\n 2015 Circulating microRNAs correlated with the level of coronary artery calcification in symptomatic patients. Sci Rep 5 16099. (https:\/\/doi.org\/10.1038\/srep16099)"},{"key":"bib43","series-title":"Methods","first-page":"402","article-title":"Analysis of relative gene expression data using real time quantitative PCR and the 2(\u2212\u0394\u0394C(T)) method","volume":"25","author":"Livak KJ","year":"2001","unstructured":"Livak KJ\n & \nSchmittgen TD\n\n 2001 Analysis of relative gene expression data using real time quantitative PCR and the 2(\u2212\u0394\u0394C(T)) method. Methods 25 402\u2013408. (https:\/\/doi.org\/10.1006\/meth.2001.1262)"},{"key":"bib44","series-title":"Cancer Lett","first-page":"90","article-title":"Dysregulation of microRNAs in autoimmune diseases: pathogenesis, biomarkers and potential therapeutic targets","volume":"428","author":"Long H","year":"2018","unstructured":"Long H\n, \nWang X\n, \nChen Y\n, et al.\n 2018 Dysregulation of microRNAs in autoimmune diseases: pathogenesis, biomarkers and potential therapeutic targets. Cancer Lett 428 90\u2013103. (https:\/\/doi.org\/10.1016\/j.canlet.2018.04.016)"},{"key":"bib45","series-title":"Inflamm Res","first-page":"919","article-title":"Antiphospholipid antibodies and sub clinical atherosclerosis in the CARDIA cohort","volume":"62","author":"Majka DS","year":"2013","unstructured":"Majka DS\n, \nLiu K\n, \nPope RM\n, et al.\n 2013 Antiphospholipid antibodies and sub clinical atherosclerosis in the CARDIA cohort. Inflamm Res 62 919\u2013927. (https:\/\/doi.org\/10.1007\/s00011-013-0652-x)"},{"key":"bib46","series-title":"J Thromb Haemostasis","first-page":"502","article-title":"Thrombophilic risk factors in patients with severe carotid atherosclerosis","volume":"3","author":"Marcucci R","year":"2005","unstructured":"Marcucci R\n, \nSofi F\n, \nFedi S\n, et al.\n 2005 Thrombophilic risk factors in patients with severe carotid atherosclerosis. J Thromb Haemostasis 3 502\u2013507. (https:\/\/doi.org\/10.1111\/j.1538-7836.2005.01173.x)"},{"key":"bib47","series-title":"Acta Obstet Gynecol Scand","first-page":"897","article-title":"Even low levels of anticardiolipin antibodies are associated with pregnancy related complications: a monocentric cohort study","volume":"104","author":"Matraszek VV","year":"2025","unstructured":"Matraszek VV\n, \nKrofta L\n & \nHromadnikova I\n\n 2025 Even low levels of anticardiolipin antibodies are associated with pregnancy related complications: a monocentric cohort study. Acta Obstet Gynecol Scand 104 897\u2013905. (https:\/\/doi.org\/10.1111\/aogs.15096)"},{"key":"bib48","series-title":"Clin Immunol","article-title":"Clinical presentation and outcomes in patients with antiphospholipid syndrome associated adrenal hemorrhage: a multicenter cohort study and systematic literature review","volume":"260","author":"Meade Aguilar JA","year":"2024","unstructured":"Meade Aguilar JA\n, \nFigueroa Parra G\n, \nYang JX\n, et al.\n 2024 Clinical presentation and outcomes in patients with antiphospholipid syndrome associated adrenal hemorrhage: a multicenter cohort study and systematic literature review. Clin Immunol 260 109906. (https:\/\/doi.org\/10.1016\/j.clim.2024.109906)"},{"key":"bib49","series-title":"Front Genet","first-page":"110","article-title":"MicroRNAs associated with cardiometabolic traits","volume":"11","author":"Mens MMJ","year":"2020","unstructured":"Mens MMJ\n, \nMaas SCE\n, \nKlap J\n, et al.\n 2020 MicroRNAs associated with cardiometabolic traits. Front Genet 11 110. (https:\/\/doi.org\/10.3389\/fgene.2020.00110)"},{"key":"bib50","series-title":"J Thromb Haemostasis","first-page":"295","article-title":"International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS)","volume":"4","author":"Miyakis S","year":"2006","unstructured":"Miyakis S\n, \nLockshin MD\n, \nAtsumi T\n, et al.\n 2006 International consensus statement on an update of the classification criteria for definite antiphospholipid syndrome (APS). J Thromb Haemostasis 4 295\u2013306. (https:\/\/doi.org\/10.1111\/j.1538-7836.2006.01753.x)"},{"key":"bib51","series-title":"Front Endocrinol","first-page":"402","article-title":"Overview of microRNA biogenesis, mechanisms of action, and circulation","volume":"9","author":"O\u2019Brien J","year":"2018","unstructured":"O\u2019Brien J\n, \nHayder H\n, \nZayed Y\n, et al.\n 2018 Overview of microRNA biogenesis, mechanisms of action, and circulation. Front Endocrinol 9 402. (https:\/\/doi.org\/10.3389\/fendo.2018.00402)"},{"key":"bib52","series-title":"Genet Test Mol Biomark","first-page":"644","article-title":"Genetic determination of ischemic vs idiopathic dilated cardiomyopathy","volume":"22","author":"Onrat ST","year":"2018","unstructured":"Onrat ST\n, \nOnrat E\n, \nErcan Onay E\n, et al.\n 2018 Genetic determination of ischemic vs idiopathic dilated cardiomyopathy. Genet Test Mol Biomark 22 644\u2013651. (https:\/\/doi.org\/10.1089\/gtmb.2018.0188)"},{"key":"bib53","series-title":"J Rheumatol","first-page":"2214","article-title":"Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a meta analysis","volume":"33","author":"Opatrny L","year":"2006","unstructured":"Opatrny L\n, \nDavid M\n, \nKahn SR\n, et al.\n 2006 Association between antiphospholipid antibodies and recurrent fetal loss in women without autoimmune disease: a meta analysis. J Rheumatol 33 2214\u20132221."},{"key":"bib54","series-title":"Lab Med","first-page":"361","article-title":"Circulating miRNAs in myocardial infarction and lipid levels","volume":"55","author":"Ozuynuk Ertugrul AS","year":"2024","unstructured":"Ozuynuk Ertugrul AS\n, \nEkici B\n, \nErkan AF\n, et al.\n 2024 Circulating miRNAs in myocardial infarction and lipid levels. Lab Med 55 361\u2013372. (https:\/\/doi.org\/10.1093\/labmed\/lmad094)"},{"key":"bib55","series-title":"Clin Appl Thromb Hemost","first-page":"89","article-title":"Current debates in antiphospholipid syndrome: the acquired antibody mediated thrombophilia","volume":"10","author":"\u00d6zt\u00fcrk MA","year":"2004","unstructured":"\u00d6zt\u00fcrk MA\n, \nHaznedaro\u011flu IC\n, \nTurgut M\n, et al.\n 2004 Current debates in antiphospholipid syndrome: the acquired antibody mediated thrombophilia. Clin Appl Thromb Hemost 10 89\u2013126. (https:\/\/doi.org\/10.1177\/107602960401000201)"},{"key":"bib56","series-title":"J Biol Chem","article-title":"miR 210 3p from adipose macrophages disrupts insulin sensitivity","volume":"300","author":"Patra D","year":"2024","unstructured":"Patra D\n, \nRamprasad P\n, \nSharma S\n, et al.\n 2024 miR 210 3p from adipose macrophages disrupts insulin sensitivity. J Biol Chem 300 107328. (https:\/\/doi.org\/10.1016\/j.jbc.2024.107328)"},{"key":"bib57","series-title":"Sci Rep","article-title":"Atherothrombosis associated microRNAs in antiphospholipid syndrome and systemic lupus erythematosus patients","volume":"6","author":"P\u00e9rez S\u00e1nchez C","year":"2016","unstructured":"P\u00e9rez S\u00e1nchez C\n, \nAguirre MA\n, \nRuiz Lim\u00f3n P\n, et al.\n 2016 Atherothrombosis associated microRNAs in antiphospholipid syndrome and systemic lupus erythematosus patients. Sci Rep 6 31375. (https:\/\/doi.org\/10.1038\/srep31375)"},{"key":"bib58","series-title":"Haematologica","first-page":"908","article-title":"Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome","volume":"103","author":"P\u00e9rez S\u00e1nchez C","year":"2018","unstructured":"P\u00e9rez S\u00e1nchez C\n, \nArias de la Rosa I\n, \nAguirre M\u00c1\n, et al.\n 2018 Circulating microRNAs as biomarkers of disease and typification of the atherothrombotic status in antiphospholipid syndrome. Haematologica 103 908\u2013918. (https:\/\/doi.org\/10.3324\/haematol.2017.184416)"},{"key":"bib59","series-title":"PLoS One","article-title":"Circulating miRNAs of the \u2018Asian Indian phenotype\u2019 in impaired glucose tolerance and type 2 diabetes","volume":"10","author":"Prabu P","year":"2018","unstructured":"Prabu P\n, \nRome S\n, \nSathishkumar C\n, et al.\n 2018 Circulating miRNAs of the \u2018Asian Indian phenotype\u2019 in impaired glucose tolerance and type 2 diabetes. PLoS One 10 e0128372. (https:\/\/doi.org\/10.1371\/journal.pone.0128372)"},{"key":"bib60","series-title":"Cureus","article-title":"Unraveling the association between myocardial infarction of nonobstructive coronary arteries and antiphospholipid syndrome","volume":"13","author":"Ramjas V","year":"2021","unstructured":"Ramjas V\n, \nJain A\n, \nLee RDM\n, et al.\n 2021 Unraveling the association between myocardial infarction of nonobstructive coronary arteries and antiphospholipid syndrome. Cureus 13 17002. (https:\/\/doi.org\/10.7759\/cureus.17002)"},{"key":"bib61","series-title":"J Am Coll Cardiol","first-page":"920","article-title":"Circulating miR 29a, among other up regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy","volume":"63","author":"Roncarati R","year":"2014","unstructured":"Roncarati R\n, \nViviani Anselmi C\n, \nLosi MA\n, et al.\n 2014 Circulating miR 29a, among other up regulated microRNAs, is the only biomarker for both hypertrophy and fibrosis in patients with hypertrophic cardiomyopathy. J Am Coll Cardiol 63 920\u2013927. (https:\/\/doi.org\/10.1016\/j.jacc.2013.09.041)"},{"key":"bib62","series-title":"PLoS One","article-title":"Whole blood microRNA expression associated with stroke","volume":"14","author":"Salinas J","year":"2019","unstructured":"Salinas J\n, \nLin H\n, \nAparico HJ\n, et al.\n 2019 Whole blood microRNA expression associated with stroke. PLoS One 14 e0219261. (https:\/\/doi.org\/10.1371\/journal.pone.0219261)"},{"key":"bib63","series-title":"Thromb Res","first-page":"213","article-title":"Thrombotic antiphospholipid syndrome: a practical guide to diagnosis and management","volume":"198","author":"Sayar Z","year":"2021","unstructured":"Sayar Z\n, \nMoll R\n, \nIsenberg D\n, et al.\n 2021 Thrombotic antiphospholipid syndrome: a practical guide to diagnosis and management. Thromb Res 198 213\u2013221. (https:\/\/doi.org\/10.1016\/j.thromres.2020.10.010)"},{"key":"bib64","series-title":"Ann Rheum Dis","first-page":"2028","article-title":"The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review","volume":"74","author":"Sciascia S","year":"2015","unstructured":"Sciascia S\n, \nSanna G\n, \nKhamashta MA\n, et al.\n 2015 The estimated frequency of antiphospholipid antibodies in young adults with cerebrovascular events: a systematic review. Ann Rheum Dis 74 2028\u20132033. (https:\/\/doi.org\/10.1136\/annrheumdis-2014-205663)"},{"key":"bib65","series-title":"Int J Cardiol","first-page":"209","article-title":"Anti phospholipid antibody prevalence and association with subclinical atherosclerosis and atherothrombosis in the general population","volume":"300","author":"Selmi C","year":"2020","unstructured":"Selmi C\n, \nDe Santis M\n, \nBattezzati PM\n, et al.\n 2020 Anti phospholipid antibody prevalence and association with subclinical atherosclerosis and atherothrombosis in the general population. Int J Cardiol 300 209\u2013213. (https:\/\/doi.org\/10.1016\/j.ijcard.2019.10.042)"},{"key":"bib66","series-title":"Arthritis Care Res","first-page":"324","article-title":"Characteristics of patients with antiphospholipid antibody positivity in the APS ACTION international clinical database and repository","volume":"74","author":"Sevim E","year":"2022","unstructured":"Sevim E\n, \nZisa D\n, \nAndrade D\n, et al.\n 2022 Characteristics of patients with antiphospholipid antibody positivity in the APS ACTION international clinical database and repository. Arthritis Care Res 74 324\u2013335. (https:\/\/doi.org\/10.1002\/acr.24468)"},{"key":"bib67","series-title":"Exp Ther Med","first-page":"4356","article-title":"Effect of microRNA 133a 3p\/MMP 9 axis on atherosclerotic VSMCs","volume":"18","author":"Shi L","year":"2019","unstructured":"Shi L\n, \nYu C\n, \nTian X\n, et al.\n 2019 Effect of microRNA 133a 3p\/MMP 9 axis on atherosclerotic VSMCs. Exp Ther Med 18 4356\u20134362. (https:\/\/doi.org\/10.3892\/etm.2019.8070)"},{"key":"bib68","series-title":"Obstet Gynecol","first-page":"641","article-title":"Antiphospholipid antibodies in stillbirth","volume":"122","author":"Silver RM","year":"2013","unstructured":"Silver RM\n, \nParker CB\n, \nReddy UM\n, et al.\n 2013 Antiphospholipid antibodies in stillbirth. Obstet Gynecol 122 641\u2013657. (https:\/\/doi.org\/10.1097\/aog.0b013e3182a1060e)"},{"key":"bib69","series-title":"Int J Mol Sci","article-title":"Small extracellular vesicle derived miRNA profile identifies miR 483 3p and miR 326 as regulators in the pathogenesis of antiphospholipid syndrome","volume":"24","author":"Sol\u00e9 C","year":"2023","unstructured":"Sol\u00e9 C\n, \nRoyo M\n, \nSandoval S\n, et al.\n 2023 Small extracellular vesicle derived miRNA profile identifies miR 483 3p and miR 326 as regulators in the pathogenesis of antiphospholipid syndrome. Int J Mol Sci 24 11607. (https:\/\/doi.org\/10.3390\/ijms241411607)"},{"key":"bib70","series-title":"Sci Rep","first-page":"8419","article-title":"Differential gene expression and miRNA network in coronary slow flow","volume":"14","author":"Sun L","year":"2024","unstructured":"Sun L\n, \nWang J\n, \nLei J\n, et al.\n 2024 Differential gene expression and miRNA network in coronary slow flow. Sci Rep 14 8419. (https:\/\/doi.org\/10.1038\/s41598-024-58745-w)"},{"key":"bib71","series-title":"Cells","first-page":"3526","article-title":"Platelet miR 142 3p as biomarker for acute coronary syndrome","volume":"10","author":"Szelenberger R","year":"2021","unstructured":"Szelenberger R\n, \nKarbownik MS\n, \nKacprzak M\n, et al.\n 2021 Platelet miR 142 3p as biomarker for acute coronary syndrome. Cells 10 3526. (https:\/\/doi.org\/10.3390\/cells10123526)"},{"key":"bib72","series-title":"Gene","first-page":"213","article-title":"MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus","volume":"539","author":"Takahashi P","year":"2014","unstructured":"Takahashi P\n, \nXavier DJ\n, \nEvangelista AF\n, et al.\n 2014 MicroRNA expression profiling and functional annotation analysis of their targets in patients with type 1 diabetes mellitus. Gene 539 213\u2013223. (https:\/\/doi.org\/10.1016\/j.gene.2014.01.075)"},{"key":"bib73","series-title":"Clin Exp Hypertens","first-page":"281","article-title":"Hsa_circ_0037897 and hypertension via miR 145 5p","volume":"43","author":"Tao Z","year":"2021","unstructured":"Tao Z\n, \nZheng S\n, \nHe X\n, et al.\n 2021 Hsa_circ_0037897 and hypertension via miR 145 5p. Clin Exp Hypertens 43 281\u2013286. (https:\/\/doi.org\/10.1080\/10641963.2020.1860081)"},{"key":"bib74","series-title":"J Thromb Haemostasis","first-page":"1985","article-title":"Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome","volume":"9","author":"Teruel R","year":"2011","unstructured":"Teruel R\n, \nP\u00e9rez S\u00e1nchez C\n, \nCorral J\n, et al.\n 2011 Identification of miRNAs as potential modulators of tissue factor expression in patients with systemic lupus erythematosus and antiphospholipid syndrome. J Thromb Haemostasis 9 1985\u20131992. (https:\/\/doi.org\/10.1111\/j.1538-7836.2011.04451.x)"},{"key":"bib75","series-title":"PLoS One","article-title":"Plasma microRNA 16 as a biomarker for hyperacute cerebral infarction","volume":"11","author":"Tian C","year":"2016","unstructured":"Tian C\n, \nLi Z\n, \nYang Z\n, et al.\n 2016 Plasma microRNA 16 as a biomarker for hyperacute cerebral infarction. PLoS One 11 e0166688. (https:\/\/doi.org\/10.1371\/journal.pone.0166688)"},{"key":"bib76","series-title":"Exp Ther Med","first-page":"595","article-title":"MicroRNA 199a 5p aggravates primary hypertension by damaging vascular endothelial cells","volume":"16","author":"Tian X","year":"2018","unstructured":"Tian X\n, \nYu C\n, \nShi L\n, et al.\n 2018 MicroRNA 199a 5p aggravates primary hypertension by damaging vascular endothelial cells. Exp Ther Med 16 595\u2013602. (https:\/\/doi.org\/10.3892\/etm.2018.6252)"},{"key":"bib77","series-title":"J Mol Med","first-page":"845","article-title":"Plasma microRNAs as biomarkers for Lamin A\/C related dilated cardiomyopathy","volume":"96","author":"Toro R","year":"2018","unstructured":"Toro R\n, \nBlasco-Turri\u00f3n S\n, \nMorales Ponce FJ\n, et al.\n 2018 Plasma microRNAs as biomarkers for Lamin A\/C related dilated cardiomyopathy. J Mol Med 96 845\u2013856. (https:\/\/doi.org\/10.1007\/s00109-018-1666-1)"},{"key":"bib78","series-title":"Genome Biol","article-title":"Accurate normalization of real time quantitative RT PCR data by geometric averaging of multiple internal control genes","volume":"3","author":"Vandesompele J","year":"2002","unstructured":"Vandesompele J\n, \nDe Preter K\n, \nPattyn F\n, et al.\n 2002 Accurate normalization of real time quantitative RT PCR data by geometric averaging of multiple internal control genes. Genome Biol 3 research0034.1. (https:\/\/doi.org\/10.1186\/gb-2002-3-7-research0034)"},{"key":"bib79","series-title":"Adv Clin Exp Med","first-page":"865","article-title":"MicroRNA in cardiovascular biology and disease","volume":"26","author":"Wojciechowska A","year":"2017","unstructured":"Wojciechowska A\n, \nBraniewska A\n & \nKozar Kami\u0144ska K\n\n 2017 MicroRNA in cardiovascular biology and disease. Adv Clin Exp Med 26 865\u2013874. (https:\/\/doi.org\/10.17219\/acem\/62915)"},{"key":"bib80","series-title":"Noncoding RNA Res","first-page":"471","article-title":"Integrative analysis of miRNA\u2013mRNA networks in intracranial aneurysms","volume":"9","author":"Xu D","year":"2024","unstructured":"Xu D\n, \nGareev I\n, \nBeylerli O\n, et al.\n 2024 Integrative analysis of miRNA\u2013mRNA networks in intracranial aneurysms. Noncoding RNA Res 9 471\u2013485. (https:\/\/doi.org\/10.1016\/j.ncrna.2024.01.004)"},{"key":"bib81","series-title":"Mol Biol Rep","first-page":"2605","article-title":"MIAT\/miR 133a 3p axis in atrial fibrillation","volume":"47","author":"Yao L","year":"2020","unstructured":"Yao L\n, \nZhou B\n, \nYou L\n, et al.\n 2020 MIAT\/miR 133a 3p axis in atrial fibrillation. Mol Biol Rep 47 2605\u20132617. (https:\/\/doi.org\/10.1007\/s11033-020-05347-0)"},{"key":"bib82","series-title":"J Cell Mol Med","first-page":"1146","article-title":"Circulating microRNAs as diagnostic biomarkers for coronary artery disease","volume":"24","author":"Zhang L","year":"2020","unstructured":"Zhang L\n, \nZhang Y\n, \nXue S\n, et al.\n 2020 Circulating microRNAs as diagnostic biomarkers for coronary artery disease. J Cell Mol Med 24 1146\u20131150. (https:\/\/doi.org\/10.1111\/jcmm.14802)"},{"key":"bib83","series-title":"Int J Cardiol","first-page":"68","article-title":"miR 145 5p affects autophagy via CaMKII\u03b4 in atherosclerosis","volume":"360","author":"Zhang X","year":"2022","unstructured":"Zhang X\n, \nZai L\n, \nTao Z\n, et al.\n 2022 miR 145 5p affects autophagy via CaMKII\u03b4 in atherosclerosis. Int J Cardiol 360 68\u201375. (https:\/\/doi.org\/10.1016\/j.ijcard.2022.05.039)"},{"key":"bib84","series-title":"J Stroke Cerebrovasc Dis","article-title":"Machine learning analysis of microRNAs for ischemic stroke","volume":"30","author":"Zhao X","year":"2021","unstructured":"Zhao X\n, \nChen X\n, \nWu X\n, et al.\n 2021 Machine learning analysis of microRNAs for ischemic stroke. J Stroke Cerebrovasc Dis 30 105825. (https:\/\/doi.org\/10.1016\/j.jstrokecerebrovasdis.2021.105825)"},{"key":"bib85","series-title":"PeerJ","article-title":"The association between antiphospholipid syndrome and atrial fibrillation: a single center retrospective case control study","volume":"12","author":"Zhou Z","year":"2024","unstructured":"Zhou Z\n & \nLiu Y\n\n 2024 The association between antiphospholipid syndrome and atrial fibrillation: a single center retrospective case control study. PeerJ 12 17617. (https:\/\/doi.org\/10.7717\/peerj.17617)"},{"key":"bib86","series-title":"JAMA Netw Open","article-title":"Prevalence of antiphospholipid antibodies and association with incident cardiovascular events","volume":"6","author":"Zuo Y","year":"2023","unstructured":"Zuo Y\n, \nNavaz S\n, \nLiang W\n, et al.\n 2023 Prevalence of antiphospholipid antibodies and association with incident cardiovascular events. JAMA Netw Open 6 236530. (https:\/\/doi.org\/10.1001\/jamanetworkopen.2023.6530)"}],"container-title":["Reproduction and Fertility"],"original-title":[],"link":[{"URL":"https:\/\/raf.bioscientifica.com\/view\/journals\/raf\/7\/2\/RAF-25-0101.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/raf.bioscientifica.com\/downloadpdf\/journals\/raf\/7\/2\/RAF-25-0101.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/raf.bioscientifica.com\/downloadpdf\/journals\/raf\/7\/2\/RAF-25-0101.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,30]],"date-time":"2026-06-30T18:51:00Z","timestamp":1782845460000},"score":1,"resource":{"primary":{"URL":"https:\/\/raf.bioscientifica.com\/view\/journals\/raf\/7\/2\/RAF-25-0101.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":172,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.1530\/raf-25-0101","relation":{},"ISSN":["2633-8386"],"issn-type":[{"value":"2633-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]}}}