{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T19:20:20Z","timestamp":1783452020175,"version":"3.55.0"},"reference-count":71,"publisher":"Bioscientifica","issue":"2","license":[{"start":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T00:00:00Z","timestamp":1783382400000},"content-version":"vor","delay-in-days":97,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc-nd\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,4,1]]},"abstract":"<jats:sec>\n                    <jats:title>Graphical Abstract<\/jats:title>\n                    <jats:p\/>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Psychological imbalance is hypothesized to negatively affect reproductive function and vice versa; however, the underlying mechanisms of this relationship remain poorly understood. Therefore, this study aimed to investigate the association between infertility and anxiety and\/or depression by examining underlying genetic factors. The study was conducted in several stages: i) psychological assessment of women undergoing assisted reproductive technology (ART) due to couple infertility using the Hospital Anxiety and Depression Scale (HADS), ii) collection of endometrial samples before ART procedures, iii) isolation and cultivation of human endometrial-derived mesenchymal stromal cells (EnSCs), iv) analysis of 26 EnSC genes using reverse transcription-quantitative polymerase chain reaction (RT-qPCR), and v) statistical analysis. A total of 32 women were included in the study. Twelve participants reported considerable symptoms of anxiety, and one showed symptoms of depression. Nineteen women conceived after ART. Gene expression analysis suggested altered expression of genes involved in cell cycle regulation, transcription and translation, immune response, signal transduction, cell differentiation, secretion, angiogenesis, and hemostasis according to anxiety status. These mechanisms may influence, or at least reflect, pregnancy outcomes following ART. The findings suggest a potential relationship between anxiety symptoms and gene activity in the endometrium of women undergoing ART. However, the relatively small sample size limits the strength of the conclusions; therefore, the results should be interpreted as preliminary. Further studies with larger cohorts are required to confirm these observations and to better understand the interaction between psychological well-being and molecular mechanisms involved in fertility.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Infertility affects many couples worldwide and can be emotionally challenging. People undergoing fertility treatment often experience stress or anxiety, but it is still unclear how emotional well-being may influence reproductive health. In this study, we explored whether anxiety might be linked to biological processes involved in fertility. Women undergoing assisted reproductive treatment completed a questionnaire about anxiety and depression symptoms. We also analyzed small tissue samples from the lining of the uterus, which is important for embryo implantation and pregnancy. Our findings suggested that women who reported higher anxiety levels showed differences in some biological processes compared with women who reported lower anxiety levels. Some of these differences were also observed in women who did not become pregnant after treatment. Although the study involved a small number of participants, the results suggest that emotional well-being may be connected to reproduction and highlight the importance of psychological support during fertility treatment.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-25-0165","type":"journal-article","created":{"date-parts":[[2026,5,14]],"date-time":"2026-05-14T10:12:03Z","timestamp":1778753523000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":0,"title":["A bridge between infertility and anxiety: a novel role for genes"],"prefix":"10.1530","volume":"7","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-4183-1895","authenticated-orcid":true,"given":"Raminta","family":"Bausyte","sequence":"first","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Brigita","family":"Vaigauskaite \u2013 Mazeikiene","sequence":"additional","affiliation":[{"name":"1"},{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giedre","family":"Skliute","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Elvina","family":"Valatkaite","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Evelina","family":"Sabaityte","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edita","family":"Kazenaite","sequence":"additional","affiliation":[{"name":"3"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diana","family":"Ramasauskaite","sequence":"additional","affiliation":[{"name":"2"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruta","family":"Navakauskiene","sequence":"additional","affiliation":[{"name":"1"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,5,12]]},"reference":[{"key":"2026070714161426500_bib2","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1093\/molehr\/gap102","article-title":"Endometrial gene expression analysis at the time of embryo implantation in women with unexplained infertility","volume":"16","author":"Altm\u00e4e","year":"2010","journal-title":"Mol Hum Reprod"},{"key":"2026070714161426500_bib53","volume-title":"ScienceDaily","author":"American Physiological Society 2018 Preconception zinc deficiency could spell bad news for fertility: Micronutrient availability can have early and long-lasting effects on egg quality."},{"key":"2026070714161426500_bib4","doi-asserted-by":"crossref","first-page":"1083","DOI":"10.1016\/S0028-3908(99)00010-6","article-title":"A review of central 5-HT receptors and their function","volume":"38","author":"Barnes","year":"1999","journal-title":"Neuropharmacology"},{"key":"2026070714161426500_bib5","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1007\/s00438-014-0841-5","article-title":"Pregnancy complicated by obesity induces global transcript expression alterations in visceral and subcutaneous fat","volume":"289","author":"Bashiri","year":"2014","journal-title":"Mol Genet Genom"},{"key":"2026070714161426500_bib6","doi-asserted-by":"crossref","first-page":"144","DOI":"10.2298\/MPNS0404144B","article-title":"[Pregnancy as a psychological event]","volume":"57","author":"Bjelica","year":"2004","journal-title":"Med Pregl"},{"key":"2026070714161426500_bib7","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1016\/S0022-3999(01)00296-3","article-title":"The validity of the Hospital Anxiety and Depression Scale. An updated literature review","volume":"52","author":"Bjelland","year":"2002","journal-title":"J Psychosom Res"},{"key":"2026070714161426500_bib8","first-page":"27","volume-title":"Vitamins and Hormones","author":"Borrow","year":"2017"},{"key":"2026070714161426500_bib9","doi-asserted-by":"crossref","first-page":"942","DOI":"10.1210\/en.2015-1216","article-title":"Ephrin-A5 is required for optimal fertility and a complete ovulatory response to gonadotropins in the female mouse","volume":"157","author":"Buensuceso","year":"2016","journal-title":"Endocrinology"},{"key":"2026070714161426500_bib10","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1056\/NEJMra0804690","article-title":"Endometriosis","volume":"360","author":"Bulun","year":"2009","journal-title":"N Engl J Med"},{"key":"2026070714161426500_bib11","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/j.fertnstert.2012.06.029","article-title":"Pathogenesis and pathophysiology of endometriosis","volume":"98","author":"Burney","year":"2012","journal-title":"Fertil Steril"},{"key":"2026070714161426500_bib12","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.rbmo.2018.01.007","article-title":"Sperm count and motility are quantitatively affected by functional polymorphisms of HTR2A, MAOA and SLC18A","volume":"36","author":"Cort\u00e9s-Rodriguez","year":"2018","journal-title":"Reprod Biomed Online"},{"key":"2026070714161426500_bib13","doi-asserted-by":"crossref","first-page":"881","DOI":"10.2471\/BLT.10.011210","article-title":"Mother of nothing: the agony of infertility","volume":"88","author":"Cui","year":"2010","journal-title":"Bull World Health Organ"},{"key":"2026070714161426500_bib14","first-page":"163","article-title":"Psychopathology, emotional aspects and psychological counselling in infertility: a review","volume":"165","author":"De Berardis","year":"2014","journal-title":"La Clinica Terapeutica"},{"key":"2026070714161426500_bib15","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1016\/j.fertnstert.2019.11.025","article-title":"Definitions of infertility and recurrent pregnancy loss: a committee opinion","volume":"113","author":"Practice Committee of the American Society for Reproductive Medicine. Electronic address: asrm@asrm.org","year":"2020","journal-title":"Fertil Steril"},{"key":"2026070714161426500_bib16","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.fertnstert.2010.04.063","article-title":"A genomic diagnostic tool for human endometrial receptivity based on the transcriptomic signature","volume":"95","author":"D\u00edaz-Gimeno","year":"2011","journal-title":"Fertil Steril"},{"key":"2026070714161426500_bib17","doi-asserted-by":"crossref","DOI":"10.1093\/humrep\/deac106.011","article-title":"P-349 European atlas of fertility treatment policies \u2013 education and advocacy tool","volume":"37","author":"Fincham","year":"2022","journal-title":"Hum Reprod"},{"key":"2026070714161426500_bib3","author":"Fortune Business Insights 2019 Assisted reproductive technology market size, share & industry analysis, by procedure, by end user and regional forecast 2019\u20132026"},{"key":"2026070714161426500_bib18","doi-asserted-by":"crossref","DOI":"10.1038\/s41598-018-29462-y","article-title":"Genetic regulation of disease risk and endometrial gene expression highlights potential target genes for endometriosis and polycystic ovarian syndrome","volume":"8","author":"Fung","year":"2018","journal-title":"Sci Rep"},{"key":"2026070714161426500_bib19","doi-asserted-by":"crossref","DOI":"10.7554\/eLife.04316","article-title":"Knockdown of hypothalamic RFRP3 prevents chronic stress-induced infertility and embryo resorption","volume":"4","author":"Geraghty","year":"2015","journal-title":"Elife"},{"key":"2026070714161426500_bib20","doi-asserted-by":"crossref","first-page":"148","DOI":"10.1111\/aji.12226","article-title":"Recent advances in understanding endometrial receptivity: molecular basis and clinical applications","volume":"72","author":"von Grothusen","year":"2014","journal-title":"Am J Reprod Immunol"},{"key":"2026070714161426500_bib22","first-page":"443","article-title":"Behavioral impairments in animal models for zinc deficiency","volume":"8","author":"Hagmeyer","year":"2014","journal-title":"Front Behav Neurosci"},{"key":"2026070714161426500_bib23","article-title":"Infertility and contraception","volume-title":"Harrison\u2019s Principles of Internal Medicine","author":"Hall","year":"2018","edition":"20th edn"},{"key":"2026070714161426500_bib24","doi-asserted-by":"crossref","first-page":"1436","DOI":"10.1093\/humrep\/dep039","article-title":"Gene expression profile of human endometrial receptivity: comparison between natural and stimulated cycles for the same patients","volume":"24","author":"Haouzi","year":"2009","journal-title":"Hum Reprod"},{"key":"2026070714161426500_bib25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.rbmo.2011.09.009","article-title":"Insights into human endometrial receptivity from transcriptomic and proteomic data","volume":"24","author":"Haouzi","year":"2012","journal-title":"Reprod Biomed Online"},{"key":"2026070714161426500_bib26","doi-asserted-by":"crossref","first-page":"440","DOI":"10.1095\/biolreprod.110.088195","article-title":"IGF2 actions on trophoblast in human placenta are regulated by the insulin-like growth factor 2 receptor, which can function as both a signaling and clearance Receptor1","volume":"84","author":"Harris","year":"2011","journal-title":"Biol Reprod"},{"key":"2026070714161426500_bib21","doi-asserted-by":"crossref","first-page":"882.1","DOI":"10.1096\/fasebj.2018.32.1_supplement.882.1","article-title":"Growing Oocytes Need Zinc: Zinc Deficiency in the Preantral Ovarian Follicle","volume":"32","author":"Hester","year":"2018","journal-title":"The FASEB Journal"},{"key":"2026070714161426500_bib27","doi-asserted-by":"crossref","first-page":"4500","DOI":"10.1210\/jc.2008-0588","article-title":"Controlled ovarian stimulation induces a functional genomic delay of the endometrium with potential clinical implications","volume":"93","author":"Horcajadas","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"key":"2026070714161426500_bib30","doi-asserted-by":"crossref","first-page":"5973","DOI":"10.3892\/mmr.2015.4125","article-title":"Zinc deficiency during in vitro maturation of porcine oocytes causes meiotic block and developmental failure","volume":"12","author":"Jeon","year":"2015","journal-title":"Mol Med Rep"},{"key":"2026070714161426500_bib31","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1016\/j.mam.2012.05.011","article-title":"The SLC39 family of zinc transporters","volume":"34","author":"Jeong","year":"2013","journal-title":"Mol Aspect Med"},{"key":"2026070714161426500_bib32","doi-asserted-by":"crossref","first-page":"1237","DOI":"10.3390\/biomedicines11051237","article-title":"Tissue factor pathway inhibitors as potential targets for understanding the pathophysiology of Preeclampsia","volume":"11","author":"Kobayashi","year":"2023","journal-title":"Biomedicines"},{"key":"2026070714161426500_bib33","doi-asserted-by":"crossref","DOI":"10.1038\/srep19411","article-title":"An endometrial gene expression signature accurately predicts recurrent implantation failure after IVF","volume":"6","author":"Koot","year":"2016","journal-title":"Sci Rep"},{"key":"2026070714161426500_bib34","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1186\/s13287-019-1272-3","article-title":"Transplantation of human endometrial perivascular cells with elevated CYR61 expression induces angiogenesis and promotes repair of a full-thickness uterine injury in rat","volume":"10","author":"Li","year":"2019","journal-title":"Stem Cell Res Ther"},{"key":"2026070714161426500_bib35","doi-asserted-by":"crossref","first-page":"1299","DOI":"10.1007\/s10815-019-01483-0","article-title":"Epigenetically regulated imprinted gene expression associated with IVF and infertility: possible influence of prenatal stress and depression","volume":"36","author":"Litzky","year":"2019","journal-title":"J Assist Reprod Genet"},{"key":"2026070714161426500_bib36","doi-asserted-by":"crossref","first-page":"653","DOI":"10.1080\/15592294.2017.1336589","article-title":"Placental imprinting variation associated with assisted reproductive technologies and subfertility","volume":"12","author":"Litzky","year":"2017","journal-title":"Epigenetics"},{"key":"2026070714161426500_bib37","doi-asserted-by":"crossref","DOI":"10.1002\/advs.201900295","article-title":"RNA-Binding protein IGF2BP2\/IMP2 is a critical maternal activator in early zygotic genome activation","volume":"6","author":"Liu","year":"2019","journal-title":"Adv Sci"},{"key":"2026070714161426500_bib38","doi-asserted-by":"crossref","first-page":"2184","DOI":"10.1016\/j.fertnstert.2010.06.078","article-title":"Stress reduces conception probabilities across the fertile window: evidence in support of relaxation","volume":"95","author":"Louis","year":"2011","journal-title":"Fertil Steril"},{"key":"2026070714161426500_bib39","doi-asserted-by":"crossref","first-page":"1067","DOI":"10.1093\/humrep\/deu032","article-title":"Preconception stress increases the risk of infertility: results from a couple-based prospective cohort study \u2013 the LIFE study","volume":"29","author":"Lynch","year":"2014","journal-title":"Hum Reprod"},{"key":"2026070714161426500_bib40","doi-asserted-by":"crossref","first-page":"357","DOI":"10.1177\/1933719107311781","article-title":"The impact of ovarian stimulation with recombinant FSH in combination with GnRH antagonist on the endometrial transcriptome in the window of implantation","volume":"15","author":"Macklon","year":"2008","journal-title":"Reprod Sci"},{"key":"2026070714161426500_bib41","first-page":"1","article-title":"Fertility of men and women aged 15\u201344 years in the United States: National Survey of Family Growth, 2006\u20132010","volume":"51","author":"Martinez","year":"2012","journal-title":"Natl Health Stat Rep"},{"key":"2026070714161426500_bib42","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pmed.1001356","article-title":"National, regional, and global trends in infertility prevalence since 1990: a systematic analysis of 277 health surveys","volume":"9","author":"Mascarenhas","year":"2012","journal-title":"PLoS Med"},{"key":"2026070714161426500_bib43","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1093\/molehr\/5.6.559","article-title":"Oestrogen receptor alpha and beta mRNA expression in human endometrium throughout the menstrual cycle","volume":"5","author":"Matsuzaki","year":"1999","journal-title":"Mol Hum Reprod"},{"key":"2026070714161426500_bib44","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1186\/s13048-014-0114-2","article-title":"ESR1 and ESR2 gene polymorphisms are associated with human reproduction outcomes in Brazilian women","volume":"7","author":"de Mattos","year":"2014","journal-title":"J Ovarian Res"},{"key":"2026070714161426500_bib45","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1093\/molehr\/gax034","article-title":"Infertility diagnosis has a significant impact on the transcriptome of developing blastocysts","volume":"23","author":"McCallie","year":"2017","journal-title":"Mol Hum Reprod"},{"key":"2026070714161426500_bib46","doi-asserted-by":"crossref","first-page":"8709","DOI":"10.1128\/MCB.22.24.8709-8720.2002","article-title":"CYR61 (CCN1) is essential for placental development and vascular integrity","volume":"22","author":"Mo","year":"2002","journal-title":"Mol Cell Biol"},{"key":"2026070714161426500_bib47","doi-asserted-by":"crossref","first-page":"2118","DOI":"10.18632\/aging.202214","article-title":"IGF2 improves the developmental competency and meiotic structure of oocytes from aged mice","volume":"13","author":"Muhammad","year":"2020","journal-title":"Aging"},{"key":"2026070714161426500_bib1","author":"National Center for Biotechnology Information (NCBI) 2022a AFF3 ALF Transcription Elongation Factor 3 [Homo Sapiens (Human)]"},{"key":"2026070714161426500_bib55","author":"National Center for Biotechnology Information (NCBI) 2022b GATAD2B \u2013 GATA zinc finger domain containing 2B (human). PubChem Gene"},{"key":"2026070714161426500_bib56","volume-title":"PubChem Gene","author":"National Center for Biotechnology Information (NCBI) 2022c NR3C1 \u2013 nuclear receptor subfamily 3 group C member 1 (human)"},{"key":"2026070714161426500_bib61","author":"National Center for Biotechnology Information (NCBI) (2022d) SLC39A1 solute carrier family 39 member 1 [Homo sapiens (human)] (Gene ID: 27173). NCBI Gene"},{"key":"2026070714161426500_bib28","author":"National Center for Biotechnology Information (NCBI) 2026 HTR2A serotonin receptor 2A [Homo sapiens (human)] (Gene ID: 3356). NCBI Gene."},{"key":"2026070714161426500_bib48","article-title":"RBM5 is a male germ cell splicing factor and is required for spermatid differentiation and male fertility","volume":"9","author":"O\u2019Bryan","year":"2013","journal-title":"PLoS Genet"},{"key":"2026070714161426500_bib49","doi-asserted-by":"crossref","first-page":"605","DOI":"10.1093\/humupd\/dmn042","article-title":"Infertility and the provision of infertility medical services in developing countries","volume":"14","author":"Ombelet","year":"2008","journal-title":"Hum Reprod Update"},{"key":"2026070714161426500_bib50","doi-asserted-by":"crossref","first-page":"907","DOI":"10.1155\/2013\/796290","article-title":"ESR1 Rs9340799 is associated with endometriosis-related infertility and in vitro fertilization failure","volume":"35","author":"Paskulin","year":"2013","journal-title":"Dis Markers"},{"key":"2026070714161426500_bib51","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1093\/humrep\/den463","article-title":"Prospective longitudinal cohort study on cumulative 5-year delivery and adoption rates among 1338 couples initiating infertility treatment","volume":"24","author":"Pinborg","year":"2009","journal-title":"Hum Reprod"},{"key":"2026070714161426500_bib52","doi-asserted-by":"crossref","first-page":"611","DOI":"10.1242\/dev.116.3.611","article-title":"PAX8, a human paired box gene: isolation and expression in developing thyroid, kidney and wilms\u2019 tumors","volume":"116","author":"Poleev","year":"1992","journal-title":"Development"},{"key":"2026070714161426500_bib54","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1016\/S0165-2478(01)00311-X","article-title":"A defective expression of ICAM-1 (CD54) on secretory endometrial cells is associated with endometriosis","volume":"80","author":"Prefumo","year":"2002","journal-title":"Immunol Lett"},{"key":"2026070714161426500_bib57","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1093\/biolre\/ioy172","article-title":"A novel, noncoding-RNA-mediated, post-transcriptional mechanism of anti-Mullerian hormone regulation by the H19\/Let-7 axis\u2020","volume":"100","author":"Qin","year":"2019","journal-title":"Biol Reprod"},{"key":"2026070714161426500_bib58","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1186\/1472-6874-4-9","article-title":"A survey of relationship between anxiety, depression and duration of infertility","volume":"4","author":"Ramezanzadeh","year":"2004","journal-title":"BMC Womens Health"},{"key":"2026070714161426500_bib59","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1016\/j.bbadis.2012.05.004","article-title":"The genomics of the human endometrium","volume":"1822","author":"Ruiz-Alonso","year":"2012","journal-title":"Biochim Biophys Acta"},{"key":"2026070714161426500_bib60","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1002\/9781118849613.ch3","volume-title":"Human Reproduction","author":"Sengupta","year":"2017","edition":"H Schatten (Ed."},{"key":"2026070714161426500_bib63","doi-asserted-by":"crossref","DOI":"10.3389\/fcell.2021.765265","article-title":"Decidualization potency and epigenetic changes in human endometrial origin stem cells during propagation","volume":"9","author":"Valatkait\u0117","year":"2021","journal-title":"Front Cell Dev Biol"},{"key":"2026070714161426500_bib64","doi-asserted-by":"crossref","first-page":"1392","DOI":"10.1016\/j.fertnstert.2006.03.064","article-title":"Insulin-like growth factor-II (IGF-II), IGF-binding protein-3 (IGFBP-3), and IGFBP-4 in follicular fluid are associated with oocyte maturation and embryo development","volume":"86","author":"Wang","year":"2006","journal-title":"Fertil Steril"},{"key":"2026070714161426500_bib65","doi-asserted-by":"crossref","first-page":"4450","DOI":"10.1210\/en.2013-1652","article-title":"A role for glucocorticoids in stress-impaired reproduction: beyond the hypothalamus and pituitary","volume":"154","author":"Whirledge","year":"2013","journal-title":"Endocrinology"},{"key":"2026070714161426500_bib29","author":"World Health Organization 2004 Infecundity, Infertility, and Childlessness in Developing Countries. DHS Comparative Reports No. 9."},{"key":"2026070714161426500_bib66","article-title":"Psychological stress and functional endometrial disorders: update of mechanism insights","volume":"12","author":"Wu","year":"2021","journal-title":"Front Endocrinol"},{"key":"2026070714161426500_bib67","first-page":"3","article-title":"Biological functions and role of CCN1\/Cyr61 in embryogenesis and tumorigenesis in the female reproductive system (review)","volume":"17","author":"Yang","year":"2018","journal-title":"Mol Med Rep"},{"key":"2026070714161426500_bib68","doi-asserted-by":"crossref","first-page":"4694","DOI":"10.19082\/4694","article-title":"Counseling-supportive interventions to decrease infertile women\u2019s perceived stress: a systematic review","volume":"9","author":"Yazdani","year":"2017","journal-title":"Electron Physician"},{"key":"2026070714161426500_bib69","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1007\/s10815-016-0690-8","article-title":"The effects of psychosocial interventions on the mental health, pregnancy rates, and marital function of infertile couples undergoing in vitro fertilization: a systematic review","volume":"33","author":"Ying","year":"2016","journal-title":"J Assist Reprod Genet"},{"key":"2026070714161426500_bib70","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1093\/jmcb\/mjab034","article-title":"Sequential activation of uterine epithelial IGF1R by stromal IGF1 and embryonic IGF2 directs normal uterine preparation for embryo implantation","volume":"13","author":"Zhou","year":"2021","journal-title":"J Mol Cell Biol"},{"key":"2026070714161426500_bib62","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/s12958-020-00578-z","article-title":"The relationship between H19 and parameters of ovarian reserve","volume":"18","author":"Zhu","year":"2020","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026070714161426500_bib71","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"}],"container-title":["Reproduction and Fertility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/raf.bioscientifica.com\/view\/journals\/raf\/7\/2\/RAF-25-0165.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/raf.bioscientifica.com\/downloadpdf\/journals\/raf\/7\/2\/RAF-25-0165.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-25-0165\/521537\/raf-25-0165.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-25-0165\/521537\/raf-25-0165.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,7,7]],"date-time":"2026-07-07T18:17:22Z","timestamp":1783448242000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article\/7\/2\/RAF250165\/77677\/A-bridge-between-infertility-and-anxiety-a-novel"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,4,1]]},"references-count":71,"journal-issue":{"issue":"2","published-print":{"date-parts":[[2026,4,1]]}},"URL":"https:\/\/doi.org\/10.1530\/raf-25-0165","relation":{},"ISSN":["2633-8386"],"issn-type":[{"value":"2633-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,4,1]]},"article-number":"RAF250165"}}