{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T14:11:11Z","timestamp":1789135871428,"version":"build-2803163510"},"reference-count":51,"publisher":"Bioscientifica","issue":"3","license":[{"start":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T00:00:00Z","timestamp":1787616000000},"content-version":"vor","delay-in-days":55,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2026,7,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:sec>\n                    <jats:title>Abstract<\/jats:title>\n                    <jats:p>Endometriosis is a disease where cells similar to those of the uterine lining grow outside of the uterus, embedding into tissues and organs in the abdominal cavity, forming lesions and causing pain and infertility. Previous studies in patients with endometriosis identified single nucleotide polymorphisms associated with the disease, as well as somatic mutations in cancer-related genes. Here, we use bulk RNA sequencing to determine transcriptome mutation profiling and differentially expressed genes in endometriotic lesions, peritoneum, and eutopic endometrium of patients with endometriosis and control patients. Differential gene expression analysis revealed differences in the transcriptome in lesions based on their color, specifically increased inflammatory processes in red lesions compared with clear lesions. Furthermore, lesions expressed an increase in cell proliferation and estrogen response genes compared with eutopic endometrium. We identified an increased occurrence of somatic mutations in cancer-associated genes ARID1A, KRAS, PIK3CA, ARHGAP35, and PBRM1, which were conserved between lesions, peritoneum, and eutopic endometrium, in patients with endometriosis without cancer. These mutations arising from eutopic endometrium may have a role in the establishment and progression of the disease. Importantly, our findings suggest that excision of the visible endometriotic lesion tissue during surgery may not be sufficient for the complete removal of the lesion, leading to recurrence.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Lay summary<\/jats:title>\n                    <jats:p>Endometriosis is a condition in which tissue similar to the lining of the uterus (endometrium) grows on pelvic organs, causing pain and affecting fertility. We used RNA sequencing to measure differences in gene expression across three types of tissues: lesions, endometrium, and peritoneum (the membrane that covers internal organs where endometriosis lesions grow). We found that red lesions expressed more inflammation-related genes than clear lesions and that endometriosis lesions had more signs of cell growth and estrogen response than the other tissues. We also found mutations in genes linked to cancer across the three tissues in patients without cancer. These findings suggest that endometriosis may start or spread from changes in the uterine lining and that removing only the visible lesions during surgery may not always remove all of the disease.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-26-0057","type":"journal-article","created":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T10:54:55Z","timestamp":1787655295000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":0,"title":["Transcriptome differences in lesions by color, and cancer mutations in endometriosis"],"prefix":"10.1530","volume":"7","author":[{"given":"Jeremy Y","family":"Huang","sequence":"first","affiliation":[{"name":"Department of Genetics, Harvard Medical School 1 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University 2 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9363-1407","authenticated-orcid":true,"given":"Sona","family":"Relovska","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishi S","family":"Madnani","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Li","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School 1 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University 2 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Songlei","family":"Liu","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School 1 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University 2 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ankrish","family":"Milne","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ian N","family":"Waldman","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maya L","family":"Seshan","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne","family":"Lindholm","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emily R","family":"Disler","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rossella M","family":"Gargiulo","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ameya S","family":"Menta","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Junyi","family":"Chen","sequence":"additional","affiliation":[{"name":"Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park 5 , ,","place":["Hong Kong, China"]},{"name":"School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong 6 , ,","place":["Hong Kong, China"]},{"name":"Department of Health Technology and Informatics, The Hong Kong Polytechnic University 7 , ,","place":["Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandria N","family":"Young","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bradley J","family":"Quade","sequence":"additional","affiliation":[{"name":"Division of Women\u2019s and Perinatal Pathology, Brigham and Women\u2019s Hospital, Harvard Medical School 8 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonio R","family":"Gargiulo","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School 10 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marc R","family":"Laufer","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Division of Gynecology, Boston Children\u2019s Hospital and Harvard Medical School 9 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School 10 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joshua","family":"Ho","sequence":"additional","affiliation":[{"name":"Laboratory of Data Discovery for Health Limited (D24H), Hong Kong Science Park 5 , ,","place":["Hong Kong, China"]},{"name":"School of Biomedical Sciences, Li Ka Shing Faculty of Medicine, The University of Hong Kong 6 , ,","place":["Hong Kong, China"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark D","family":"Hornstein","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School 10 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George M","family":"Church","sequence":"additional","affiliation":[{"name":"Department of Genetics, Harvard Medical School 1 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Wyss Institute for Biologically Inspired Engineering at Harvard University 2 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5250-8434","authenticated-orcid":true,"given":"Michael S","family":"Rogers","sequence":"additional","affiliation":[{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Vascular Biology Program, Boston Children\u2019s Hospital 11 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Department of Surgery, Harvard Medical School 12 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raymond M","family":"Anchan","sequence":"additional","affiliation":[{"name":"Center for Infertility and Reproductive Surgery, Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, Brigham and Women\u2019s Hospital, Harvard Medical School 3 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Boston Center for Endometriosis 4 , , ,","place":["Boston, Massachusetts, USA"]},{"name":"Department of Obstetrics, Gynecology, and Reproductive Biology, Harvard Medical School 10 , , ,","place":["Boston, Massachusetts, USA"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,8,25]]},"reference":[{"key":"2026091109462186200_bib1","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/nmeth0410-248","article-title":"A method and server for predicting damaging missense mutations","volume":"7","author":"Adzhubei","year":"2010","journal-title":"Nat Methods"},{"key":"2026091109462186200_bib2","doi-asserted-by":"crossref","first-page":"354.e1","DOI":"10.1016\/j.ajog.2018.12.039","article-title":"Clinical diagnosis of endometriosis: a call to action","volume":"220","author":"Agarwal","year":"2019","journal-title":"Am J Obstet Gynecol"},{"key":"2026091109462186200_bib3","doi-asserted-by":"crossref","first-page":"93","DOI":"10.3390\/cancers12010093","article-title":"PIK3CA gene mutations in solid malignancies: association with clinicopathological parameters and prognosis","volume":"12","author":"Alqahtani","year":"2019","journal-title":"Cancers"},{"key":"2026091109462186200_bib4","doi-asserted-by":"crossref","first-page":"1835","DOI":"10.1056\/NEJMoa1614814","article-title":"Cancer-associated mutations in endometriosis without cancer","volume":"376","author":"Anglesio","year":"2017","journal-title":"N Engl J Med"},{"key":"2026091109462186200_bib5","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1016\/j.cell.2018.02.060","article-title":"Comprehensive characterization of cancer driver genes and mutations article comprehensive characterization of cancer driver genes and mutations","volume":"173","author":"Bailey","year":"2018","journal-title":"Cell"},{"key":"2026091109462186200_bib6","first-page":"361","article-title":"Gephi: an open source software for exploring and manipulating networks","volume":"3","author":"Bastian","year":"2009","journal-title":"Int AAAI Conf Weblogs Soc Media"},{"key":"2026091109462186200_bib7","doi-asserted-by":"crossref","first-page":"702","DOI":"10.3324\/haematol.2020.274506","article-title":"Deregulation of JAK2 signaling underlies primary cutaneous CD8+ aggressive epidermotropic cytotoxic T-cell lymphoma","volume":"107","author":"Bastidas Torres","year":"2021","journal-title":"Haematologica"},{"key":"2026091109462186200_bib8","article-title":"Calling Somatic SNVs and Indels with Mutect2","author":"Benjamin","year":"2019","journal-title":"bioRxiv"},{"key":"2026091109462186200_bib9","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.3007988","article-title":"Endometriosis: molecular network analysis of endometriosis reveals a role for c-Jun-regulated macrophage activation","volume":"6","author":"Beste","year":"2014","journal-title":"Sci Transl Med"},{"key":"2026091109462186200_bib10","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1016\/j.ejogrb.2005.02.002","article-title":"Interobserver variability in the diagnosis of minimal and mild endometriosis","volume":"122","author":"Buchweitz","year":"2005","journal-title":"Eur J Obstet Gynecol Reprod Biol"},{"key":"2026091109462186200_bib11","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1007\/s10815-010-9436-1","article-title":"Endometriosis and infertility","volume":"27","author":"Bulletti","year":"2010","journal-title":"J Assist Reprod Genet"},{"key":"2026091109462186200_bib12","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms7118","article-title":"Coexistent ARID1A-PIK3CA mutations promote ovarian clear-cell tumorigenesis through pro-tumorigenic inflammatory cytokine signalling","volume":"6","author":"Chandler","year":"2015","journal-title":"Nat Commun"},{"key":"2026091109462186200_bib13","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1093\/bioinformatics\/bts635","article-title":"STAR: ultrafast universal RNA-seq aligner","volume":"29","author":"Dobin","year":"2013","journal-title":"Bioinformatics"},{"key":"2026091109462186200_bib14","doi-asserted-by":"crossref","first-page":"2389","DOI":"10.1056\/NEJMcp1000274","article-title":"Endometriosis","volume":"362","author":"Giudice","year":"2010","journal-title":"N Engl J Med"},{"key":"2026091109462186200_bib15","doi-asserted-by":"crossref","first-page":"716","DOI":"10.1007\/s00261-009-9587-7","article-title":"Diagnosis of deep infiltrating endometriosis: accuracy of magnetic resonance imaging and transvaginal 3D ultrasonography","volume":"35","author":"Grasso","year":"2010","journal-title":"Abdom Imaging"},{"key":"2026091109462186200_bib16","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/ijgo.13303","article-title":"Prevalence of occult microscopic endometriosis in clinically negative peritoneum during laparoscopy for chronic pelvic pain","volume":"151","author":"Gubbels","year":"2020","journal-title":"Int J Gynaecol Obstet"},{"key":"2026091109462186200_bib17","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/aogs.12026","article-title":"The rASRM score and the Enzian classification for endometriosis: their strengths and weaknesses","volume":"92","author":"Haas","year":"2013","journal-title":"Acta Obstet Gynecol Scand"},{"key":"2026091109462186200_bib18","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1093\/oxfordjournals.humrep.a019270","article-title":"Delay in the diagnosis of endometriosis: a survey of women from the USA and the UK","volume":"11","author":"Hadfield","year":"1996","journal-title":"Hum Reprod"},{"key":"2026091109462186200_bib19","first-page":"151","article-title":"Retrograde menstruation in healthy women and in patients with endometriosis","volume":"64","author":"Halme","year":"1984","journal-title":"Obstet Gynecol"},{"key":"2026091109462186200_bib20","doi-asserted-by":"crossref","first-page":"875","DOI":"10.1126\/science.aaz9761","article-title":"Structure of nucleosome-bound human BAF complex","volume":"367","author":"He","year":"2020","journal-title":"Science"},{"key":"2026091109462186200_bib21","doi-asserted-by":"crossref","first-page":"315","DOI":"10.1093\/humrep\/dew293","article-title":"World endometriosis society consensus on the classification of endometriosis","volume":"32","author":"Johnson","year":"2017","journal-title":"Hum Reprod"},{"key":"2026091109462186200_bib22","doi-asserted-by":"crossref","first-page":"1191","DOI":"10.1016\/j.fertnstert.2017.03.013","article-title":"Peritoneal fluid cytokines related to endometriosis in patients evaluated for infertility","volume":"107","author":"J\u00f8rgensen","year":"2017","journal-title":"Fertil Steril"},{"key":"2026091109462186200_bib23","first-page":"263","article-title":"Correction: heterogeneity of endometriosis lesions requires individualisation of diagnosis and treatment and a different approach to research and evidence based medicine","volume":"11","author":"Koninckx","year":"2020","journal-title":"Facts Views Vis Obgyn"},{"key":"2026091109462186200_bib24","article-title":"Fast gene set enrichment analysis","author":"Korotkevich","year":"2016","journal-title":"bioRxiv"},{"key":"2026091109462186200_bib25","doi-asserted-by":"crossref","first-page":"550","DOI":"10.1186\/s13059-014-0550-8","article-title":"Moderated estimation of fold change and dispersion for RNA-seq data with DESeq2","volume":"15","author":"Love","year":"2014","journal-title":"Genome Biol"},{"key":"2026091109462186200_bib26","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1186\/s13059-016-0974-4","article-title":"The ensembl variant effect predictor","volume":"17","author":"McLaren","year":"2016","journal-title":"Genome Biol"},{"key":"2026091109462186200_bib27","doi-asserted-by":"crossref","DOI":"10.1016\/j.ctrv.2021.102287","article-title":"Targeting ARID1A mutations in cancer","volume":"100","author":"Mullen","year":"2021","journal-title":"Cancer Treat Rev"},{"key":"2026091109462186200_bib28","doi-asserted-by":"crossref","first-page":"312","DOI":"10.3390\/diagnostics14030312","article-title":"Endometriosis and the role of pro-inflammatory and anti-inflammatory cytokines in pathophysiology: a narrative review of the literature","volume":"14","author":"Oal\u0103","year":"2024","journal-title":"Diagnostics"},{"key":"2026091109462186200_bib29","article-title":"Endometriosis lesions are oligoclonal structures derived from the normal endometrium","author":"\u00d3lafsson","year":"2026","journal-title":"bioRxiv"},{"key":"2026091109462186200_bib30","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1002\/cjp2.317","article-title":"KRAS mutations and endometriosis burden of disease","volume":"9","author":"Orr","year":"2023","journal-title":"J Pathol Clin Res"},{"key":"2026091109462186200_bib31","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1038\/nrg2934","article-title":"RNA sequencing: advances, challenges and opportunities","volume":"12","author":"Ozsolak","year":"2011","journal-title":"Nat Rev Genet"},{"key":"2026091109462186200_bib32","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1038\/s41588-023-01323-z","article-title":"The genetic basis of endometriosis and comorbidity with other pain and inflammatory conditions","volume":"55","author":"Rahmioglu","year":"2023","journal-title":"Nat Genet"},{"key":"2026091109462186200_bib33","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1038\/nbt.1754","article-title":"Integrative genomics viewer","volume":"29","author":"Robinson","year":"2011","journal-title":"Nat Biotechnol"},{"key":"2026091109462186200_bib34","doi-asserted-by":"crossref","first-page":"947","DOI":"10.1016\/j.fertnstert.2015.06.035","article-title":"Heritability of endometriosis","volume":"104","author":"Saha","year":"2015","journal-title":"Fertil Steril"},{"key":"2026091109462186200_bib35","first-page":"93","article-title":"Metastatic or embolic endometriosis, due to the menstrual dissemination of endometrial tissue into the venous circulation","volume":"3","author":"Sampson","year":"1927","journal-title":"Am J Pathol"},{"key":"2026091109462186200_bib36","doi-asserted-by":"crossref","DOI":"10.1038\/ncomms15539","article-title":"Meta-analysis identifies five novel loci associated with endometriosis highlighting key genes involved in hormone metabolism","volume":"8","author":"Sapkota","year":"2017","journal-title":"Nat Commun"},{"key":"2026091109462186200_bib37","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/S0889-8545(02)00052-9","article-title":"Pathogenesis of endometriosis","volume":"30","author":"Seli","year":"2003","journal-title":"Obstet Gynecol Clin N Am"},{"key":"2026091109462186200_bib38","doi-asserted-by":"crossref","first-page":"W452","DOI":"10.1093\/nar\/gks539","article-title":"SIFT web server: predicting effects of amino acid substitutions on proteins","volume":"40","author":"Sim","year":"2012","journal-title":"Nucleic Acids Res"},{"key":"2026091109462186200_bib39","doi-asserted-by":"crossref","first-page":"3012","DOI":"10.1093\/bioinformatics\/btw325","article-title":"GenVisR: genomic visualizations in R","volume":"32","author":"Skidmore","year":"2016","journal-title":"Bioinformatics"},{"key":"2026091109462186200_bib40","doi-asserted-by":"crossref","first-page":"15545","DOI":"10.1073\/pnas.0506580102","article-title":"Gene set enrichment analysis: a knowledge-based approach for interpreting genome-wide expression profiles","volume":"102","author":"Subramanian","year":"2005","journal-title":"Proc Natl Acad Sci U S A"},{"key":"2026091109462186200_bib41","doi-asserted-by":"crossref","first-page":"D362","DOI":"10.1093\/nar\/gkw937","article-title":"The STRING database in 2017: quality-controlled protein-protein association networks, made broadly accessible","volume":"45","author":"Szklarczyk","year":"2017","journal-title":"Nucleic Acids Res"},{"key":"2026091109462186200_bib42","doi-asserted-by":"crossref","DOI":"10.1126\/scitranslmed.abd6469","article-title":"Neuropeptide S receptor 1 is a nonhormonal treatment target in endometriosis","volume":"13","author":"Tapmeier","year":"2021","journal-title":"Sci Transl Med"},{"key":"2026091109462186200_bib43","volume-title":"Molecular Graphics System Version 2.0 [Computer software]","author":"The PyMOL"},{"key":"2026091109462186200_bib44","doi-asserted-by":"crossref","first-page":"701","DOI":"10.1016\/S0015-0282(98)00540-8","article-title":"Genetic influences on endometriosis in an Australian twin sample","volume":"71","author":"Treloar","year":"1999","journal-title":"Fertil Steril"},{"key":"2026091109462186200_bib45","doi-asserted-by":"crossref","first-page":"D956","DOI":"10.1093\/nar\/gkx1090","article-title":"LinkedOmics: analyzing multi-omics data within and across 32 cancer types","volume":"46","author":"Vasaikar","year":"2018","journal-title":"Nucleic Acids Res"},{"key":"2026091109462186200_bib46","doi-asserted-by":"crossref","first-page":"1223","DOI":"10.1016\/j.fertnstert.2014.07.1244","article-title":"World endometriosis Research Foundation Endometriosis Phenome and biobanking harmonization project: II. Clinical and covariate phenotype data collection in endometriosis research","volume":"102","author":"Vitonis","year":"2014","journal-title":"Fertil Steril"},{"key":"2026091109462186200_bib47","article-title":"Targeted therapies in gynecological cancers: a comprehensive review of clinical evidence","volume":"5","author":"Wang","year":"2020","journal-title":"Signal Transduct Target Ther"},{"key":"2026091109462186200_bib48","doi-asserted-by":"crossref","DOI":"10.1016\/j.celrep.2020.108366","article-title":"ARID1A mutations promote P300-Dependent endometrial invasion through super-enhancer hyperacetylation","volume":"33","author":"Wilson","year":"2020","journal-title":"Cell Rep"},{"key":"2026091109462186200_bib49","doi-asserted-by":"crossref","first-page":"943","DOI":"10.1038\/s41467-022-28568-2","article-title":"Spatiotemporal dynamics of clonal selection and diversification in normal endometrial epithelium","volume":"13","author":"Yamaguchi","year":"2022","journal-title":"Nat Commun"},{"key":"2026091109462186200_bib50","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1089\/omi.2011.0118","article-title":"ClusterProfiler: an R package for comparing biological themes among gene clusters","volume":"16","author":"Yu","year":"2012","journal-title":"Omi A J Integr Biol"},{"key":"2026091109462186200_bib51","doi-asserted-by":"crossref","first-page":"477","DOI":"10.1097\/GRF.0000000000000291","article-title":"Surgery and endometriosis","volume":"60","author":"Zanelotti","year":"2017","journal-title":"Clin Obstet Gynecol"}],"container-title":["Reproduction and Fertility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-26-0057\/524222\/raf-26-0057.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-26-0057\/524222\/raf-26-0057.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T13:46:35Z","timestamp":1789134395000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article\/7\/3\/RAF260057\/78080\/Transcriptome-differences-in-lesions-by-color-and"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,7,1]]},"references-count":51,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2026,7,1]]}},"URL":"https:\/\/doi.org\/10.1530\/raf-26-0057","relation":{},"ISSN":["2633-8386"],"issn-type":[{"value":"2633-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,7,1]]},"article-number":"RAF260057"}}