{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:49:01Z","timestamp":1792176541517,"version":"4.4.0"},"reference-count":0,"publisher":"Bioscientifica","license":[{"start":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:00:00Z","timestamp":1792108800000},"content-version":"vor","delay-in-days":2,"URL":"https:\/\/creativecommons.org\/licenses\/by-nc\/4.0\/"}],"content-domain":{"domain":["journals.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>There is substantial heterogeneity in the relationship between paternal obesity and pregnancy outcomes following assisted reproduction, possibly related to the presence of obesity-related metabolic complications (e.g. insulin resistance, dyslipidemia). A retrospective study of heterosexual couples over age 18 who underwent metabolic function testing (fasting total cholesterol, triglycerides, high density lipoproteins, low density lipoproteins, insulin, or glucose) within one year of embryo transfer was performed. Couples utilising donor sperm\/oocytes or assisted reproduction in the context of malignancy were excluded. Binomial logistic regression was utilised to examine the relationship between pregnancy outcomes (conception \/ pregnancy loss) and both paternal \u2018metabolic dysfunction\u2019 (any metabolic test exceeding laboratory reference range) and individual metabolic parameters. 363 couples met inclusion criteria and of these, 229 underwent fresh embryo transfers (63.1%) and 134 underwent frozen embryo transfers (36.9%). The overall pregnancy rate was 40.8%. Metabolic dysfunction was present in 58.4% of men and 39.4% of women. Neither paternal BMI nor metabolic dysfunction was associated with likelihood of conception. Metabolic dysfunction was associated with pregnancy loss (Odds ratio [OR] 2.57, 95% Confidence interval [CI]=[1.10, 6.04]). Specifically, serum triglyceride concentration was associated with pregnancy loss both numerically (OR 1.84, 95% CI=[1.09, 3.13]) and categorically (&amp;gt;1.7 mmol\/L: OR 2.88, 95% CI=[1.17, 7.10]), as was a Homeostatic Model Assessment of insulin resistance score &amp;gt;2 (OR 2.70, 95% CI=[1.10, 6.61]). These data support an association between paternal peri-conception metabolic state and pregnancy loss. Further prospective studies are necessary to validate this association and determine if paternal therapeutic interventions can reduce pregnancy loss.<\/jats:p>\n                  <jats:sec>\n                    <jats:title>Lay Summary<\/jats:title>\n                    <jats:p>We studied whether a man\u2019s metabolic health around the time of undergoing assisted reproduction was linked to pregnancy outcomes (conception and pregnancy loss). Men\u2019s weight and metabolic blood tests including cholesterol, triglyceride, insulin and glucose were assessed in 363 couples, of which 41% became pregnant. More than half of all men had at least one abnormal metabolic result. We found that male body mass index and overall metabolic problems were not associated with the likelihood of conceiving, however among couples who conceived, abnormalities in male metabolic blood tests were linked to more than twice the risk of pregnancy loss. High triglyceride levels and insulin resistance were most closely associated with pregnancy loss. Overall, the study suggests that father\u2019s metabolic health may affect the risk of losing a pregnancy, however further research is needed to confirm this.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.1530\/raf-26-0089","type":"journal-article","created":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:10:08Z","timestamp":1792174208000},"update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-13","source":"Crossref","is-referenced-by-count":0,"title":["Paternal metabolic dysfunction and pregnancy loss following assisted reproduction: A cross-sectional study"],"prefix":"10.1530","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7498-8571","authenticated-orcid":true,"given":"Andrew","family":"Peel","sequence":"first","affiliation":[{"name":"Freemasons Centre for Male Health and Wellbeing, Adelaide University 1 , , ,","place":["Adelaide, South Australia, Australia"]},{"name":"Robinson Research Institute, Adelaide University 2 , ,","place":["South Australia, Australia"]},{"name":"Adelaide Health and Medical School, College of Health, Discipline of Reproduction and Development, Adelaide University 3 , ,","place":["South Australia, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rashmi","family":"Baid","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, Adelaide University 2 , ,","place":["South Australia, Australia"]},{"name":"Adelaide Health and Medical School, College of Health, Discipline of Reproduction and Development, Adelaide University 3 , ,","place":["South Australia, Australia"]},{"name":"Embrace Fertility, 1 The Parade 4 , ,","place":["Norwood, South Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew D.","family":"Vincent","sequence":"additional","affiliation":[{"name":"Freemasons Centre for Male Health and Wellbeing, Adelaide University 1 , , ,","place":["Adelaide, South Australia, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Jesudason","sequence":"additional","affiliation":[{"name":"The Queen Elizabeth Hospital 5 , , ,","place":["Woodville, South Australia, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lachlan M.","family":"Moldenhauer","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, Adelaide University 2 , ,","place":["South Australia, Australia"]},{"name":"School of Pharmacy and Biomedical Science, College of Health, Adelaide University 6 , ,","place":["South Australia, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leanne","family":"Pacella-Ince","sequence":"additional","affiliation":[{"name":"Repromed, 180 Fullarton Road 7 , ,","place":["Dulwich, South Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3492-9403","authenticated-orcid":true,"given":"Nicole O.","family":"McPherson","sequence":"additional","affiliation":[{"name":"Freemasons Centre for Male Health and Wellbeing, Adelaide University 1 , , ,","place":["Adelaide, South Australia, Australia"]},{"name":"Robinson Research Institute, Adelaide University 2 , ,","place":["South Australia, Australia"]},{"name":"Adelaide Health and Medical School, College of Health, Discipline of Reproduction and Development, Adelaide University 3 , ,","place":["South Australia, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary","family":"Wittert","sequence":"additional","affiliation":[{"name":"Freemasons Centre for Male Health and Wellbeing, Adelaide University 1 , , ,","place":["Adelaide, South Australia, Australia"]},{"name":"Robinson Research Institute, Adelaide University 2 , ,","place":["South Australia, Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Louise","family":"Hull","sequence":"additional","affiliation":[{"name":"Robinson Research Institute, Adelaide University 2 , ,","place":["South Australia, Australia"]},{"name":"Embrace Fertility, 1 The Parade 4 , ,","place":["Norwood, South Australia"]}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"416","published-online":{"date-parts":[[2026,10,14]]},"container-title":["Reproduction and Fertility"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-26-0089\/526536\/raf-26-0089.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article-pdf\/doi\/10.1530\/RAF-26-0089\/526536\/raf-26-0089.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T18:10:08Z","timestamp":1792174208000},"score":1,"resource":{"primary":{"URL":"https:\/\/journals.bioscientifica.com\/raf\/article\/doi\/10.1530\/RAF-26-0089\/78381\/Paternal-metabolic-dysfunction-and-pregnancy-loss"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2026,10,14]]},"references-count":0,"URL":"https:\/\/doi.org\/10.1530\/raf-26-0089","relation":{},"ISSN":["2633-8386"],"issn-type":[{"value":"2633-8386","type":"electronic"}],"subject":[],"published":{"date-parts":[[2026,10,14]]},"article-number":"RAF-26-0089"}}