{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,8]],"date-time":"2026-07-08T04:00:31Z","timestamp":1783483231316,"version":"3.55.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"1","license":[{"start":{"date-parts":[[2007,1,1]],"date-time":"2007-01-01T00:00:00Z","timestamp":1167609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,1,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>It has been shown that hypothyroidism in the rat produces a prolongation of pregnancy associated with a delay in the fall of circulating progesterone (P4) at term. The aim of the present work is to determine whether the delayed P4 decline in hypothyroid mother rats is due to a retarded induction of P4 degradation to 20\u03b1OH P4 or to a stimulation of its synthesis, and to investigate the possible mechanisms that may underlie the altered luteal function. We determined by RIA the circulating profile of the hormones (TSH, PRL, LH, P4, PGF2\u03b1, and PGE2) involved in luteal regulation at the end of pregnancy and, by semiquantitative RT-PCR, the expression of factors involved in P4 synthesis (CytP450scc, StAR, 3\u03b2HSD, PRLR) and metabolism (20\u03b1HSD, PGF2\u03b1R, iNOS and COX2). Our results show that the delay in P4 decline and parturition is the resultant of retarded luteal regression, caused by a combination of decreases in luteolytic factors, mainly luteal PGF2\u03b1, iNOS mRNA expression and also circulating LH, and increased synthesis or action of luteotrophic factors, such as luteal and circulating PGE2 and circulating PRL. All these changes may be direct causes of the decreased 20\u03b1HSD mRNA and protein (measured by western blot analysis) expression, which in the presence of unchanged expression of the factors involved in P4 synthesis results in elevated luteal and circulating P4 that prolonged pregnancy and also may favor longer survival of the corpus luteum.<\/jats:p>","DOI":"10.1530\/rep-06-0035","type":"journal-article","created":{"date-parts":[[2007,1,23]],"date-time":"2007-01-23T15:15:54Z","timestamp":1169565354000},"page":"197-205","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":25,"title":["Hypothyroidism prolongs corpus luteum function in the pregnant rat"],"prefix":"10.1093","volume":"133","author":[{"given":"Mari\u0301a Bele\u0301n","family":"Hapon","sequence":"first","affiliation":[{"name":"Laboratorio de Reproduccio\u0301n y Lactancia, IMBECU-CONICET, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alicia B","family":"Motta","sequence":"additional","affiliation":[{"name":"Laboratorio de Fisiopatologia Ovarica, CEFYBO-CONICET, Buenos Aires, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcelo","family":"Ezquer","sequence":"additional","affiliation":[{"name":"Laboratorio de Reproduccio\u0301n y Lactancia, IMBECU-CONICET, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melisa","family":"Bonafede","sequence":"additional","affiliation":[{"name":"Laboratorio de Reproduccio\u0301n y Lactancia, IMBECU-CONICET, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Graciela A","family":"Jahn","sequence":"additional","affiliation":[{"name":"Laboratorio de Reproduccio\u0301n y Lactancia, IMBECU-CONICET, Mendoza, Argentina"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,1,1]]},"reference":[{"key":"2026010713150884000_ALBARRACIN-AND-GIBORI-1991","doi-asserted-by":"crossref","first-page":"1821","DOI":"10.1210\/endo-129-4-1821","volume":"129","year":"1991","journal-title":"Endocrinology"},{"key":"2026010713150884000_ALBARRACIN-ETAL-1994","doi-asserted-by":"crossref","first-page":"2453","DOI":"10.1210\/endo.134.6.8194472","volume":"134","year":"1994","journal-title":"Endocrinology"},{"key":"2026010713150884000_AROSH-ETAL-2004","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.1210\/en.2003-1607","volume":"145","year":"2004","journal-title":"Endocrinology"},{"key":"2026010713150884000_AZHAR-ETAL-1981","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/0005-2760(81)90248-4","volume":"665","year":"1981","journal-title":"Biochimica et Biophysica Acta"},{"key":"2026010713150884000_CAI-AND-STOCCO-2005","doi-asserted-by":"crossref","first-page":"5522","DOI":"10.1210\/en.2005-0759","volume":"146","year":"2005","journal-title":"Endocrinology"},{"key":"2026010713150884000_CHOMCZYNSKI-1993","first-page":"536","volume":"532\u20134","year":"1993","journal-title":"Biotechniques"},{"key":"2026010713150884000_CHRISTENSON-AND-DEVOTO-2003","first-page":"1","volume":"10","year":"2003","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026010713150884000_DALLA-VALLE-ETAL-2004","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1016\/j.jsbmb.2003.11.001","volume":"88","year":"2004","journal-title":"Journal of Steroid Biochemistry and Molecular Biology"},{"key":"2026010713150884000_ENGSTROM-2001","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1677\/joe.0.1690033","volume":"169","year":"2001","journal-title":"Journal of Endocrinology"},{"key":"2026010713150884000_FAVRE-YOUNG-ETAL-2000","first-page":"1411","volume":"14","year":"2000","journal-title":"Molecular Endocrinology"},{"key":"2026010713150884000_GIBORI-AND-KEYES-1980","doi-asserted-by":"crossref","first-page":"1584","DOI":"10.1210\/endo-106-5-1584","volume":"106","year":"1980","journal-title":"Endocrinology"},{"key":"2026010713150884000_GOYENECHE-ETAL-2003","doi-asserted-by":"crossref","first-page":"151","DOI":"10.1095\/biolreprod.102.007898","volume":"68","year":"2003","journal-title":"Biology of Reproduction"},{"key":"2026010713150884000_GUO-ETAL-1998","doi-asserted-by":"crossref","first-page":"739","DOI":"10.1095\/biolreprod58.3.739","volume":"58","year":"1998","journal-title":"Biology of Reproduction"},{"key":"2026010713150884000_GWYNNE-AND-STRAUSS-1982","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1210\/edrv-3-3-299","volume":"3","year":"1982","journal-title":"Endocrine Reviews"},{"key":"2026010713150884000_HABENICHT-ETAL-1986","doi-asserted-by":"crossref","first-page":"1344","DOI":"10.1073\/pnas.83.5.1344","volume":"83","year":"1986","journal-title":"PNAS"},{"key":"2026010713150884000_HAPON-ETAL-2003","doi-asserted-by":"crossref","first-page":"371","DOI":"10.1530\/rep.0.1260371","volume":"126","year":"2003","journal-title":"Reproduction"},{"key":"2026010713150884000_HAPON-ETAL-2005","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1194\/jlr.M400325-JLR200","volume":"46","year":"2005","journal-title":"Journal of Lipid Research"},{"key":"2026010713150884000_HORVATH-ETAL-1986","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1095\/biolreprod35.1.44","volume":"35","year":"1986","journal-title":"Biology of Reproduction"},{"key":"2026010713150884000_IWATA-ETAL-2005","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.ejphar.2004.11.002","volume":"507","year":"2005","journal-title":"European Journal of Pharmacology"},{"key":"2026010713150884000_LOWRY-ETAL-1951","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0021-9258(19)52451-6","volume":"193","year":"1951","journal-title":"Journal of Biological Chemistry"},{"key":"2026010713150884000_MARKEWITZ-ETAL-1993","doi-asserted-by":"crossref","first-page":"2138","DOI":"10.1172\/JCI116439","volume":"91","year":"1993","journal-title":"Journal of Clinical Investigation"},{"key":"2026010713150884000_MOTTA-ETAL-1995","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1016\/0952-3278(95)90126-4","volume":"53","year":"1995","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"2026010713150884000_MOTTA-ETAL-1999","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1093\/molehr\/5.11.1011","volume":"5","year":"1999","journal-title":"Molecular Human Reproduction"},{"key":"2026010713150884000_MOTTA-ETAL-2001","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1530\/rep.0.1210631","volume":"121","year":"2001","journal-title":"Reproduction"},{"key":"2026010713150884000_OLOFSSON-ETAL-1996","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/0303-7207(96)03894-4","volume":"123","year":"1996","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010713150884000_OLSON-ETAL-1996","doi-asserted-by":"crossref","first-page":"3531","DOI":"10.1210\/endo.137.8.8754783","volume":"137","year":"1996","journal-title":"Endocrinology"},{"key":"2026010713150884000_ORLICKY-ETAL-1992","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/0952-3278(92)90075-T","volume":"46","year":"1992","journal-title":"Prostaglandins, Leukotrienes, and Essential Fatty Acids"},{"key":"2026010713150884000_PIEKORZ-ETAL-2005","doi-asserted-by":"crossref","first-page":"431","DOI":"10.1210\/me.2004-0302","volume":"19","year":"2005","journal-title":"Molecular Endocrinology"},{"key":"2026010713150884000_RISK-AND-GIBORI-2001","year":"2001"},{"key":"2026010713150884000_ROSATO-ETAL-1992","first-page":"547","volume":"127","year":"1992","journal-title":"Acta Endocrinologica"},{"key":"2026010713150884000_ROSATO-ETAL-1998","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1080\/07435809809135534","volume":"24","year":"1998","journal-title":"Endocrine Research"},{"key":"2026010713150884000_SAWADA-AND-CARLSON-1991","doi-asserted-by":"crossref","first-page":"2992","DOI":"10.1210\/endo-128-6-2992","volume":"128","year":"1991","journal-title":"Endocrinology"},{"key":"2026010713150884000_SNEDECOR-AND-COCHRAN-1967","year":"1967"},{"key":"2026010713150884000_STOCCO-AND-DEIS-1996","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1677\/joe.0.1500423","volume":"150","year":"1996","journal-title":"Journal of Endocrinology"},{"key":"2026010713150884000_STOCCO-AND-DEIS-1998","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1677\/joe.0.1560253","volume":"156","year":"1998","journal-title":"Journal of Endocrinology"},{"key":"2026010713150884000_STOCCO-ETAL-2003","doi-asserted-by":"crossref","first-page":"3301","DOI":"10.1210\/en.2003-0420","volume":"144","year":"2003","journal-title":"Endocrinology"},{"key":"2026010713150884000_SUGINO-ETAL-1997","doi-asserted-by":"crossref","first-page":"4497","DOI":"10.1210\/endo.138.10.5572","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"2026010713150884000_SUGINO-ETAL-1998","doi-asserted-by":"crossref","first-page":"1936","DOI":"10.1210\/endo.139.4.5929","volume":"139","year":"1998","journal-title":"Endocrinology"},{"key":"2026010713150884000_TELLERIA-ETAL-1997","doi-asserted-by":"crossref","first-page":"4812","DOI":"10.1210\/endo.138.11.5479","volume":"138","year":"1997","journal-title":"Endocrinology"},{"key":"2026010713150884000_TELLERIA-ETAL-1999","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1016\/S0039-128X(99)00061-6","volume":"64","year":"1999","journal-title":"Steroids"},{"key":"2026010713150884000_TERRANOVA-AND-GREENWALD-1981","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1677\/joe.0.0900019","volume":"90","year":"1981","journal-title":"Journal of Endocrinology"},{"key":"2026010713150884000_UETA-ETAL-1995","doi-asserted-by":"crossref","first-page":"4182","DOI":"10.1210\/endo.136.10.7545100","volume":"136","year":"1995","journal-title":"Endocrinology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/133\/1\/1330197.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/133\/1\/1330197.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/133\/1\/197\/64609855\/1330197.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/133\/1\/197\/64609855\/1330197.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:29:56Z","timestamp":1767810596000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/133\/1\/197\/8252797"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,1,1]]},"references-count":42,"journal-issue":{"issue":"1","published-print":{"date-parts":[[2007,1,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-06-0035","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,1,1]]},"published":{"date-parts":[[2007,1,1]]}}}