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Male mice missing Fkbp52 are infertile, and this infertility has been ascribed to compromised sensitivity of the anterior prostate, external genitalia, and other accessory sex organs to androgen. Here, we show additional defects contributing to infertility. We found that epididymal Fkbp52\u2212\/\u2212 sperm are sparse often with aberrant morphology, and they have reduced fertilizing capacity. This phenotype, initially observed in null males on a C57BL\/6\/129 background, is also maintained on a CD1 background. Expression studies show that while FKBP52 and androgen receptor are co-expressed in similar cell types in the epididymis, FKBP52 is also present in epididymal sperm flagella. Collectively, our results suggest that reduced number and abnormal morphology contribute to compromised fertilizing capacity of Fkbp52\u2212\/\u2212 sperm. This study is clinically relevant because unraveling the role of immunophilin signaling in male fertility will help identify new targets for male contraceptives and\/or alleviate male infertility.<\/jats:p>","DOI":"10.1530\/rep-06-0180","type":"journal-article","created":{"date-parts":[[2007,2,16]],"date-time":"2007-02-16T11:48:14Z","timestamp":1171626494000},"page":"395-403","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":23,"title":["Deficiency of co-chaperone immunophilin FKBP52 compromises sperm fertilizing capacity"],"prefix":"10.1093","volume":"133","author":[{"given":"Jiyoung","family":"Hong","sequence":"first","affiliation":[{"name":"Departments of Pediatrics"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Tae","family":"Kim","sequence":"additional","affiliation":[{"name":"Departments of 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