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Here, we show that the signal transducer and activator of transcription 1 (Stat1), but not Stat4, was phosphorylated in response to capacitation and the acrosomal reaction (AR). Moreover, Stat1 phosphorylation correlated with changes in its localization: during capacitation, Stat1 moved from the cytoplasm to the theca\/flagellum fraction. During AR, Stat1 phosphorylation increased again. In addition, blocking protein kinase A (PKA) and PKC during capacitation abolished both phosphorylation and migration of Stat1. Our results show tight spatio\u2013temporal rearrangements of Stat1, suggesting that after fertilization Stat1 participates in the first rounds of transcription within the male pronucleus.<\/jats:p>","DOI":"10.1530\/rep-06-0264","type":"journal-article","created":{"date-parts":[[2007,8,20]],"date-time":"2007-08-20T14:18:13Z","timestamp":1187619493000},"page":"425-433","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":10,"title":["In spermatozoa, Stat1 is activated during capacitation and the acrosomal reaction"],"prefix":"10.1093","volume":"134","author":[{"given":"Yadira","family":"Bastia\u0301n","sequence":"first","affiliation":[{"name":"Departamento de Biologi\u0301a Celular, Centro de Investigacio\u0301n y de Estudios Avanzados del Instituto Polite\u0301cnico Nacional (Cinvestav-IPN), Me\u0301xico DF, 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