{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,5]],"date-time":"2026-10-05T12:01:44Z","timestamp":1791201704756,"version":"4.2.0"},"reference-count":50,"publisher":"Oxford University Press (OUP)","issue":"3","license":[{"start":{"date-parts":[[2007,3,1]],"date-time":"2007-03-01T00:00:00Z","timestamp":1172707200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2007,3,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>In the male reproductive organs of mammals, the formation of spermatozoa takes place during two successive phases: differentiation (in the testis) and maturation (in the epididymis). The first phase, spermiogenesis, relies on a unique adherens junction, the apical ectoplasmic specialization linking the epithelial Sertoli cells to immature differentiating spermatids. Vezatin is a transmembrane protein associated with adherens junctions and the actin cytoskeleton in most epithelial cells. We report here the expression profile of vezatin during spermatogenesis. Vezatin is exclusively expressed in haploid germ cells. Immunocytochemical and ultrastructural analyses showed that vezatin intimately coincides, temporally and spatially, with acrosome formation. While vezatin is a transmembrane protein associated with adherens junctions in many epithelial cells, it is not seen at the ectoplasmic specializations, neither at the basal nor at the apical sites, in the seminiferous epithelium. In particular, vezatin does not colocalize with espin and myosin VIIa, two molecular markers of the ectoplasmic specialization. In differentiating spermatids, ultrastructural data indicate that vezatin localizes in the acrosome. In epididymal sperm, vezatin localizes also to the outer acrosomal membrane. Considering its developmental and molecular characteristics, vezatin may be involved in the assembly\/stability of this spermatic membrane.<\/jats:p>","DOI":"10.1530\/rep-06-0271","type":"journal-article","created":{"date-parts":[[2007,3,22]],"date-time":"2007-03-22T09:51:21Z","timestamp":1174557081000},"page":"563-574","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":20,"title":["Vezatin, a ubiquitous protein of adherens cell\u2013cell junctions, is exclusively expressed in germ cells in mouse testis"],"prefix":"10.1093","volume":"133","author":[{"given":"Vincent","family":"Hyenne","sequence":"first","affiliation":[{"name":"Biologie Cellulaire du De\u0301veloppement, UMR 7622, CNRS, Universite\u0301 Pierre et Marie Curie, 9 Quai St Bernard, 75252 Paris cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen C","family":"Harf","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Zoologie, Johannes Gutenberg-Universita\u0308t, Mu\u0308llerweg 6, 55099 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin","family":"Latz","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Zoologie, Johannes Gutenberg-Universita\u0308t, Mu\u0308llerweg 6, 55099 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernard","family":"Maro","sequence":"additional","affiliation":[{"name":"Biologie Cellulaire du De\u0301veloppement, UMR 7622, CNRS, Universite\u0301 Pierre et Marie Curie, 9 Quai St Bernard, 75252 Paris cedex 05, France"},{"name":"Sackler Faculty of Medicine, Tel Aviv University, Ramat Aviv 69978, Israel"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Wolfrum","sequence":"additional","affiliation":[{"name":"Institut fu\u0308r Zoologie, Johannes Gutenberg-Universita\u0308t, Mu\u0308llerweg 6, 55099 Mainz, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie-Christine","family":"Simmler","sequence":"additional","affiliation":[{"name":"Biologie Cellulaire du De\u0301veloppement, UMR 7622, CNRS, Universite\u0301 Pierre et Marie Curie, 9 Quai St Bernard, 75252 Paris cedex 05, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,3,1]]},"reference":[{"key":"2026010713122264600_ABOU-HAILA-AND-TULSIANI-2000","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1006\/abbi.2000.1880","volume":"379","year":"2000","journal-title":"Archives of Biochemistry and Biophysics"},{"key":"2026010713122264600_ADATO-ETAL-2005","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1093\/hmg\/ddi031","volume":"14","year":"2005","journal-title":"Human Molecular Genetics"},{"key":"2026010713122264600_BARTLES-ETAL-1996","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1242\/jcs.109.6.1229","volume":"109","year":"1996","journal-title":"Journal of Cell Science"},{"key":"2026010713122264600_BENOFF-1997","doi-asserted-by":"crossref","first-page":"599","DOI":"10.1093\/molehr\/3.7.599","volume":"3","year":"1997","journal-title":"Molecular Human Reproduction"},{"key":"2026010713122264600_BOEDA-ETAL-2002","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.1093\/emboj\/cdf689","volume":"21","year":"2002","journal-title":"EMBO Journal"},{"key":"2026010713122264600_BOUCHARD-ETAL-2000","doi-asserted-by":"crossref","first-page":"2865","DOI":"10.1128\/MCB.20.8.2865-2873.2000","volume":"20","year":"2000","journal-title":"Molecular and Cellular Biology"},{"key":"2026010713122264600_BURKIN-ETAL-2004","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1002\/mrd.20108","volume":"68","year":"2004","journal-title":"Molecular Reproduction and Development"},{"key":"2026010713122264600_BYERS-ETAL-1994","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1210\/endo.134.2.7507830","volume":"134","year":"1994","journal-title":"Endocrinology"},{"key":"2026010713122264600_CHENG-AND-MRUK-2002","doi-asserted-by":"crossref","first-page":"825","DOI":"10.1152\/physrev.00009.2002","volume":"82","year":"2002","journal-title":"Physiological Reviews"},{"key":"2026010713122264600_CHRISTOVA-ETAL-2004","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.mce.2003.10.075","volume":"216","year":"2004","journal-title":"Molecular and Cellular Endocrinology"},{"key":"2026010713122264600_DANSCHER-1981","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/BF00507822","volume":"71","year":"1981","journal-title":"Histochemistry"},{"key":"2026010713122264600_DEBELLEFEUILLE-ETAL-2003","doi-asserted-by":"crossref","first-page":"5040","DOI":"10.1210\/en.2002-0139","volume":"144","year":"2003","journal-title":"Endocrinology"},{"key":"2026010713122264600_DRENCKHAHN-AND-GROSCHEL-STEWART-1980","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1083\/jcb.86.2.475","volume":"86","year":"1980","journal-title":"Journal of Cell Biology"},{"key":"2026010713122264600_FUJITA-ETAL-2006","doi-asserted-by":"crossref","first-page":"718","DOI":"10.1128\/MCB.26.2.718-726.2006","volume":"26","year":"2006","journal-title":"Molecular and Cellular Biology"},{"key":"2026010713122264600_GLIKI-ETAL-2004","doi-asserted-by":"crossref","first-page":"320","DOI":"10.1038\/nature02877","volume":"431","year":"2004","journal-title":"Nature"},{"key":"2026010713122264600_GOOSSENS-AND-VAN-ROY-2005","doi-asserted-by":"crossref","first-page":"398","DOI":"10.2741\/1537","volume":"10","year":"2005","journal-title":"Frontiers in Bioscience"},{"key":"2026010713122264600_HASSON-ETAL-1997","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1002\/(SICI)1097-0169(1997)37:2<127::AID-CM5>3.0.CO;2-5","volume":"37","year":"1997","journal-title":"Cell Motility and the Cytoskeleton"},{"key":"2026010713122264600_HYENNE-ETAL-2005","doi-asserted-by":"crossref","first-page":"180","DOI":"10.1016\/j.ydbio.2005.09.004","volume":"287","year":"2005","journal-title":"Developmental Biology"},{"key":"2026010713122264600_INAGAKI-ETAL-2005","doi-asserted-by":"crossref","first-page":"1525","DOI":"10.1242\/dev.01697","volume":"132","year":"2005","journal-title":"Development"},{"key":"2026010713122264600_JOHNSTON-ETAL-2005","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1095\/biolreprod.105.039719","volume":"73","year":"2005","journal-title":"Biology of Reproduction"},{"key":"2026010713122264600_KIERSZENBAUM-2000","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1002\/1098-2795(200012)57:4<309::AID-MRD1>3.0.CO;2-W","volume":"57","year":"2000","journal-title":"Molecular Reproduction and Development"},{"key":"2026010713122264600_KOTAJA-ETAL-2004","doi-asserted-by":"crossref","first-page":"249","DOI":"10.1038\/nmeth1204-249","volume":"1","year":"2004","journal-title":"Nature Methods"},{"key":"2026010713122264600_KREMLING-ETAL-1991","doi-asserted-by":"crossref","first-page":"828","DOI":"10.1016\/0888-7543(91)90005-Y","volume":"11","year":"1991","journal-title":"Genomics"},{"key":"2026010713122264600_KUSSEL-ANDERMANN-ETAL-2000","doi-asserted-by":"crossref","first-page":"6020","DOI":"10.1093\/emboj\/19.22.6020","volume":"19","year":"2000","journal-title":"EMBO Journal"},{"key":"2026010713122264600_LEE-ETAL-2003","doi-asserted-by":"crossref","first-page":"489","DOI":"10.1095\/biolreprod.102.005793","volume":"68","year":"2003","journal-title":"Biology of Reproduction"},{"key":"2026010713122264600_LESSARD-1988","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1002\/cm.970100302","volume":"10","year":"1988","journal-title":"Cell Motility and the Cytoskeleton"},{"key":"2026010713122264600_MRUK-AND-CHENG-2004","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1210\/er.2003-0022","volume":"25","year":"2004","journal-title":"Endocrine Reviews"},{"key":"2026010713122264600_MULHOLLAND-ETAL-2001","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1095\/biolreprod64.1.396","volume":"64","year":"2001","journal-title":"Biology of Reproduction"},{"key":"2026010713122264600_NEWTON-ETAL-1993","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/aja.1001970102","volume":"197","year":"1993","journal-title":"Developmental Dynamics"},{"key":"2026010713122264600_ORGEBIN-CRIST-1967","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1038\/216816a0","volume":"216","year":"1967","journal-title":"Nature"},{"key":"2026010713122264600_OZAKI-KURODA-ETAL-2002","doi-asserted-by":"crossref","first-page":"1145","DOI":"10.1016\/S0960-9822(02)00922-3","volume":"12","year":"2002","journal-title":"Current Biology"},{"key":"2026010713122264600_PALOMBI-ETAL-1992","doi-asserted-by":"crossref","first-page":"1173","DOI":"10.1095\/biolreprod47.6.1173","volume":"47","year":"1992","journal-title":"Biology of Reproduction"},{"key":"2026010713122264600_PETERSON-ETAL-1992","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0040-8166(92)90076-J","volume":"24","year":"1992","journal-title":"Tissue Cell"},{"key":"2026010713122264600_RAMALHO-SANTOS-ETAL-2001","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1006\/excr.2000.5119","volume":"267","year":"2001","journal-title":"Experimental Cell Research"},{"key":"2026010713122264600_RAMALHO-SANTOS-ETAL-2002","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1095\/biolreprod67.4.1043","volume":"67","year":"2002","journal-title":"Biology of Reproduction"},{"key":"2026010713122264600_REINERS-ETAL-2005","doi-asserted-by":"crossref","first-page":"3933","DOI":"10.1093\/hmg\/ddi417","volume":"14","year":"2005","journal-title":"Human Molecular Genetics"},{"key":"2026010713122264600_REINERS-ETAL-2006","doi-asserted-by":"crossref","first-page":"97","DOI":"10.1016\/j.exer.2005.11.010","volume":"83","year":"2006","journal-title":"Experimental Eye Research"},{"key":"2026010713122264600_RUSSELL-ETAL-1990","year":"1990"},{"key":"2026010713122264600_SALANOVA-ETAL-1995","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1095\/biolreprod52.1.79","volume":"52","year":"1995","journal-title":"Biology of Reproduction"},{"key":"2026010713122264600_SENFTEN-ETAL-2006","doi-asserted-by":"crossref","first-page":"2060","DOI":"10.1523\/JNEUROSCI.4251-05.2006","volume":"26","year":"2006","journal-title":"Journal of Neuroscience"},{"key":"2026010713122264600_SULLIVAN-ETAL-2005","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcmd.2005.03.005","volume":"35","year":"2005","journal-title":"Blood Cells, Molecules and Diseases"},{"key":"2026010713122264600_TOSHIMORI-1998","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1007\/s004410051110","volume":"293","year":"1998","journal-title":"Cell and Tissue Research"},{"key":"2026010713122264600_TOSHIMORI-AND-ITO-2003","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1679\/aohc.66.383","volume":"66","year":"2003","journal-title":"Archives of Histology and Cytology"},{"key":"2026010713122264600_WEST-AND-WILLISON-1996","first-page":"315","volume":"70","year":"1996","journal-title":"European Journal of Cell Biology"},{"key":"2026010713122264600_WOLFRUM-1992","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0248-4900(92)90441-3","volume":"76","year":"1992","journal-title":"Biologie Cellulaire"},{"key":"2026010713122264600_WOLFRUM-AND-SALISBURY-1998","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1006\/excr.1998.4038","volume":"242","year":"1998","journal-title":"Experimental Cell Research"},{"key":"2026010713122264600_WOLFRUM-ETAL-1998","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/(SICI)1097-0169(1998)40:3<261::AID-CM5>3.0.CO;2-G","volume":"40","year":"1998","journal-title":"Cell Motility and the Cytoskeleton"},{"key":"2026010713122264600_YOSHINAGA-AND-TOSHIMORI-2003","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1002\/jemt.10315","volume":"61","year":"2003","journal-title":"Microscopy Research and Technique"},{"key":"2026010713122264600_YOSHINAGA-ETAL-2001","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1007\/s004410000308","volume":"303","year":"2001","journal-title":"Cell and Tissue Research"},{"key":"2026010713122264600_ZHOU-ETAL-2004","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1038\/ncb1127","volume":"6","year":"2004","journal-title":"Nature Cell Biology"}],"container-title":["Reproduction"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/rep.bioscientifica.com\/view\/journals\/rep\/133\/3\/1330563.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/rep.bioscientifica.com\/downloadpdf\/journals\/rep\/133\/3\/1330563.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/133\/3\/563\/64609002\/1330563.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/133\/3\/563\/64609002\/1330563.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:24:13Z","timestamp":1767810253000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/133\/3\/563\/8252554"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2007,3,1]]},"references-count":50,"journal-issue":{"issue":"3","published-print":{"date-parts":[[2007,3,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-06-0271","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2007,3,1]]},"published":{"date-parts":[[2007,3,1]]}}}