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Apart from the pivotal action of Sry, many other genes are known to be involved in sex determination and subsequent differentiation. Much is still unknown regarding the regulatory hierarchy governing these events and many more sex differentiation genes are yet to be discovered. In this study, we investigated the expression of Tmem184a, a novel gene encoding a protein of unknown function, but with predicted kinase activity, during mouse embryogenesis. We show that Tmem184a is expressed at high levels in the developing testis from 11.5 dpc, a time of active proliferation and differentiation. Tmem184a expression is further shown to be expressed exclusively within the Sertoli cells of the developing testis cords, suggesting that it may mediate sex-specific signaling events during Sertoli cell differentiation.<\/jats:p>","DOI":"10.1530\/rep-06-0379","type":"journal-article","created":{"date-parts":[[2007,7,6]],"date-time":"2007-07-06T14:52:55Z","timestamp":1183733575000},"page":"983-989","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":16,"title":["Sex-specific expression of a novel gene\n                    <i>Tmem184a<\/i>\n                    during mouse testis differentiation"],"prefix":"10.1093","volume":"133","author":[{"given":"Terje","family":"Svingen","sequence":"first","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Annemiek","family":"Beverdam","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pascal","family":"Bernard","sequence":"additional","affiliation":[{"name":"Human Molecular Genetics Laboratory, Prince Henry\u2019s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"McClive","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children\u2019s Hospital, Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent R","family":"Harley","sequence":"additional","affiliation":[{"name":"Human Molecular Genetics Laboratory, Prince Henry\u2019s Institute of Medical Research, Monash Medical Centre, Clayton, Victoria 3168, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew H","family":"Sinclair","sequence":"additional","affiliation":[{"name":"Murdoch Children\u2019s Research Institute and Department of Paediatrics, University of Melbourne, Royal Children\u2019s Hospital, Parkville, Victoria 3052, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Koopman","sequence":"additional","affiliation":[{"name":"Institute for Molecular Bioscience, The University of Queensland, Brisbane, Queensland 4072, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2007,5,1]]},"reference":[{"key":"2026010713125978500_ALBRECHT-AND-EICHER-2001","doi-asserted-by":"crossref","first-page":"92","DOI":"10.1006\/dbio.2001.0438","volume":"240","year":"2001","journal-title":"Developmental Biology"},{"key":"2026010713125978500_BARRIONUEVO-ETAL-2006","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1095\/biolreprod.105.045930","volume":"74","year":"2006","journal-title":"Biology of Reproduction"},{"key":"2026010713125978500_BEVERDAM-AND-KOOPMAN-2006","doi-asserted-by":"crossref","first-page":"417","DOI":"10.1093\/hmg\/ddi463","volume":"15","year":"2006","journal-title":"Human Molecular Genetics"},{"key":"2026010713125978500_BRENNAN-AND-CAPEL-2004","first-page":"509","volume":"5","year":"2004","journal-title":"Nature Reviews. 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