{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T23:53:28Z","timestamp":1791158008439,"version":"4.1.0"},"reference-count":42,"publisher":"Oxford University Press (OUP)","issue":"2","license":[{"start":{"date-parts":[[2008,2,1]],"date-time":"2008-02-01T00:00:00Z","timestamp":1201824000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["rep.bioscientifica.com"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,2,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Sexual differentiation of the germ cells follows gonadal differentiation, which is determined by the presence or the absence of the Y-chromosome. Consequently, oogenesis and spermatogenesis take place in the germ cells with XX and XY sex chromosomal compositions respectively. It is unclear how sexual dimorphic regulation of meiosis is associated with the sex-chromosomal composition. In the present study, we examined the behavior of the sex chromosomes in the oocytes of the B6.YTIR sex-reversed female mouse, in comparison with XO and XX females. As the sex chromosomes fail to pair in both XY and XO oocytes during meiotic prophase, we anticipated that the pairing failure may lead to excessive oocyte loss. However, the total number of germ cells, identified by immunolabeling of germ cell nuclear antigen 1 (GCNA1), did not differ between XY and XX ovaries or XO and XX ovaries up to the day of delivery. The progression of meiotic prophase, assessed by immunolabeling of synaptonemal complex components, was also similar between the two genotypes of ovaries. These observations suggest that the failure in sex-chromosome pairing is not sufficient to cause oocyte loss. On the other hand, labeling of phosphorylated histone \u03b3H2AX, known to be associated with asynapsis and transcriptional repression, was seen over the X-chromosome but not over the Y-chromosome in the majority of XY oocytes at the pachytene stage. For comparison, \u03b3H2AX labeling was seen only in the minority of XX oocytes at the same stage. We speculate that the transcriptional activity of sex chromosomes in the XY oocyte may be incompatible with ooplasmic maturation.<\/jats:p>","DOI":"10.1530\/rep-07-0383","type":"journal-article","created":{"date-parts":[[2008,1,31]],"date-time":"2008-01-31T14:03:12Z","timestamp":1201788192000},"page":"241-252","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-1","source":"Crossref","is-referenced-by-count":28,"title":["The behavior of the X- and Y-chromosomes in the oocyte during meiotic prophase in the B6.YTIR sex-reversed mouse ovary"],"prefix":"10.1093","volume":"135","author":[{"given":"Michelle","family":"Alton","sequence":"first","affiliation":[{"name":"Department of Biology McGill University, Montreal, Quebec H3A 1B1, Canada and 2Urology Research Laboratory Department of Surgery, Royal Victoria Hospital, McGill University, 687 Pine Avenues West, Montreal, Quebec H3A 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mau Pan","family":"Lau","sequence":"additional","affiliation":[{"name":"Department of Biology McGill University, Montreal, Quebec H3A 1B1, Canada and 2Urology Research Laboratory Department of Surgery, Royal Victoria Hospital, McGill University, 687 Pine Avenues West, Montreal, Quebec H3A 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michele","family":"Villemure","sequence":"additional","affiliation":[{"name":"Department of Biology McGill University, Montreal, Quebec H3A 1B1, Canada and 2Urology Research Laboratory Department of Surgery, Royal Victoria Hospital, McGill University, 687 Pine Avenues West, Montreal, Quebec H3A 1A1, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teruko","family":"Taketo","sequence":"additional","affiliation":[{"name":"Department of Biology McGill University, Montreal, Quebec H3A 1B1, Canada and 2Urology Research Laboratory Department of Surgery, Royal Victoria Hospital, McGill University, 687 Pine Avenues 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