{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T03:13:45Z","timestamp":1787022825950,"version":"build-2736575974"},"reference-count":52,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Preterm labour (PTL) is the most important cause of neonatal morbidity and mortality. While some causes have been identified, the mechanisms involved remain elusive. This study investigates whether term labour (TL) is an appropriate model for PTL by examining pro-labour gene expression, using quantitative rtPCR, and protein synthesis, using Western analysis, in preterm and term myometrial samples obtained from the upper and lower uterine segments before and after the onset of labour. In the lower segment, the levels of prostaglandin H synthase type-2 (PGHS-2), interleukin-1\u03b2 (IL-1\u03b2), IL-6 and IL-8 mRNA expression were significantly higher in TL compared with PTL samples. Compared with non-labour controls, the expression of IL-1\u03b2 and IL-8 mRNA was increased in both PTL and TL samples and the expression of PGHS-2 and IL-6 mRNA was increased in TL samples only. In the upper segment, there were no differences between PTL and TL samples and the mRNA expression of PGHS-2 and IL-1\u03b2 was increased in TL compared with term no labour samples. No effect of PTL or TL was seen on either oxytocin receptor or connexin-43 mRNA expression or protein levels. The multiple regression analysis and studies in primary cultures of uterine myocytes suggest that the inflammatory cytokines, IL-1\u03b2 and tumour necrosis factor-\u03b1, are the most important regulators of PGHS-2 and IL-8. Our data show that preterm and term labouring myometrium are significantly different and that the most marked labour-induced changes in gene expression are in the lower segment. These changes may occur in response to the release of inflammatory cytokines by the labour-associated inflammatory infiltration.<\/jats:p>","DOI":"10.1530\/rep-07-0461","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T20:47:28Z","timestamp":1206564448000},"page":"569-579","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":86,"title":["Pro-labour myometrial gene expression: are preterm labour and term labour the same?"],"prefix":"10.1093","volume":"135","author":[{"given":"Mark","family":"Tattersall","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neelam","family":"Engineer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shirin","family":"Khanjani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suren R","family":"Sooranna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Victoria H","family":"Roberts","sequence":"additional","affiliation":[{"name":"Imperial College Parturition Research Group Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK 1Department of Obstetrics and Gynecology University of Cincinnati College of Medicine, 21 Bethesda Avenue, Cincinnati, Ohio 45267, USA 2Department of Obstetrics and Gynaecology Southwest Hospital, Third Military Medical University, Chonqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peta L","family":"Grigsby","sequence":"additional","affiliation":[{"name":"Imperial College Parturition Research Group Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK 1Department of Obstetrics and Gynecology University of Cincinnati College of Medicine, 21 Bethesda Avenue, Cincinnati, Ohio 45267, USA 2Department of Obstetrics and Gynaecology Southwest Hospital, Third Military Medical University, Chonqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiqing","family":"Liang","sequence":"additional","affiliation":[{"name":"Imperial College Parturition Research Group Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK 1Department of Obstetrics and Gynecology University of Cincinnati College of Medicine, 21 Bethesda Avenue, Cincinnati, Ohio 45267, USA 2Department of Obstetrics and Gynaecology Southwest Hospital, Third Military Medical University, Chonqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Les","family":"Myatt","sequence":"additional","affiliation":[{"name":"Imperial College Parturition Research Group Department of Maternal Fetal Medicine, Imperial College School of Medicine, Chelsea and Westminster Hospital, 369 Fulham Road, London SW10 9NH, UK 1Department of Obstetrics and Gynecology University of Cincinnati College of Medicine, 21 Bethesda Avenue, Cincinnati, Ohio 45267, USA 2Department of Obstetrics and Gynaecology Southwest Hospital, Third Military Medical University, Chonqing 400038, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mark R","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2026010713143956800_bib1","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1093\/molehr\/6.12.1141","article-title":"Application of a functional genomics approach to identify differentially expressed genes in human myometrium during pregnancy and labour","volume":"6","author":"Aguan","year":"2000","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib2","doi-asserted-by":"crossref","first-page":"581","DOI":"10.1093\/molehr\/7.6.581","article-title":"Human labour is associated with nuclear factor-\u03baB activity which mediates cyclo-oxygenase-2 expression and is involved with the \u2018functional progesterone withdrawal\u2019","volume":"7","author":"Allport","year":"2001","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib3","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1093\/molehr\/gal093","article-title":"Expression and regulation of prostaglandin E synthase isoforms in human myometrium with labour","volume":"13","author":"Astle","year":"2007","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib4","doi-asserted-by":"crossref","first-page":"3392","DOI":"10.1210\/jc.2002-021212","article-title":"Paracrine oxytocin and estradiol demonstrate a spatial increase in human intrauterine tissues with labor","volume":"88","author":"Blanks","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010713143956800_bib5","doi-asserted-by":"crossref","first-page":"345","DOI":"10.1111\/j.1471-0528.1985.tb01107.x","article-title":"Maternal plasma prostaglandin E2 metabolite levels during human pregnancy and parturition","volume":"92","author":"Brennecke","year":"1985","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"2026010713143956800_bib6","doi-asserted-by":"crossref","first-page":"e169","DOI":"10.1371\/journal.pmed.0030169","article-title":"Labor-associated gene expression in the human uterine fundus, lower segment, and cervix","volume":"3","author":"Bukowski","year":"2006","journal-title":"PLoS Medicine"},{"key":"2026010713143956800_bib7","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.1210\/jcem.87.6.8439","article-title":"Human myometrial genes are differentially expressed in labor: a suppression subtractive hybridization study","volume":"87","author":"Chan","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010713143956800_bib8","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1095\/biolreprod.102.013763","article-title":"A functional genomic study to identify differential gene expression in the preterm and term human myometrium","volume":"68","author":"Charpigny","year":"2003","journal-title":"Biology of Reproduction"},{"key":"2026010713143956800_bib9","doi-asserted-by":"crossref","first-page":"788","DOI":"10.1016\/S0002-9378(94)70284-5","article-title":"Expression of the gap junction protein connexin-43 is increased in the human myometrium toward term and with the onset of labor","volume":"170","author":"Chow","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib10","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1186\/1477-7827-4-24","article-title":"Prolonged labour associated with lower expression of syndecan 3 and connexin 43 in human uterine tissue","volume":"4","author":"Cluff","year":"2006","journal-title":"Reproductive Biology and Endocrinology"},{"key":"2026010713143956800_bib11","doi-asserted-by":"crossref","first-page":"9518","DOI":"10.1073\/pnas.1633616100","article-title":"A decline in the levels of progesterone receptor coactivators in the pregnant uterus at term may antagonize progesterone receptor function and contribute to the initiation of parturition","volume":"100","author":"Condon","year":"2003","journal-title":"PNAS"},{"key":"2026010713143956800_bib12","doi-asserted-by":"crossref","first-page":"1718","DOI":"10.1210\/endo.141.5.7474","article-title":"Expression of myometrial activation and stimulation genes in a mouse model of preterm labor: myometrial activation, stimulation, and preterm labor","volume":"141","author":"Cook","year":"2000","journal-title":"Endocrinology"},{"key":"2026010713143956800_bib13","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1242\/jcs.02892","article-title":"Ablation of connexin43 in uterine smooth muscle cells of the mouse causes delayed parturition","volume":"119","author":"Doring","year":"2006","journal-title":"Journal of Cell Science"},{"key":"2026010713143956800_bib14","doi-asserted-by":"crossref","first-page":"272","DOI":"10.1111\/j.8755-8920.2000.430505.x","article-title":"Interleukin 8 expression in human myometrium: changes in relation to labor onset and with gestational age","volume":"43","author":"Elliott","year":"2000","journal-title":"American Journal of Reproductive Immunology"},{"key":"2026010713143956800_bib15","doi-asserted-by":"crossref","first-page":"404","DOI":"10.1016\/j.ajog.2004.12.021","article-title":"The use of cDNA microarray to identify differentially expressed labor-associated genes within the human myometrium during labor","volume":"193","author":"Esplin","year":"2005","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib16","doi-asserted-by":"crossref","first-page":"742","DOI":"10.1210\/endo-113-2-742","article-title":"Correlation between oxytocin receptor concentration and responsiveness to oxytocin in pregnant rat myometrium: effects of ovarian steroids","volume":"113","author":"Fuchs","year":"1983","journal-title":"Endocrinology"},{"key":"2026010713143956800_bib17","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1016\/0002-9378(84)90677-X","article-title":"Oxytocin receptors in the human uterus during pregnancy and parturition","volume":"150","author":"Fuchs","year":"1984","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib18","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1095\/biolreprod.104.032979","article-title":"Human myometrial gene expression before and during parturition","volume":"72","author":"Havelock","year":"2005","journal-title":"Biology of Reproduction"},{"key":"2026010713143956800_bib19","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1177\/107155760200900104","article-title":"Production of oxytocin receptor and cytokines in primary uterine smooth muscle cells cultivated under inflammatory conditions","volume":"9","author":"Helmer","year":"2002","journal-title":"Journal of the Society of Gynecological Investigation"},{"key":"2026010713143956800_bib20","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.1016\/j.ajog.2005.11.004","article-title":"Signaling via the type I IL-1 and TNF receptors is necessary for bacterially induced preterm labor in a murine model","volume":"194","author":"Hirsch","year":"2006","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib21","doi-asserted-by":"crossref","first-page":"841","DOI":"10.1053\/hupa.2000.8449","article-title":"Intrauterine inflammation at term: a histopathologic study","volume":"31","author":"Keski-Nisula","year":"2000","journal-title":"Human Pathology"},{"key":"2026010713143956800_bib22","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1093\/humrep\/14.2.560","article-title":"Interleukin-8 potentiates the effect of interleukin-1-induced uterine contractions","volume":"14","author":"Khatun","year":"1999","journal-title":"Human Reproduction"},{"key":"2026010713143956800_bib23","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1210\/endo.137.2.8593830","article-title":"Expression of oxytocin receptor in human pregnant myometrium","volume":"137","author":"Kimura","year":"1996","journal-title":"Endocrinology"},{"key":"2026010713143956800_bib24","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1093\/molehr\/gah112","article-title":"Mechanical stretch of human uterine smooth muscle cells increases IL-8 mRNA expression and peptide synthesis","volume":"10","author":"Loudon","year":"2004","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib25","doi-asserted-by":"crossref","first-page":"2380","DOI":"10.1210\/endo.132.6.8389279","article-title":"Increased expression of connexin-43 in the rat myometrium during labor is associated with an increase in the plasma estrogen:progesterone ratio","volume":"132","author":"Lye","year":"1993","journal-title":"Endocrinology"},{"key":"2026010713143956800_bib26","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/S0301-2115(01)00606-6","article-title":"Messenger ribonucleic acid levels of interleukin-1 beta, interleukin-6 and interleukin-8 in the lower uterine segment increased significantly at final cervical dilatation during term parturition, while those of tumor necrosis factor alpha remained unchanged","volume":"102","author":"Maul","year":"2002","journal-title":"European Journal of Obstetrics, Gynecology, and Reproductive Biology"},{"key":"2026010713143956800_bib27","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1677\/joe.0.1410195","article-title":"ACTH-induced preterm labour in the ewe is associated with increased mRNA and protein levels of myometrial gap junction protein, connexin-43","volume":"141","author":"McNutt","year":"1994","journal-title":"Journal of Endocrinology"},{"key":"2026010713143956800_bib28","doi-asserted-by":"crossref","first-page":"2924","DOI":"10.1210\/jcem.87.6.8609","article-title":"Progesterone withdrawal and estrogen activation in human parturition are coordinated by progesterone receptor A expression in the myometrium","volume":"87","author":"Mesiano","year":"2002","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010713143956800_bib29","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1093\/molehr\/gag001","article-title":"Leukocyte density and pro-inflammatory cytokine expression in human fetal membranes, decidua, cervix and myometrium before and during labour at term","volume":"9","author":"Osman","year":"2003","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib30","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1111\/j.1447-0756.1995.tb01092.x","article-title":"Biochemical events in cervical ripening dilatation during pregnancy and parturition","volume":"21","author":"Osmers","year":"1995","journal-title":"Journal of Obstetrics and Gynaecology"},{"key":"2026010713143956800_bib31","doi-asserted-by":"crossref","first-page":"5398","DOI":"10.1210\/endo.138.12.5624","article-title":"Expression of connexin-43 and connexin-26 in the rat myometrium during pregnancy and labor is differentially regulated by mechanical and hormonal signals","volume":"138","author":"Ou","year":"1997","journal-title":"Endocrinology"},{"key":"2026010713143956800_bib32","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1530\/jrf.0.1200091","article-title":"Loss of myometrial oxytocin receptors during oxytocin-induced and oxytocin-augmented labour","volume":"120","author":"Phaneuf","year":"2000","journal-title":"Journal of Reproduction and Fertility"},{"key":"2026010713143956800_bib33","doi-asserted-by":"crossref","first-page":"504","DOI":"10.1067\/mob.2002.121108","article-title":"Connexin 43 expression in normal versus dysfunctional labor","volume":"186","author":"Pierce","year":"2002","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib34","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1093\/humrep\/12.1.159","article-title":"Quantitative immunoconfocal analysis of human myometrial gap junction connexin43 in relation to steroid hormone concentrations at term labour","volume":"12","author":"Rezapour","year":"1997","journal-title":"Human Reproduction"},{"key":"2026010713143956800_bib35","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1083\/jcb.110.2.269","article-title":"Modulation of gap junction transcript and protein expression during pregnancy in the rat","volume":"110","author":"Risek","year":"1990","journal-title":"Journal of Cell Biology"},{"key":"2026010713143956800_bib36","doi-asserted-by":"crossref","first-page":"1613","DOI":"10.1016\/0002-9378(94)90412-X","article-title":"Amniotic fluid prostanoid concentrations increase early during the course of spontaneous labor at term","volume":"171","author":"Romero","year":"1994","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib37","doi-asserted-by":"crossref","first-page":"1578","DOI":"10.1016\/j.ajog.2006.06.072","article-title":"Preterm labor is induced by intraamniotic infusions of interleukin-1\u03b2 and tumor necrosis factor-alpha but not by interleukin-6 or interleukin-8 in a nonhuman primate model","volume":"195","author":"Sadowsky","year":"2006","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib38","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.1210\/endo.142.4.8107","article-title":"Transcriptional regulation of oxytocin receptor by interleukin-1\u03b2 and interleukin-6","volume":"142","author":"Schmid","year":"2001","journal-title":"Endocrinology"},{"key":"2026010713143956800_bib39","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1111\/j.1471-0528.1981.tb00997.x","article-title":"A comparison of plasma prostaglandin levels in term and preterm labour","volume":"88","author":"Sellers","year":"1981","journal-title":"British Journal of Obstetrics and Gynaecology"},{"key":"2026010713143956800_bib40","doi-asserted-by":"crossref","first-page":"519","DOI":"10.1016\/0002-9378(85)90281-9","article-title":"Changes in the synthesis and metabolism of prostaglandins by human fetal membranes and decidua at labor","volume":"151","author":"Skinner","year":"1985","journal-title":"American Journal of Obstetrics and Gynecology"},{"key":"2026010713143956800_bib41","doi-asserted-by":"crossref","first-page":"1313","DOI":"10.1126\/science.221972","article-title":"Oxytocin receptors: triggers for parturition and lactation?","volume":"204","author":"Soloff","year":"1979","journal-title":"Science"},{"key":"2026010713143956800_bib42","doi-asserted-by":"crossref","first-page":"619","DOI":"10.1093\/molehr\/gal067","article-title":"Interleukin-1-induced NF-\u03baB recruitment to the oxytocin receptor gene inhibits RNA polymerase II-promoter interactions in cultured human myometrial cells","volume":"12","author":"Soloff","year":"2006","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib43","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/molehr\/gah021","article-title":"Mechanical stretch activates type 2 cyclooxygenase via activator protein-1 transcription factor in human myometrial cells","volume":"10","author":"Sooranna","year":"2004","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib44","doi-asserted-by":"crossref","first-page":"3517","DOI":"10.1210\/jc.2004-1390","article-title":"The mitogen-activated protein kinase dependent expression of prostaglandin H synthase-2 and interleukin-8 messenger ribonucleic acid by myometrial cells: the differential effect of stretch and interleukin-1\u03b2","volume":"90","author":"Sooranna","year":"2005","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010713143956800_bib45","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1093\/molehr\/gal061","article-title":"Myometrial prostaglandin E2 synthetic enzyme mRNA expression: spatial and temporal variations with pregnancy and labour","volume":"12","author":"Sooranna","year":"2006","journal-title":"Molecular Human Reproduction"},{"key":"2026010713143956800_bib46","first-page":"1705","article-title":"The differential expression of myometrial connexin-43, cyclooxygenase-1 and -2, and Gs alpha proteins in the upper and lower segments of the human uterus during pregnancy and labor","volume":"84","author":"Sparey","year":"1999","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010713143956800_bib47","first-page":"E634","article-title":"ERK2 mediates oxytocin-stimulated PGE2 synthesis","volume":"274","author":"Strakova","year":"1998","journal-title":"American Journal of Physiology"},{"key":"2026010713143956800_bib48","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1210\/jc.2004-0277","article-title":"Mechanical stretch up-regulates the human oxytocin receptor in primary human uterine myocytes","volume":"90","author":"Terzidou","year":"2005","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010713143956800_bib49","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1093\/humrep\/14.1.229","article-title":"Leukocytes infiltrate the myometrium during human parturition: further evidence that labour is an inflammatory process","volume":"14","author":"Thomson","year":"1999","journal-title":"Human Reproduction"},{"key":"2026010713143956800_bib50","first-page":"427","article-title":"Human parturition","volume":"47","author":"Turnbull","year":"1977","journal-title":"Ciba Foundation Symposia"},{"key":"2026010713143956800_bib51","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1677\/joe.0.1610143","article-title":"Oxytocin receptor expression in human term and preterm gestational tissues prior to and following the onset of labour","volume":"161","author":"Wathes","year":"1999","journal-title":"Journal of Endocrinology"},{"key":"2026010713143956800_bib52","doi-asserted-by":"crossref","first-page":"1096","DOI":"10.1093\/humrep\/14.4.1096","article-title":"Parturition at term: parallel increases in interleukin-8 and proteinase concentrations and neutrophil count in the lower uterine segment","volume":"14","author":"Winkler","year":"1999","journal-title":"Human Reproduction"}],"container-title":["REPRODUCTION"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/135\/4\/569\/64611287\/569.pdf","content-type":"application\/pdf","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/academic.oup.com\/reproduction\/article-pdf\/135\/4\/569\/64611287\/569.pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,1,7]],"date-time":"2026-01-07T18:28:45Z","timestamp":1767810525000},"score":1,"resource":{"primary":{"URL":"https:\/\/academic.oup.com\/reproduction\/article\/135\/4\/569\/8252755"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2008,4,1]]},"references-count":52,"journal-issue":{"issue":"4","published-print":{"date-parts":[[2008,4,1]]}},"URL":"https:\/\/doi.org\/10.1530\/rep-07-0461","relation":{},"ISSN":["1470-1626","1741-7899"],"issn-type":[{"value":"1470-1626","type":"print"},{"value":"1741-7899","type":"electronic"}],"subject":[],"published-other":{"date-parts":[[2008,4,1]]},"published":{"date-parts":[[2008,4,1]]}}}