{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,14]],"date-time":"2026-07-14T23:44:02Z","timestamp":1784072642125,"version":"3.55.0"},"reference-count":68,"publisher":"Oxford University Press (OUP)","issue":"4","license":[{"start":{"date-parts":[[2008,4,1]],"date-time":"2008-04-01T00:00:00Z","timestamp":1207008000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/academic.oup.com\/pages\/standard-publication-reuse-rights"}],"content-domain":{"domain":["reproduction-online.org"],"crossmark-restriction":true},"short-container-title":[],"published-print":{"date-parts":[[2008,4,1]]},"abstract":"<jats:title>Abstract<\/jats:title>\n                  <jats:p>Prostaglandin F2\u03b1 (PGF2\u03b1) released from the uterus causes alterations in luteal blood flow, reduces progesterone secretion, and induces luteolysis in the bovine corpus luteum (CL). We have recently discovered that luteal blood flow in the periphery of the mature CL acutely increases coincidently with pulsatile increases in a metabolite of PGF2\u03b1 (PGFM). In this study, we characterized changes in regional luteal blood flow together with regional alterations in endothelial nitric oxide synthase (eNOS) expression during spontaneous luteolysis and in response to PGF2\u03b1. Smooth muscle actin-positive blood vessels larger than 20\u200a\u03bcm were observed mainly in the periphery of mature CL. PGF2\u03b1 receptor was localized to luteal cells and large blood vessels in the periphery of mid-CL. PGF2\u03b1 acutely stimulated eNOS expression in the periphery but not in the center of mature CL. Injection of the NO donor S-nitroso-N-acetylpenicillamine into CL induced an acute increase in luteal blood flow and shortened the estrous cycle. In contrast, injection of the NOS inhibitor l-NAME into CL completely suppressed the acute increase in luteal blood flow induced by PGF2\u03b1 and delayed the onset of luteolysis. In conclusion, PGF2\u03b1 has a site-restricted action depending on not only luteal phase but also the region in the CL. PGF2\u03b1 stimulates eNOS expression, vasodilation of blood vessels, and increased luteal blood flow in periphery of mature CL. Furthermore, the increased blood flow is mediated by NO, suggesting that the acute increase in peripheral blood flow to CL is one of the first physiological indicators of NO action in response to PGF2\u03b1.<\/jats:p>","DOI":"10.1530\/rep-07-0496","type":"journal-article","created":{"date-parts":[[2008,3,26]],"date-time":"2008-03-26T20:47:28Z","timestamp":1206564448000},"page":"527-539","update-policy":"https:\/\/doi.org\/10.1530\/rep\/crossmarkpolicy","source":"Crossref","is-referenced-by-count":53,"title":["Prostaglandin F2\u03b1 increases endothelial nitric oxide synthase in the periphery of the bovine corpus luteum: the possible regulation of blood flow at an early stage of luteolysis"],"prefix":"10.1093","volume":"135","author":[{"given":"Koumei","family":"Shirasuna","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sho","family":"Watanabe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takayuki","family":"Asahi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Missaka P B","family":"Wijayagunawardane","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan 1Department of Animal Science University of Peradeniya, Peradeniya 20400, Sri Lanka 2Department of Obstetrics and Gynecology Olson Center for Women's Health, University Nebraska Medical Center and Veterans Affairs Medical Center, Omaha, Nebraska 68198, USA, Departments of 3Clinical Veterinary Science 4Basic Veterinary Sciences Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kiemi","family":"Sasahara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chao","family":"Jiang","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan 1Department of Animal Science University of Peradeniya, Peradeniya 20400, Sri Lanka 2Department of Obstetrics and Gynecology Olson Center for Women's Health, University Nebraska Medical Center and Veterans Affairs Medical Center, Omaha, Nebraska 68198, USA, Departments of 3Clinical Veterinary Science 4Basic Veterinary Sciences Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motozumi","family":"Matsui","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan 1Department of Animal Science University of Peradeniya, Peradeniya 20400, Sri Lanka 2Department of Obstetrics and Gynecology Olson Center for Women's Health, University Nebraska Medical Center and Veterans Affairs Medical Center, Omaha, Nebraska 68198, USA, Departments of 3Clinical Veterinary Science 4Basic Veterinary Sciences Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motoki","family":"Sasaki","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan 1Department of Animal Science University of Peradeniya, Peradeniya 20400, Sri Lanka 2Department of Obstetrics and Gynecology Olson Center for Women's Health, University Nebraska Medical Center and Veterans Affairs Medical Center, Omaha, Nebraska 68198, USA, Departments of 3Clinical Veterinary Science 4Basic Veterinary Sciences Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Takashi","family":"Shimizu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John S","family":"Davis","sequence":"additional","affiliation":[{"name":"Graduate School of Animal and Food Hygiene Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan 1Department of Animal Science University of Peradeniya, Peradeniya 20400, Sri Lanka 2Department of Obstetrics and Gynecology Olson Center for Women's Health, University Nebraska Medical Center and Veterans Affairs Medical Center, Omaha, Nebraska 68198, USA, Departments of 3Clinical Veterinary Science 4Basic Veterinary Sciences Obihiro University of Agriculture and Veterinary Medicine, Obihiro 080-8555, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akio","family":"Miyamoto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,4,1]]},"reference":[{"key":"2026010713135215000_bib1","doi-asserted-by":"crossref","first-page":"1253","DOI":"10.1095\/biolreprod63.5.1253","article-title":"Periovulatory changes in the local release of vasoactive peptides, prostaglandin F2\u03b1, and steroid hormones from bovine mature follicles in vivo","volume":"63","author":"Acosta","year":"2000","journal-title":"Biology of Reproduction"},{"key":"2026010713135215000_bib2","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1095\/biolreprod66.3.651","article-title":"Local changes in blood flow within the early and 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