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Developmental changes in the expression of the ligand for KISS1R, kisspeptin, support its critical role in the pubertal transition. In addition, kisspeptin, a powerful stimulus of GNRH-induced gonadotropin secretion and may modulate both positive and negative sex steroid feedback effects at the hypothalamic level. Genetic studies in humans have revealed both loss-of-function and gain-of-function mutations in patients with idiopathic hypogonadotropic hypogonadism and precocious puberty respectively. This review examines the kisspeptin\/KISS1R pathway in the reproductive system.<\/jats:p>","DOI":"10.1530\/rep-08-0091","type":"journal-article","created":{"date-parts":[[2008,5,30]],"date-time":"2008-05-30T20:44:55Z","timestamp":1212180295000},"page":"295-301","update-policy":"https:\/\/doi.org\/10.1530\/crossmarkpolicy-11","source":"Crossref","is-referenced-by-count":39,"title":["Kisspeptin and KISS1R: a critical pathway in the reproductive system"],"prefix":"10.1093","volume":"136","author":[{"given":"Elena","family":"Gianetti","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephanie","family":"Seminara","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"286","published-online":{"date-parts":[[2008,9,1]]},"reference":[{"key":"2026010712465056100_bib1","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1262\/jrd.18146","article-title":"Involvement of anteroventral periventricular metastin\/kisspeptin neurons in estrogen positive feedback action on luteinizing hormone release in female rats","volume":"53","author":"Adachi","year":"2007","journal-title":"Journal of Reproduction and Development"},{"key":"2026010712465056100_bib2","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1126\/science.100883","article-title":"Hypophysial responses to continuous and intermittent delivery of hypopthalamic gonadotropin-releasing hormone","volume":"202","author":"Belchetz","year":"1978","journal-title":"Science"},{"key":"2026010712465056100_bib3","first-page":"1580","article-title":"Prevalence, phenotypic spectrum, and modes of inheritance of gonadotropin-releasing hormone receptor mutations in idiopathic hypogonadotropic hypogonadism","volume":"86","author":"Beranova","year":"2001","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712465056100_bib4","doi-asserted-by":"crossref","first-page":"913","DOI":"10.1159\/000126324","article-title":"Short-term starvation decreases POMC mRNA but does not alter GnRH mRNA in rat brain","volume":"56","author":"Bergendahl","year":"1992","journal-title":"Neuroendocrinology"},{"key":"2026010712465056100_bib5","doi-asserted-by":"crossref","first-page":"1319","DOI":"10.1242\/jcs.00971","article-title":"Kisspeptin-10, a KiSS-1\/metastin-derived decapeptide, is a physiological invasion inhibitor of primary human trophoblasts","volume":"117","author":"Bilban","year":"2004","journal-title":"Journal of Cell Science"},{"key":"2026010712465056100_bib6","doi-asserted-by":"crossref","first-page":"2730","DOI":"10.1210\/jc.2002-021948","article-title":"Autosomal recessive idiopathic hypogonadotropic hypogonadism: genetic analysis excludes mutations in the gonadotropin-releasing hormone (GnRH) and GnRH receptor genes","volume":"88","author":"Bo-Abbas","year":"2003","journal-title":"Journal of Clinical Endocrinology and Metabolism"},{"key":"2026010712465056100_bib7","doi-asserted-by":"crossref","first-page":"5258","DOI":"10.1210\/en.2007-0554","article-title":"Kisspeptin synchronizes preovulatory surges in cyclical ewes and causes ovulation in seasonally acyclic ewes","volume":"148","author":"Caraty","year":"2007","journal-title":"Endocrinology"},{"key":"2026010712465056100_bib8","doi-asserted-by":"crossref","first-page":"3917","DOI":"10.1210\/en.2005-0337","article-title":"Changes in hypothalamic KiSS-1 system and restoration of pubertal activation of the reproductive axis by kisspeptin in undernutrition","volume":"146","author":"Castellano","year":"2005","journal-title":"Endocrinology"},{"key":"2026010712465056100_bib9","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.2337\/db05-1584","article-title":"Expression of hypothalamic KiSS-1 system and rescue of defective gonadotropic responses by kisspeptin in streptozotocin-induced diabetic male rats","volume":"55","author":"Castellano","year":"2006","journal-title":"Diabetes"},{"issue":"Supplement 1","key":"2026010712465056100_bib10","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1530\/eje.1.02235","article-title":"Coding sequence analysis of GNRHR and GPR54 in patients with congenital and adult-onset forms of hypogonadotropic hypogonadism","volume":"155","author":"Cerrato","year":"2006","journal-title":"European Journal of Endocrinology"},{"key":"2026010712465056100_bib11","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1385\/ENDO:8:1:37","article-title":"Reproductive endocrinopathy in acute streptozotocin-induced diabetic male rats. 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